Dynamic Neural Mechanisms of Audiovisual Speech Perception

• Sponsor: University of Pennsylvania (Other)
• Overall Status: Enrolling by invitation
• CT.gov ID: NCT04290130
• Collaborator: Columbia University (Other), Baylor College of Medicine (Other)
• Enrollment: 100
• Location: 1
• Anticipated Duration (Months): 56.5
• Patients Per Site Per Month: 1.8

Study Details

Study Description

Brief Summary

Understanding speech is one of the most important functions of the human brain. We use information from both the auditory modality (the voice the of person we are talking to) and the visual modality (the facial movements of the person we are talking to) to understand speech. We will use intracranial encephalography to study the organization and operation of the brain during audiovisual speech perception.

Condition or Disease	Intervention/Treatment	Phase
Speech Perception	Other: Measurement of brain activity using electrodes.	Early Phase 1

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 100 participants
• Allocation: N/A
• Intervention Model: Single Group Assignment
• Masking: None (Open Label)
• Primary Purpose: Basic Science
• Official Title: Dynamic Neural Mechanisms of Audiovisual Speech Perception
• Actual Study Start Date: Sep 15, 2019
• Anticipated Primary Completion Date: May 31, 2024
• Anticipated Study Completion Date: May 31, 2024

Outcome Measures

Primary Outcome Measures

1. Measurement of neural activity [During the procedure.]

   The name of the measurement is the broadband high-frequency activity (BHA) in the brain in response to audiovisual speech. The unit of measure is % increase in power from pre-stimulus baseline. The name of the measurement tool is intracranial EEG, recordings of the raw voltage signal from each electrode implanted in the brain. The voltage-by-time signal will be converted to spectral space using a wavelet transform, and the magnitude of the power between 70 and 150 Hz inclusive in a time window between 0 ms and 500 ms after stimulus onset will be calculated.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 21 Years to 65 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• must be undergoing neurosurgery for the treatment of a brain disorder

Exclusion Criteria:

• must have corrected-to-normal vision and hearing

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Pennsylvania	Philadelphia	Pennsylvania	United States	19104

Sponsors and Collaborators

• University of Pennsylvania
• Columbia University
• Baylor College of Medicine

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Michael Beauchamp, PhD, Professor, University of Pennsylvania
• ClinicalTrials.gov Identifier: NCT04290130
• Other Study ID Numbers: 844668
• First Posted: Feb 28, 2020
• Last Update Posted: Jul 8, 2021
• Last Verified: Jul 1, 2021

• Individual Participant Data (IPD) Sharing Statement: No
• Plan to Share IPD: No
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No

Study Results

No Results Posted as of Jul 8, 2021