Sensory Memory in Speech Motor Learning

• Sponsor: Yale University (Other)
• Overall Status: Recruiting
• CT.gov ID: NCT04818268
• Collaborator: National Institute on Deafness and Other Communication Disorders (NIDCD) (NIH)
• Enrollment: 120
• Location: 1
• Arms: 5
• Anticipated Duration (Months): 60
• Patients Per Site Per Month: 2

Study Details

Study Description

Brief Summary

The proposed studies focus on memory for speech movements and sounds and its relation to learning. Continuous theta-burst transcranial magnetic stimulation (cTBS) will be used to suppress activity in a region of pre-frontal cortex associated with somatic and auditory working memory (Brodmann area 46v) to test its involvement in learning.

Condition or Disease	Intervention/Treatment	Phase
Speech; Consolidation	Behavioral: Adaptation; Other: cTBS	N/A

Detailed Description

This study will assess the relationship between sensory working memory and speech motor adaptation using a between subjects design. Participants will be assigned to one of two groups. Each group will undergo both auditory and somatosensory working memory tests. This will be followed by adaptation to altered auditory feedback. Using a different group of subjects, cTBS will be used to disrupt neural activity in Brodmann area 46v in ventrolateral prefrontal cortex to test its involvement in adaptation. One set of tests will focus on the effects of cTBS on both auditory and somatosensory working memory. A second set of tests will focus on the effects of cTBS on speech motor adaptation to altered auditory feedback. Both working memory and adaptation are assessed on 0 to 100 scales.

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 120 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Basic Science
• Official Title: Role of Sensory Working Memory in Speech Motor Learning Aim 2
• Actual Study Start Date: Aug 1, 2019
• Anticipated Primary Completion Date: Jan 31, 2024
• Anticipated Study Completion Date: Jul 31, 2024

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Adaptation to Altered Auditory Feedback Adaptation to Altered Auditory Feedback	Behavioral: Adaptation; Sensorimotor adaptation in speech
Experimental: Auditory Sensory Memory Auditory Sensory Memory	Behavioral: Adaptation; Sensorimotor adaptation in speech
Experimental: Somatosensory Sensory Memory Somatosensory Sensory Memory	Behavioral: Adaptation; Sensorimotor adaptation in speech
Experimental: Adaptation to Altered Auditory Feedback + cTBS to 46v Adaptation to Altered Auditory Feedback + cTBS to 46v	Behavioral: Adaptation; Sensorimotor adaptation in speech; Other: cTBS; continuous theta-burst stimulation
Experimental: Sensory Memory + cTBS to 46v Sensory Memory + cTBS to 46v	Behavioral: Adaptation; Sensorimotor adaptation in speech; Other: cTBS; continuous theta-burst stimulation

Outcome Measures

Primary Outcome Measures

1. Speech Motor Learning [Performance as measured at the end of learning (single day experiment)]

   Learning is assessed on a 0 to 100 scale as change in speech sounds (speech formant frequencies). A score of 100 corresponds to complete adaptation.

2. Sensory Memory [Single day experiment]

   Sensory Memory is measured on a 0 to 100 scale. A score of 100 corresponds to perfect memory.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 21 Years to 40 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• right handed adults

• no known physical or neurological abnormalities

Exclusion Criteria:

• patients with:

• cardiac pacemaker

• surgical clips or values on the heart

• implants

• metal or metallic fragments in any part of the body

• pregnancy

• claustrophobia

• a personal or family history of epilepsy

• currently taking antipsychotic drugs

• currently taking antidepressant drugs

• currently taking antianxiety drugs

• history of concussion.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	McGill Univeristy	Montréal	Quebec	Canada	H3A1G1

Sponsors and Collaborators

• Yale University
• National Institute on Deafness and Other Communication Disorders (NIDCD)

Investigators

• Principal Investigator: David Ostry, Haskins Laboratories

Study Documents (Full-Text)

• Informed Consent Form - Jun 15, 2019

More Information

Publications

None provided.

• Responsible Party: Yale University
• ClinicalTrials.gov Identifier: NCT04818268
• Other Study ID Numbers: 2000025475_a; R01DC017439
• First Posted: Mar 26, 2021
• Last Update Posted: May 18, 2022
• Last Verified: May 1, 2022

• Individual Participant Data (IPD) Sharing Statement: No
• Plan to Share IPD: No
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No

Study Results

No Results Posted as of May 18, 2022