A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection
Study Details
Study Description
Brief Summary
The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Other: Spontaneous coronary artery dissection (SCAD) group Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function. |
Other: Arterial Tonometry
We will measure arterial stiffness using arterial tonometry.
Diagnostic Test: Echocardiogram
We will collect limited ultrasound images of the heart.
Diagnostic Test: Carotid Ultrasounds
We will perform ultrasound imaging of the carotid artery.
Diagnostic Test: Elastography
We will measure the elastic properties of the arteries using elastography.
Other: Ankle-Brachial Index
We will measure the ankle-brachial index to assess peripheral artery blood flow.
Other: Microneurography with sympathoexcitatory maneuvers
We will measure sympathetic nerve activity at rest and in response to isometric handgrip, mental stress test, cold pressor test, Valsalva maneuvers.
|
| Other: Healthy Control Group Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function. |
Other: Arterial Tonometry
We will measure arterial stiffness using arterial tonometry.
Diagnostic Test: Echocardiogram
We will collect limited ultrasound images of the heart.
Diagnostic Test: Carotid Ultrasounds
We will perform ultrasound imaging of the carotid artery.
Diagnostic Test: Elastography
We will measure the elastic properties of the arteries using elastography.
Other: Ankle-Brachial Index
We will measure the ankle-brachial index to assess peripheral artery blood flow.
Other: Microneurography with sympathoexcitatory maneuvers
We will measure sympathetic nerve activity at rest and in response to isometric handgrip, mental stress test, cold pressor test, Valsalva maneuvers.
|
Outcome Measures
Primary Outcome Measures
- Arterial thickness [Baseline]
Measured by carotid ultrasound intimal media thickness reporting in mm
- Arterial stiffness [Baseline]
Measured by carotid ultrasound pulse wave velocity reporting in m/s
- Baroreflex sensitivity [Baseline]
The slope between heart rate and blood pressure at rest and during the Valsalva Maneuver (ms/mmHg)
- Sympathetic response to stress [Baseline]
Blood pressure or muscle sympathetic nerve activity response to sympathoexcitatory stressors (mm/Hg or bursts/min).
Eligibility Criteria
Criteria
Inclusion Criteria:
-
For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography
-
For controls: no cardiac disease history
Exclusion Criteria:
-
Pregnancy
-
Known or suspected unstable cardiac condition within 4 weeks of the study
-
Active treatment with anticoagulation or dual antiplatelet therapy
-
Prisoner
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Mayo Clinic Rochester | Rochester | Minnesota | United States | 55905 |
Sponsors and Collaborators
- Mayo Clinic
- National Heart, Lung, and Blood Institute (NHLBI)
Investigators
- Principal Investigator: Marysia Tweet, MD, MS, Mayo Clinic
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
None provided.- 21-005636
- 1K23HL155506