The Effect of β-hydroxy-β-methylbutyrate Supplementation on Physical Capacity and Body Composition in Trained Athletes
Study Details
Study Description
Brief Summary
The purpose of this study was to verify the effect of 12-week with β-hydroxy-β-methylbutyrate (HMB) and a placebo (PLA) supplementation on body composition, anaerobic and aerobic capacity, as well as concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Detailed Description
The effect of HMB supplementation is of great interest in sport. In view of the inconclusive character of the results of the studies conducted to date and of a relatively low number of studies investigating the effectiveness of HMB supplementation over a longer period on a large population of trained athletes, the aim of this study was to verify the effect of 12-week with HMB and a placebo supplementation on body composition, anaerobic and aerobic capacity, as well as concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: β-hydroxy-β-methylbutyrate (HMB) Group taking oral supplementation with calcium salt of β-hydroxy-β-methylbutyric acid produced by Olimp Laboratories. A single capsule contained 1250 mg Ca-HMB, which corresponds to 1000 mg of β-hydroxy-β-methylbutyrate. Interventions: The experimental procedure for each athlete included a 12-week HMB supplementation - 3 capsules of the assigned preparation a day in 3 doses: upon waking, immediately after training, and before sleep. On non-training days, the participants were instructed to consume one serving with each of three separate meals throughout the day. Between the 12-week HMB and PLA or a PLA and HMB treatment, a 10-day washout period was introduced. |
Dietary Supplement: β-hydroxy-β-methylbutyrate and a placebo supplementation
|
| Placebo Comparator: Placebo (maltodextrin) Group taking oral supplementation with placebo (maltodextrin). A single capsule contained 1000 mg of maltodextrin. Interventions: The experimental procedure for each athlete included a 12-week placebo administration - 3 capsules of the assigned preparation a day in 3 doses: upon waking, immediately after training, and before sleep. On non-training days, the participants were instructed to consume one serving with each of three separate meals throughout the day. Between the 12-week HMB and PLA or a PLA and HMB treatment, a 10-day washout period was introduced. |
Dietary Supplement: β-hydroxy-β-methylbutyrate and a placebo supplementation
|
Outcome Measures
Primary Outcome Measures
- Changes of body composition indices after HMB supplementation [Baseline and after 12 weeks]
Analysis of the fat mass and fat free mass
- Changes of body composition indices after placebo treatment [Baseline and after 12 weeks]
Analysis of the fat mass and fat free mass
- Changes of aerobic capacity after HMB supplementation [Baseline and after 12 weeks]
- Changes of aerobic capacity after placebo treatment [Baseline and after 12 weeks]
- Changes of anaerobic capacity after HMB supplementation [Baseline and after 12 weeks]
- Changes of anaerobic capacity after placebo treatment [Baseline and after 12 weeks]
- Changes of creatine kinase and lactate dehydrogenase activity in blood after HMB supplementation [Baseline and after 12 weeks]
- Changes of creatine kinase and lactate dehydrogenase activity in blood after placebo treatment [Baseline and after 12 weeks]
- Changes of testosterone, cortisol and lactate levels in blood after HMB supplementation [Baseline and after 12 weeks]
- Changes of testosterone, cortisol and lactate levels in blood after placebo treatment [Baseline and after 12 weeks]
Secondary Outcome Measures
- Statistical evaluation of the significance of differences between the changes in body composition (fat mass and fat free mass) [1 year]
- Statistical evaluation of the significance of differences between the changes in aerobic capacity indices [1 year]
- Statistical evaluation of the significance of differences between the changes in anaerobic capacity indices [1 year]
- Statistical evaluation of the significance of differences between the changes in creatine kinase and lactate dehydrogenase activity and testosterone, cortisol and lactate levels in blood [1 year]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
written consent to participate,
-
male
-
a current medical clearance to practice sports,
-
training experience: at least 5 years,
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minimum of 6 workout sessions a week (minimum 3 in the practiced sports discipline).
Exclusion Criteria:
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current injury,
-
any health-related contraindication,
-
declared general feeling of being unwell,
-
unwilling to follow the study protocol.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Poznan University of Life Sciences, ul.Wojska Polskiego 31 | Poznan | Wielkopolska | Poland | 60-624 |
Sponsors and Collaborators
- Poznan University of Medical Sciences
- Poznan University of Life Sciences
- National Science Centre, Poland
Investigators
- Study Chair: Jan Jeszka, Professor, Department of Hygiene and Human Nutrition, Poznan University of Life Sciences, Poznan, Poland
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NN312262340