Evaluation of Serum Amyloid A in Early Diagnosis of Spontaneous Bacterial Peritonitis
Study Details
Study Description
Brief Summary
One of the most common and serious complications in decompensated cirrhotic patients (DCPs) is bacterial infection.The most common infections in DCPs are cases of spontaneous bacterial peritonitis (SBP), which account for 40% 70% of cases, followed by urinary tract infections, pneumonia and cellulitis.
Serum amyloid A (SAA) and C-reactive protein (CRP) are acute-phase proteins predominantly produced and secreted by hepatocytes. Other cells including lymphocytes, monocytes, and macrophages can also produce these proteins. The induction of SAA and CRP synthesis is triggered by a number of cytokines, chiefly IL-6, which is released from a variety of cell types, but mainly from macrophages and monocytes at inflammatory sites
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Increased serum CRP and SAA levels have been found in a number of disorders, including bacterial infections, malignancies tissue injuries and tissue rejection. Therefore, new studies of early diagnosis, prevention and treatment are needed to improve clinical outcomes.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Serum amyloid A level in SBP serum amyloid A level |
Other: serum amyloid A level
serum amyloid A level (SAA)
|
| Serum amyloid A level in cirrhosis Serum amyloid A level |
Other: serum amyloid A level
serum amyloid A level (SAA)
|
Outcome Measures
Primary Outcome Measures
- Number of patients with elevated serum amyloid A [6months]
Eligibility Criteria
Criteria
Inclusion Criteria:
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• Decompansated cirrhosis with ascites, defined by a combination of any of the following:
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Laboratory findings
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Endoscopic results
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Ultrasound
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Histology
Exclusion Criteria:
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Creatinine>1.5 mg/dl
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Other infection e.grespiratory,UTI ,gastrointestinal and skin infection.
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Hepatocellular carcinoma
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Other extrahepatic malignancy e.g ; chest
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Any significant psychiatric illness or other medical comorbidity.
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Any degenerative diseases.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Sherief Abd-Elsalam | Cairo | Egypt |
Sponsors and Collaborators
- Tanta University
Investigators
- Principal Investigator: Rehab Badawi, Consultant, Hepatology and gastroenterology dept.-Tanta
- Study Chair: Sherief Abd-Elsalam, Consultant, Division of Gastroenterology and Hepatology- Tanta
- Study Chair: Walaa Elkhalawany, Consultant, Hepatology and gastroenterology dept.-Tanta
- Study Chair: Reham Elkhouly, Consultant, Hepatology and gastroenterology dept.-Tanta
- Study Chair: Mona Watany, Consultant, clinical pathology dept.-Tanta
- Study Chair: Samah Soliman, Consultant, Hepatology and gastroenterology dept.-Tanta
- Study Chair: Mai Khalaf, resident, hepatology dept.-Tanta
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- sbp diagnosis