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Incorporating Flow Limitation Into the Diagnosis and Quantification of Sleep Disordered Breathing

Sponsor
National Center for Research Resources (NCRR) (NIH)
Overall Status
Completed
CT.gov ID
NCT00004569
Collaborator
(none)
1
Location

Study Details

Study Description

Brief Summary

The diagnosis and treatment of sleep disordered breathing have come to the forefront of clinical medicine following recognition of the high prevalence and associated morbidity of sleep apnea. The effects on quality of life as well as societal costs have been well documented. The NYU Sleep Research Laboratory has spent the last several years working on the problem of improving the diagnosis of mild sleep disordered breathing which manifests as the upper airway resistance syndrome. Our approach has been to develop a non-invasive technique to detect increased upper airway resistance directly from analysis of the airflow signal. A characteristic intermittent change of the inspiratory flow contour, which is indicative of the occurrence of flow limitation, correlates well with increased airway resistance.

Currently all respiratory events are identified manually and totaled. This is time consuming and subject to variability. The objective of the present project is to improve upon the manual approach by implementing an artificially intelligent system for the identification and quantification of sleep disordered breathing based solely on non-invasive cardiopulmonary signals collected during a routine sleep study. The utility of other reported indices of sleep disordered breathing obtained during a sleep study will be evaluated.

Successful development of an automated system that can identify and classify upper airway resistance events will simplify, standardize and improve the diagnosis of sleep disordered breathing, and greatly facilitate research and clinical work in this area. Using a physiological based determination of disease should allow better assessment of treatment responses in mild disease.

Condition or Disease Intervention/Treatment Phase
  • Procedure: Non-invasive technique to diagnose and quantitate sleep-disordered breathing
 N/A

Study Design

Study Type:
Interventional
Primary Purpose:
Diagnostic

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • Patients with sleep disordered breathing

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 NYU Sleep Disorders Center New York New York United States 10016

    Sponsors and Collaborators

    • National Center for Research Resources (NCRR)

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00004569
    Other Study ID Numbers:
    • NCRR-M01RR00096-0938
    • M01RR000096
    First Posted:
    Feb 14, 2000
    Last Update Posted:
    Jun 24, 2005
    Last Verified:
    Jan 1, 2004
    Additional relevant MeSH terms:
    Respiratory Aspiration
    Sleep Apnea Syndromes

    Study Results

    No Results Posted as of Jun 24, 2005