Avelumab With or Without Cetuximab in Treating Patients With Advanced Skin Squamous Cell Cancer
Sponsor
Alliance for Clinical Trials in Oncology (Other)
Overall Status
Recruiting
CT.gov ID
NCT03944941
Collaborator
National Cancer Institute (NCI) (NIH)
59
420
2
54.5
0.1
0
Study Details
Study Description
Brief Summary
This phase II trial studies how well avelumab with or without cetuximab work in treating patients with skin squamous cell cancer that has spread to other places in the body. Immunotherapy with monoclonal antibodies, such as avelumab and cetuximab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
| Phase 2 |
Detailed Description
PRIMARY OBJECTIVES:
- To evaluate whether treatment with avelumab plus cetuximab prolongs progression free survival (PFS) compared to avelumab alone.
SECONDARY OBJECTIVES:
-
To evaluate the confirmed objective response rate of each treatment arm. II. To evaluate the clinical benefit rate of each treatment arm. III. To evaluate the PFS of cetuximab plus avelumab in patients that have progressed on single agent avelumab.
-
To evaluate the overall survival (OS) for each treatment arm. V. To evaluate toxicity across treatment arms of avelumab plus cetuximab and avelumab alone.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM I: Patients receive avelumab intravenously (IV) over 60 minutes on days 1 and 15. Treatment repeats every 28 days for up to 24 cycles in the absence of disease progression or unacceptable toxicity. Patients with avelumab failure will crossover to arm II.
ARM II: Patients receive cetuximab IV over 1-2 hours on days 1, 8,15, and 22 and avelumab IV over 60 minutes on days 1 and 15. Treatment repeats every 28 days for up to 12 cycles for cetuximab and 24 cycles for avelumab in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months until disease progression, then every 6 months for up to 2 years.
Study Design
Study Type:
Interventional
Anticipated Enrollment
:
59 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
Phase II Randomized Trial of Avelumab Plus Cetuximab Versus Avelumab Alone in Advanced Cutaneous Squamous Cell Carcinoma of the Skin (cSCC)
Actual Study Start Date
:
May 17, 2019
Anticipated Primary Completion Date
:
Dec 1, 2022
Anticipated Study Completion Date
:
Dec 1, 2023
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: Arm I (Avelumab) Patients receive avelumab IV over 60 minutes on days 1 and 15. Treatment repeats every 28 days for up to 24 cycles in the absence of disease progression or unacceptable toxicity. Patients with avelumab failure will crossover to Arm II. |
Drug: Avelumab
Given IV
|
| Experimental: Arm II (Avelumab, cetuximab) Patients receive cetuximab IV over 1-2 hours on days 1, 8,15, and 22 and avelumab IV over 60 minutes on days 1 and 15. Treatment repeats every 28 days for up to 12 cycles for cetuximab and 24 cycles for avelumab in the absence of disease progression or unacceptable toxicity. |
Drug: Avelumab
Given IV
Drug: Cetuximab
Given IV
|
Outcome Measures
Primary Outcome Measures
- Prolonging of progression free survival (PFS) on avelumab and cetuximab compared to avelumab alone [Time between registration and evidence of disease progression or death, assessed up to 2 years post treatment]
The study will be declared promising if, after the 37th PFS event, the hazard ratio is less than 0.758.
Secondary Outcome Measures
- Confirmed objective response rate (RR) [Up to 2 years post treatment]
A patient will be declared a success for RR if they achieve a partial response (PR) or better on two consecutive evaluations (at least 8 weeks apart). The number of successes will be divided by the number of evaluable patients to estimate the RR for each treatment arm and exact 95% confidence intervals will be calculated based on the properties of the binomial distribution.
- Clinical benefit rate (CBR) [Up to 2 years post treatment]
The CBR is will be estimated as the number of successes divided by the total number of evaluable patients. An exact 95% confidence interval will be constructed around the CBR using the properties of the binomial distribution.
- PFS in patients who have progressed on avelumab alone [From time of enrollment to documented progression (or death), assessed up to 2 years]
Will explore the PFS for those patients that crossover to combination therapy (avelumab + cetuximab) after progressing on avelumab alone (baseline time being the time of crossover). The Kaplan-Meier method will be used to calculate a median PFS as well as a 95% confidence interval.
- Overall Survival (OS) [Time between enrollment and or death, assessed up to 2 years post treatment]
The Kaplan-Meier method will be used to calculate a median OS as well as a 95% confidence interval.
- Incidence of adverse events [Up to 30 days post treatment]
Will be described and graded using the National Cancer Institute Common Terminology Criteria for Adverse Events, version 5.0. Maximum grade adverse events will be summarized in a tabular setting by treatment arm.
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
PRE-REGISTRATION ELIGIBILITY CRITERIA
-
Provide adequate tissue for PD-L1 testing
- Fresh tissue or archival tissue can be used. Sample must be at least core needle biopsy. Fine needle aspiration is not adequate. This specimen submission is mandatory prior to registration as results will be used for stratification
-
REGISTRATION ELIGIBILITY CRITERIA
-
• Biopsy-proven advanced cutaneous squamous cell carcinoma. Advanced disease is defined as either metastatic cutaneous squamous cell carcinoma or locally advanced cutaneous squamous cell carcinoma not amenable to curative surgical resection, or the patient declines surgical resection
-
The patient must have at least one lesion that is measurable disease based on Response Evaluation Criteria in Solid Tumors (RECIST) 1.1
-
If patient received major surgery, they must have recovered adequately from the toxicity and/or complications from the intervention prior to starting therapy
-
This study involves an investigational agent whose genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are unknown. Therefore, for women of childbearing potential only, a negative urine or serum pregnancy test done =< 7 days prior to registration is required
-
Eastern Cooperative Oncology Group (ECOG) performance status 0-2
-
If human immunodeficiency virus (HIV) positive the HIV viral load must be < 200 copies/mL and CD4 count > 200. If an HIV positive patient is on highly active antiretroviral therapy (HAART) the patient must have been so for > 4 weeks
-
Absolute neutrophil count (ANC) >= 1,500/mm^3
-
Platelet count >= 100,000/mm^3
-
Calculated creatinine clearance >= 30 mL/min
-
Total bilirubin =< 1.5 x upper limit of normal (ULN)
-
Aspartate aminotransferases (AST) / alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)
Exclusion Criteria:
-
Patients who received prior treatment with cetuximab as palliative treatment for advanced cutaneous squamous cell carcinoma (cSCC) are excluded. Patients that received cetuximab based chemoradiation (either definitive or adjuvant) as prior treatment for locally advanced disease are eligible as long as the last dosage was given >= 6 months prior to registration
-
Patients who received prior cetuximab and had a severe infusion reaction requiring discontinuation of cetuximab are excluded
-
Patients treated with prior anti-PD-1 or anti-PD-L1 monoclonal antibodies (mAbs) are excluded
-
Patients cannot have received treatment with radiation or chemotherapy including another investigational agent within 2 weeks of registration. Other than as stated above for cetuximab there are no limits on the number of lines of other therapies given for advanced cSCC
-
Patients with a "currently active" second malignancy will be excluded with the exception of other non-melanoma skin cancers or cervical carcinoma in situ. Patients are not considered to have a "currently active" malignancy if they have completed therapy and are free of disease for 3 years
-
No history of the following:
-
Autoimmune disease (including inflammatory bowel disease) with the exception of patients with diabetes type I, vitiligo, psoriasis, or hypo- or hyperthyroid diseases not requiring immunosuppressive treatment
-
Non-infectious pneumonitis that required steroids within 5 years
-
Organ transplant including prior stem cell transplant
-
Receipt of a live vaccine =< 4 weeks
-
Cerebral vascular accident/stroke within 6 months of enrollment
-
Myocardial infarction within 6 months of enrollment
-
Active unstable angina
-
Congestive heart failure (>= New York Heart Association Classification class II)
-
Serious cardiac arrhythmia requiring medication. Whether an arrhythmia is considered "serious" is at the discretion of the investigator
-
Active infection requiring systemic treatment
-
Use of immunosuppressive medication =< 7 days of registration, EXCEPT for the following:
-
Intranasal, inhaled, topical steroids, or local steroid injection (e.g., intra-articular injection)
-
Systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone or equivalent
-
Steroids as premedication for hypersensitivity reactions (e.g., computed tomography [CT] scan premedication)"
-
Other severe acute or chronic medical conditions including but not limited to immune colitis, pulmonary fibrosis or psychiatric conditions including recent (within the past year) or active suicidal ideation or behavior; or laboratory abnormalities that may increase the risk associated with study participation or study treatment administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the patient inappropriate for entry into this study
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | United States | 35233 |
| 2 | Anchorage Associates in Radiation Medicine | Anchorage | Alaska | United States | 98508 |
| 3 | Anchorage Radiation Therapy Center | Anchorage | Alaska | United States | 99504 |
| 4 | Alaska Breast Care and Surgery LLC | Anchorage | Alaska | United States | 99508 |
| 5 | Alaska Oncology and Hematology LLC | Anchorage | Alaska | United States | 99508 |
| 6 | Alaska Women's Cancer Care | Anchorage | Alaska | United States | 99508 |
| 7 | Anchorage Oncology Centre | Anchorage | Alaska | United States | 99508 |
| 8 | Katmai Oncology Group | Anchorage | Alaska | United States | 99508 |
| 9 | Providence Alaska Medical Center | Anchorage | Alaska | United States | 99508 |
| 10 | Fairbanks Memorial Hospital | Fairbanks | Alaska | United States | 99701 |
| 11 | Kingman Regional Medical Center | Kingman | Arizona | United States | 86401 |
| 12 | University of Arizona Cancer Center-Orange Grove Campus | Tucson | Arizona | United States | 85704 |
| 13 | Banner University Medical Center - Tucson | Tucson | Arizona | United States | 85719 |
| 14 | University of Arizona Cancer Center-North Campus | Tucson | Arizona | United States | 85719 |
| 15 | Mercy Hospital Fort Smith | Fort Smith | Arkansas | United States | 72903 |
| 16 | PCR Oncology | Arroyo Grande | California | United States | 93420 |
| 17 | Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California | United States | 91505 |
| 18 | Epic Care-Dublin | Dublin | California | United States | 94568 |
| 19 | Bay Area Breast Surgeons Inc | Emeryville | California | United States | 94608 |
| 20 | Epic Care Partners in Cancer Care | Emeryville | California | United States | 94608 |
| 21 | Los Angeles County-USC Medical Center | Los Angeles | California | United States | 90033 |
| 22 | USC / Norris Comprehensive Cancer Center | Los Angeles | California | United States | 90033 |
| 23 | Contra Costa Regional Medical Center | Martinez | California | United States | 94553-3156 |
| 24 | USC Norris Oncology/Hematology-Newport Beach | Newport Beach | California | United States | 92663 |
| 25 | Alta Bates Summit Medical Center - Summit Campus | Oakland | California | United States | 94609 |
| 26 | Bay Area Tumor Institute | Oakland | California | United States | 94609 |
| 27 | Keck Medical Center of USC Pasadena | Pasadena | California | United States | 91105 |
| 28 | Epic Care Cyberknife Center | Walnut Creek | California | United States | 94597 |
| 29 | Rocky Mountain Cancer Centers-Aurora | Aurora | Colorado | United States | 80012 |
| 30 | The Medical Center of Aurora | Aurora | Colorado | United States | 80012 |
| 31 | Boulder Community Foothills Hospital | Boulder | Colorado | United States | 80303 |
| 32 | Rocky Mountain Cancer Centers-Boulder | Boulder | Colorado | United States | 80304 |
| 33 | Rocky Mountain Cancer Centers - Centennial | Centennial | Colorado | United States | 80112 |
| 34 | The Women's Imaging Center | Denver | Colorado | United States | 80209 |
| 35 | Colorado Blood Cancer Institute | Denver | Colorado | United States | 80218 |
| 36 | Presbyterian - Saint Lukes Medical Center - Health One | Denver | Colorado | United States | 80218 |
| 37 | Rocky Mountain Cancer Centers-Midtown | Denver | Colorado | United States | 80218 |
| 38 | Rocky Mountain Cancer Centers-Rose | Denver | Colorado | United States | 80220 |
| 39 | Rose Medical Center | Denver | Colorado | United States | 80220 |
| 40 | Western Surgical Care | Denver | Colorado | United States | 80220 |
| 41 | Mountain Blue Cancer Care Center - Swedish | Englewood | Colorado | United States | 80113 |
| 42 | Rocky Mountain Cancer Centers - Swedish | Englewood | Colorado | United States | 80113 |
| 43 | Swedish Medical Center | Englewood | Colorado | United States | 80113 |
| 44 | The Melanoma and Skin Cancer Institute | Englewood | Colorado | United States | 80113 |
| 45 | North Colorado Medical Center | Greeley | Colorado | United States | 80631 |
| 46 | Rocky Mountain Cancer Centers-Lakewood | Lakewood | Colorado | United States | 80228 |
| 47 | Rocky Mountain Cancer Centers-Littleton | Littleton | Colorado | United States | 80120 |
| 48 | Rocky Mountain Cancer Centers-Sky Ridge | Lone Tree | Colorado | United States | 80124 |
| 49 | Sky Ridge Medical Center | Lone Tree | Colorado | United States | 80124 |
| 50 | McKee Medical Center | Loveland | Colorado | United States | 80539 |
| 51 | Rocky Mountain Cancer Centers-Thornton | Thornton | Colorado | United States | 80260 |
| 52 | Emory University Hospital Midtown | Atlanta | Georgia | United States | 30308 |
| 53 | Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | United States | 30322 |
| 54 | Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia | United States | 31405 |
| 55 | Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | United States | 83706 |
| 56 | Saint Luke's Cancer Institute - Boise | Boise | Idaho | United States | 83712 |
| 57 | Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | United States | 83605 |
| 58 | Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | United States | 83814 |
| 59 | Walter Knox Memorial Hospital | Emmett | Idaho | United States | 83617 |
| 60 | Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | United States | 83619 |
| 61 | Idaho Urologic Institute-Meridian | Meridian | Idaho | United States | 83642 |
| 62 | Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | United States | 83642 |
| 63 | Saint Alphonsus Medical Center-Nampa | Nampa | Idaho | United States | 83686 |
| 64 | Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | United States | 83686 |
| 65 | Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | United States | 83854 |
| 66 | Kootenai Cancer Clinic | Sandpoint | Idaho | United States | 83864 |
| 67 | Saint Luke's Cancer Institute - Twin Falls | Twin Falls | Idaho | United States | 83301 |
| 68 | Saint Anthony's Health | Alton | Illinois | United States | 62002 |
| 69 | Rush - Copley Medical Center | Aurora | Illinois | United States | 60504 |
| 70 | Illinois CancerCare-Bloomington | Bloomington | Illinois | United States | 61704 |
| 71 | Illinois CancerCare-Canton | Canton | Illinois | United States | 61520 |
| 72 | Memorial Hospital of Carbondale | Carbondale | Illinois | United States | 62902 |
| 73 | SIH Cancer Institute | Carterville | Illinois | United States | 62918 |
| 74 | Illinois CancerCare-Carthage | Carthage | Illinois | United States | 62321 |
| 75 | Centralia Oncology Clinic | Centralia | Illinois | United States | 62801 |
| 76 | Northwestern University | Chicago | Illinois | United States | 60611 |
| 77 | University of Chicago Comprehensive Cancer Center | Chicago | Illinois | United States | 60637 |
| 78 | Carle on Vermilion | Danville | Illinois | United States | 61832 |
| 79 | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | United States | 62526 |
| 80 | Decatur Memorial Hospital | Decatur | Illinois | United States | 62526 |
| 81 | Illinois CancerCare-Dixon | Dixon | Illinois | United States | 61021 |
| 82 | Carle Physician Group-Effingham | Effingham | Illinois | United States | 62401 |
| 83 | Crossroads Cancer Center | Effingham | Illinois | United States | 62401 |
| 84 | Illinois CancerCare-Eureka | Eureka | Illinois | United States | 61530 |
| 85 | Illinois CancerCare-Galesburg | Galesburg | Illinois | United States | 61401 |
| 86 | Western Illinois Cancer Treatment Center | Galesburg | Illinois | United States | 61401 |
| 87 | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | United States | 61443 |
| 88 | Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois | United States | 60045 |
| 89 | Illinois CancerCare-Macomb | Macomb | Illinois | United States | 61455 |
| 90 | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | United States | 61938 |
| 91 | Good Samaritan Regional Health Center | Mount Vernon | Illinois | United States | 62864 |
| 92 | UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois | United States | 60451 |
| 93 | Cancer Care Center of O'Fallon | O'Fallon | Illinois | United States | 62269 |
| 94 | University of Chicago Medicine-Orland Park | Orland Park | Illinois | United States | 60462 |
| 95 | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | United States | 61350 |
| 96 | Illinois CancerCare-Pekin | Pekin | Illinois | United States | 61554 |
| 97 | Illinois CancerCare-Peoria | Peoria | Illinois | United States | 61615 |
| 98 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
| 99 | Illinois CancerCare-Peru | Peru | Illinois | United States | 61354 |
| 100 | Valley Radiation Oncology | Peru | Illinois | United States | 61354 |
| 101 | Illinois CancerCare-Princeton | Princeton | Illinois | United States | 61356 |
| 102 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62702 |
| 103 | Springfield Clinic | Springfield | Illinois | United States | 62702 |
| 104 | Memorial Medical Center | Springfield | Illinois | United States | 62781 |
| 105 | Carle Cancer Center | Urbana | Illinois | United States | 61801 |
| 106 | The Carle Foundation Hospital | Urbana | Illinois | United States | 61801 |
| 107 | Illinois CancerCare - Washington | Washington | Illinois | United States | 61571 |
| 108 | Rush-Copley Healthcare Center | Yorkville | Illinois | United States | 60560 |
| 109 | Reid Health | Richmond | Indiana | United States | 47374 |
| 110 | Mary Greeley Medical Center | Ames | Iowa | United States | 50010 |
| 111 | McFarland Clinic PC - Ames | Ames | Iowa | United States | 50010 |
| 112 | McFarland Clinic PC-Boone | Boone | Iowa | United States | 50036 |
| 113 | Saint Anthony Regional Hospital | Carroll | Iowa | United States | 51401 |
| 114 | Jennie Edmundson Memorial Hospital | Council Bluffs | Iowa | United States | 51502 |
| 115 | Heartland Oncology and Hematology LLP | Council Bluffs | Iowa | United States | 51503 |
| 116 | Iowa Methodist Medical Center | Des Moines | Iowa | United States | 50309 |
| 117 | Medical Oncology and Hematology Associates-Des Moines | Des Moines | Iowa | United States | 50309 |
| 118 | Broadlawns Medical Center | Des Moines | Iowa | United States | 50314 |
| 119 | Iowa Lutheran Hospital | Des Moines | Iowa | United States | 50316 |
| 120 | McFarland Clinic PC-Trinity Cancer Center | Fort Dodge | Iowa | United States | 50501 |
| 121 | Trinity Regional Medical Center | Fort Dodge | Iowa | United States | 50501 |
| 122 | McFarland Clinic PC-Jefferson | Jefferson | Iowa | United States | 50129 |
| 123 | McFarland Clinic PC-Marshalltown | Marshalltown | Iowa | United States | 50158 |
| 124 | Methodist West Hospital | West Des Moines | Iowa | United States | 50266-7700 |
| 125 | Central Care Cancer Center - Garden City | Garden City | Kansas | United States | 67846 |
| 126 | Central Care Cancer Center - Great Bend | Great Bend | Kansas | United States | 67530 |
| 127 | Ochsner Medical Center Kenner | Kenner | Louisiana | United States | 70065 |
| 128 | Ochsner Medical Center Jefferson | New Orleans | Louisiana | United States | 70121 |
| 129 | University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | United States | 21201 |
| 130 | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | United States | 48109 |
| 131 | Bronson Battle Creek | Battle Creek | Michigan | United States | 49017 |
| 132 | Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids | Michigan | United States | 49503 |
| 133 | Mercy Health Saint Mary's | Grand Rapids | Michigan | United States | 49503 |
| 134 | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | United States | 49503 |
| 135 | Bronson Methodist Hospital | Kalamazoo | Michigan | United States | 49007 |
| 136 | West Michigan Cancer Center | Kalamazoo | Michigan | United States | 49007 |
| 137 | Borgess Medical Center | Kalamazoo | Michigan | United States | 49048 |
| 138 | Mercy Health Mercy Campus | Muskegon | Michigan | United States | 49444 |
| 139 | Lakeland Hospital Niles | Niles | Michigan | United States | 49120 |
| 140 | Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores | Michigan | United States | 49444 |
| 141 | Huron Medical Center PC | Port Huron | Michigan | United States | 48060 |
| 142 | Lake Huron Medical Center | Port Huron | Michigan | United States | 48060 |
| 143 | Spectrum Health Reed City Hospital | Reed City | Michigan | United States | 49677 |
| 144 | Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan | United States | 49085 |
| 145 | Marie Yeager Cancer Center | Saint Joseph | Michigan | United States | 49085 |
| 146 | Munson Medical Center | Traverse City | Michigan | United States | 49684 |
| 147 | Metro Health Hospital | Wyoming | Michigan | United States | 49519 |
| 148 | Riverwood Healthcare Center | Aitkin | Minnesota | United States | 56431 |
| 149 | Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota | United States | 56401 |
| 150 | Fairview Ridges Hospital | Burnsville | Minnesota | United States | 55337 |
| 151 | Minnesota Oncology - Burnsville | Burnsville | Minnesota | United States | 55337 |
| 152 | Cambridge Medical Center | Cambridge | Minnesota | United States | 55008 |
| 153 | Mercy Hospital | Coon Rapids | Minnesota | United States | 55433 |
| 154 | Essentia Health - Deer River Clinic | Deer River | Minnesota | United States | 56636 |
| 155 | Essentia Health Saint Mary's - Detroit Lakes Clinic | Detroit Lakes | Minnesota | United States | 56501 |
| 156 | Essentia Health Cancer Center | Duluth | Minnesota | United States | 55805 |
| 157 | Essentia Health Saint Mary's Medical Center | Duluth | Minnesota | United States | 55805 |
| 158 | Miller-Dwan Hospital | Duluth | Minnesota | United States | 55805 |
| 159 | Fairview Southdale Hospital | Edina | Minnesota | United States | 55435 |
| 160 | Lake Region Healthcare Corporation-Cancer Care | Fergus Falls | Minnesota | United States | 56537 |
| 161 | Essentia Health - Fosston | Fosston | Minnesota | United States | 56542 |
| 162 | Unity Hospital | Fridley | Minnesota | United States | 55432 |
| 163 | Essentia Health Hibbing Clinic | Hibbing | Minnesota | United States | 55746 |
| 164 | Fairview Clinics and Surgery Center Maple Grove | Maple Grove | Minnesota | United States | 55369 |
| 165 | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | United States | 55109 |
| 166 | Saint John's Hospital - Healtheast | Maplewood | Minnesota | United States | 55109 |
| 167 | Abbott-Northwestern Hospital | Minneapolis | Minnesota | United States | 55407 |
| 168 | Hennepin County Medical Center | Minneapolis | Minnesota | United States | 55415 |
| 169 | Health Partners Inc | Minneapolis | Minnesota | United States | 55454 |
| 170 | Monticello Cancer Center | Monticello | Minnesota | United States | 55362 |
| 171 | New Ulm Medical Center | New Ulm | Minnesota | United States | 56073 |
| 172 | Essentia Health - Park Rapids | Park Rapids | Minnesota | United States | 56470 |
| 173 | Fairview Northland Medical Center | Princeton | Minnesota | United States | 55371 |
| 174 | North Memorial Medical Health Center | Robbinsdale | Minnesota | United States | 55422 |
| 175 | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | United States | 55416 |
| 176 | Regions Hospital | Saint Paul | Minnesota | United States | 55101 |
| 177 | United Hospital | Saint Paul | Minnesota | United States | 55102 |
| 178 | Essentia Health Sandstone | Sandstone | Minnesota | United States | 55072 |
| 179 | Saint Francis Regional Medical Center | Shakopee | Minnesota | United States | 55379 |
| 180 | Lakeview Hospital | Stillwater | Minnesota | United States | 55082 |
| 181 | Essentia Health Virginia Clinic | Virginia | Minnesota | United States | 55792 |
| 182 | Ridgeview Medical Center | Waconia | Minnesota | United States | 55387 |
| 183 | Rice Memorial Hospital | Willmar | Minnesota | United States | 56201 |
| 184 | Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | United States | 55125 |
| 185 | Fairview Lakes Medical Center | Wyoming | Minnesota | United States | 55092 |
| 186 | Saint Louis Cancer and Breast Institute-Ballwin | Ballwin | Missouri | United States | 63011 |
| 187 | Central Care Cancer Center - Bolivar | Bolivar | Missouri | United States | 65613 |
| 188 | Cox Cancer Center Branson | Branson | Missouri | United States | 65616 |
| 189 | Saint Francis Medical Center | Cape Girardeau | Missouri | United States | 63703 |
| 190 | Southeast Cancer Center | Cape Girardeau | Missouri | United States | 63703 |
| 191 | Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | United States | 63141 |
| 192 | Parkland Health Center - Farmington | Farmington | Missouri | United States | 63640 |
| 193 | Capital Region Southwest Campus | Jefferson City | Missouri | United States | 65109 |
| 194 | Freeman Health System | Joplin | Missouri | United States | 64804 |
| 195 | Mercy Hospital Joplin | Joplin | Missouri | United States | 64804 |
| 196 | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | United States | 65401 |
| 197 | Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | United States | 65401 |
| 198 | Heartland Regional Medical Center | Saint Joseph | Missouri | United States | 64506 |
| 199 | Saint Louis Cancer and Breast Institute-South City | Saint Louis | Missouri | United States | 63109 |
| 200 | Washington University School of Medicine | Saint Louis | Missouri | United States | 63110 |
| 201 | Mercy Hospital South | Saint Louis | Missouri | United States | 63128 |
| 202 | Siteman Cancer Center-South County | Saint Louis | Missouri | United States | 63129 |
| 203 | Missouri Baptist Medical Center | Saint Louis | Missouri | United States | 63131 |
| 204 | Mercy Hospital Saint Louis | Saint Louis | Missouri | United States | 63141 |
| 205 | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | United States | 63670 |
| 206 | Mercy Hospital Springfield | Springfield | Missouri | United States | 65804 |
| 207 | CoxHealth South Hospital | Springfield | Missouri | United States | 65807 |
| 208 | Missouri Baptist Sullivan Hospital | Sullivan | Missouri | United States | 63080 |
| 209 | Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri | United States | 63127 |
| 210 | Mercy Hospital Washington | Washington | Missouri | United States | 63090 |
| 211 | Community Hospital of Anaconda | Anaconda | Montana | United States | 59711 |
| 212 | Billings Clinic Cancer Center | Billings | Montana | United States | 59101 |
| 213 | Bozeman Deaconess Hospital | Bozeman | Montana | United States | 59715 |
| 214 | Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | United States | 59405 |
| 215 | Great Falls Clinic | Great Falls | Montana | United States | 59405 |
| 216 | Saint Peter's Community Hospital | Helena | Montana | United States | 59601 |
| 217 | Kalispell Regional Medical Center | Kalispell | Montana | United States | 59901 |
| 218 | Saint Patrick Hospital - Community Hospital | Missoula | Montana | United States | 59802 |
| 219 | Community Medical Hospital | Missoula | Montana | United States | 59804 |
| 220 | Nebraska Methodist Hospital | Omaha | Nebraska | United States | 68114 |
| 221 | Carson Tahoe Regional Medical Center | Carson City | Nevada | United States | 89703 |
| 222 | Cancer and Blood Specialists-Henderson | Henderson | Nevada | United States | 89052 |
| 223 | Comprehensive Cancer Centers of Nevada - Henderson | Henderson | Nevada | United States | 89052 |
| 224 | Comprehensive Cancer Centers of Nevada-Horizon Ridge | Henderson | Nevada | United States | 89052 |
| 225 | Las Vegas Cancer Center-Henderson | Henderson | Nevada | United States | 89052 |
| 226 | OptumCare Cancer Care at Seven Hills | Henderson | Nevada | United States | 89052 |
| 227 | Comprehensive Cancer Centers of Nevada-Southeast Henderson | Henderson | Nevada | United States | 89074 |
| 228 | GenesisCare USA - Henderson | Henderson | Nevada | United States | 89074 |
| 229 | Las Vegas Urology - Green Valley | Henderson | Nevada | United States | 89074 |
| 230 | Las Vegas Urology - Pebble | Henderson | Nevada | United States | 89074 |
| 231 | Urology Specialists of Nevada - Green Valley | Henderson | Nevada | United States | 89074 |
| 232 | Las Vegas Urology - Pecos | Las Vegas | Nevada | United States | 89074 |
| 233 | Desert West Surgery | Las Vegas | Nevada | United States | 89102 |
| 234 | OptumCare Cancer Care at Charleston | Las Vegas | Nevada | United States | 89102 |
| 235 | University Medical Center of Southern Nevada | Las Vegas | Nevada | United States | 89102 |
| 236 | Hope Cancer Care of Nevada | Las Vegas | Nevada | United States | 89103 |
| 237 | Cancer and Blood Specialists-Shadow | Las Vegas | Nevada | United States | 89106 |
| 238 | Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada | United States | 89106 |
| 239 | Urology Specialists of Nevada - Central | Las Vegas | Nevada | United States | 89106 |
| 240 | GenesisCare USA - Las Vegas | Las Vegas | Nevada | United States | 89109 |
| 241 | HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway | Las Vegas | Nevada | United States | 89109 |
| 242 | Sunrise Hospital and Medical Center | Las Vegas | Nevada | United States | 89109 |
| 243 | HealthCare Partners Medical Group Oncology/Hematology-San Martin | Las Vegas | Nevada | United States | 89113 |
| 244 | Las Vegas Prostate Cancer Center | Las Vegas | Nevada | United States | 89113 |
| 245 | Las Vegas Urology - Sunset | Las Vegas | Nevada | United States | 89113 |
| 246 | Urology Specialists of Nevada - Southwest | Las Vegas | Nevada | United States | 89113 |
| 247 | Radiation Oncology Centers of Nevada Southeast | Las Vegas | Nevada | United States | 89119 |
| 248 | Ann M Wierman MD LTD | Las Vegas | Nevada | United States | 89128 |
| 249 | Cancer and Blood Specialists-Tenaya | Las Vegas | Nevada | United States | 89128 |
| 250 | Comprehensive Cancer Centers of Nevada - Northwest | Las Vegas | Nevada | United States | 89128 |
| 251 | GenesisCare USA - Vegas Tenaya | Las Vegas | Nevada | United States | 89128 |
| 252 | HealthCare Partners Medical Group Oncology/Hematology-Tenaya | Las Vegas | Nevada | United States | 89128 |
| 253 | Las Vegas Urology - Cathedral Rock | Las Vegas | Nevada | United States | 89128 |
| 254 | Las Vegas Urology - Smoke Ranch | Las Vegas | Nevada | United States | 89128 |
| 255 | OptumCare Cancer Care at MountainView | Las Vegas | Nevada | United States | 89128 |
| 256 | Urology Specialists of Nevada - Northwest | Las Vegas | Nevada | United States | 89128 |
| 257 | Alliance for Childhood Diseases/Cure 4 the Kids Foundation | Las Vegas | Nevada | United States | 89135 |
| 258 | Comprehensive Cancer Centers of Nevada - Town Center | Las Vegas | Nevada | United States | 89144 |
| 259 | Comprehensive Cancer Centers of Nevada-Summerlin | Las Vegas | Nevada | United States | 89144 |
| 260 | Summerlin Hospital Medical Center | Las Vegas | Nevada | United States | 89144 |
| 261 | Las Vegas Cancer Center-Medical Center | Las Vegas | Nevada | United States | 89148-2405 |
| 262 | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | United States | 89148 |
| 263 | GenesisCare USA - Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 264 | OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 265 | HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills | Las Vegas | Nevada | United States | 89149 |
| 266 | Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada | United States | 89169 |
| 267 | University Cancer Center | Las Vegas | Nevada | United States | 89169 |
| 268 | Hope Cancer Care of Nevada-Pahrump | Pahrump | Nevada | United States | 89048 |
| 269 | Renown Regional Medical Center | Reno | Nevada | United States | 89502 |
| 270 | Saint Mary's Regional Medical Center | Reno | Nevada | United States | 89503 |
| 271 | Radiation Oncology Associates | Reno | Nevada | United States | 89509 |
| 272 | Hackensack University Medical Center | Hackensack | New Jersey | United States | 07601 |
| 273 | University of New Mexico Cancer Center | Albuquerque | New Mexico | United States | 87102 |
| 274 | NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York | United States | 10032 |
| 275 | Southeastern Medical Oncology Center-Clinton | Clinton | North Carolina | United States | 28328 |
| 276 | Southeastern Medical Oncology Center-Goldsboro | Goldsboro | North Carolina | United States | 27534 |
| 277 | Southeastern Medical Oncology Center-Jacksonville | Jacksonville | North Carolina | United States | 28546 |
| 278 | Essentia Health Cancer Center-South University Clinic | Fargo | North Dakota | United States | 58103 |
| 279 | Essentia Health - Jamestown Clinic | Jamestown | North Dakota | United States | 58401 |
| 280 | Indu and Raj Soin Medical Center | Beavercreek | Ohio | United States | 45431 |
| 281 | Strecker Cancer Center-Belpre | Belpre | Ohio | United States | 45714 |
| 282 | Saint Elizabeth Boardman Hospital | Boardman | Ohio | United States | 44512 |
| 283 | Dayton Physicians LLC-Miami Valley South | Centerville | Ohio | United States | 45459 |
| 284 | Miami Valley Hospital South | Centerville | Ohio | United States | 45459 |
| 285 | Adena Regional Medical Center | Chillicothe | Ohio | United States | 45601 |
| 286 | Oncology Hematology Care Inc-Kenwood | Cincinnati | Ohio | United States | 45236 |
| 287 | Ohio State University Comprehensive Cancer Center | Columbus | Ohio | United States | 43210 |
| 288 | Mount Carmel East Hospital | Columbus | Ohio | United States | 43213 |
| 289 | Columbus Oncology and Hematology Associates Inc | Columbus | Ohio | United States | 43214 |
| 290 | Riverside Methodist Hospital | Columbus | Ohio | United States | 43214 |
| 291 | Grant Medical Center | Columbus | Ohio | United States | 43215 |
| 292 | The Mark H Zangmeister Center | Columbus | Ohio | United States | 43219 |
| 293 | Mount Carmel Health Center West | Columbus | Ohio | United States | 43222 |
| 294 | Doctors Hospital | Columbus | Ohio | United States | 43228 |
| 295 | Miami Valley Hospital | Dayton | Ohio | United States | 45409 |
| 296 | Dayton Physician LLC-Miami Valley Hospital North | Dayton | Ohio | United States | 45415 |
| 297 | Miami Valley Hospital North | Dayton | Ohio | United States | 45415 |
| 298 | Delaware Health Center-Grady Cancer Center | Delaware | Ohio | United States | 43015 |
| 299 | Grady Memorial Hospital | Delaware | Ohio | United States | 43015 |
| 300 | Dublin Methodist Hospital | Dublin | Ohio | United States | 43016 |
| 301 | Armes Family Cancer Center | Findlay | Ohio | United States | 45840 |
| 302 | Blanchard Valley Hospital | Findlay | Ohio | United States | 45840 |
| 303 | Orion Cancer Care | Findlay | Ohio | United States | 45840 |
| 304 | Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | United States | 45005-1066 |
| 305 | Dayton Physicians LLC-Atrium | Franklin | Ohio | United States | 45005 |
| 306 | Central Ohio Breast and Endocrine Surgery | Gahanna | Ohio | United States | 43230 |
| 307 | Dayton Physicians LLC-Wayne | Greenville | Ohio | United States | 45331 |
| 308 | Wayne Hospital | Greenville | Ohio | United States | 45331 |
| 309 | Mount Carmel Grove City Hospital | Grove City | Ohio | United States | 43123 |
| 310 | Greater Dayton Cancer Center | Kettering | Ohio | United States | 45409 |
| 311 | First Dayton Cancer Care | Kettering | Ohio | United States | 45420 |
| 312 | Kettering Medical Center | Kettering | Ohio | United States | 45429 |
| 313 | Fairfield Medical Center | Lancaster | Ohio | United States | 43130 |
| 314 | Saint Rita's Medical Center | Lima | Ohio | United States | 45801 |
| 315 | OhioHealth Mansfield Hospital | Mansfield | Ohio | United States | 44903 |
| 316 | Marietta Memorial Hospital | Marietta | Ohio | United States | 45750 |
| 317 | OhioHealth Marion General Hospital | Marion | Ohio | United States | 43302 |
| 318 | Knox Community Hospital | Mount Vernon | Ohio | United States | 43050 |
| 319 | Licking Memorial Hospital | Newark | Ohio | United States | 43055 |
| 320 | Newark Radiation Oncology | Newark | Ohio | United States | 43055 |
| 321 | Mercy Health Perrysburg Cancer Center | Perrysburg | Ohio | United States | 43551 |
| 322 | Southern Ohio Medical Center | Portsmouth | Ohio | United States | 45662 |
| 323 | Springfield Regional Cancer Center | Springfield | Ohio | United States | 45504 |
| 324 | Springfield Regional Medical Center | Springfield | Ohio | United States | 45505 |
| 325 | Saint Vincent Mercy Medical Center | Toledo | Ohio | United States | 43608 |
| 326 | Mercy Health - Saint Anne Hospital | Toledo | Ohio | United States | 43623 |
| 327 | Dayton Physicians LLC-Upper Valley | Troy | Ohio | United States | 45373 |
| 328 | Upper Valley Medical Center | Troy | Ohio | United States | 45373 |
| 329 | Saint Joseph Warren Hospital | Warren | Ohio | United States | 44484 |
| 330 | Saint Ann's Hospital | Westerville | Ohio | United States | 43081 |
| 331 | Saint Elizabeth Youngstown Hospital | Youngstown | Ohio | United States | 44501 |
| 332 | Genesis Healthcare System Cancer Care Center | Zanesville | Ohio | United States | 43701 |
| 333 | Cancer Centers of Southwest Oklahoma Research | Lawton | Oklahoma | United States | 73505 |
| 334 | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 335 | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | United States | 73120 |
| 336 | Saint Alphonsus Medical Center-Baker City | Baker City | Oregon | United States | 97814 |
| 337 | Saint Charles Health System | Bend | Oregon | United States | 97701 |
| 338 | Clackamas Radiation Oncology Center | Clackamas | Oregon | United States | 97015 |
| 339 | Providence Cancer Institute Clackamas Clinic | Clackamas | Oregon | United States | 97015 |
| 340 | Bay Area Hospital | Coos Bay | Oregon | United States | 97420 |
| 341 | Providence Newberg Medical Center | Newberg | Oregon | United States | 97132 |
| 342 | Saint Alphonsus Medical Center-Ontario | Ontario | Oregon | United States | 97914 |
| 343 | Providence Portland Medical Center | Portland | Oregon | United States | 97213 |
| 344 | Providence Saint Vincent Medical Center | Portland | Oregon | United States | 97225 |
| 345 | Saint Charles Health System-Redmond | Redmond | Oregon | United States | 97756 |
| 346 | UPMC Altoona | Altoona | Pennsylvania | United States | 16601 |
| 347 | UPMC-Heritage Valley Health System Beaver | Beaver | Pennsylvania | United States | 15009 |
| 348 | UPMC Cancer Center-Bethel Park | Bethel Park | Pennsylvania | United States | 15102 |
| 349 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822 |
| 350 | UPMC Hamot | Erie | Pennsylvania | United States | 16550 |
| 351 | UPMC Cancer Center at UPMC Horizon | Farrell | Pennsylvania | United States | 16121 |
| 352 | UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania | United States | 15601 |
| 353 | Oncology Hematology Associates | Greenville | Pennsylvania | United States | 16125 |
| 354 | UPMC Pinnacle Harrisburg | Harrisburg | Pennsylvania | United States | 17101 |
| 355 | UPMC Pinnacle Cancer Center/Community Osteopathic Campus | Harrisburg | Pennsylvania | United States | 17109 |
| 356 | Geisinger Medical Center-Cancer Center Hazleton | Hazleton | Pennsylvania | United States | 18201 |
| 357 | IRMC Cancer Center | Indiana | Pennsylvania | United States | 15701 |
| 358 | UPMC-Johnstown/John P. Murtha Regional Cancer Center | Johnstown | Pennsylvania | United States | 15901 |
| 359 | Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania | United States | 17837 |
| 360 | Lewistown Hospital | Lewistown | Pennsylvania | United States | 17044 |
| 361 | UPMC Cancer Center at UPMC McKeesport | McKeesport | Pennsylvania | United States | 15132 |
| 362 | UPMC Cancer Center - Monroeville | Monroeville | Pennsylvania | United States | 15146 |
| 363 | UPMC Hillman Cancer Center - Part of Frick Hospital | Mount Pleasant | Pennsylvania | United States | 15666 |
| 364 | Arnold Palmer Cancer Center Medical Oncology Norwin | N. Huntingdon | Pennsylvania | United States | 15642 |
| 365 | Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | United States | 19107 |
| 366 | Fox Chase Cancer Center | Philadelphia | Pennsylvania | United States | 19111 |
| 367 | Oncology Hematology Association | Pittsburgh | Pennsylvania | United States | 15215 |
| 368 | UPMC-Saint Margaret | Pittsburgh | Pennsylvania | United States | 15215 |
| 369 | University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | United States | 15232 |
| 370 | UPMC-Shadyside Hospital | Pittsburgh | Pennsylvania | United States | 15232 |
| 371 | UPMC-Passavant Hospital | Pittsburgh | Pennsylvania | United States | 15237 |
| 372 | UPMC-Saint Clair Hospital Cancer Center | Pittsburgh | Pennsylvania | United States | 15243 |
| 373 | Geisinger Cancer Services-Pottsville | Pottsville | Pennsylvania | United States | 17901 |
| 374 | Community Medical Center | Scranton | Pennsylvania | United States | 18510 |
| 375 | Geisinger Medical Oncology-Selinsgrove | Selinsgrove | Pennsylvania | United States | 17870 |
| 376 | UPMC Cancer Center at UPMC Northwest | Seneca | Pennsylvania | United States | 16346 |
| 377 | Geisinger Medical Group | State College | Pennsylvania | United States | 16801 |
| 378 | UPMC Cancer Center-Uniontown | Uniontown | Pennsylvania | United States | 15401 |
| 379 | UPMC Cancer Center-Washington | Washington | Pennsylvania | United States | 15301 |
| 380 | UPMC West Mifflin-Cancer Center Jefferson | West Mifflin | Pennsylvania | United States | 15122 |
| 381 | Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | United States | 18711 |
| 382 | UPMC Susquehanna | Williamsport | Pennsylvania | United States | 17701 |
| 383 | Medical University of South Carolina | Charleston | South Carolina | United States | 29425 |
| 384 | University of Tennessee - Knoxville | Knoxville | Tennessee | United States | 37920 |
| 385 | Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia | United States | 23298 |
| 386 | Providence Regional Cancer System-Aberdeen | Aberdeen | Washington | United States | 98520 |
| 387 | Overlake Medical Center | Bellevue | Washington | United States | 98004 |
| 388 | PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | United States | 98225 |
| 389 | Providence Regional Cancer System-Centralia | Centralia | Washington | United States | 98531 |
| 390 | Swedish Cancer Institute-Edmonds | Edmonds | Washington | United States | 98026 |
| 391 | Providence Regional Cancer Partnership | Everett | Washington | United States | 98201 |
| 392 | Swedish Cancer Institute-Issaquah | Issaquah | Washington | United States | 98029 |
| 393 | Kadlec Clinic Hematology and Oncology | Kennewick | Washington | United States | 99336 |
| 394 | Providence Regional Cancer System-Lacey | Lacey | Washington | United States | 98503 |
| 395 | PeaceHealth Saint John Medical Center | Longview | Washington | United States | 98632 |
| 396 | Jefferson Healthcare | Port Townsend | Washington | United States | 98368 |
| 397 | Valley Medical Center | Renton | Washington | United States | 98055 |
| 398 | Pacific Gynecology Specialists | Seattle | Washington | United States | 98104 |
| 399 | Swedish Medical Center-Ballard Campus | Seattle | Washington | United States | 98107 |
| 400 | Swedish Medical Center-First Hill | Seattle | Washington | United States | 98122-4307 |
| 401 | Swedish Medical Center-Cherry Hill | Seattle | Washington | United States | 98122-5711 |
| 402 | PeaceHealth United General Medical Center | Sedro-Woolley | Washington | United States | 98284 |
| 403 | Providence Regional Cancer System-Shelton | Shelton | Washington | United States | 98584 |
| 404 | PeaceHealth Southwest Medical Center | Vancouver | Washington | United States | 98664 |
| 405 | Providence Saint Mary Regional Cancer Center | Walla Walla | Washington | United States | 99362 |
| 406 | North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima | Washington | United States | 98902 |
| 407 | Providence Regional Cancer System-Yelm | Yelm | Washington | United States | 98597 |
| 408 | Duluth Clinic Ashland | Ashland | Wisconsin | United States | 54806 |
| 409 | Northwest Wisconsin Cancer Center | Ashland | Wisconsin | United States | 54806 |
| 410 | Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin | United States | 54701 |
| 411 | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | United States | 54449 |
| 412 | Medical College of Wisconsin | Milwaukee | Wisconsin | United States | 53226 |
| 413 | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin | United States | 54548 |
| 414 | Cancer Center of Western Wisconsin | New Richmond | Wisconsin | United States | 54017 |
| 415 | Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | United States | 54868 |
| 416 | Marshfield Clinic Stevens Point Center | Stevens Point | Wisconsin | United States | 54482 |
| 417 | Marshfield Medical Center - Weston | Weston | Wisconsin | United States | 54476 |
| 418 | Cheyenne Regional Medical Center-West | Cheyenne | Wyoming | United States | 82001 |
| 419 | Billings Clinic-Cody | Cody | Wyoming | United States | 82414 |
| 420 | Welch Cancer Center | Sheridan | Wyoming | United States | 82801 |
Sponsors and Collaborators
- Alliance for Clinical Trials in Oncology
- National Cancer Institute (NCI)
Investigators
- Study Chair: Dan P. Zandberg, MD, University of Pittsburgh Medical Center Hillman Cancer Center
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Alliance for Clinical Trials in Oncology
ClinicalTrials.gov Identifier:
NCT03944941
Other Study ID Numbers:
- A091802
- NCI-2018-02652
- U10CA180821
First Posted:
May 10, 2019
Last Update Posted:
Mar 24, 2022
Last Verified:
Mar 1, 2022
Studies a U.S. FDA-regulated Drug Product:
Yes
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms: