Effect of Intraoperative Muscle Relaxation Depth on Postoperative Sore Throat and Hoarseness After General Anesthesia
Study Details
Study Description
Brief Summary
Investigators assess and compare postoperative sore throat and hoarseness in the group maintaining moderate relaxation and deep relaxation during operation.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
| N/A |
Detailed Description
In this sturdy, the deep block is applied when the surgeon requests for deep muscle relaxation to improve surgical field condition in the surgery such as laparotomy known that the deep block is helpful and in the other surgeries, the moderate block is maintained. The investigators assess the postoperative sore throat and hoarseness and compare the effect of muscle relaxation depth in the deep block group and moderate block group in terms of the incidence and severity of postoperative sore throat and hoarseness.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: Moderate muscle relaxation Rocuronium is administered to maintain moderate relaxation during operation. This is conventional muscle relaxation level of this institute. |
Drug: Rocuronium(moderate)
In the group with deep relaxation during surgery, rocuronium is given by bolus dose(0.15mg/kg) induced a train of four count of 1-2.
|
| Experimental: Deep muscle relaxation Rocuronium is administered to maintain deep relaxation during operation. |
Drug: Rocuronium(deep)
In the group with deep relaxation during surgery, rocuronium is given by continuous infusion (0.6 mg/kg/h).
|
Outcome Measures
Primary Outcome Measures
- Overall incidence of postoperative sore throat [Within 24 hrs after operation]
The overall cumulative incidence of postoperative sore throat is assessed in the 24-hr evaluation period
Secondary Outcome Measures
- The incidence of postoperative sore throat [At 1,6, and 24 hrs after operation]
The presence of sore throat is assessed.
- The severity of postoperative sore throat [At 1,6, and 24 hrs after operation]
The severity of sore throat is assessed by using a 100-point numerical ratig scale (NRS, 0 [no pain], 100 [worst pain imaginable]).
- Incidence and severity of postoperative hoarseness [At 1,6, and 24 hrs after operation]
Hoarseness is defined as a voice quality different from the preoperative voice and graded as follows: none (no hoarseness), mild (recognized by the patient), moderate (obvious to the investigator), and severe (aphonia).
- Postoperative analgesic consumption [Within 24 hrs after operation]
The amount of patient-controlled analgesia and other analgesic medication used
Eligibility Criteria
Criteria
Inclusion Criteria:
- Requirement for mechanical ventilation under general anesthesia
Exclusion Criteria:
-
Hoarseness and sore throat existed before surgery
-
Upper respiratory infection
-
Known or predicted difficult airway
-
Liver, renal disease
-
Requirement of postoperative ventilator care
-
the operation within 2hrs
-
Laparoscopic surgery
-
Other positions except supine during surgery
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Jee-Eun Chang | Seoul | Korea, Republic of | 07061 |
Sponsors and Collaborators
- SMG-SNU Boramae Medical Center
Investigators
- Principal Investigator: Jee-eun Chang, M.D, SMG-SNU Boramae Medical Center
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 20170601/10-2017-4/071