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ST Elevation in Acute Chest Pain; Could Measurement of Lipoprotein-associated Phospholipase A2 (Lp-PLA2) be Helpful to the Clinician?

Sponsor
Alexhander Izhaki (Other)
Overall Status
Completed
CT.gov ID
NCT01041339
Collaborator
(none)
40
Enrollment
1
Location
24
Duration (Months)
1.7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

A blood test (2-3 cc peripheral venous blood) drawn /used from already available required lab tests to distinguish between pericarditis accompanied with electrocardiogram (ECG) signs mimicking infarction. A test of clinical potential if proven to be able to support either origin of acute chest pain etiology.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Too many times young patients presenting with acute chest pain are referred to invasive angiography or treated with anticoagulation therapy a measure of detrimental effect in those inflicted with acute pericarditis.

    A simple blood test (the PLAC test) may have some value in aiding rapid diagnosis saving need for cath.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    40 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Prospective
    Official Title:
    ST Elevation (Acute Coronary Syndrome Versus Pericarditis;Could Measurement of Lp-associated PLA2 -a Vascular Specific Marker of Inflammation- be Helpful to the Clinician?
    Study Start Date :
    Jan 1, 2010
    Actual Primary Completion Date :
    Nov 1, 2011
    Actual Study Completion Date :
    Jan 1, 2012

    Arms and Interventions

    Arm Intervention/Treatment
    acute chest pain ST elevation

    patients admitted with acute chest pain sharing ST elevation in ER-ECG and elevated troponin
    controls

    asymptomatic patients

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years to 70 Years
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes
      Inclusion Criteria:

      • acute chest pain

      • acute ST elevation

      • elevated troponin I

      Exclusion Criteria:

      • patients with recent (> 24 hour chest pain) myocardial infarction

      • refusing to provide blood samples

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 The E.Wolfson MC Holon Israel 52100

      Sponsors and Collaborators

      • Alexhander Izhaki

      Investigators

      • Principal Investigator: Alexander J Izhaki, MD, The E.Wolfson MC

      Study Documents (Full-Text)

      None provided.

      More Information

      Additional Information:

      Publications

      None provided.
      Responsible Party:
      Alexhander Izhaki, MD, Wolfson Medical Center
      ClinicalTrials.gov Identifier:
      NCT01041339
      Other Study ID Numbers:
      • 0075-09-WOMC
      First Posted:
      Dec 31, 2009
      Last Update Posted:
      Dec 15, 2015
      Last Verified:
      Jun 1, 2011
      Keywords provided by Alexhander Izhaki, MD, Wolfson Medical Center
      LpPLA2
      ST elevation
      acute pericarditis
      Additional relevant MeSH terms:
      Acute Chest Syndrome
      Syndrome

      Study Results

      No Results Posted as of Dec 15, 2015