Serum Kisspeptin Levels in Infertile Women
Study Details
Study Description
Brief Summary
The study population is comprise of 90 women those age varies between 18-38 year-old. The first group will comprise of 30 women with polycystic ovaries or anovulatory cycles, the second group will comprise of 30 women with diagnosis of unexplained infertility and the third group will comprise of 30 women those partners with male subfertility. A 2 cc blood sample for Kisspeptin analysis will be drawn from the antecubital vein from each participants. The patients will receive 50 mg clomiphene citrate at the fifth day of the menstrual period and follicular development will be measured with serial ultrasound follow up.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
The study population is comprise of 90 women those age varies between 18-38 year-old with wish of baby for at least one year despite of unprotected sexual intercourse, patent tubes confirmed in hysterosalpingography , follicle stimulating hormone levels <12 IU. The first group will comprise of 30 women with polycystic ovaries in ultrasound examination or anovulatory cycles, the second group will comprise of 30 women with diagnosis of unexplained infertility, normal menstrual periods and without known male factor infertility and the third group will comprise of 30 women those partners with sperm count between 5x106 -15x106 /mL, type A + type B motility <%32 and Kruger morphology <4%. A 2 cc blood sample for Kisspeptin analysis will be drawn from the antecubital vein from each participants and centrifuged and sera will be kept in -80 C till recruitment has been completed. Kisspeptin, E2, Progesterone, anti-mullerian hormone levels will be measured with ELISA method. The patients will receive 50 mg clomiphene citrate at the fifth day of the menstrual period and follicular development will be measured with serial ultrasound follow up.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Group 1 The first group will comprise of 30 women with polycystic ovaries in ultrasound examination or anovulatory cycles. |
Other: Blood sample
Serum analysis
Other Names:
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| Group 2 The second group will comprise of 30 women with diagnosis of unexplained infertility, normal menstrual periods and without known male factor infertility. |
Other: Blood sample
Serum analysis
Other Names:
|
| Group 3 The third group will comprise of 30 women those partners with sperm count between 5x106 -15x106 /mL, type A + type B motility <%32 and Kruger morphology <4%. |
Other: Blood sample
Serum analysis
Other Names:
|
Outcome Measures
Primary Outcome Measures
- The relation of Kisspeptin levels and female infertility [1 year]
Secondary Outcome Measures
- The relation of Kisspeptin levels and follicular growth [1 year]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
ages varying between 18-38 year-old with wish of baby for at least one year despite of unprotected sexual intercourse
-
patent tubes confirmed in hysterosalpingography
-
follicle stimulating hormone levels <12 IU
-
no other relevant medical history
Exclusion Criteria:
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ages other than 18-38 year-old with wish of baby for least than one year despite of unprotected sexual intercourse
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obstructed tubes confirmed in hysterosalpingography
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follicle stimulating hormone levels >12 IU
-
history thyroid disease
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increased prolactin levels
-
history of chemo/radiation therapy
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Bakirkoy Dr Sadi Konuk Teaching and Research Hospital, Department of Obstetrics and Gynecology | Istanbul | Turkey | 34250 |
Sponsors and Collaborators
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Investigators
- Principal Investigator: Cihan Kaya, M.D., Bakırkoy Dr. Sadi Konuk Training and Research Hospital
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
- 2016/165