Aerobic Exercise and Blood Biochemical Factors in Spinal Cord Injury

Sponsor

National Taiwan University Hospital (Other)

Overall Status

Completed

CT.gov ID

NCT02850133

Collaborator

National Science Council, Taiwan (Other)

Enrollment

Arm

Duration (Months)

Study Details

Study Description

Brief Summary

Background:

Patients with spinal cord injury (SCI) have a higher prevalence of cardiovascular diseases compared to the healthy population. Aerobic exercise training is one of the recommended treatments. However, literature regarding the effect of aerobic training on patients with SCI is scarce. This study evaluated changes in parameters of exercise physiology and serum myokines immediately after exercise and after a training program among patients with SCI.

Method:

Male patients with SCI and age- and sex-matched healthy individuals were recruited. Cardio-pulmonary exercise testing (CPET) was used to determine oxygen uptake at peak exercise and anaerobic threshold in both groups. The patients with SCI attended aerobic exercise training for 36 sessions within 12-16 weeks. Basic data, hemodynamic and exercise physiology parameters, and serum myokine (myostatin, insulin like growth factor, and follistatin) concentrations were measured pre- and post-exercise in both groups, and were repeated in patients with SCI post-training.

Condition or Disease	Intervention/Treatment	Phase
Spinal Cord Injury	Other: aerobic exercise training	N/A

Detailed Description

The patients with SCI were invited to undergo a 12- to 16-week exercise training by arm ergometry. The exercise physiology and measurements of hemodynamic parameters and cytokines were repeated after completion of the training.

Study Design

Study Type:

Interventional

Actual Enrollment :

32 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Basic Science

Official Title:

Effect of Aerobic Exercise Training on the Blood Biochemical Factors and Peripheral Hemodynamics in Person With Spinal Cord Injury

Study Start Date :

Aug 1, 2010

Actual Primary Completion Date :

Jul 1, 2013

Actual Study Completion Date :

Jul 1, 2013

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Spinal cord injury Cardio-pulmonary exercise testing and aerobic exercise training	Other: aerobic exercise training aerobic exercise training for 36 sessions within 12-16 weeks

Arm

Intervention/Treatment

Experimental: Spinal cord injury

Cardio-pulmonary exercise testing and aerobic exercise training

Other: aerobic exercise training

aerobic exercise training for 36 sessions within 12-16 weeks

Outcome Measures

Primary Outcome Measures

serum myokines [12-16 weeks]

Eligibility Criteria

Criteria

Ages Eligible for Study:

20 Years and Older

Sexes Eligible for Study:

Male

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

age >20 years, male sex, and onset of injury more than one year

Exclusion Criteria:

known heart disease, atrial fibrillation/flutter, ventricular bigeminy, active inflammatory disease, malignancy, and cardiac pacemakers

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

National Taiwan University Hospital
National Science Council, Taiwan

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

National Taiwan University Hospital

ClinicalTrials.gov Identifier:

NCT02850133

Other Study ID Numbers:

201007031R

First Posted:

Jul 29, 2016

Last Update Posted:

Jul 29, 2016

Last Verified:

Jul 1, 2016

Individual Participant Data (IPD) Sharing Statement:

Yes

Plan to Share IPD:

Yes

Additional relevant MeSH terms:

Spinal Cord Injuries

Wounds and Injuries

Study Results

No Results Posted as of Jul 29, 2016