Oxytocin Effects on Likeability After Being Liked or Disliked

• Sponsor: University of Electronic Science and Technology of China (Other)
• Overall Status: Completed
• CT.gov ID: NCT02745431
• Collaborator: (none)
• Enrollment: 86
• Location: 1
• Arms: 2
• Duration (Months): 12
• Patients Per Site Per Month: 7.2

Study Details

Study Description

Brief Summary

The current study aimed to investigate oxytocin effect on the response after the experience of being liked or disliked.

Condition or Disease	Intervention/Treatment	Phase
Social Behavior	Drug: Oxytocin; Drug: Placebo	N/A

Detailed Description

In a double-blind, between-subject, placebo controlled design study, the researchers aimed to investigate the intranasal OXT (40IU) treatment on rating response after being liked or disliked in healthy male subjects. All subjects completed a range of questionnaires measuring personality and affective traits and levels of anxiety: Positive and Negative Affect Schedule (PANAS) , State-Trait Anxiety Inventory (STAI) , Beck Depression Inventory (BDI), Cheek and Buss shyness Scale (CBSS),Autism Spectrum Quotient (ASQ), Empathy Quotient(EQ) before self-administration.Study participants were led to believe that other participants had formed an opinion on their likability based on their appearance in a photograph and they passively viewed the responses (like or dislike) from 'other participants'. After that, they rated 'other participants' about likeability (how much do you like the person), accuracy (have you seen the person), feeling (how good do you feel), and tendency (how much would do like have him/her as a friend). Likeability, tendency, feeling and accuracy were included into analysis as dependent variables.

Study Design

• Study Type: Interventional
• Actual Enrollment: 86 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Double (Participant, Investigator)
• Primary Purpose: Basic Science
• Study Start Date: Jun 1, 2015
• Actual Primary Completion Date: Jun 1, 2016
• Actual Study Completion Date: Jun 1, 2016

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Oxytocin nasal spray Oxytocin nasal spray	Drug: Oxytocin
Placebo Comparator: Placebo nasal spray Placebo nasal spray	Drug: Placebo

Outcome Measures

Primary Outcome Measures

1. Oxytocin effect on likeability after being liked or disliked [2 hour]

   Likeability rating was included into analysis as dependent factor.

Secondary Outcome Measures

1. Relationship status may influence oxytocin effect [2 hour]

   subjects were subdivided into two subgroups

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 30 Years
• Sexes Eligible for Study: Male
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Healthy subjects without past or current psychiatric or neurological disorder

Exclusion Criteria:

• history of head injury;

• claustrophobia;

• medical or psychiatric illness.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	School of Life Science and Technology, University of Electronic Science and Technology	Chengdu	Sichuan	China	611731

Sponsors and Collaborators

• University of Electronic Science and Technology of China

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: University of Electronic Science and Technology of China
• ClinicalTrials.gov Identifier: NCT02745431
• Other Study ID Numbers: UESTC-neuSCAN-06
• First Posted: Apr 20, 2016
• Last Update Posted: Aug 1, 2017
• Last Verified: Nov 1, 2016

• Keywords provided by University of Electronic Science and Technology of China: Likeability; Being liked
• Additional relevant MeSH terms: Oxytocin

Study Results

No Results Posted as of Aug 1, 2017