BRAVA²: Somesthesic Role of the Ventro-lateral Prefrontal Cortex in Speech Motor Learning

Sponsor

University Hospital, Grenoble (Other)

Overall Status

Completed

CT.gov ID

NCT04547569

Collaborator

Laboratoire de Psychologie et NeuroCognition (Other), GIPSA-LAB (Other), McGill University (Other)

Enrollment

Location

Arms

8.5

Actual Duration (Months)

1.9

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

These studies test the hypothesis that frontal areas of the brain participate in the cortical networks involved in the somotosensory processing that happens during speech motor learning.

Condition or Disease	Intervention/Treatment	Phase
Speech Motor Activity	Behavioral: Speech adaptation Behavioral: Vibrotactile Discrimination Other: fMRI Behavioral: Speech production	N/A

Detailed Description

This work aims to study the role of sensory systems in human motor learning and specifically addresses the involvement of somatosensory cortical networks in motor learning of speech. Previous studies in the literature have highlighted the plasticity of cortical sensory networks, notably the primary and secondary somatosensory cortex and the ventral premotor cortex, during motor learning tasks. The present project focuses on the somatosensory region with connections to the sensorimotor regions of the frontal and parietal cortex. We propose to use neuroimaging (fMRI), in order to verify which areas in the prefrontal cortex are part of the sensorimotor network used in the learning of speech motor tasks in humans. Subjects will be tested in the fMRI scanner while performing either a behavioral task in which the auditory feedback of their own speech is altered or while performing a vibrotactile discrimination task.

Study Design

Study Type:

Interventional

Actual Enrollment :

16 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

None (Open Label)

Primary Purpose:

Basic Science

Official Title:

Somesthesic Role of the Ventro-lateral Prefrontal Cortex in Speech Motor Learning fMRI Study

Actual Study Start Date :

Oct 20, 2020

Actual Primary Completion Date :

Jul 6, 2021

Actual Study Completion Date :

Jul 6, 2021

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Adaptation to altered auditory feedback fMRI measurement of brain activity during speech production under altered auditory feedback	Behavioral: Speech adaptation Sensorimotor adaptation in speech Other: fMRI fMRI measurement of brain activity
Experimental: Speech production fMRI measurement of brain activity during normal speech production	Other: fMRI fMRI measurement of brain activity Behavioral: Speech production Speech production task
Experimental: Vibrotactile discrimination fMRI measurement of brain activity during a vibrotactile discrimination task	Behavioral: Vibrotactile Discrimination Vibrotactile Discrimination Other: fMRI fMRI measurement of brain activity

Arm

Intervention/Treatment

Experimental: Adaptation to altered auditory feedback

fMRI measurement of brain activity during speech production under altered auditory feedback

Behavioral: Speech adaptation

Sensorimotor adaptation in speech

Other: fMRI

fMRI measurement of brain activity

Experimental: Speech production

fMRI measurement of brain activity during normal speech production

Other: fMRI

fMRI measurement of brain activity

Behavioral: Speech production

Speech production task

Experimental: Vibrotactile discrimination

fMRI measurement of brain activity during a vibrotactile discrimination task

Behavioral: Vibrotactile Discrimination

Vibrotactile Discrimination

Other: fMRI

fMRI measurement of brain activity

Outcome Measures

Primary Outcome Measures

Motor Learning [Performance as measured at the end of learning (during the 1h30 scanner session)]
Learning is assessed as percentage change in speech sounds (speech formant frequencies) relative to baseline.
Brain activity [1h30 scanner session]
Brain activity are measure by the BOLD signal during both task-based and resting-state blocks

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 35 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Right-handed subjects
Subjects fluent in French
Signed informed consent
Affiliation to or beneficiary of a Social Security scheme

Exclusion Criteria:

Left-handed subjects
Criteria for contraindications to protocol fMRI scans
Existence of a severe general condition: cardiac, respiratory, hematological, renal, hepatic, cancerous.
Hearing, language (including dyslexia), neurological or psychiatric disorders.
Participation in other ongoing intervention research protocols with exclusionary period or within the previous week
Drug treatment likely to modulate brain activity: benzodiazepines, antidepressants, neuroleptics, lithium, etc.
Protected persons referred to in articles L1121 5 to L1121 8 of the French CSP:
Pregnant women, parturients, nursing mothers,
Persons deprived of liberty by a judicial or administrative decision,
Persons under psychiatric care,
Individuals admitted to a health or social institution for purposes other than research,
Minors,
Persons over the age of majority who are subject to a legal protection measure or who are unable to express their consent

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	CHU Grenoble-Alpes	Grenoble		France	38043

Sponsors and Collaborators

University Hospital, Grenoble
Laboratoire de Psychologie et NeuroCognition
GIPSA-LAB
McGill University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

University Hospital, Grenoble

ClinicalTrials.gov Identifier:

NCT04547569

Other Study ID Numbers:

38RC18.173

First Posted:

Sep 14, 2020

Last Update Posted:

Jun 1, 2022

Last Verified:

May 1, 2022

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Study Results

No Results Posted as of Jun 1, 2022