The Effects of Red Spinach Extract Supplementation on Isometric Strength, Resistance Exercise and Cognitive Performance

Sponsor

Lipscomb University (Other)

Overall Status

Completed

CT.gov ID

NCT04292106

Collaborator

(none)

Enrollment

Location

Arms

6.1

Actual Duration (Months)

1.8

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Red Spinach is a natural food which is a rich source of nitrates, which are beneficial in hemodynamics, cardiovascular function, and have natural hypotensive and antianginal effects. Red spinach extract has been shown to be beneficial in exercise performance, albeit mostly in aerobic exercise. In a previous study in our lab, we found that dietary nitrate consumption resulted in significantly greater isometric force production in teenage males. However, currently there is little know regarding the effects of dietary nitrate supplementation on isometric strength, resistance exercise and cognitive performance.

Condition or Disease	Intervention/Treatment	Phase
Sports	Dietary Supplement: Red Spinach Extract (RSE) Dietary Supplement: Placebo	N/A

Detailed Description

This research study is designed to measure the effects of red spinach extract (RSE) on markers of physical and cognitive performance during and following anaerobic exercise.

Study Design

Study Type:

Interventional

Actual Enrollment :

11 participants

Allocation:

Randomized

Intervention Model:

Crossover Assignment

Masking:

Double (Participant, Investigator)

Primary Purpose:

Basic Science

Official Title:

The Effects of Red Spinach Extract Supplementation on Isometric Strength, Resistance Exercise and Cognitive Performance.

Actual Study Start Date :

Sep 26, 2019

Actual Primary Completion Date :

Mar 30, 2020

Actual Study Completion Date :

Mar 30, 2020

Arms and Interventions

Arm	Intervention/Treatment
Placebo Comparator: Placebo	Dietary Supplement: Placebo Oral placebo capsules will be taken consisting of maltodrextrin daily for 7 days
Experimental: Red Spinach Extract (RSE)	Dietary Supplement: Red Spinach Extract (RSE) Oral capsules containing 2g of Red Spinach Extract will be consumed daily for 7 days

Arm

Intervention/Treatment

Placebo Comparator: Placebo

Dietary Supplement: Placebo

Oral placebo capsules will be taken consisting of maltodrextrin daily for 7 days

Experimental: Red Spinach Extract (RSE)

Dietary Supplement: Red Spinach Extract (RSE)

Oral capsules containing 2g of Red Spinach Extract will be consumed daily for 7 days

Outcome Measures

Primary Outcome Measures

Bench Press Repetitions to Fatiuge [Through study completion, during both treatments (~4 weeks)]
Number of repetitions completed in each set during the acute exercise bout will be recorded and analyzed
Bench Press Power [Through study completion, during both treatments (~4 weeks)]
Power during bench press repetitions will be measured via a linear transducer.
Isometric Mid-thigh pull (IMTP) Peak Force [Through study completion, during both treatments (~4 weeks)]
Peak Force will be measured via dual force plates during a full-body isometric strength test.
Isometric Mid-thigh pull (IMTP) Rate of Force Development [Through study completion, during both treatments (~4 weeks)]
Rate of Force development will be measured via dual force plates during a full-body isometric strength test.

Secondary Outcome Measures

Estimated Muscle Blood Flow via Near-infrared Spectroscopy (NIRS) [Through study completion, during both treatments (~4 weeks)]
Measures of muscle oxygenation of the anterior deltoid will be estimated using a NIRS Device.
Cognitive Performance via Stroop Test [Through study completion, during both treatments (~4 weeks)]
The Stroop Color and Word Test (SCWT) is a neuropsychological test used to assess cognitive performance. This will be administered before and after the fatiguing bench press protocol

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 34 Years

Sexes Eligible for Study:

Male

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

18-34 years old Participants must have at least 1 year of resistance training experience.
Free of any physical limitations, medications, and supplements that may affect performance, as determined by a health and activity questionnaire.
Are free of musculoskeletal injuries
Are not taking medications that may interfere with study measurements

Exclusion Criteria:

Participants that cannot take either the RSE or placebo supplement will be excluded, as this will be a double-blind study.
Furthermore, participants that cannot participate in pre- and post-research testing, and/or those that cannot commit to regular training sessions will be excluded.
Inability to perform physical exercise (determined by health and activity questionnaire)
Taking any other nutritional supplement or performance enhancing drug.
Any chronic illness that causes continuous medical care

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Jeremy Townsend	Nashville	Tennessee	United States	37215

Sponsors and Collaborators

Lipscomb University

Investigators

Principal Investigator: Jeremy Townsend, PhD, Lipscomb University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Jeremy Townsend, Assistant Professor, Lipscomb University

ClinicalTrials.gov Identifier:

NCT04292106

Other Study ID Numbers:

092619

First Posted:

Mar 2, 2020

Last Update Posted:

Jan 14, 2022

Last Verified:

Jan 1, 2022

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Study Results

No Results Posted as of Jan 14, 2022