Effects of Sodium Bicarbonate Supplementation on Intermittent and Intense Task

Sponsor

University of Nove de Julho (Other)

Overall Status

Unknown status

CT.gov ID

NCT03837886

Collaborator

Marcelo Martins Kalytczak (Other)

Enrollment

Location

Arms

1.3

Anticipated Duration (Months)

8.9

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aim of this study was to verify if sodium bicarbonate (NaHCO3) suplementation promotes changes in the performance, muscular activity and strength of individuals trained during the intermittent and intense task . Twelve trained adult men will participate in this randomized, double-blind, crossover clinical trial. Each participant should receive two types of intervention with a 14-day interval between conditions: alkalosis (ALK) in which gelatinous capsules containing 0.3 g.kg -1 of NaHCO 3 and placebo (PLA) are administered, in which 0.3 g.kg-1 of Calcium Carbonate (CaCO3). The following results will be considered: electromyographic activity (EMG) of the quadriceps muscle, peak torque, pH, lactate, and perception of effort, recovery and pain questionnaires, which will be collected during intermittent and high intensity DI protocol. ANOVA of repeated measures will be used to verify possible differences between groups.

Condition or Disease	Intervention/Treatment	Phase
Sodium Bicarbonate Alkalosis, Metabolic Electromyography Fatigue	Dietary Supplement: Sodium bicarbonate Dietary Supplement: Calcium carbonate	N/A

Study Design

Study Type:

Interventional

Anticipated Enrollment :

12 participants

Allocation:

Randomized

Intervention Model:

Crossover Assignment

Masking:

Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Primary Purpose:

Other

Official Title:

Sodium Bicarbonate Supplementation Promotes Changes in Performance, Muscle Activity and Strength of Individuals Trained During the Performance of Intermittent and Intense Task? Randomized, Double-blind, Crossover Trial

Anticipated Study Start Date :

Oct 20, 2019

Anticipated Primary Completion Date :

Oct 30, 2019

Anticipated Study Completion Date :

Nov 30, 2019

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Alkalosis group The subjects should receive gelatinous capsules containing 0.3 g.kg -1 of sodium bicarbonate	Dietary Supplement: Sodium bicarbonate The subjects should ingest 0.3g.kg of sodium bicarbonate 90 minutes before the beginning of the protocol task.
Placebo Comparator: Placebo group The subjects should receive gelatinous capsules containing 0.3 g.kg -1 of Calcium Carbonate	Dietary Supplement: Calcium carbonate The subjects should receive gelatinous capsules containing 0.3 g.kg -1 of Calcium Carbonate

Arm

Intervention/Treatment

Experimental: Alkalosis group

The subjects should receive gelatinous capsules containing 0.3 g.kg -1 of sodium bicarbonate

Dietary Supplement: Sodium bicarbonate

The subjects should ingest 0.3g.kg of sodium bicarbonate 90 minutes before the beginning of the protocol task.

Placebo Comparator: Placebo group

The subjects should receive gelatinous capsules containing 0.3 g.kg -1 of Calcium Carbonate

Dietary Supplement: Calcium carbonate

The subjects should receive gelatinous capsules containing 0.3 g.kg -1 of Calcium Carbonate

Outcome Measures

Primary Outcome Measures

Electromyographic activity of the femoral quadriceps evaluated with electromyography equipment [60 minutes]
The electromyographic activity will be obtained during the execution of 10 series composed of ten repetitions of extension (concentric phase) and flexion (eccentric phase) of the knee joint, at an angular velocity of 120os-1 (radians per second), with interval of 1 minute interval between sets in an isokinetic dynamometer.
Peak torque assessed with isokinetic dynamometer equipment [60 minutes]
The peak torque will be obtained during the execution of 10 series composed of ten repetitions of extension (concentric phase) and flexion (eccentric phase) of the knee joint, at an angular velocity of 120os-1 (radians per second), with interval of 1 minute interval between sets.

Secondary Outcome Measures

Lactate assessed with portable lactometer [15 seconds]
The lactate quantification will be performed before and after the test session characterized by the execution of 10 series composed of ten repetitions of extension (concentric phase) and flexion (eccentric phase) of the knee joint, at an angular velocity of 120os-1 (radians per second), with an interval of 1 minute between sets in an isokinetic dynamometer.

Eligibility Criteria

Criteria

Ages Eligible for Study:

20 Years to 42 Years

Sexes Eligible for Study:

Male

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

resistance trained men (minimum 12 moths resistance training experience)

Exclusion Criteria:

diabetes mellitus;
respiratory (asthma, COPD), renal, metabolic, rheumatic and cardiovascular disorders;
acid-base balance disorder;
continuous use of some type of medication;
use of high-protein supplementation and creatine supplementation;
users of anabolic steroids.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Nove de Julho University	São Paulo		Brazil	06454050

Sponsors and Collaborators

University of Nove de Julho
Marcelo Martins Kalytczak

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Fabiano Politti, Principal Investigator, University of Nove de Julho

ClinicalTrials.gov Identifier:

NCT03837886

Other Study ID Numbers:

FP001

First Posted:

Feb 12, 2019

Last Update Posted:

Oct 17, 2019

Last Verified:

Oct 1, 2019

Individual Participant Data (IPD) Sharing Statement:

Undecided

Plan to Share IPD:

Undecided

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Additional relevant MeSH terms:

Alkalosis

Calcium Carbonate

Calcium

Study Results

No Results Posted as of Oct 17, 2019