Denosumab for Smoldering Multiple Myeloma

Sponsor

University of Rochester (Other)

Overall Status

Active, not recruiting

CT.gov ID

NCT03839459

Collaborator

Amgen (Industry)

Enrollment

Location

Arm

61.4

Anticipated Duration (Months)

0.3

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study will assess the safety and tolerability of denosumab in smoldering multiple myeloma subjects as well to see if denosumab can reduce subjects' risk of getting multiple myeloma.

Condition or Disease	Intervention/Treatment	Phase
Smoldering Multiple Myeloma	Drug: Denosumab	Phase 2

Detailed Description

This is an open label, Phase II trial of denosumab 120mg subcutaneous (SC) for patients with smoldering multiple myeloma (SMM). Subjects will be recruited from the James P. Wilmot Cancer Center, University of Rochester in Rochester, New York. Patients seen in the inpatient or outpatient setting with histologically confirmed SMM will be evaluated for this study.

20 patients will be treated as follows: Denosumab: day 1 = 120mg SC every 4 weeks for 12 cycles. Cycles will be 28 days in length. Patients will be followed after completion of the study per standard of care for progression free survival for an additional 2 years after the last dose of denosumab. All patients will take daily vitamin D and calcium supplements of at least 1200mg elemental calcium and 800IU of vitamin D unless documented hypercalcemia develops on study. Pre-existing hypocalcemia must be corrected prior to initiating therapy with denosumab. Serum vitamin D levels will be checked during screening and should be repleted to a total 25-hydroxyvitamin D level ≥30ng/mL.

Study Design

Study Type:

Interventional

Actual Enrollment :

20 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

Denosumab for Smoldering Multiple Myeloma

Actual Study Start Date :

Apr 19, 2019

Actual Primary Completion Date :

Aug 30, 2021

Anticipated Study Completion Date :

Jun 1, 2024

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Denosumab	Drug: Denosumab 120mg of Denosumab will be administered subcutaneously once every 4 weeks

Arm

Intervention/Treatment

Experimental: Denosumab

Drug: Denosumab

120mg of Denosumab will be administered subcutaneously once every 4 weeks

Outcome Measures

Primary Outcome Measures

Proportion of subjects with a downgraded risk of progression of smoldering multiple myeloma if the risk category decreases. [1 year]
Risk Categories: Low Risk:Patient has SMM, but none of the listed risk factors Low-Intermediate Risk: 1 risk factor is present High-Intermediate Risk: 2 risk factors are present High Risk: 3 risk factors are present Risk Factors: BM plasma cell % ≥50 M-protein ≥ 3g/dL Involved/ un-involved free light chains ≥ 8

Secondary Outcome Measures

Proportion of subjects with Skeletal related Events [1 year]
To be determined by the investigator
Proportion of subjects with disease progression to Multiple Myeloma [1 year]
Risk Categories: Low Risk:Patient has SMM, but none of the listed risk factors Low-Intermediate Risk: 1 risk factor is present High-Intermediate Risk: 2 risk factors are present High Risk: 3 risk factors are present Risk Factors: BM plasma cell % ≥50 M-protein ≥ 3g/dL Involved/ un-involved free light chains ≥ 8
Proportion of subjects with progression free survival [3 year]
time to progression or death from any cause, whichever occurs first.
Proportion of subjects with change in bone mineral density [1 year]
baseline and each post-treatment point

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Patient has confirmed SMM according to the definition of the International Myeloma Working Group (IMWG) definition: serum M-protein ≥3 g/dL or BMPC >10% but less than 60%, or both, along with normal organ and marrow function (CRAB) within 4 weeks prior to baseline. C: Absence of hypercalcemia, evidenced by a calcium ≤11 mg/dL. R: Absence of renal failure, evidenced by a creatinine ≤ 2.0mg/dL A: Absence of anemia, evidenced by a hemoglobin ≥10 g/dL.

B: Absence of lytic bone lesions per IMWG recommendations:

One of either PET-CT, low-dose whole-body CT (LDWBCT) or MRI of the whole body or spine. Increased uptake on PET-CT alone is not adequate for the diagnosis of multiple myeloma; evidence of underlying osteolytic bone destruction is needed on the CT portion of the examination.

One of the risk factors below that portends for an increased risk of progression to

MM:

An abnormal free light chain ratio
M-spike ≥ 4 g/dL
≥ 50% bone marrow plasma cells
Immunoparesis ≥ 20% less than the institutional normal standard of the uninvolved immunoglobulins

Serum calcium or albumin-adjusted serum calcium ≥ 2.1 mmol/L (8.4 mg/dL) and ≤ 2.9mmol/L (11.5 mg/dL) (Reference range 8.5-10.8 mg/dL)
Able to tolerate daily supplementation of calcium and vitamin D
Must have a vitamin D level ≥ 30 ng/mL after repletion
Participants must have normal organ as defined below:

Total bilirubin ≤ 2.0 x institutional upper limit of normal (ULN); patients diagnosed with Gilbert's syndrome can enroll with a total bilirubin > 2 after review of the principal investigator
AST(SGOT) ≤2.5 × institutional ULN
ALT(SGPT) ≤2.5 × institutional ULN

Age ≥ 18 years.
ECOG PS ≤1
Life expectancy greater than 12 months
Subjects with reproductive potential must be willing to use, in combination with his/her partner, 2 highly effective methods of effective contraception or practice sexual abstinence throughout the study and continue for 5 months after the study duration. Subjects who are surgically sterile (e.g. history of bilateral tubal ligation, hysterectomy) or whose sexual partner is sterile (e.g. history of vasectomy) are not required to use additional contraceptive measures.
Ability to understand and the willingness to sign a written informed consent document.

-Patient is willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations including follow up.

Statement on Inclusion of Women and Minorities - Men and women of all ethnicities and racial backgrounds are eligible for this study.

Exclusion Criteria:

Prior administration of denosumab.
Any history of IV bisphosphonate use prior to or during the study
Prescription oral fluorides or bisphosphonate usage > 3 months within the past 2 years
Systemic corticosteroids > 10mg prednisone per day
Known secondary cause for osteopenia or osteoporosis
Patient has symptomatic MM, as defined by any of the following:

Lytic lesions or pathologic fractures.
Anemia (hemoglobin <10 g/dL)
Hypercalcemia (corrected serum calcium > 11.0 mg/dL)
Renal insufficiency (creatinine > 2.0 mg/dL).
Clonal bone marrow plasma cells > 60%
An involved serum free light chain (kappa or Lambda) > 100mg/L with the ratio of the involved/uninvolved free light chains also > 100 mg/L
One or more osteolytic lesions on radiography, but more than one lesion is required if < 10% marrow plasma cells. From MRI imaging, there must be more than one lesion of > 5mm in size.

Other: symptomatic hyperviscosity, amyloidosis, plasma cell leukemia, POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein)
Prior history or current evidence of osteonecrosis/osteomyelitis of the jaw.
Active dental or jaw condition that requires oral surgery, including tooth extraction.
Non-healed dental/oral surgery, including tooth extraction.
Planned invasive dental procedures during the course of study.
Evidence of any of the following conditions per subject self-report or medical chart review:

Any prior invasive malignancy within 3 years of enrollment that may affect outcome of study
Any non-invasive malignancy not treated with curative intent or with known active disease within 3 years before enrollment that may affect outcome of study
Major surgery or significant traumatic injury occurring within 4 weeks before enrollment
Active infection with Hepatitis B virus or Hepatitis C virus
Known infection with human immunodeficiency virus (HIV) requiring IV anti-infective therapy

Subject is pregnant or breast feeding, or planning to become pregnant within 5 months after the end of treatment.
Female subject of child-bearing potential is not willing to use, in combination with her partner, 2 methods of highly effective contraception during treatment and for 5 months after the end of treatment.
Clinically significant hypersensitivity to denosumab or any components of denosumab 120mg.
Known sensitivity to any of the products to be administered during the study (e.g., calcium, or vitamin D).
Subject is receiving or is less than 14 days since ending other experimental drug (no marketing authorization for any indication).
Any major medical or psychiatric disorder that, in the opinion of the investigator, might prevent the subject from completing the study or interfere with the interpretation of the study results.