Sleep, Circadian Rhythm & Skin Health
Study Details
Study Description
Brief Summary
The purpose of this study is to explore the mechanisms behind how sleep quality may affect skin aging, skin integrity and skin disease.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Normal, healthy volunteers Normal, healthy volunteers without any skin pathology will be asked to undergo various procedures to evaluate their sleep and skin health. |
|
| Volunteers with skin pathology Volunteers with skin pathology including but not limited to eczema, psoriasis, acne, and other inflammatory dermatoses will be asked to undergo various procedures to evaluate their sleep and skin health. |
Outcome Measures
Primary Outcome Measures
- Analysis of Sleep Pattern via Actigraphy, Polysomnography & Questionnaires [7-14 days]
The volunteers may be asked to wear a wrist actigraph to measure movement. This watch would be worn for 24 hours per day for 7-14 days. The volunteer may also be asked to fill out questionnaires regarding their sleep patterns. Note: Other methods of assessing sleep patterns may also be used including a portable polysomnogram or a standard, overnight sleep study.
- Evaluation of skin (both in terms of skin aging and skin disease) [Only once during the study or at specific time points depending on what other procedures are being performed]
The volunteers may have their skin evaluated for skin aging using the SCINEXA tool. Volunteers with psoriasis may have their skin evaluated via PASI and/or PGA assessments. Volunteers may have photographs taken to compare clinical appearance with laboratory and research findings.
Secondary Outcome Measures
- Sample Analysis (from skin, blood, urine, saliva and hair follicle samples) [Only once during the study or at specific time points depending on what other procedures are being performed]
Skin, blood, urine, saliva and hair follicle samples may be collected from some volunteers to look at various markers related to sleep, the circadian rhythm and skin disease.
- Skin Barrier Recovery (via TEWL measurement) [Only once during the study or at specific time points depending on what other procedures are being performed]
Skin barrier recovery via Transepidermal Water Loss (TEWL) measurement may be assessed in some volunteers.
- MED Testing & Recovery from UV-induced erythema [24 hours]
MED Testing & Recovery from UV-induced erythema may be assessed in some volunteers.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Males or females ages 18 years and above
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Capable of giving informed consent
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Adults who are either healthy, normal volunteers or those with a skin disease including but not limited to eczema, psoriasis, acne or other inflammatory dermatoses
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Fitzpatrick Skin Type I-VI
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In good general health
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Willing to cooperate with study instructions
Exclusion Criteria:
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Volunteers 18 years or younger
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Any serious medical or physical condition that would cause the subject significant discomfort with study procedures
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Women who are pregnant, nursing, or who may become pregnant in the next 3 months
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University Hospitals Cleveland Medical Center | Cleveland | Ohio | United States | 44118 |
Sponsors and Collaborators
- University Hospitals Cleveland Medical Center
Investigators
- Principal Investigator: Kevin Cooper, MD, University Hospitals Cleveland Medical Center
Study Documents (Full-Text)
None provided.More Information
Publications
- Oyetakin-White P, Suggs A, Koo B, Matsui MS, Yarosh D, Cooper KD, Baron ED. Does poor sleep quality affect skin ageing? Clin Exp Dermatol. 2015 Jan;40(1):17-22. doi: 10.1111/ced.12455. Epub 2014 Sep 30.
- Rogiers V; EEMCO Group. EEMCO guidance for the assessment of transepidermal water loss in cosmetic sciences. Skin Pharmacol Appl Skin Physiol. 2001 Mar-Apr;14(2):117-28.
- Vierkötter A, Ranft U, Krämer U, Sugiri D, Reimann V, Krutmann J. The SCINEXA: a novel, validated score to simultaneously assess and differentiate between intrinsic and extrinsic skin ageing. J Dermatol Sci. 2009 Mar;53(3):207-11. doi: 10.1016/j.jdermsci.2008.10.001. Epub 2008 Dec 6.
- 12-14-23