Sex or no Sex: That is the Question.
Study Details
Study Description
Brief Summary
This study aims to evaluate the impact of sexual intercourse and orgasm in the 72 hrs following embryo transfer of blastocysts on the clinical pregnancy rate.
An impact on sexual activity and a decrease in the frequency of intercourse has been observed in infertile couples. In couples who undergo assisted reproductive technology (ART), sexual relations have an additional component that can condition them, such as the fear of influencing the outcome of the cycle.
The usual practice in ART cycles has evolved towards a preference for blastocyst-stage embryo transfer, both in fresh in vitro fertilization (IVF) cycles and in frozen embryo transfer (FET) cycles.
The investigators consider it important to elucidate whether coital intercourse after embryo transfer (ET) has an impact on the clinical pregnancy rate after the transfer of blastocyst-stage embryos.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
It is proposed to carry out an observational, prospective study, in which women with a heterosexual sexual relationship are included, who carry out an embryo transfer, in a FET cycle in the Dexeus Woman Reproduction Medicine Service and who agree to participate in the same.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Sex Intercourse women with a heterosexual sexual relationship after embryo transfer |
Other: Sex intercourse
A heterosexual sexual relationship
|
| Non sex intercourse women without a heterosexual sexual relationship after embryo transfer |
Outcome Measures
Primary Outcome Measures
- Clinical pregnancy rate [6-7 weeks after transfer]
Clinical pregnancy rate measured by ultrasound with the presence of a positive fetal heartbeat
Secondary Outcome Measures
- Miscarriage rate [Until 13 weeks after embryo transfer procedure]
The loss of a pregnancy during the first 13 weeks of pregnancy
- Live birth rate [Until 42 weeks after embryo transfer]
Number of live birth after embryo transfer
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Women with a heterosexual sexual relationship
-
That they carry out an embryo transfer, in a FET cycle
Exclusion Criteria:
- Exclusion criteria are not foreseen
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Hospital Universitario Quiron Dexeus | Barcelona | Spain | 08028 |
Sponsors and Collaborators
- Fundación Santiago Dexeus Font
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
- Ata B, Abou-Setta AM, Seyhan A, Buckett W. Application of seminal plasma to female genital tract prior to embryo transfer in assisted reproductive technology cycles (IVF, ICSI and frozen embryo transfer). Cochrane Database Syst Rev. 2018 Feb 28;2:CD011809. doi: 10.1002/14651858.CD011809.pub2. Review.
- Fanchin R, Harmas A, Benaoudia F, Lundkvist U, Olivennes F, Frydman R. Microbial flora of the cervix assessed at the time of embryo transfer adversely affects in vitro fertilization outcome. Fertil Steril. 1998 Nov;70(5):866-70.
- Fanchin R, Righini C, Olivennes F, Taylor S, de Ziegler D, Frydman R. Uterine contractions at the time of embryo transfer alter pregnancy rates after in-vitro fertilization. Hum Reprod. 1998 Jul;13(7):1968-74.
- Robertson SA, Prins JR, Sharkey DJ, Moldenhauer LM. Seminal fluid and the generation of regulatory T cells for embryo implantation. Am J Reprod Immunol. 2013 Apr;69(4):315-30. doi: 10.1111/aji.12107. Review.
- Stanford JB, Hansen JL, Willis SK, Hu N, Thomas A. Peri-implantation intercourse does not lower fecundability. Hum Reprod. 2020 Sep 1;35(9):2107-2112. doi: 10.1093/humrep/deaa156.
- Tao P, Coates R, Maycock B. The impact of infertility on sexuality: A literature review. Australas Med J. 2011;4(11):620-7. doi: 10.4066/AMJ.20111055. Epub 2011 Nov 30.
- Tremellen KP, Valbuena D, Landeras J, Ballesteros A, Martinez J, Mendoza S, Norman RJ, Robertson SA, Simón C. The effect of intercourse on pregnancy rates during assisted human reproduction. Hum Reprod. 2000 Dec;15(12):2653-8.
- FSD-SEX-2021-05