REAL 8: A Research Study to Compare Somapacitan Once a Week With Norditropin® Once a Day in Children Who Need Help to Grow
Study Details
Study Description
Brief Summary
The study compares two medicines for treatment of children born small and who stay small, or with Turner Syndrome, Noonan Syndrome, or idiopathic short stature. The purpose of the study is to see how well treatment with somapacitan works compared to treatment with Norditropin®. Somapacitan is a new medicine, and Norditropin® is a medicine doctors can already prescribe in some countries. The study will last for about 3 years. The participants will either get somapacitan once a week for 3 years or Norditropin® once a day for 1 year followed by somapacitan once a week for 2 years. Which treatment the participants get is decided by chance.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
| Phase 3 |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Somapacitan Participants will receive Somapacitan for 156 weeks |
Drug: Somapacitan
Somapacitan will be administered subcutaneously (s.c.) once weekly using PDS290 pen-injector.
|
| Active Comparator: Norditropin® Participants will receive Norditropin® for 52 weeks (main phase) and Somapacitan for 104 weeks (extension phase) |
Drug: Norditropin®
Norditropin® will be administered s.c. once daily using FlexPro® pen-injector.
|
Outcome Measures
Primary Outcome Measures
- Height velocity reported separately for small for gestational age (SGA), Turner syndrome (TS), Noonan syndrome (NS) and idiopathic short stature (ISS) [From baseline (week 0) to visit 7 (week 52)]
Measured in centimeter per year (cm/year)
Secondary Outcome Measures
- Change in Height standard deviation scores (SDS) reported separately for SGA, TS, NS and ISS [From baseline (week 0) to visit 7 (week 52)]
Measured in SDS ranging from -10 to +10
- Change in Height Velocity SDS reported separately for SGA, TS, NS and ISS [From baseline (week 0) to visit 7 (week 52)]
Measured in SDS ranging from -10 to +10
- Change in bone age reported separately for SGA, TS and NS [From baseline (week 0) to visit 7 (week 52)]
Measured in years
- Change in bone age for ISS [From screening (visit 1) to visit 7 (week 52)]
Measured in years
- Change in insulin-like growth factor 1 (IGF-1) SDS reported separately for SGA, TS, NA and ISS [From baseline (week 0) to visit 7 (week 52).]
Measured in SDS ranging from -10 to +10
- Change in insulin-like growth factor binding protein-3 (IGFBP-3) SDS reported separately for SGA, TS, NA and ISS [From baseline (week 0) to visit 7 (week 52).]
Measured in SDS ranging from -10 to +10
- Change in fasting plasma glucose reported separately for SGA, TS, NS and ISS [From screening (visit 1) to visit 7 (week 52)]
Measured in millimoles per litre (mmol/L)
- Change in homeostatic model assessment-B (HOMA-B) reported separately for SGA, TS, NS and ISS [From screening (visit 1) to visit 7 (week 52)]
Measured in percentage (%)
- Change in homeostatic model assessment of insulin resistance (HOMAIR) reported separately for SGA, TS, NS and ISS [From screening (visit 1) to visit 7 (week 52)]
Measured in %
- Change in glycated haemoglobin (HbA1c) reported separately for SGA, TS, NS and ISS [From screening (visit 1) to visit 7 (week 52)]
Measured in percentage of HbA1c
- Weekly average somapacitan concentration (Cavg) based on population PK analysis [From visit 3 (week 4) to visit 7 (week 52)]
Measured in nanograms per milliliter (ng/mL)
- Change in fasting plasma glucose reported separately for SGA, TS, NS and ISS [From screening (visit 1) to visit 15 (week 156)]
Measured in mmol/L
- Change in homeostatic model assessment-B (HOMA-B) reported separately for SGA, TS, NS and ISS [From screening (visit 1) to visit 15 (week 156)]
Measured in %
- Change in homeostatic model assessment of insulin resistance (HOMA-IR) reported separately for SGA, TS, NS and ISS [From screening (visit 1) to visit 15 (week 156)]
Measured in %
- Change in glycated haemoglobin (HbA1c) reported separately for SGA, TS, NS and ISS [From screening (visit 1) to visit 15 (week 156)]
Measured in percentage of HbA1c
Eligibility Criteria
Criteria
Inclusion criteria
-
Informed consent of parent or legally acceptable representative of participant and child assent, as age appropriate must be obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study.
-
No prior exposure to growth promoting therapy, including but not limited to growth hormone, IGF-I and ghrelin analogues.
Applicable to children with SGA:
-
Born small for gestational age (birth length below -2 SDS OR birth weight below -2 SDS OR both) (according to national standards).
-
Prepubertal children:
-
Boys:
-
Age above or equal to 2 years and 26 weeks and below 11.0 years at screening.
-
Testis volume below 4 mL
- Girls:
-
Age above or equal to 2 years and 26 weeks and below 10.0 years at screening.
-
Tanner stage 1 for breast development: No palpable glandular breast tissue)
-
Impaired height defined as at least 2.5 standard deviations below the mean height for chronological age and sex at screening according to the standards of Centers for Disease Control and Prevention.
-
Impaired height velocity defined as annualised height velocity below the 50th percentile for chronological age and sex according to the standards of Prader calculated over a time span of minimum 6 months and maximum 18 months prior to screening.
-
Body Mass Index below the 95th percentile according to Centers for Disease Control and Prevention, Body Mass Index-for-age growth charts.
Applicable to girls with TS:
-
Confirmed diagnosis of TS by 30-cell (or more) lymphocyte chromosomal analysis.*
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Prepubertal girls:
-
Age above or equal to 2 years and 26 weeks and below 10.0 years at screening.
-
Tanner stage 1 for breast development: No palpable glandular breast tissue)
-
Impaired height defined as at least 2.0 standard deviations below the mean height for chronological age and sex at screening according to the standards of Centers for Disease Control and Prevention.
-
Historical height measured 6-18 months prior to screening.
-
Thyroid hormone replacement therapy should be adequate and stable for at least 90 days prior to randomisation, if applicable.
Applicable to children with NS:
-
Clinical diagnosis of NS according to van der Burgt score list
-
Prepubertal children:
-
Boys:
-
Age above or equal to 2 years and 26 weeks and below 11.0 years at screening.
-
Testis volume below 4 mL
- Girls:
-
Age above or equal to 2 years and 26 weeks and below 10.0 years at screening.
-
Tanner stage 1 for breast development: No palpable glandular breast tissue)
-
Impaired height defined as at least 2.0 standard deviations below the mean height for chronological age and sex at screening according to the standards of Centers for Disease Control and Prevention.
-
Historical height measured 6-18 months prior to screening.
-
Thyroid hormone replacement therapy should be adequate and stable for at least 90 days prior to randomisation, if applicable.
Applicable to children with ISS:
-
Prepubertal children:
-
Boys:
-
Age above or equal to 2 years and 26 weeks and below 11.0 years at screening.
-
Testis volume below 4 mL
- Girls:
-
Age above or equal to 2 years and 26 weeks and below 10.0 years at screening.
-
Tanner stage 1 for breast development: No palpable glandular breast tissue)
-
Bone age:
-
Boys:
-
Bone age below or equal to 12 years.
-
Bone age not delayed or advanced more than 2 years compared to chronological age.
- Girls:
-
Bone age below or equal to 11 years.
-
Bone age not delayed or advanced more than 2 years compared to chronological age.
-
Impaired height defined as at least 2.5 standard deviations below the mean height for chronological age and sex at screening according to the standards of Centers for Disease Control and Prevention.
-
Historical height measured 6-18 months prior to screening.
-
One normal GH secretion (GH peak above 7 ng/mL) during GH stimulation test performed within 18 months prior to screening or if such a test is not available for children with ISS, a test should be performed as part of the screening assessments and the result must be available prior to randomisation.
- If a 30-cell count is not available for patients with TS, a test should be done, and results must be available prior to randomisation.
Exclusion criteria
-
Known or suspected hypersensitivity to study intervention(s) or related products.
-
Previous randomisation into same sub-study in this study.
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Receipt of any investigational medicinal product within 3 months before screening or participation in another clinical study at the time of randomisation.
-
Children with suspected or confirmed growth hormone deficiency according to local practice.
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Children diagnosed with diabetes mellitus or screening values from the central laboratory of
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fasting plasma glucose above or equal to 126 mg/dL (7.0 mmol/L) or
-
HbA1c above or equal to 6.5%.
-
Current inflammatory diseases requiring systemic corticosteroid treatment for longer than 2 consecutive weeks within the last 3 months prior to screening.
-
Children requiring inhaled glucocorticoid therapy at a dose greater than 400 µg/day of inhaled budesonide or equivalent (i.e., 250 µg/day for fluticasone propionate) for longer than 4 consecutive weeks within the last 12 months prior to screening.
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Concomitant administration of other treatments that may have an effect on growth, e.g., but not limited to methylphenidate for treatment of attention deficit hyperactivity disorder (ADHD).
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Diagnosis of attention deficit hyperactivity disorder (ADHD).
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History or known presence of malignancy including intracranial tumours.
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History or known presence of active Hepatitis B or Hepatitis C (exceptions to this exclusion criterion is the presence of antibodies due to vaccination against Hepatitis B).
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Any disorder, which in the investigator's opinion, might jeopardise participant's safety or compliance with the protocol.
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The participant or the parent/legally acceptable representative is likely to be non-compliant in respect to study conduct, as judged by the investigator.
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Current treatment with sex hormones or aromatase inhibitors.
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Any known or suspected clinically significant abnormality likely to affect growth or the ability to evaluate growth with standing height measurements, such as, but not limited to:
-
Known family history of skeletal dysplasia.
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Significant spinal abnormalities including but not limited to scoliosis, kyphosis and spina bifida variants.
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Any other disorder/condition that can cause short stature such as, but not limited to, psychosocial deprivation, nutritional disorders, chronic systemic illness and chronic renal disease.
Applicable to children with SGA:
-
TS (including mosaicism).
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NS.
-
Hormonal deficiencies.
-
Children who are small due to malnutrition defined as -2 standard deviations according to standards. 0¬-5 years: weight for height on World Health Organisation Multicentre Growth Reference Study 2006. Above 5 years: World Health Organisation 2007 Body Mass Index.
-
Known chromosomal aneuploidy or significant gene mutations causing medical 'syndromes' with short stature, including but not limited to Laron syndrome, Prader-Willi syndrome, Russell-Silver Syndrome, skeletal dysplasias, abnormal SHOX gene analysis or absence of GH receptors.
Applicable to children with TS:
-
NS.
-
Mosaicism below 10%.
-
TS with Y-chromosome mosaicism where gonadectomy has not been performed.
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NYHA class II or above or requiring medication for any heart condition.
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Coeliac disease where participant is not stable on gluten free diet for the previous 12 months prior to screening.
Applicable to children with NS:
-
TS (including mosaicism).
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Noonan-related disorders: Noonan syndrome with multiple lentigines (formerly called 'LEOPARD' syndrome), Noonan syndrome with loose anagen hair, cardiofaciocutaneous syndrome (CFC), Costello syndrome, neurofibromatosis type 1 (NF1) and Legius syndrome. Molecular genetic testing results must be available prior to randomisation to exclude these.
-
Coeliac disease where participant is not stable on gluten free diet for the previous 12 months prior to screening.
Applicable to children with ISS:
-
TS (including mosaicism).
-
NS.
-
Hormonal deficiencies.
-
Born small for gestational age (defined as birth length below -2 SDS OR birth weight below -2 SDS OR both) (according to national standards).
-
Known chromosomal aneuploidy or significant gene mutations causing medical 'syndromes' with short stature, including but not limited to Laron syndrome, Prader-Willi syndrome, Russell-Silver Syndrome, skeletal dysplasias, abnormal SHOX gene analysis or absence of GH receptors.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Novo Nordisk A/S
Investigators
- Study Director: Clinical Transparency dept. 2834, Novo Nordisk A/S
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NN8640-4467
- 2021-005607-13
- U1111-1270-0862