Efficacy Testing of Collagen Elixir
Study Details
Study Description
Brief Summary
To assess Isagenix-Collagen Elixir on skin condition improvement
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Placebo Comparator: Placebo drink
|
Dietary Supplement: Blank
Placebo drink
|
| Experimental: Collagen drink
|
Dietary Supplement: Collagen drink
Testing product
Other Names:
|
Outcome Measures
Primary Outcome Measures
- The change of skin wrinkles [Change from Baseline skin wrinkles at 4 weeks]
VISIA Complexion Analysis System was utilized to measure skin wrinkles. Units: arbitrary units
- The change of skin texture [Change from Baseline skin texture at 4 weeks]
VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units
- The change of skin collagen density [Change from Baseline skin collagen density at 4 weeks]
DermaLab® Series SkinLab Combo was utilized to measure skin pores. Units: arbitrary units
- The change of skin elasticity [Change from Baseline skin elasticity at 4 weeks]
Soft Plus was utilized to measure skin elasticity. Units: arbitrary units
- The change of MMP-1 of blood [Change from Baseline MMP-1 at 4 weeks]
Venous blood was sampled to measure MMP-1
- The change of TIMP-1 of blood [Change from Baseline TIMP-1 at 4 weeks]
Venous blood was sampled to measure TIMP-1
Secondary Outcome Measures
- The change of skin melanin index [Change from Baseline skin melanin index at 4 weeks]
Soft Plus was utilized to measure skin melanin index. Units: arbitrary units
- The change of skin L* value [Change from Baseline L* value at 4 weeks]
Chroma Meter MM500 was utilized to measure skin L* value. Units: arbitrary units, 0-100
- The change of skin moisture [Change from Baseline skin moisture at 4 weeks]
Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120
- The change of skin spots [Change from Baseline skin spots at 4 weeks]
VISIA Complexion Analysis System was utilized to measure skin spots. Units: arbitrary units
- The change of skin UV spots [Change from Baseline skin UV spots at 4 weeks]
VISIA Complexion Analysis System was utilized to measure skin UV spots. Units: arbitrary units
- The change of skin brown spots [Change from Baseline skin brown spots at 4 weeks]
VISIA Complexion Analysis System was utilized to measure skin brown spots. Units: arbitrary units
- The change of TNF-α of blood [Change from Baseline TNF-α at 4 weeks]
Venous blood was sampled to measure TNF-α
- The change of IL-10 of blood [Change from Baseline IL-10 at 4 weeks]
Venous blood was sampled to measure IL-10
- The change of SOD-RBC of blood [Change from Baseline SOD-RBC at 4 weeks]
Venous blood was sampled to measure SOD-RBC
- The change of f-thiols of blood [Change from Baseline f-thiols at 4 weeks]
Venous blood was sampled to measure f-thiols
- The change of t-GSH of blood [Change from Baseline t-GSH at 4 weeks]
Venous blood was sampled to measure t-GSH
- The change of GST-RBC of blood [Change from Baseline GST-RBC at 4 weeks]
Venous blood was sampled to measure GST-RBC
- The change of MDA of blood [Change from Baseline MDA at 4 weeks]
Venous blood was sampled to measure MDA
- The change of blood total antioxidant capacity (TAC) [Change from Baseline TAC at 4 weeks]
Venous blood was sampled to measure concentrations of TAC
Other Outcome Measures
- The change of total cholesterol of blood [Change from Baseline total cholesterol at 4 weeks]
Venous blood was sampled to measure total cholesterol
- The change of triglyceride of blood [Change from Baseline triglyceride at 4 weeks]
Venous blood was sampled to measure triglyceride
- The change of SGOT of blood [Change from Baseline SGOT at 4 weeks]
Venous blood was sampled to measure SGOT
- The change of SGPT of blood [Change from Baseline SGPT at 4 weeks]
Venous blood was sampled to measure SGPT
- The change of BUN of blood [Change from Baseline BUN at 4 weeks]
Venous blood was sampled to measure BUN
- The change of creatinine of blood [Change from Baseline creatinine at 4 weeks]
Venous blood was sampled to measure creatinine
- The change of uric acid of blood [Change from Baseline uric acid at 4 weeks]
Venous blood was sampled to measure uric acid
Eligibility Criteria
Criteria
Inclusion Criteria:
- Healthy adults aged above 20 years old
Exclusion Criteria:
-
Subject who is not willing to participate in this study.
-
Patients with diseases of the skin, liver, kidney.
-
Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder.
-
Female who is pregnant or nursing or planning to become pregnant during the course of the study.
-
Received facial laser therapy, chemical peeling or UV overexposure in the past 4 weeks.
-
Constant drug use
-
Participated cosmetic product human study in the past 3 months.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Chia Nan University of Pharmacy & Science | Tainan City | Taiwan | 71710 |
Sponsors and Collaborators
- TCI Co., Ltd.
Investigators
- Principal Investigator: Chia-Hua Liang, Chia Nan University of Pharmacy ＆ Science
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 21-042-B