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Immunologic Aspects of the Pathogenesis of Chronic Sinusitis in Children

Sponsor
National Center for Research Resources (NCRR) (NIH)
Overall Status
Completed
CT.gov ID
NCT00004638
Collaborator
(none)
1
Location

Study Details

Study Description

Brief Summary

Chronic sinusitis is a common pediatric disease; it ranks among the top five infectious diseases of the upper respiratory tract. Its treatment is limited and may be due largely in part to a lack of understanding of its cause. The investigators have preliminary data to support the notion that pediatric chronic sinusitis is a distinct disease, different from acute sinusitis and adult chronic sinusitis. We are proposing to perform pathogenesis studies in children with chronic sinusitis. Specifically, we wish to elucidate the microbiologic features and immunologic factors involved in the formation of this disease. The study plan calls for microbiologic (bacterial, viral, and fungal) and immunologic (inflammatory mediators and leukocyte populations) data to be evaluated through a maxillary sinus washing and mucosal biopsies. Four populations will be studied and they are: 10 children with chronic sinusitis, 5 children with acute sinusitis (positive control), 5 children without sinusitis (negative control) and 5 adults with chronic sinusitis (positive secondary control).

Condition or Disease Intervention/Treatment Phase
  • Procedure: pathogenesis study
 N/A

Study Design

Study Type:
Interventional
Primary Purpose:
Diagnostic

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    0 Years to 18 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • chronic sinusitis confirmed by imaging study for greater than 12 weeks subjects have failed medical therapy

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 The Children's Hospital Denver Colorado United States 80218

    Sponsors and Collaborators

    • National Center for Research Resources (NCRR)

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00004638
    Other Study ID Numbers:
    • NCRR-M01RR00069-0609
    • M01RR000069
    First Posted:
    Feb 24, 2000
    Last Update Posted:
    Jun 24, 2005
    Last Verified:
    Nov 1, 2001
    Keywords provided by , ,
    chronic sinusitis
    Additional relevant MeSH terms:
    Sinusitis

    Study Results

    No Results Posted as of Jun 24, 2005