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The Interaction Between Severe Acute Respiratory Distress Syndrome Viral Proteins and Monocytes

Sponsor
National Taiwan University Hospital (Other)
Overall Status
Withdrawn
CT.gov ID
NCT00172263
Collaborator
(none)
0
Enrollment
1
Location

Study Details

Study Description

Brief Summary

Severe acute respiratory syndrome (SARS) is a new threat to public health since November, 2002. The SARS is highly contagious and is believed to be transmitted by person-to-person through droplet and direct contact. The patients present with fever, chills, cough, myalgia, dyspnea, and diarrhea. The symptoms aggravate in the second week and nearly 40% of the patients develop respiratory failure that requires assisted ventilation. The mortality rate is reported as 6.5%-7%.

After several months, the world scientists found the etiology to be a new coronavirus not belonging to the previous coronavirus group I, II and III. The new virus is called SARS associated coronavirus (SARS-CoV).

Although the high morbidity and mortality of SARS occurred in adults, there was rare mortality reported in the children. The report from Hong Kong pointed out that the symptoms of SARS in younger children were milder and the clinical course was not as aggressive as in adults. Therefore, the aim of the project is to design the experiment to see the differences of immunological responses to SARS-CoV protein in healthy younger children, teenagers, and adults. The investigators hope that the result could explain the reason for milder disease in younger children and the immunological pathogenesis of SARS.

Condition or Disease Intervention/Treatment Phase
  • Procedure: blood sampling
 N/A

Study Design

Study Type:
Interventional
Actual Enrollment :
0 participants
Allocation:
Non-Randomized
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    N/A and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • Healthy adults, children and cord blood

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Li-Chieh Wang, MD Taipei Taiwan China 100

    Sponsors and Collaborators

    • National Taiwan University Hospital

    Investigators

    • Principal Investigator: Li-Chieh Wang, MD, National Taiwan University Hospital

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00172263
    Other Study ID Numbers:
    • 9261701054
    First Posted:
    Sep 15, 2005
    Last Update Posted:
    Dec 10, 2012
    Last Verified:
    Dec 1, 2012
    Keywords provided by , ,
    Immunology
    Additional relevant MeSH terms:
    Severe Acute Respiratory Syndrome
    Syndrome

    Study Results

    No Results Posted as of Dec 10, 2012