Intermittent Hypoxia and Upper Extremity EMG Recordings in Individuals With Spinal Cord Injury

Sponsor

Shirley Ryan AbilityLab (Other)

Overall Status

Completed

CT.gov ID

NCT05513911

Collaborator

(none)

Enrollment

Location

Arm

37.7

Actual Duration (Months)

0.2

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

In this current study, the examiners examine some of the mechanisms of how Acute Intermittent Hypoxia (AIH) effects the upper extremity of survivors of spinal cord injury. This is accomplished both with the use of a load cell to determine elbow strength changes and high density grid electromyography (EMG) to record bicep muscle activations before and after bouts of AIH

Condition or Disease	Intervention/Treatment	Phase
Spinal Cord Injuries	Other: Acute Intermittent Hypoxia	N/A

Detailed Description

It has been shown previously that there is an increase in strength in survivors of spinal cord injury after brief bouts of Acute Intermittent Hypoxia. In this study, participants are fitted with a high density EMG electrode on the biceps brachii, and attached to a load cell at the wrist, they are asked to flex and extend their elbow at various levels of intensity. This is performed before and after the 30 minute session of AIH. The investigators hope to identify specific types of motor units of the upper extremity of survivors of spinal cord injury after AIH to help further our understanding of what mechanisms may be causing the known increase in muscle strength post AIH

Study Design

Study Type:

Interventional

Actual Enrollment :

8 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Intervention Model Description:

Every participant in this study will receive the interventionEvery participant in this study will receive the intervention

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

Intermittent Hypoxia and Upper Limb Training in Individuals With Spinal Cord Injury

Actual Study Start Date :

Feb 3, 2016

Actual Primary Completion Date :

Nov 8, 2016

Actual Study Completion Date :

Mar 25, 2019

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Acute intermittent Hypoxia Therapy This group will receive the acute intermittent hypoxia therapy (9% O2) for 30 minutes. Before and after the intervention the participant will perform flexion of the elbow at various levels of intensity	Other: Acute Intermittent Hypoxia Acute Intermittent Hypoxia is administered in 30-60 second bouts of 9% O2 concentration, followed by 60-90 seconds of normoxic air concentrations (21% O2, room air). This procedure is repeated 15 times for a 30 minute session Other Names: AIH

Arm

Intervention/Treatment

Experimental: Acute intermittent Hypoxia Therapy

This group will receive the acute intermittent hypoxia therapy (9% O2) for 30 minutes. Before and after the intervention the participant will perform flexion of the elbow at various levels of intensity

Other: Acute Intermittent Hypoxia

Acute Intermittent Hypoxia is administered in 30-60 second bouts of 9% O2 concentration, followed by 60-90 seconds of normoxic air concentrations (21% O2, room air). This procedure is repeated 15 times for a 30 minute session

Other Names:

AIH

Outcome Measures

Primary Outcome Measures

Maximal Elbow Strength [Newtons] [30 minutes Post intervention]
Recordings of the elbow joint torque are taken while the participant is asked to flex and extend the elbow voluntarily at a maximum level of intensity

Secondary Outcome Measures

Biceps Brachii Muscle activation [μv] [30 minutes post intervention]
Peak electromyographic activation of the biceps brachii muscle during maximum voluntary flexion and extension tasks

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 70 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

History of Spinal Cord Injury from C3-T4
Non-progressive spinal cord injury
More than 6 months since initial Spinal Cord injury
Ability to understand and willingness to sign written informed consent

Exclusion Criteria:

Presence of any of the following medical conditions: Congestive heart failure, arrhythmia, uncontrolled high blood pressure, uncontrolled diabetes mellitus, COPD/emphysema and severe asthma
Persons with known coronary artery disease, a history of myocardial infarction, or known carotid or intracerebral artery stenosis
Medical clearance will be required if participant is taking any other investigational agents
Women who are pregnant or nursing
Individuals with tracheostomy
Cannot pursue other research studies which may interfere
Unable to consent
Individuals who are not yet adults (infants, children, teenagers)
Prisoners