Role of K+ and Ca2+ in Development of Muscle Fatigue

Sponsor

University of Copenhagen (Other)

Overall Status

Completed

CT.gov ID

NCT02712658

Collaborator

(none)

Enrollment

Location

Arms

Duration (Months)

1.7

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aim of the study is to investigate the role of K+ and Ca2+ in development of muscle fatigue in trained young men.

Condition or Disease	Intervention/Treatment	Phase
Skeletal Muscle Fatigue in Humans	Drug: Terbutaline Drug: Placebo	N/A

Study Design

Study Type:

Interventional

Actual Enrollment :

10 participants

Allocation:

Randomized

Intervention Model:

Crossover Assignment

Masking:

Double (Participant, Investigator)

Primary Purpose:

Basic Science

Study Start Date :

Sep 1, 2015

Actual Primary Completion Date :

Mar 1, 2016

Actual Study Completion Date :

Mar 1, 2016

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: terbutaline terbutaline is administered by injection (0.25-0.5 mg Bricanyl, AstraZeneca diluted in 9 ml isotonic saline)	Drug: Terbutaline K+ transport and Ca2+ release and uptake function are stimulated by administration of terbutaline
Placebo Comparator: Placebo placebo is administered as isotonic saline (10 ml)	Drug: Placebo

Arm

Intervention/Treatment

Active Comparator: terbutaline

terbutaline is administered by injection (0.25-0.5 mg Bricanyl, AstraZeneca diluted in 9 ml isotonic saline)

Drug: Terbutaline

K+ transport and Ca2+ release and uptake function are stimulated by administration of terbutaline

Placebo Comparator: Placebo

placebo is administered as isotonic saline (10 ml)

Drug: Placebo

Outcome Measures

Primary Outcome Measures

Change in time to fatigue during knee-extensor exercise [1 day]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 40 Years

Sexes Eligible for Study:

Male

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

physical active healthy men
aged 18-40 years

Exclusion Criteria:

smokers
allergy towards terbutaline
chronic disease

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Department of Nutrition, Exercise and Sports	Copenhagen		Denmark	2100

Sponsors and Collaborators

University of Copenhagen

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Morten Nielsen, Post.Doc, University of Copenhagen

ClinicalTrials.gov Identifier:

NCT02712658

Other Study ID Numbers:

First Posted:

Mar 18, 2016

Last Update Posted:

Jan 31, 2017

Last Verified:

Jan 1, 2017

Additional relevant MeSH terms:

Fatigue

Terbutaline

Study Results

No Results Posted as of Jan 31, 2017