ENGAGE-HU: Shared-Decision Making for Hydroxyurea

Sponsor

Children's Hospital Medical Center, Cincinnati (Other)

Overall Status

Recruiting

CT.gov ID

NCT03442114

Collaborator

(none)

260

Enrollment

Locations

Arms

43.6

Anticipated Duration (Months)

23.6

Patients Per Site

0.5

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The goal of the study is to understand how best to help parents of young children with sickle cell disease and their clinicians have a shared discussion about hydroxyurea (one that takes into account medical evidence and parent values and preferences). The study will compare two methods to help clinicians facilitate this-a clinician pocket guide and a clinician hydroxyurea shared decision making toolkit-in a group of parents of children ages 0-5 with sickle cell disease. The investigators hope that both methods lead to parents reaching a high-quality, well-informed decision. In addition, the team hopes to demonstrate that parents who experience a shared decision will have lower anxiety and decisional uncertainty. The researchers also expect these parents to be more likely to choose hydroxyurea and that their children will have less pain, fewer hospitalizations, better developmental outcomes, and higher quality of life. The project team hopes to show that the toolkit method is easy for clinicians to use and gives parents the support needed to make an informed decision.

Condition or Disease	Intervention/Treatment	Phase
Sickle Cell Anemia Children, Only	Behavioral: Hydroxyurea SDM Toolkit Behavioral: Clinician Pocket Guide	N/A

Detailed Description

Sickle cell disease (SCD) is a genetic blood disorder that places children at risk for serious medical complications, early morbidity and mortality, and high healthcare utilization. In the U.S., SCD primarily affects African-American and Latino children. Hydroxyurea is one of the only disease-modifying treatment for this devastating and life-threatening disease. National Evidence-Based Guidelines recommend the use of a shared decision making approach to offer hydroxyurea to all children with SCD as early as nine months of age. Hydroxyurea uptake remains low because parents lack information about hydroxyurea and have concerns about its safety and potential long-term side effects (e.g. cancer, infertility, birth defects). Clinicians do not have the training or tools to facilitate a shared discussion with parents that provides medical evidence and considers parent preferences and values. The current study compares two methods for disseminating hydroxyurea guidelines and facilitating shared decision-making: the American Society of Hematology's hydroxyurea clinician pocket guide (usual care method) and a clinician hydroxyurea shared decision-making toolkit (H-SDM toolkit). The specific aims of the study are to evaluate the effectiveness of the usual care dissemination method (clinician pocket guide) and the H-SDM clinician toolkit dissemination method on: parent report of decisional uncertainty (primary outcome chosen by parents of children with SCD), parent perception of experiencing shared decision-making, parent knowledge of hydroxyurea, the number of children offered hydroxyurea, hydroxyurea uptake (those with active prescriptions), and child health outcomes (pain, neurocognitive functioning, sickle cell related quality of life and healthcare utilization). Eligible children must be between the ages of 0 and 5 and a candidate for hydroxyurea to participate. The trial will use a stepped-wedge design (clinic is the unit of randomization). The long-term objective of the research team is to improve the quality of care for children with SCD. The investigators propose that suboptimal care for patients with SCD is preventable with the use of multicomponent dissemination methods if developed with key stakeholders and designed to address barriers to high quality care at multiple levels (patient, clinician, healthcare system, and community).

Study Design

Study Type:

Interventional

Anticipated Enrollment :

260 participants

Allocation:

Non-Randomized

Intervention Model:

Sequential Assignment

Intervention Model Description:

Stepped Wedge Randomized Clinical TrialStepped Wedge Randomized Clinical Trial

Masking:

None (Open Label)

Primary Purpose:

Health Services Research

Official Title:

Engaging Parents of Children With Sickle Cell Anemia and Their Providers in Shared-Decision Making for Hydroxyurea (ENGAGE HU)

Actual Study Start Date :

Jul 12, 2018

Anticipated Primary Completion Date :

Feb 28, 2022

Anticipated Study Completion Date :

Feb 28, 2022

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Hydroxyurea SDM Toolkit (H-SDM) During the H-SDM toolkit condition, sites will develop methods for identifying Eligible Patients & Monitoring Progress, have the opportunity to use Implementation Tools, and will use the Visit Decision Aids. The H-SDM toolkit has four visit decision aids to support parents in their decision about hydroxyurea: pre-visit brochure, in-visit issue card, after-visit booklet and video narratives {videos of parents telling their story about how they made a decision about hydroxyurea).	Behavioral: Hydroxyurea SDM Toolkit Implementation tools and visit decision aids
Active Comparator: Clinician Pocket Guide In this condition, sites will provide current guidelines for offering hydroxyurea and use the American Society of Hematology (ASH) pocket guide as a reference. ASH developed 'The Hydroxyurea and Transfusion Therapy for the Treatment of Sickle Cell Disease' clinician pocket guide based on the National Heart, Lung, and Blood Institute's Evidence Based Management of Sickle Cell Disease: Expert Panel Report, 2014.'	Behavioral: Clinician Pocket Guide current hydroxyurea protocol and ASH pocket guide

Arm

Intervention/Treatment

Experimental: Hydroxyurea SDM Toolkit (H-SDM)

During the H-SDM toolkit condition, sites will develop methods for identifying Eligible Patients & Monitoring Progress, have the opportunity to use Implementation Tools, and will use the Visit Decision Aids. The H-SDM toolkit has four visit decision aids to support parents in their decision about hydroxyurea: pre-visit brochure, in-visit issue card, after-visit booklet and video narratives {videos of parents telling their story about how they made a decision about hydroxyurea).

Behavioral: Hydroxyurea SDM Toolkit

Implementation tools and visit decision aids

Active Comparator: Clinician Pocket Guide

In this condition, sites will provide current guidelines for offering hydroxyurea and use the American Society of Hematology (ASH) pocket guide as a reference. ASH developed 'The Hydroxyurea and Transfusion Therapy for the Treatment of Sickle Cell Disease' clinician pocket guide based on the National Heart, Lung, and Blood Institute's Evidence Based Management of Sickle Cell Disease: Expert Panel Report, 2014.'

Behavioral: Clinician Pocket Guide

current hydroxyurea protocol and ASH pocket guide

Outcome Measures

Primary Outcome Measures

Decisional conflict [up to 4 weeks]
Decisional Conflict Scale (DCS)

Secondary Outcome Measures

Shared decision making [up to 4 weeks]
Dyadic OPTION
Hydroxyurea offered [From date of randomization until the date of first documented offering or prescription, whichever came first, assessed up to 7 months]
electronic medical record (EMR) data

Eligibility Criteria

Criteria

Ages Eligible for Study:

1 Month to 5 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Diagnosis: sickle cell disease
Age: birth-5 years, inclusive
Eligible for hydroxyurea (genotype SS, Sβ0Thal or other genotype + clinical complications)
Child's parent, legal guardian, or designated decision maker (caregiver) must participate in both study visits
Child's parent, legal guardian, or designated decision maker (caregiver) must able to read, understand, and speak English

Exclusion Criteria:

Parent/legal guardian has previously been approached OR made a decision about whether to initiate hydroxyurea.
Any and all other diagnoses or conditions which, in the opinion of the site investigator or hematologist, would prevent the patient from being a suitable candidate for the study.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	UCSF Beinoff Children's Hospital and Research Center at Oakland	Oakland	California	United States	94609
2	Nemours Children's Health	Wilmington	Delaware	United States	19803
3	Howard University	Washington	District of Columbia	United States	20060
4	Ann & Robert H Lurie Children's Hospital of Chicago	Chicago	Illinois	United States	60611
5	Indiana Hemophilia & Thrombosis Center	Indianapolis	Indiana	United States	46260
6	Boston Children's Hospital	Boston	Massachusetts	United States	02118
7	The Washington University	Saint Louis	Missouri	United States	63110
8	Nationwide Children's Hospital	Columbus	Ohio	United States	43205
9	Children's Hospital of Philadelphia	Philadelphia	Pennsylvania	United States	19104
10	Vanderbilt University Medical Center	Nashville	Tennessee	United States	37232
11	Baylor College of Medicine	Houston	Texas	United States	77030