Chemotherapy With or Without Bevacizumab in Treating Patients With Stage IB, Stage II, or Stage IIIA Non-small Cell Lung Cancer That Was Removed By Surgery

• Sponsor: National Cancer Institute (NCI) (NIH)
• Overall Status: Active, not recruiting
• CT.gov ID: NCT00324805
• Collaborator: Cancer and Leukemia Group B (Other), NCIC Clinical Trials Group (Other), North Central Cancer Treatment Group (Other), Southwest Oncology Group (Other)
• Enrollment: 1,501
• Locations: 1175
• Arms: 2
• Anticipated Duration (Months): 196.5
• Patients Per Site: 1.3
• Patients Per Site Per Month: 0

Study Details

Study Description

Brief Summary

This randomized phase III trial studies chemotherapy and bevacizumab to see how well they work compared to chemotherapy alone in treating patients with stage IB, stage II, or stage IIIA non-small cell lung cancer that was removed by surgery. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread. Bevacizumab also may stop the growth of non-small cell lung cancer by blocking the growth of new blood vessels necessary for tumor growth. It is not yet known whether chemotherapy is more effective with or without bevacizumab in treating non-small cell lung cancer.

Condition or Disease	Intervention/Treatment	Phase
Stage IB Lung Non-Small Cell Carcinoma AJCC v7; Stage IIA Lung Non-Small Cell Carcinoma AJCC v7; Stage IIB Lung Non-Small Cell Carcinoma AJCC v7; Stage IIIA Lung Non-Small Cell Cancer AJCC v7	Biological: Bevacizumab; Drug: Cisplatin; Drug: Docetaxel; Drug: Gemcitabine Hydrochloride; Other: Laboratory Biomarker Analysis; Drug: Pemetrexed Disodium; Other: Questionnaire Administration; Drug: Vinorelbine Tartrate	Phase 3

Detailed Description

PRIMARY OBJECTIVES:

1. To evaluate overall survival with chemotherapy with or without bevacizumab used in the adjuvant setting in patients with resected stage IB (>= 4 cm) - IIIA non-small cell lung cancer (NSCLC).

SECONDARY OBJECTIVES:

1. To evaluate disease-free survival and toxicity with chemotherapy with or without bevacizumab used in the adjuvant setting in patients with resected stage IB (>= 4 cm) - IIIA NSCLC.

CORRELATIVE OBJECTIVES:

1. To perform analyses of tissue and blood to establish factors that predict clinical outcome in patients receiving chemotherapy, with or without bevacizumab, for resected early stage NSCLC.

2. To determine whether smoking status is linked to outcome for patients with resected stage IB (>= 4 cm) - IIIA NSCLC treated with chemotherapy with or without bevacizumab in the adjuvant setting.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I (adjuvant chemotherapy without bevacizumab): Patients receive 1 of 4 chemotherapy regimens.

REGIMEN 1: Patients receive vinorelbine ditartrate intravenously (IV) over 10 minutes on days 1 and 8 and cisplatin IV over 60 minutes on day 1 immediately following vinorelbine ditartrate administration.

REGIMEN 2: Patients receive docetaxel IV over 1 hour on day 1 and cisplatin over 1 hour on day 1 immediately following docetaxel administration.

REGIMEN 3: Patients receive gemcitabine hydrochloride IV over 30 minutes on days 1 and 8 and cisplatin IV over 60 minutes on day 1 immediately following gemcitabine administration.

REGIMEN 4 (non-squamous histology only): Patients receive pemetrexed disodium IV over 10 minutes and cisplatin IV over 1 hour on day 1 immediately following pemetrexed disodium administration.

In all regimens, treatment repeats every 21 days for up to 4 courses in the absence of disease progression or unacceptable toxicity.

ARM II (adjuvant chemotherapy with bevacizumab): Patients receive chemotherapy as in Arm I. Patients also receive bevacizumab IV over 30-90 minutes on day 1. Treatment with bevacizumab repeats every 21 days for up to 1 year.

After completion of study treatment, patients are followed up periodically for 10 years.

Study Design

• Study Type: Interventional
• Actual Enrollment: 1501 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: A Phase III Randomized Trial of Adjuvant Chemotherapy With or Without Bevacizumab for Patients With Completely Resected Stage IB (≥ 4 cm) - IIIA Non-small Cell Lung Cancer (NSCLC)
• Actual Study Start Date: Jun 1, 2007
• Actual Primary Completion Date: Oct 20, 2015
• Anticipated Study Completion Date: Oct 16, 2023

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: Arm I (chemotherapy) Patients receive one of the following. For all, treatment repeats every 21 days for up to 4 courses in the absence of disease progression or unacceptable toxicity. REGIMEN 1: Vinorelbine ditartrate 30 mg/m2 IV on days 1 and 8, cisplatin 75 mg/m2 IV over 60 minutes on day 1 REGIMEN 2: Docetaxel 75 mg/m2 IV and cisplastin 75 mg/m2 IV on day 1 REGIMEN 3: Gemcitabine hydrochloride 1200 mg/m2 IV on days 1 and 8, cisplatin 75 mg/m2 IV on day 1 REGIMEN 4 (non-squamous histology only): Pemetrexed disodium 500mg/m2 IV and cisplatin 75 mg/m2 IV on day 1	Drug: Cisplatin; Given IV; Other Names: Abiplatin Blastolem Briplatin CDDP Cis-diammine-dichloroplatinum Cis-diamminedichloridoplatinum Cis-diamminedichloro Platinum (II) Cis-diamminedichloroplatinum Cis-dichloroammine Platinum (II) Cis-platinous Diamine Dichloride Cis-platinum Cis-platinum II Cis-platinum II Diamine Dichloride Cismaplat Cisplatina Cisplatinum Cisplatyl Citoplatino Citosin Cysplatyna DDP Lederplatin Metaplatin Neoplatin Peyrone's Chloride Peyrone's Salt Placis Plastistil Platamine Platiblastin Platiblastin-S Platinex Platinol Platinol- AQ Platinol-AQ Platinol-AQ VHA Plus Platinoxan Platinum Platinum Diamminodichloride Platiran Platistin Platosin ; Drug: Docetaxel; Given IV; Other Names: Docecad RP56976 Taxotere Taxotere Injection Concentrate ; Drug: Gemcitabine Hydrochloride; Given IV; Other Names: dFdCyd Difluorodeoxycytidine Hydrochloride FF 10832 FF-10832 FF10832 Gemcitabine HCI Gemzar LY-188011 LY188011 ; Other: Laboratory Biomarker Analysis; Correlative studies; Drug: Pemetrexed Disodium; Given IV; Other Names: Alimta Almita LY231514 N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium Salt ; Other: Questionnaire Administration; Ancillary studies; Drug: Vinorelbine Tartrate; Given IV; Other Names: Biovelbin Eunades KW-2307 Navelbine Navelbine Ditartrate NVB Vinorelbine Ditartrate
Experimental: Arm II (chemotherapy, bevacizumab) Patients receive chemotherapy as in Arm I. Patients also receive bevacizumab IV over 30-90 minutes on day 1. Treatment with bevacizumab repeats every 21 days for up to 1 year.	Biological: Bevacizumab; Given IV; Other Names: ABP 215 Anti-VEGF Anti-VEGF Humanized Monoclonal Antibody Anti-VEGF Monoclonal Antibody SIBP04 Anti-VEGF rhuMAb Avastin Bevacizumab awwb Bevacizumab Biosimilar ABP 215 Bevacizumab Biosimilar BEVZ92 Bevacizumab Biosimilar BI 695502 Bevacizumab Biosimilar CBT 124 Bevacizumab Biosimilar CT-P16 Bevacizumab Biosimilar FKB238 Bevacizumab Biosimilar GB-222 Bevacizumab Biosimilar HD204 Bevacizumab Biosimilar HLX04 Bevacizumab Biosimilar IBI305 Bevacizumab Biosimilar LY01008 Bevacizumab Biosimilar MIL60 Bevacizumab Biosimilar Mvasi Bevacizumab Biosimilar MYL-1402O Bevacizumab Biosimilar QL 1101 Bevacizumab Biosimilar RPH-001 Bevacizumab Biosimilar SCT501 Bevacizumab Biosimilar Zirabev Bevacizumab-awwb Bevacizumab-bvzr BP102 BP102 Biosimilar HD204 Immunoglobulin G1 (Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF Light Chain, Dimer Mvasi MYL-1402O Recombinant Humanized Anti-VEGF Monoclonal Antibody rhuMab-VEGF SCT501 SIBP 04 SIBP-04 SIBP04 Zirabev ; Drug: Cisplatin; Given IV; Other Names: Abiplatin Blastolem Briplatin CDDP Cis-diammine-dichloroplatinum Cis-diamminedichloridoplatinum Cis-diamminedichloro Platinum (II) Cis-diamminedichloroplatinum Cis-dichloroammine Platinum (II) Cis-platinous Diamine Dichloride Cis-platinum Cis-platinum II Cis-platinum II Diamine Dichloride Cismaplat Cisplatina Cisplatinum Cisplatyl Citoplatino Citosin Cysplatyna DDP Lederplatin Metaplatin Neoplatin Peyrone's Chloride Peyrone's Salt Placis Plastistil Platamine Platiblastin Platiblastin-S Platinex Platinol Platinol- AQ Platinol-AQ Platinol-AQ VHA Plus Platinoxan Platinum Platinum Diamminodichloride Platiran Platistin Platosin ; Drug: Docetaxel; Given IV; Other Names: Docecad RP56976 Taxotere Taxotere Injection Concentrate ; Drug: Gemcitabine Hydrochloride; Given IV; Other Names: dFdCyd Difluorodeoxycytidine Hydrochloride FF 10832 FF-10832 FF10832 Gemcitabine HCI Gemzar LY-188011 LY188011 ; Other: Laboratory Biomarker Analysis; Correlative studies; Drug: Pemetrexed Disodium; Given IV; Other Names: Alimta Almita LY231514 N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium Salt ; Other: Questionnaire Administration; Ancillary studies; Drug: Vinorelbine Tartrate; Given IV; Other Names: Biovelbin Eunades KW-2307 Navelbine Navelbine Ditartrate NVB Vinorelbine Ditartrate

Outcome Measures

Primary Outcome Measures

1. Overall Survival [From registration to death, up to 10 years]

   Overall survival (OS) was defined as the time from randomization to death from any cause, and patients who were thought to be alive at the time of final analysis were censored at the last date of contact. The study failed to meet its primary endpoint.

Secondary Outcome Measures

1. Disease-free Survival [From registration to death, up to 10 years]

   Disease-free survival (DFS) was defined as the time from randomization to an event. Events include disease recurrence, new primary of lung cancer, second primaries or death, whichever occurred first; however, it should be noted that patients with new primaries at other non-lung sites should have continued followup for recurrence of the original cancer. Patients that have not had an event reported at analysis were censored at their last date of disease assessment.

Other Outcome Measures

1. Toxicity Rates as Assessed by the National Cancer Institute Common Terminology Criteria for Adverse Events Version 4.0 [Up to 1 year post-treatment]

   If the difference in the rate of a particular category of toxicities between the 2 arms (N=750 per arm) is at least 5% (4% vs. 9%), 96% power can be attained assuming a significance level of 5% (two-sided Chi Square test) and that the lower toxicity rate for one arm is 4%. A difference in the rates of grade 3-5 arterial thromboembolic events and bleeding events will be monitored and assessed between the treatment arms.

2. Perform Analyses of Tissue and Blood to Establish Factors That Predict for Clinical Outcome in Patients Receiving Chemotherapy, With or Without Bevacizumab, for Resected Early Stage NSCLC. [From registration to death, up to 10 years]

3. To Determine Whether Smoking Status is Linked to Outcome for Patients With Resected Stage IB - IIIA NSCLC Treated With Chemotherapy With or Without Bevacizumab in the Adjuvant Setting. [From registration to death, up to 10 years]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• In order to be eligible for this trial, patients must have undergone complete resection of their non-small cell lung cancer (NSCLC) [stage IB (>= 4 cm)] - [IIIA (T2-3N0, T1-3N1, T1-3N2] prior to enrollment; accepted types of resection will consist of lobectomy, sleeve lobectomy, bi-lobectomy or pneumonectomy; resections by segmentectomy or wedge resection will not be accepted; mediastinal lymph node sampling at specified levels is required pre-operatively (mediastinoscopy) or intraoperatively (level 7 and 4 for right sided tumors or level 7 and 5 and/or 6 for left sided tumors)

• Patients must be no less than 6 weeks (42 days) and no more than 12 weeks (84 days) post-thoracotomy at the time of randomization and must be adequately recovered from surgery

• Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

• Patients must not have received the following:

• Prior systemic chemotherapy at any time; methotrexate (MTX) given in low doses for non-malignant conditions with last dose at least 2 weeks prior to date of registration will be allowed; other low dose chemotherapeutics for non-malignant conditions will be considered, but review by the study chair is required

• Hormonal cancer therapy or radiation therapy as prior cancer treatment within 5 years of randomization; (prior surgery, biologic therapy, hormonal therapy, or radiation therapy for a malignancy over 5 years prior to enrollment that is now considered cured is acceptable)

• Patients must not have any history of cancer within 5 years from randomization, with the exception of in-situ carcinoma of the cervix or completely resected non-melanoma skin cancer

• Absolute neutrophil count (ANC) >= 1500 mm^3

• Platelets >= 100,000/mm^3

• Prothrombin time/international normalized ratio (INR) =< 1.5

• Or, if patient is on therapeutic anticoagulation, prothrombin time/INR =< 3.0

• Partial thromboplastin time (PTT) =< institutional upper limit of normal (ULN) OR, if patient is on therapeutic anticoagulation, PTT must be =< 1.5 x ULN

• Total bilirubin =< 1.5 mg/dL

• Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) < 5 x upper limit of normal (ULN)

• Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) < 5 x upper limit of normal (ULN)

• Serum creatinine =< 1.5 x institutional upper limit of normal (ULN)

• Urine protein should be screened by urine analysis for urine protein creatinine (UPC) ratio; for UPC ratio > 0.5, 24-hour urine protein must be obtained and the level must be < 1000 mg (1 g) for patient enrollment

• Patients with a known history of myocardial infarction or other evidence of arterial thrombotic disease (angina) will be allowed on study only if they have had no evidence of active disease for at least 12 months prior to randomization

• Patients with any history of cerebral vascular accident (CVA) or transient ischemic attack (TIA) will not be allowed on trial

• Women must not be pregnant or breast-feeding

• All females of childbearing potential must have a blood or urine test within 2 weeks prior to randomization to rule out pregnancy

• Both fertile men and women must agree to use adequate contraceptive measures during study treatment and for at least 6 months after completion of bevacizumab

• Patients must not have any clinically significant ongoing, active or serious infection, symptomatic or uncontrolled congestive heart failure, symptomatic or uncontrolled cardiac arrhythmia or any other medical condition or psychiatric illness/social situations that would limit compliance with study requirements

• Patients must have no history of bleeding diathesis or coagulopathy

• All patients must have a documented blood pressure (BP) with systolic =< 150 and diastolic =< 90 within 28 days of registration; patients with known hypertension must be on a stable regimen of anti-hypertensive therapy

• Patients receiving daily treatment with aspirin or non-steroidal anti-inflammatory agents (NSAIDS) are eligible; treatment with dipyridamole (Persantine), ticlopine (Ticlid), clopidogrel (Plavix) and/or cilostazol (Pletal) is not allowed; patients must have stopped taking any of these agents at least 7 days prior to randomization

• Patients must not have serious non-healing wound, ulcer, bone fracture, or have undergone a major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to randomization OR core biopsy within 7 days prior to randomization

• Patients must not have a history of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess within 28 days prior to randomization

• Patients must not have any anticipated major surgical procedure(s) during the course of the study

• Patients must not have known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies

• Patients may be on a stable regimen of therapeutic anticoagulation or may be receiving prophylactic anticoagulation of venous access devices, provided that coagulation studies meet entry criteria above; caution must be exercised for patients requiring anticoagulation, including treatment with low dose heparin or low molecular weight heparin for deep vein thrombosis (DVT) prophylaxis while on study

• Patients with ongoing post-operative hemoptysis (defined as bright red blood of 1/2 teaspoon or more) are not eligible; patients with pre-operative hemoptysis that has resolved post-operatively are eligible

• Patients who will receive pemetrexed (pemetrexed disodium)/cisplatin therapy must also meet the following criteria:

• Patients assigned to pemetrexed/cisplatin therapy must NOT have squamous cell histology

• Calculated creatinine clearance must be obtained within 2 weeks of randomization and calculated creatinine clearance (CrCl) must be >= 45 mL/min using the standard Cockcroft and Gault formula, or the measured glomerular filtration rate (GFR) using the appropriate radiolabeled method ([51]chromium-labeled ethylenediaminetetraacetic acid [51-CrEDTA] or technetium 99m diethylenetriamine-pentaacetic acid [Tc99m-DTPA]) must be used to calculate CrCl

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Northeast Alabama Regional Medical Center	Anniston	Alabama	United States	36202
2	Clearview Cancer Institute	Huntsville	Alabama	United States	35805
3	Providence Hospital	Mobile	Alabama	United States	36608
4	University of South Alabama Mitchell Cancer Institute	Mobile	Alabama	United States	36688
5	Alaska Regional Hospital	Anchorage	Alaska	United States	99508
6	Providence Alaska Medical Center	Anchorage	Alaska	United States	99508
7	Mayo Clinic in Arizona	Scottsdale	Arizona	United States	85259
8	University of Arizona Cancer Center-Orange Grove Campus	Tucson	Arizona	United States	85704
9	Banner University Medical Center - Tucson	Tucson	Arizona	United States	85719
10	University of Arizona Cancer Center-North Campus	Tucson	Arizona	United States	85719
11	Mercy Hospital Fort Smith	Fort Smith	Arkansas	United States	72903
12	NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro	Jonesboro	Arkansas	United States	72401
13	NEA Baptist Memorial Hospital	Jonesboro	Arkansas	United States	72401
14	Saint Bernards Regional Medical Center	Jonesboro	Arkansas	United States	72401
15	John L McClellan Memorial Veterans Hospital	Little Rock	Arkansas	United States	72205
16	University of Arkansas for Medical Sciences	Little Rock	Arkansas	United States	72205
17	Kaiser Permanente-Anaheim	Anaheim	California	United States	92806
18	Kaiser Permanente-Deer Valley Medical Center	Antioch	California	United States	94531
19	PCR Oncology	Arroyo Grande	California	United States	93420
20	Kaiser Permanente-Baldwin Park	Baldwin Park	California	United States	91706
21	Kaiser Permanente-Bellflower	Bellflower	California	United States	90706
22	Alta Bates Summit Medical Center-Herrick Campus	Berkeley	California	United States	94704
23	Providence Saint Joseph Medical Center/Disney Family Cancer Center	Burbank	California	United States	91505
24	Mills-Peninsula Medical Center	Burlingame	California	United States	94010
25	East Bay Radiation Oncology Center	Castro Valley	California	United States	94546
26	Eden Hospital Medical Center	Castro Valley	California	United States	94546
27	Valley Medical Oncology Consultants-Castro Valley	Castro Valley	California	United States	94546
28	Adventist Health Cancer Care Center Chico	Chico	California	United States	95973
29	Community Cancer Institute	Clovis	California	United States	93611
30	City of Hope Comprehensive Cancer Center	Duarte	California	United States	91010
31	Bay Area Breast Surgeons Inc	Emeryville	California	United States	94608
32	Epic Care Partners in Cancer Care	Emeryville	California	United States	94608
33	Kaiser Permanente-Fontana	Fontana	California	United States	92335
34	Kaiser Permanente-Fremont	Fremont	California	United States	94538
35	Valley Medical Oncology Consultants-Fremont	Fremont	California	United States	94538
36	California Cancer Associates for Research and Excellence (cCare)	Fresno	California	United States	93720
37	Kaiser Permanente-Fresno	Fresno	California	United States	93720
38	Saint Jude Medical Center	Fullerton	California	United States	92835
39	Glendale Memorial Hospital and Health Center	Glendale	California	United States	91204
40	Marin Cancer Care Inc	Greenbrae	California	United States	94904
41	Marin General Hospital	Greenbrae	California	United States	94904
42	Kaiser Permanente - Harbor City	Harbor City	California	United States	90710
43	Saint Rose Hospital	Hayward	California	United States	94545
44	Kaiser Permanente-Irvine	Irvine	California	United States	92618
45	Loma Linda University Medical Center	Loma Linda	California	United States	92354
46	Long Beach Memorial Medical Center-Todd Cancer Institute	Long Beach	California	United States	90806
47	Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	United States	90027
48	Los Angeles County-USC Medical Center	Los Angeles	California	United States	90033
49	USC / Norris Comprehensive Cancer Center	Los Angeles	California	United States	90033
50	Kaiser Permanente West Los Angeles	Los Angeles	California	United States	90034
51	Contra Costa Regional Medical Center	Martinez	California	United States	94553-3156
52	Fremont - Rideout Cancer Center	Marysville	California	United States	95901
53	Mercy UC Davis Cancer Center	Merced	California	United States	95340
54	Memorial Medical Center	Modesto	California	United States	95355
55	Kaiser Permanente-Modesto	Modesto	California	United States	95356
56	Community Hospital of Monterey Peninsula	Monterey	California	United States	93940
57	El Camino Hospital	Mountain View	California	United States	94040
58	Palo Alto Medical Foundation-Camino Division	Mountain View	California	United States	94040
59	Sutter Cancer Research Consortium	Novato	California	United States	94945
60	Highland General Hospital	Oakland	California	United States	94602
61	Alta Bates Summit Medical Center - Summit Campus	Oakland	California	United States	94609
62	Bay Area Tumor Institute	Oakland	California	United States	94609
63	Hematology and Oncology Associates-Oakland	Oakland	California	United States	94609
64	Tom K Lee Inc	Oakland	California	United States	94609
65	Kaiser Permanente Oakland-Broadway	Oakland	California	United States	94611
66	Kaiser Permanente-Oakland	Oakland	California	United States	94611
67	Saint Joseph Hospital - Orange	Orange	California	United States	92868
68	UC Irvine Health/Chao Family Comprehensive Cancer Center	Orange	California	United States	92868
69	Desert Regional Medical Center	Palm Springs	California	United States	92262
70	Palo Alto Medical Foundation Health Care	Palo Alto	California	United States	94301
71	Stanford Cancer Institute Palo Alto	Palo Alto	California	United States	94304
72	Kaiser Permanente - Panorama City	Panorama City	California	United States	91402
73	Valley Care Health System - Pleasanton	Pleasanton	California	United States	94588
74	Valley Medical Oncology Consultants	Pleasanton	California	United States	94588
75	Pomona Valley Hospital Medical Center	Pomona	California	United States	91767
76	Kaiser Permanente-Rancho Cordova Cancer Center	Rancho Cordova	California	United States	95670
77	Eisenhower Medical Center	Rancho Mirage	California	United States	92270
78	Kaiser Permanente-Redwood City	Redwood City	California	United States	94063
79	Kaiser Permanente-Richmond	Richmond	California	United States	94801
80	Kaiser Permanente-Riverside	Riverside	California	United States	92505
81	Rohnert Park Cancer Center	Rohnert Park	California	United States	94928
82	Kaiser Permanente-Roseville	Roseville	California	United States	95661
83	Sutter Roseville Medical Center	Roseville	California	United States	95661
84	The Permanente Medical Group-Roseville Radiation Oncology	Roseville	California	United States	95678
85	Sutter Medical Center Sacramento	Sacramento	California	United States	95816
86	University of California Davis Comprehensive Cancer Center	Sacramento	California	United States	95817
87	Mercy General Hospital	Sacramento	California	United States	95819
88	Kaiser Permanente-South Sacramento	Sacramento	California	United States	95823
89	South Sacramento Cancer Center	Sacramento	California	United States	95823
90	Kaiser Permanente - Sacramento	Sacramento	California	United States	95825
91	Saint Helena Hospital	Saint Helena	California	United States	94574
92	Salinas Valley Memorial	Salinas	California	United States	93901
93	Kaiser Permanente-San Diego Mission	San Diego	California	United States	92108
94	Kaiser Permanente-San Diego Zion	San Diego	California	United States	92120
95	Zuckerberg San Francisco General Hospital	San Francisco	California	United States	94110
96	California Pacific Medical Center-Pacific Campus	San Francisco	California	United States	94115
97	Kaiser Permanente-San Francisco	San Francisco	California	United States	94115
98	UCSF Medical Center-Mount Zion	San Francisco	California	United States	94115
99	Kaiser Permanente-Santa Teresa-San Jose	San Jose	California	United States	95119
100	Kaiser Permanente San Leandro	San Leandro	California	United States	94577
101	Kaiser Permanente-San Marcos	San Marcos	California	United States	92078
102	Doctors Medical Center- JC Robinson Regional Cancer Center	San Pablo	California	United States	94806
103	Kaiser Permanente-San Rafael	San Rafael	California	United States	94903
104	Kaiser Permanente Medical Center - Santa Clara	Santa Clara	California	United States	95051
105	Kaiser Permanente-Santa Rosa	Santa Rosa	California	United States	95403
106	Sutter Pacific Medical Foundation	Santa Rosa	California	United States	95403
107	Providence Santa Rosa Memorial Hospital	Santa Rosa	California	United States	95405
108	Kaiser Permanente Cancer Treatment Center	South San Francisco	California	United States	94080
109	Kaiser Permanente-South San Francisco	South San Francisco	California	United States	94080
110	Kaiser Permanente-Stockton	Stockton	California	United States	95210
111	Palo Alto Medical Foundation-Sunnyvale	Sunnyvale	California	United States	94086
112	Gene Upshaw Memorial Tahoe Forest Cancer Center	Truckee	California	United States	96161
113	Northbay Cancer Center	Vacaville	California	United States	95687
114	Kaiser Permanente Medical Center-Vacaville	Vacaville	California	United States	95688
115	Kaiser Permanente-Vallejo	Vallejo	California	United States	94589
116	Sutter Solano Medical Center/Cancer Center	Vallejo	California	United States	94589
117	Kaiser Permanente-Walnut Creek	Walnut Creek	California	United States	94596
118	Kaiser Permanente-Woodland Hills	Woodland Hills	California	United States	91367
119	San Luis Valley Regional Medical Center	Alamosa	Colorado	United States	81101
120	The Medical Center of Aurora	Aurora	Colorado	United States	80012
121	Rocky Mountain Regional VA Medical Center	Aurora	Colorado	United States	80045
122	University of Colorado Hospital	Aurora	Colorado	United States	80045
123	Boulder Community Hospital	Boulder	Colorado	United States	80301
124	Penrose-Saint Francis Healthcare	Colorado Springs	Colorado	United States	80907
125	UCHealth Memorial Hospital Central	Colorado Springs	Colorado	United States	80909
126	Denver Health Medical Center	Denver	Colorado	United States	80204
127	Kaiser Permanente-Franklin	Denver	Colorado	United States	80205
128	Porter Adventist Hospital	Denver	Colorado	United States	80210
129	University of Colorado	Denver	Colorado	United States	80217-3364
130	Presbyterian - Saint Lukes Medical Center - Health One	Denver	Colorado	United States	80218
131	SCL Health Saint Joseph Hospital	Denver	Colorado	United States	80218
132	Rose Medical Center	Denver	Colorado	United States	80220
133	Western States Cancer Research NCORP	Denver	Colorado	United States	80222
134	Shaw Cancer Center	Edwards	Colorado	United States	81632
135	Swedish Medical Center	Englewood	Colorado	United States	80113
136	Poudre Valley Hospital	Fort Collins	Colorado	United States	80524
137	Valley View Hospital Cancer Center	Glenwood Springs	Colorado	United States	81601
138	Saint Mary's Hospital and Regional Medical Center	Grand Junction	Colorado	United States	81501
139	North Colorado Medical Center	Greeley	Colorado	United States	80631
140	Kaiser Permanente-Rock Creek	Lafayette	Colorado	United States	80026
141	Saint Anthony Hospital	Lakewood	Colorado	United States	80228
142	Littleton Adventist Hospital	Littleton	Colorado	United States	80122
143	Sky Ridge Medical Center	Lone Tree	Colorado	United States	80124
144	Longmont United Hospital	Longmont	Colorado	United States	80501
145	McKee Medical Center	Loveland	Colorado	United States	80539
146	Montrose Memorial Hospital	Montrose	Colorado	United States	81401
147	Parker Adventist Hospital	Parker	Colorado	United States	80138
148	Saint Mary Corwin Medical Center	Pueblo	Colorado	United States	81004
149	North Suburban Medical Center	Thornton	Colorado	United States	80229
150	SCL Health Lutheran Medical Center	Wheat Ridge	Colorado	United States	80033
151	Hartford HealthCare - Saint Vincent's Medical Center	Bridgeport	Connecticut	United States	06606
152	Bridgeport Hospital	Bridgeport	Connecticut	United States	06610
153	Greenwich Hospital	Greenwich	Connecticut	United States	06830
154	Hartford Hospital	Hartford	Connecticut	United States	06102
155	Smilow Cancer Hospital Care Center at Saint Francis	Hartford	Connecticut	United States	06105
156	Midstate Medical Center	Meriden	Connecticut	United States	06451
157	Middlesex Hospital	Middletown	Connecticut	United States	06457
158	The Hospital of Central Connecticut	New Britain	Connecticut	United States	06050
159	Yale University	New Haven	Connecticut	United States	06520
160	Norwalk Hospital	Norwalk	Connecticut	United States	06856
161	Eastern Connecticut Hematology and Oncology Associates	Norwich	Connecticut	United States	06360
162	Stamford Hospital/Bennett Cancer Center	Stamford	Connecticut	United States	06904
163	Smilow Cancer Hospital-Torrington Care Center	Torrington	Connecticut	United States	06790
164	Harold Leever Regional Cancer Center	Waterbury	Connecticut	United States	06708
165	Bayhealth Hospital Kent Campus	Dover	Delaware	United States	19901
166	Beebe Medical Center	Lewes	Delaware	United States	19958
167	Christiana Care Health System-Christiana Hospital	Newark	Delaware	United States	19718
168	MedStar Georgetown University Hospital	Washington	District of Columbia	United States	20007
169	MedStar Washington Hospital Center	Washington	District of Columbia	United States	20010
170	Sibley Memorial Hospital	Washington	District of Columbia	United States	20016
171	George Washington University Medical Center	Washington	District of Columbia	United States	20037
172	Lynn Regional Cancer Center - West	Boca Raton	Florida	United States	33428
173	Boca Raton Comprehensive Cancer Center	Boca Raton	Florida	United States	33486
174	Boca Raton Regional Hospital	Boca Raton	Florida	United States	33486
175	Halifax Health Medical Center-Centers for Oncology	Daytona Beach	Florida	United States	32114
176	Florida Hospital Memorial Medical Center	Daytona Beach	Florida	United States	32117
177	Holy Cross Hospital	Fort Lauderdale	Florida	United States	33308
178	Broward Health Medical Center	Fort Lauderdale	Florida	United States	33316
179	Florida Cancer Specialists-Gainesville Cancer Center	Gainesville	Florida	United States	32605
180	Memorial Regional Hospital/Joe DiMaggio Children's Hospital	Hollywood	Florida	United States	33021
181	Baptist MD Anderson Cancer Center	Jacksonville	Florida	United States	32207
182	Mayo Clinic in Florida	Jacksonville	Florida	United States	32224-9980
183	Jupiter Medical Center	Jupiter	Florida	United States	33458
184	Lakeland Regional Health Hollis Cancer Center	Lakeland	Florida	United States	33805
185	The Watson Clinic	Lakeland	Florida	United States	33805
186	Mount Sinai Medical Center	Miami Beach	Florida	United States	33140
187	University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	United States	33136
188	AdventHealth Orlando	Orlando	Florida	United States	32803
189	Sacred Heart Hospital	Pensacola	Florida	United States	32504
190	Moffitt Cancer Center	Tampa	Florida	United States	33612
191	Florida Cancer Specialists-West Palm Beach	West Palm Beach	Florida	United States	33401
192	Cleveland Clinic-Weston	Weston	Florida	United States	33331
193	Phoebe Putney Memorial Hospital	Albany	Georgia	United States	31701
194	University Cancer and Blood Center LLC	Athens	Georgia	United States	30607
195	Emory University Hospital Midtown	Atlanta	Georgia	United States	30308
196	Piedmont Hospital	Atlanta	Georgia	United States	30309
197	Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	United States	30322
198	Atlanta Regional CCOP	Atlanta	Georgia	United States	30342
199	Emory Saint Joseph's Hospital	Atlanta	Georgia	United States	30342
200	Northside Hospital	Atlanta	Georgia	United States	30342
201	Augusta Oncology Associates PC-D'Antignac	Augusta	Georgia	United States	30901
202	Augusta University Medical Center	Augusta	Georgia	United States	30912
203	WellStar Cobb Hospital	Austell	Georgia	United States	30106
204	John B Amos Cancer Center	Columbus	Georgia	United States	31904
205	Atlanta VA Medical Center	Decatur	Georgia	United States	30033
206	Dekalb Medical Center	Decatur	Georgia	United States	30033
207	Piedmont Fayette Hospital	Fayetteville	Georgia	United States	30214
208	Northeast Georgia Medical Center-Gainesville	Gainesville	Georgia	United States	30501
209	Northside Hospital - Gwinnett	Lawrenceville	Georgia	United States	30046
210	Medical Center of Central Georgia	Macon	Georgia	United States	31201
211	Wellstar Kennestone Hospital	Marietta	Georgia	United States	30060
212	Southern Regional Medical Center	Riverdale	Georgia	United States	30274
213	Harbin Clinic Medical Oncology and Clinical Research	Rome	Georgia	United States	30165
214	Memorial Health University Medical Center	Savannah	Georgia	United States	31404
215	Lewis Cancer and Research Pavilion at Saint Joseph's/Candler	Savannah	Georgia	United States	31405
216	Pali Momi Medical Center	'Aiea	Hawaii	United States	96701
217	Hawaii Cancer Care Inc - Waterfront Plaza	Honolulu	Hawaii	United States	96813
218	Queen's Medical Center	Honolulu	Hawaii	United States	96813
219	Straub Clinic and Hospital	Honolulu	Hawaii	United States	96813
220	University of Hawaii Cancer Center	Honolulu	Hawaii	United States	96813
221	Hawaii Cancer Care Inc-Liliha	Honolulu	Hawaii	United States	96817
222	Queen's Cancer Center - Kuakini	Honolulu	Hawaii	United States	96817
223	The Cancer Center of Hawaii-Liliha	Honolulu	Hawaii	United States	96817
224	Kaiser Permanente Moanalua Medical Center	Honolulu	Hawaii	United States	96819
225	Kapiolani Medical Center for Women and Children	Honolulu	Hawaii	United States	96826
226	Tripler Army Medical Center	Honolulu	Hawaii	United States	96859
227	Castle Medical Center	Kailua	Hawaii	United States	96734
228	Wilcox Memorial Hospital and Kauai Medical Clinic	Lihue	Hawaii	United States	96766
229	Maui Memorial Medical Center	Wailuku	Hawaii	United States	96793
230	Pacific Cancer Institute of Maui	Wailuku	Hawaii	United States	96793
231	Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	United States	83706
232	Saint Luke's Cancer Institute - Boise	Boise	Idaho	United States	83712
233	Saint Luke's Cancer Institute - Fruitland	Fruitland	Idaho	United States	83619
234	Saint Joseph Regional Medical Center	Lewiston	Idaho	United States	83501
235	Saint Luke's Cancer Institute - Meridian	Meridian	Idaho	United States	83642
236	Saint Luke's Cancer Institute - Nampa	Nampa	Idaho	United States	83686
237	Portneuf Medical Center	Pocatello	Idaho	United States	83201
238	Saint Luke's Cancer Institute - Twin Falls	Twin Falls	Idaho	United States	83301
239	Saint Anthony's Health	Alton	Illinois	United States	62002
240	Rush - Copley Medical Center	Aurora	Illinois	United States	60504
241	MacNeal Hospital and Cancer Center	Berwyn	Illinois	United States	60402
242	Saint Joseph Medical Center	Bloomington	Illinois	United States	61701
243	Illinois CancerCare-Bloomington	Bloomington	Illinois	United States	61704
244	Graham Hospital Association	Canton	Illinois	United States	61520
245	Illinois CancerCare-Canton	Canton	Illinois	United States	61520
246	Illinois CancerCare-Carthage	Carthage	Illinois	United States	62321
247	Memorial Hospital	Carthage	Illinois	United States	62321
248	Mount Sinai Hospital Medical Center	Chicago	Illinois	United States	60608
249	Hematology and Oncology Associates	Chicago	Illinois	United States	60611
250	Northwestern University	Chicago	Illinois	United States	60611
251	Jesse Brown Veterans Affairs Medical Center	Chicago	Illinois	United States	60612
252	John H Stroger Jr Hospital of Cook County	Chicago	Illinois	United States	60612
253	Rush University Medical Center	Chicago	Illinois	United States	60612
254	University of Illinois	Chicago	Illinois	United States	60612
255	Swedish Covenant Hospital	Chicago	Illinois	United States	60625
256	Presence Resurrection Medical Center	Chicago	Illinois	United States	60631
257	University of Chicago Comprehensive Cancer Center	Chicago	Illinois	United States	60637
258	Weiss Memorial Hospital	Chicago	Illinois	United States	60640
259	UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital	Chicago	Illinois	United States	60657
260	Decatur Memorial Hospital	Decatur	Illinois	United States	62526
261	Heartland Cancer Research NCORP	Decatur	Illinois	United States	62526
262	Advocate Good Samaritan Hospital	Downers Grove	Illinois	United States	60515
263	Saint Anthony Memorial Hospital	Effingham	Illinois	United States	62401
264	Advocate Sherman Hospital	Elgin	Illinois	United States	60123
265	AMITA Health Alexian Brothers Medical Center	Elk Grove Village	Illinois	United States	60007
266	Elmhurst Memorial Hospital	Elmhurst	Illinois	United States	60126
267	Eureka Hospital	Eureka	Illinois	United States	61530
268	Illinois CancerCare-Eureka	Eureka	Illinois	United States	61530
269	NorthShore University HealthSystem-Evanston Hospital	Evanston	Illinois	United States	60201
270	Saint Francis Hospital	Evanston	Illinois	United States	60202
271	Galesburg Cottage Hospital	Galesburg	Illinois	United States	61401
272	Illinois CancerCare-Cottage	Galesburg	Illinois	United States	61401
273	Illinois CancerCare-Galesburg	Galesburg	Illinois	United States	61401
274	Western Illinois Cancer Treatment Center	Galesburg	Illinois	United States	61401
275	LaGrange Oncology Associates	Geneva	Illinois	United States	60134
276	Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	United States	60134
277	Ingalls Memorial Hospital	Harvey	Illinois	United States	60426
278	Illinois CancerCare-Havana	Havana	Illinois	United States	62644
279	Mason District Hospital	Havana	Illinois	United States	62644
280	Hematology Oncology Associates of Illinois-Highland Park	Highland Park	Illinois	United States	60035
281	Hinsdale Hematology Oncology Associates Incorporated	Hinsdale	Illinois	United States	60521
282	Hopedale Medical Complex - Hospital	Hopedale	Illinois	United States	61747
283	Midwest Center for Hematology Oncology	Joliet	Illinois	United States	60432
284	Duly Health and Care Joliet	Joliet	Illinois	United States	60435
285	Presence Saint Mary's Hospital	Kankakee	Illinois	United States	60901
286	Illinois CancerCare-Kewanee Clinic	Kewanee	Illinois	United States	61443
287	AMITA Health Adventist Medical Center	La Grange	Illinois	United States	60525
288	AMG Libertyville - Oncology	Libertyville	Illinois	United States	60048
289	Illinois CancerCare-Macomb	Macomb	Illinois	United States	61455
290	Mcdonough District Hospital	Macomb	Illinois	United States	61455
291	Loyola University Medical Center	Maywood	Illinois	United States	60153
292	Garneau, Stewart C MD (UIA Investigator)	Moline	Illinois	United States	61265
293	Porubcin, Michael MD (UIA Investigator)	Moline	Illinois	United States	61265
294	Sharis, Christine M MD (UIA Investigator)	Moline	Illinois	United States	61265
295	Spector, David MD (UIA Investigator)	Moline	Illinois	United States	61265
296	Stoffel, Thomas J MD (UIA Investigator)	Moline	Illinois	United States	61265
297	Trinity Medical Center	Moline	Illinois	United States	61265
298	Vigliotti, Antonio, P.G. M.D. (UIA Investigator)	Moline	Illinois	United States	61265
299	Holy Family Medical Center	Monmouth	Illinois	United States	61462
300	Illinois CancerCare-Monmouth	Monmouth	Illinois	United States	61462
301	Good Samaritan Regional Health Center	Mount Vernon	Illinois	United States	62864
302	Edward Hospital/Cancer Center	Naperville	Illinois	United States	60540
303	DuPage Medical Group-Ogden	Naperville	Illinois	United States	60563
304	Illinois Cancer Specialists-Niles	Niles	Illinois	United States	60714
305	Bromenn Regional Medical Center	Normal	Illinois	United States	61761
306	Carle Cancer Institute Normal	Normal	Illinois	United States	61761
307	Illinois CancerCare-Community Cancer Center	Normal	Illinois	United States	61761
308	Mid-Illinois Hematology Oncology Associates Limited	Normal	Illinois	United States	61761
309	Advocate Christ Medical Center	Oak Lawn	Illinois	United States	60453-2699
310	Illinois CancerCare-Ottawa Clinic	Ottawa	Illinois	United States	61350
311	Ottawa Regional Hospital and Healthcare Center	Ottawa	Illinois	United States	61350
312	Illinois CancerCare-Pekin	Pekin	Illinois	United States	61554
313	OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center	Pekin	Illinois	United States	61554
314	Pekin Hospital	Pekin	Illinois	United States	61554
315	Proctor Hospital	Peoria	Illinois	United States	61614
316	Illinois CancerCare-Peoria	Peoria	Illinois	United States	61615
317	OSF Saint Francis Radiation Oncology at Peoria Cancer Center	Peoria	Illinois	United States	61615
318	Methodist Medical Center of Illinois	Peoria	Illinois	United States	61636
319	OSF Saint Francis Medical Center	Peoria	Illinois	United States	61637
320	Illinois CancerCare-Peru	Peru	Illinois	United States	61354
321	Illinois Valley Hospital	Peru	Illinois	United States	61354
322	Valley Radiation Oncology	Peru	Illinois	United States	61354
323	Illinois CancerCare-Princeton	Princeton	Illinois	United States	61356
324	Perry Memorial Hospital	Princeton	Illinois	United States	61356
325	West Suburban Medical Center	River Forest	Illinois	United States	60305
326	Swedish American Hospital	Rockford	Illinois	United States	61104
327	OSF Saint Anthony Medical Center	Rockford	Illinois	United States	61108
328	SwedishAmerican Regional Cancer Center/ACT	Rockford	Illinois	United States	61114
329	Edward H Kaplan MD and Associates	Skokie	Illinois	United States	60076
330	Hematology Oncology Associates of Illinois - Skokie	Skokie	Illinois	United States	60076
331	Illinois CancerCare-Spring Valley	Spring Valley	Illinois	United States	61362
332	Saint Margaret's Hospital	Spring Valley	Illinois	United States	61362
333	Memorial Medical Center	Springfield	Illinois	United States	62781
334	Carle Cancer Center	Urbana	Illinois	United States	61801
335	Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	United States	60555
336	Northwestern Medicine Central DuPage Hospital	Winfield	Illinois	United States	60190
337	Saint Vincent Anderson Regional Hospital/Cancer Center	Anderson	Indiana	United States	46016
338	Franciscan Saint Francis Health-Beech Grove	Beech Grove	Indiana	United States	46107
339	Elkhart Clinic	Elkhart	Indiana	United States	46514-2098
340	Michiana Hematology Oncology PC-Elkhart	Elkhart	Indiana	United States	46514
341	Elkhart General Hospital	Elkhart	Indiana	United States	46515
342	Fort Wayne Medical Oncology and Hematology Inc-Parkview	Fort Wayne	Indiana	United States	46845
343	Indiana University/Melvin and Bren Simon Cancer Center	Indianapolis	Indiana	United States	46202
344	Richard L. Roudebush Veterans Affairs Medical Center	Indianapolis	Indiana	United States	46202
345	Sidney and Lois Eskenazi Hospital	Indianapolis	Indiana	United States	46202
346	Franciscan Health Indianapolis	Indianapolis	Indiana	United States	46237
347	Saint Vincent Hospital and Health Care Center	Indianapolis	Indiana	United States	46260
348	Community Howard Regional Health	Kokomo	Indiana	United States	46904
349	IU Health La Porte Hospital	La Porte	Indiana	United States	46350
350	IU Health Arnett Cancer Care	Lafayette	Indiana	United States	47904
351	Premier Oncology Hematology Associates	Merrillville	Indiana	United States	46410
352	Franciscan Saint Anthony Health-Michigan City	Michigan City	Indiana	United States	46360
353	Michiana Hematology Oncology PC-Mishawaka	Mishawaka	Indiana	United States	46545
354	Saint Joseph Regional Medical Center-Mishawaka	Mishawaka	Indiana	United States	46545
355	IU Health Ball Memorial Hospital	Muncie	Indiana	United States	47303
356	The Community Hospital	Munster	Indiana	United States	46321
357	Michiana Hematology Oncology PC-Plymouth	Plymouth	Indiana	United States	46563
358	Reid Health	Richmond	Indiana	United States	47374
359	Memorial Hospital of South Bend	South Bend	Indiana	United States	46601
360	Michiana Hematology Oncology PC-South Bend	South Bend	Indiana	United States	46601
361	South Bend Clinic	South Bend	Indiana	United States	46617
362	Northern Indiana Cancer Research Consortium	South Bend	Indiana	United States	46628
363	Michiana Hematology Oncology PC-Westville	Westville	Indiana	United States	46391
364	McFarland Clinic PC - Ames	Ames	Iowa	United States	50010
365	Constantinou, Costas L MD (UIA Investigator)	Bettendorf	Iowa	United States	52722
366	University of Iowa Healthcare Cancer Services Quad Cities	Bettendorf	Iowa	United States	52722
367	Physicians' Clinic of Iowa PC	Cedar Rapids	Iowa	United States	52402
368	Saint Luke's Hospital	Cedar Rapids	Iowa	United States	52402
369	Mercy Hospital	Cedar Rapids	Iowa	United States	52403
370	Oncology Associates at Mercy Medical Center	Cedar Rapids	Iowa	United States	52403
371	Medical Oncology and Hematology Associates-West Des Moines	Clive	Iowa	United States	50325
372	Genesis Medical Center - East Campus	Davenport	Iowa	United States	52803
373	Genesis Cancer Care Institute	Davenport	Iowa	United States	52804
374	Mercy Capitol	Des Moines	Iowa	United States	50307
375	Iowa Methodist Medical Center	Des Moines	Iowa	United States	50309
376	Iowa-Wide Oncology Research Coalition NCORP	Des Moines	Iowa	United States	50309
377	Medical Oncology and Hematology Associates-Des Moines	Des Moines	Iowa	United States	50309
378	Medical Oncology and Hematology Associates-Laurel	Des Moines	Iowa	United States	50314
379	Mercy Medical Center - Des Moines	Des Moines	Iowa	United States	50314
380	Iowa Lutheran Hospital	Des Moines	Iowa	United States	50316
381	University of Iowa/Holden Comprehensive Cancer Center	Iowa City	Iowa	United States	52242
382	Mercy Medical Center - North Iowa	Mason City	Iowa	United States	50401
383	Ottumwa Regional Health Center	Ottumwa	Iowa	United States	52501
384	Siouxland Regional Cancer Center	Sioux City	Iowa	United States	51101
385	Mercy Medical Center-Sioux City	Sioux City	Iowa	United States	51102
386	Saint Luke's Regional Medical Center	Sioux City	Iowa	United States	51104
387	Cedar Valley Medical Specialists	Waterloo	Iowa	United States	50701
388	MercyOne Waterloo Medical Center	Waterloo	Iowa	United States	50702
389	Methodist West Hospital	West Des Moines	Iowa	United States	50266-7700
390	Hospital District Sixth of Harper County	Anthony	Kansas	United States	67003
391	Cancer Center of Kansas - Chanute	Chanute	Kansas	United States	66720
392	Cancer Center of Kansas - Dodge City	Dodge City	Kansas	United States	67801
393	Cancer Center of Kansas - El Dorado	El Dorado	Kansas	United States	67042
394	Cancer Center of Kansas - Fort Scott	Fort Scott	Kansas	United States	66701
395	Saint Rose Ambulatory and Surgery Center	Great Bend	Kansas	United States	67530
396	HaysMed University of Kansas Health System	Hays	Kansas	United States	67601
397	Hutchinson Regional Medical Center	Hutchinson	Kansas	United States	67502
398	Cancer Center of Kansas-Independence	Independence	Kansas	United States	67301
399	Providence Medical Center	Kansas City	Kansas	United States	66112
400	University of Kansas Cancer Center-West	Kansas City	Kansas	United States	66112
401	University of Kansas Cancer Center	Kansas City	Kansas	United States	66160
402	Cancer Center of Kansas-Kingman	Kingman	Kansas	United States	67068
403	Lawrence Memorial Hospital	Lawrence	Kansas	United States	66044
404	Southwest Medical Center	Liberal	Kansas	United States	67901
405	Cancer Center of Kansas-Liberal	Liberal	Kansas	United States	67905
406	Cancer Center of Kansas - McPherson	McPherson	Kansas	United States	67460
407	Cancer Center of Kansas - Newton	Newton	Kansas	United States	67114
408	Olathe Cancer Center	Olathe	Kansas	United States	66061
409	Menorah Medical Center	Overland Park	Kansas	United States	66209
410	University of Kansas Cancer Center-Overland Park	Overland Park	Kansas	United States	66210
411	Saint Luke's South Hospital	Overland Park	Kansas	United States	66213
412	Cancer Center of Kansas - Parsons	Parsons	Kansas	United States	67357
413	Ascension Via Christi - Pittsburg	Pittsburg	Kansas	United States	66762
414	Kansas City NCI Community Oncology Research Program	Prairie Village	Kansas	United States	66208
415	Cancer Center of Kansas - Pratt	Pratt	Kansas	United States	67124
416	Cancer Center of Kansas - Salina	Salina	Kansas	United States	67401
417	Salina Regional Health Center	Salina	Kansas	United States	67401
418	Advent Health - Shawnee Mission Medical Center	Shawnee Mission	Kansas	United States	66204
419	Cotton O'Neil Cancer Center / Stormont Vail Health	Topeka	Kansas	United States	66606
420	University of Kansas Health System Saint Francis Campus	Topeka	Kansas	United States	66606
421	Cancer Center of Kansas - Wellington	Wellington	Kansas	United States	67152
422	Associates In Womens Health	Wichita	Kansas	United States	67208
423	Cancer Center of Kansas-Wichita Medical Arts Tower	Wichita	Kansas	United States	67208
424	Ascension Via Christi Hospitals Wichita	Wichita	Kansas	United States	67214
425	Cancer Center of Kansas - Wichita	Wichita	Kansas	United States	67214
426	Wichita NCI Community Oncology Research Program	Wichita	Kansas	United States	67214
427	Cancer Center of Kansas - Winfield	Winfield	Kansas	United States	67156
428	King's Daughter's Medical Center	Ashland	Kentucky	United States	41101
429	Our Lady Bellefonte Hospital	Ashland	Kentucky	United States	41101
430	University of Kentucky/Markey Cancer Center	Lexington	Kentucky	United States	40536
431	The James Graham Brown Cancer Center at University of Louisville	Louisville	Kentucky	United States	40202
432	Baptist Health Louisville	Louisville	Kentucky	United States	40207
433	Doctors Carrol, Sheth, Raghavan	Louisville	Kentucky	United States	40215
434	Owensboro Health Mitchell Memorial Cancer Center	Owensboro	Kentucky	United States	42303
435	Baton Rouge General Medical Center	Baton Rouge	Louisiana	United States	70806
436	Hematology/Oncology Clinic PLLC	Baton Rouge	Louisiana	United States	70809
437	Mary Bird Perkins Cancer Center	Baton Rouge	Louisiana	United States	70809
438	Ochsner Health Center-Summa	Baton Rouge	Louisiana	United States	70809
439	Ochsner Health Center-Covington	Covington	Louisiana	United States	70433
440	Cancer Center of Acadiana	Lafayette	Louisiana	United States	70503
441	Louisiana State University Health Science Center	New Orleans	Louisiana	United States	70112
442	Tulane University Health Sciences Center	New Orleans	Louisiana	United States	70112
443	University Medical Center New Orleans	New Orleans	Louisiana	United States	70112
444	Ochsner Baptist Medical Center	New Orleans	Louisiana	United States	70115
445	Ochsner Medical Center Jefferson	New Orleans	Louisiana	United States	70121
446	Harold Alfond Center for Cancer Care	Augusta	Maine	United States	04330
447	Eastern Maine Medical Center	Bangor	Maine	United States	04401
448	Central Maine Medical Center	Lewiston	Maine	United States	04240
449	Saint Mary's Regional Medical Center	Lewiston	Maine	United States	04240
450	Mercy Hospital	Portland	Maine	United States	04101
451	Maine Center for Cancer Medicine-Scarborough	Scarborough	Maine	United States	04074
452	Maine General Medical Center-Thayer	Waterville	Maine	United States	04901
453	York Hospital	York	Maine	United States	03909
454	University of Maryland/Greenebaum Cancer Center	Baltimore	Maryland	United States	21201
455	Veterans Administration Medical Center-Baltimore	Baltimore	Maryland	United States	21201
456	Greater Baltimore Medical Center	Baltimore	Maryland	United States	21204
457	Sinai Hospital of Baltimore	Baltimore	Maryland	United States	21215
458	MedStar Franklin Square Medical Center/Weinberg Cancer Institute	Baltimore	Maryland	United States	21237
459	Johns Hopkins University/Sidney Kimmel Cancer Center	Baltimore	Maryland	United States	21287
460	UM Upper Chesapeake Medical Center	Bel Air	Maryland	United States	21014
461	Walter Reed National Military Medical Center	Bethesda	Maryland	United States	20889-5600
462	Western Maryland Regional Medical Center	Cumberland	Maryland	United States	21502
463	University of Maryland Shore Medical Center at Easton	Easton	Maryland	United States	21601
464	Christiana Care - Union Hospital	Elkton	Maryland	United States	21921
465	Frederick Memorial Hospital	Frederick	Maryland	United States	21701
466	Meritus Medical Center	Hagerstown	Maryland	United States	21742
467	Associates in Oncology Hematology PC -Kensington	Kensington	Maryland	United States	20895
468	Maryland Oncology Hematology PA-Aquilino Cancer Center	Rockville	Maryland	United States	20850
469	TidalHealth Peninsula Regional	Salisbury	Maryland	United States	21801
470	Holy Cross Hospital	Silver Spring	Maryland	United States	20910
471	UM Saint Joseph Medical Center	Towson	Maryland	United States	21204
472	Sturdy Memorial Hospital	Attleboro	Massachusetts	United States	02703
473	Beverly Hospital	Beverly	Massachusetts	United States	01915
474	Tufts Medical Center	Boston	Massachusetts	United States	02111
475	Massachusetts General Hospital Cancer Center	Boston	Massachusetts	United States	02114
476	Brigham and Women's Hospital	Boston	Massachusetts	United States	02115
477	Boston Medical Center	Boston	Massachusetts	United States	02118
478	Beth Israel Deaconess Medical Center	Boston	Massachusetts	United States	02215
479	Dana-Farber Cancer Institute	Boston	Massachusetts	United States	02215
480	Steward Saint Elizabeth's Medical Center	Brighton	Massachusetts	United States	02135
481	Lahey Hospital and Medical Center	Burlington	Massachusetts	United States	01805
482	Commonwealth Hematology Oncology PC-Concord	Concord	Massachusetts	United States	01742
483	Mass General/North Shore Cancer Center	Danvers	Massachusetts	United States	01923
484	Simonds-Sinon Regional Cancer Center	Fitchburg	Massachusetts	United States	01420
485	MetroWest Medical Center-Framingham Union Hospital	Framingham	Massachusetts	United States	01702
486	Addison Gilbert Hospital	Gloucester	Massachusetts	United States	01930
487	Dana Farber Community Cancer Care-Haverhill	Haverhill	Massachusetts	United States	01830
488	Dana Farber-Merrimack Valley	Methuen	Massachusetts	United States	01844
489	Holy Family Hospital	Methuen	Massachusetts	United States	01844
490	Norwood Hospital	Norwood	Massachusetts	United States	02062
491	Berkshire Medical Center - Cancer Center	Pittsfield	Massachusetts	United States	01201
492	Dana Farber Community Cancer Care-Quincy	Quincy	Massachusetts	United States	02169
493	Baystate Medical Center	Springfield	Massachusetts	United States	01199
494	Dana Farber Community Cancer Care-Stoneham	Stoneham	Massachusetts	United States	02180
495	Noble Hospital	Westfield	Massachusetts	United States	01085
496	Dana Farber Community Cancer Care-Weymouth	Weymouth	Massachusetts	United States	02189
497	Commonwealth Hematology Oncology PC-Worcester	Worcester	Massachusetts	United States	01605
498	UMass Memorial Medical Center - University Campus	Worcester	Massachusetts	United States	01655
499	Bixby Medical Center	Adrian	Michigan	United States	49221
500	Hickman Cancer Center	Adrian	Michigan	United States	49221
501	Michigan Cancer Research Consortium NCORP	Ann Arbor	Michigan	United States	48106
502	Saint Joseph Mercy Hospital	Ann Arbor	Michigan	United States	48106
503	University of Michigan Comprehensive Cancer Center	Ann Arbor	Michigan	United States	48109
504	Bronson Battle Creek	Battle Creek	Michigan	United States	49017
505	McLaren Cancer Institute-Bay City	Bay City	Michigan	United States	48706
506	Spectrum Health Big Rapids Hospital	Big Rapids	Michigan	United States	49307
507	McLaren Cancer Institute-Clarkston	Clarkston	Michigan	United States	48346
508	Beaumont Hospital - Dearborn	Dearborn	Michigan	United States	48124
509	Wayne State University/Karmanos Cancer Institute	Detroit	Michigan	United States	48201
510	Henry Ford Hospital	Detroit	Michigan	United States	48202
511	Ascension Saint John Hospital	Detroit	Michigan	United States	48236
512	Michigan State University Clinical Center	East Lansing	Michigan	United States	48824-7016
513	Green Bay Oncology - Escanaba	Escanaba	Michigan	United States	49829
514	Beaumont Hospital - Farmington Hills	Farmington Hills	Michigan	United States	48336
515	Genesys Hurley Cancer Institute	Flint	Michigan	United States	48503
516	Hurley Medical Center	Flint	Michigan	United States	48503
517	Genesys Regional Medical Center-West Flint Campus	Flint	Michigan	United States	48532
518	McLaren Cancer Institute-Flint	Flint	Michigan	United States	48532
519	Singh and Arora Hematology Oncology PC	Flint	Michigan	United States	48532
520	Cancer Research Consortium of West Michigan NCORP	Grand Rapids	Michigan	United States	49503
521	Mercy Health Saint Mary's	Grand Rapids	Michigan	United States	49503
522	Spectrum Health at Butterworth Campus	Grand Rapids	Michigan	United States	49503
523	Holland Community Hospital	Holland	Michigan	United States	49423
524	Green Bay Oncology - Iron Mountain	Iron Mountain	Michigan	United States	49801
525	Allegiance Health	Jackson	Michigan	United States	49201
526	Bronson Methodist Hospital	Kalamazoo	Michigan	United States	49007
527	West Michigan Cancer Center	Kalamazoo	Michigan	United States	49007
528	Borgess Medical Center	Kalamazoo	Michigan	United States	49048
529	Karmanos Cancer Institute at McLaren Greater Lansing	Lansing	Michigan	United States	48910
530	Sparrow Hospital	Lansing	Michigan	United States	48912
531	Lapeer Regional Hospital	Lapeer	Michigan	United States	48446
532	McLaren Cancer Institute-Lapeer Region	Lapeer	Michigan	United States	48446
533	Trinity Health Saint Mary Mercy Livonia Hospital	Livonia	Michigan	United States	48154
534	UP Health System Marquette	Marquette	Michigan	United States	49855
535	MyMichigan Medical Center Midland	Midland	Michigan	United States	48670
536	Mercy Memorial Hospital	Monroe	Michigan	United States	48162
537	Toledo Clinic Cancer Centers-Monroe	Monroe	Michigan	United States	48162
538	McLaren Cancer Institute-Macomb	Mount Clemens	Michigan	United States	48043
539	Mercy Health Partners-Hackley Campus	Muskegon	Michigan	United States	49442
540	Mercy Health Mercy Campus	Muskegon	Michigan	United States	49444
541	Lakeland Hospital Niles	Niles	Michigan	United States	49120
542	McLaren Cancer Institute-Northern Michigan	Petoskey	Michigan	United States	49770
543	Saint Joseph Mercy Oakland	Pontiac	Michigan	United States	48341
544	Lake Huron Medical Center	Port Huron	Michigan	United States	48060
545	Spectrum Health Reed City Hospital	Reed City	Michigan	United States	49677
546	William Beaumont Hospital-Royal Oak	Royal Oak	Michigan	United States	48073
547	Ascension Saint Mary's Hospital	Saginaw	Michigan	United States	48601
548	Lakeland Medical Center Saint Joseph	Saint Joseph	Michigan	United States	49085
549	Marie Yeager Cancer Center	Saint Joseph	Michigan	United States	49085
550	Oncology Care Associates PLLC	Saint Joseph	Michigan	United States	49085
551	Ascension Providence Hospitals - Southfield	Southfield	Michigan	United States	48075
552	Munson Medical Center	Traverse City	Michigan	United States	49684
553	William Beaumont Hospital - Troy	Troy	Michigan	United States	48085
554	Saint John Macomb-Oakland Hospital	Warren	Michigan	United States	48093
555	Metro Health Hospital	Wyoming	Michigan	United States	49519
556	Medini, Eitan MD (UIA Investigator)	Alexandria	Minnesota	United States	56308
557	Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	United States	56601
558	Essentia Health Saint Joseph's Medical Center	Brainerd	Minnesota	United States	56401
559	Fairview Ridges Hospital	Burnsville	Minnesota	United States	55337
560	Mercy Hospital	Coon Rapids	Minnesota	United States	55433
561	Essentia Health Cancer Center	Duluth	Minnesota	United States	55805
562	Essentia Health Saint Mary's Medical Center	Duluth	Minnesota	United States	55805
563	Miller-Dwan Hospital	Duluth	Minnesota	United States	55805
564	Saint Luke's Hospital of Duluth	Duluth	Minnesota	United States	55805
565	Fairview Southdale Hospital	Edina	Minnesota	United States	55435
566	Etzell, Paul S MD (UIA Investigator)	Fergus Falls	Minnesota	United States	56537
567	Lake Region Healthcare Corporation-Cancer Care	Fergus Falls	Minnesota	United States	56537
568	Swenson, Wade II, MD (UIA Investigator)	Fergus Falls	Minnesota	United States	56537
569	Unity Hospital	Fridley	Minnesota	United States	55432
570	Hutchinson Area Health Care	Hutchinson	Minnesota	United States	55350
571	Meeker County Memorial Hospital	Litchfield	Minnesota	United States	55355
572	Minnesota Oncology Hematology PA-Maplewood	Maplewood	Minnesota	United States	55109
573	Saint John's Hospital - Healtheast	Maplewood	Minnesota	United States	55109
574	Abbott-Northwestern Hospital	Minneapolis	Minnesota	United States	55407
575	Virginia Piper Cancer Institute	Minneapolis	Minnesota	United States	55407
576	Hennepin County Medical Center	Minneapolis	Minnesota	United States	55415
577	Minneapolis VA Medical Center	Minneapolis	Minnesota	United States	55417
578	University of Minnesota/Masonic Cancer Center	Minneapolis	Minnesota	United States	55455
579	New Ulm Medical Center	New Ulm	Minnesota	United States	56073
580	North Memorial Medical Health Center	Robbinsdale	Minnesota	United States	55422
581	Mayo Clinic in Rochester	Rochester	Minnesota	United States	55905
582	Coborn Cancer Center at Saint Cloud Hospital	Saint Cloud	Minnesota	United States	56303
583	Saint Cloud Hospital	Saint Cloud	Minnesota	United States	56303
584	Metro Minnesota Community Oncology Research Consortium	Saint Louis Park	Minnesota	United States	55416
585	Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	United States	55416
586	Regions Hospital	Saint Paul	Minnesota	United States	55101
587	Saint Joseph's Hospital - Healtheast	Saint Paul	Minnesota	United States	55102
588	United Hospital	Saint Paul	Minnesota	United States	55102
589	Saint Francis Regional Medical Center	Shakopee	Minnesota	United States	55379
590	Lakeview Hospital	Stillwater	Minnesota	United States	55082
591	Ridgeview Medical Center	Waconia	Minnesota	United States	55387
592	Rice Memorial Hospital	Willmar	Minnesota	United States	56201
593	Minnesota Oncology Hematology PA-Woodbury	Woodbury	Minnesota	United States	55125
594	Woodwinds Health Campus	Woodbury	Minnesota	United States	55125
595	Hattiesburg Clinic - Hematology/Oncology Clinic	Hattiesburg	Mississippi	United States	39401
596	University of Mississippi Medical Center	Jackson	Mississippi	United States	39216
597	Veterans Affairs Medical Center	Jackson	Mississippi	United States	39216
598	Keesler Medical Center	Keesler Air Force Base	Mississippi	United States	39534
599	Singing River Hospital	Pascagoula	Mississippi	United States	39581
600	Central Care Cancer Center - Bolivar	Bolivar	Missouri	United States	65613
601	Cox Cancer Center Branson	Branson	Missouri	United States	65616
602	Southeast Missouri Hospital	Cape Girardeau	Missouri	United States	63701
603	Saint Francis Medical Center	Cape Girardeau	Missouri	United States	63703
604	Southeast Cancer Center	Cape Girardeau	Missouri	United States	63703
605	Saint Luke's Hospital	Chesterfield	Missouri	United States	63017
606	Veterans Administration	Columbia	Missouri	United States	65201
607	University of Missouri - Ellis Fischel	Columbia	Missouri	United States	65212
608	Centerpoint Medical Center LLC	Independence	Missouri	United States	64057
609	Capital Region Medical Center	Jefferson City	Missouri	United States	65101
610	Capital Region Southwest Campus	Jefferson City	Missouri	United States	65109
611	Freeman Health System	Joplin	Missouri	United States	64804
612	Mercy Hospital Joplin	Joplin	Missouri	United States	64804
613	Truman Medical Centers	Kansas City	Missouri	United States	64108
614	Saint Luke's Hospital of Kansas City	Kansas City	Missouri	United States	64111
615	Saint Joseph Health Center	Kansas City	Missouri	United States	64114
616	North Kansas City Hospital	Kansas City	Missouri	United States	64116
617	Heartland Hematology and Oncology Associates Incorporated	Kansas City	Missouri	United States	64118
618	Kansas City Veterans Affairs Medical Center	Kansas City	Missouri	United States	64128
619	The University of Kansas Cancer Center-South	Kansas City	Missouri	United States	64131
620	Research Medical Center	Kansas City	Missouri	United States	64132
621	University of Kansas Cancer Center - North	Kansas City	Missouri	United States	64154
622	University of Kansas Cancer Center - Lee's Summit	Lee's Summit	Missouri	United States	64064
623	Saint Luke's East - Lee's Summit	Lee's Summit	Missouri	United States	64086
624	Liberty Radiation Oncology Center	Liberty	Missouri	United States	64068
625	Delbert Day Cancer Institute at PCRMC	Rolla	Missouri	United States	65401
626	Mercy Clinic-Rolla-Cancer and Hematology	Rolla	Missouri	United States	65401
627	Heartland Regional Medical Center	Saint Joseph	Missouri	United States	64506
628	Saint Joseph Oncology Inc	Saint Joseph	Missouri	United States	64507
629	Saint Louis Cancer and Breast Institute-South City	Saint Louis	Missouri	United States	63109
630	Washington University School of Medicine	Saint Louis	Missouri	United States	63110
631	Mercy Hospital South	Saint Louis	Missouri	United States	63128
632	Missouri Baptist Medical Center	Saint Louis	Missouri	United States	63131
633	Siteman Cancer Center at Christian Hospital	Saint Louis	Missouri	United States	63136
634	Center for Cancer Care and Research	Saint Louis	Missouri	United States	63141
635	Comprehensive Cancer Care PC	Saint Louis	Missouri	United States	63141
636	Mercy Hospital Saint Louis	Saint Louis	Missouri	United States	63141
637	Saint Louis-Cape Girardeau CCOP	Saint Louis	Missouri	United States	63141
638	Cancer Research for the Ozarks NCORP	Springfield	Missouri	United States	65804
639	Mercy Hospital Springfield	Springfield	Missouri	United States	65804
640	CoxHealth South Hospital	Springfield	Missouri	United States	65807
641	Billings Clinic Cancer Center	Billings	Montana	United States	59101
642	Northern Rockies Radiation Oncology Center	Billings	Montana	United States	59101
643	Saint Vincent Healthcare	Billings	Montana	United States	59101
644	Montana Cancer Consortium NCORP	Billings	Montana	United States	59102
645	Saint Vincent Frontier Cancer Center	Billings	Montana	United States	59102
646	Bozeman Deaconess Hospital	Bozeman	Montana	United States	59715
647	Saint James Community Hospital and Cancer Treatment Center	Butte	Montana	United States	59701
648	Benefis Healthcare- Sletten Cancer Institute	Great Falls	Montana	United States	59405
649	Berdeaux, Donald MD (UIA Investigator)	Great Falls	Montana	United States	59405
650	Great Falls Clinic	Great Falls	Montana	United States	59405
651	Northern Montana Hospital	Havre	Montana	United States	59501
652	Saint Peter's Community Hospital	Helena	Montana	United States	59601
653	Glacier Oncology PLLC	Kalispell	Montana	United States	59901
654	Kalispell Medical Oncology	Kalispell	Montana	United States	59901
655	Kalispell Regional Medical Center	Kalispell	Montana	United States	59901
656	Montana Cancer Specialists	Missoula	Montana	United States	59802
657	Saint Patrick Hospital - Community Hospital	Missoula	Montana	United States	59802
658	Community Medical Hospital	Missoula	Montana	United States	59804
659	Guardian Oncology and Center for Wellness	Missoula	Montana	United States	59804
660	CHI Health Saint Francis	Grand Island	Nebraska	United States	68803
661	CHI Health Good Samaritan	Kearney	Nebraska	United States	68847
662	Nebraska Cancer Research Center	Lincoln	Nebraska	United States	68510
663	Great Plains Health Callahan Cancer Center	North Platte	Nebraska	United States	69101
664	Missouri Valley Cancer Consortium	Omaha	Nebraska	United States	68106
665	Alegent Health Immanuel Medical Center	Omaha	Nebraska	United States	68122
666	Alegent Health Bergan Mercy Medical Center	Omaha	Nebraska	United States	68124
667	Alegent Health Lakeside Hospital	Omaha	Nebraska	United States	68130
668	Creighton University Medical Center	Omaha	Nebraska	United States	68131
669	University of Nebraska Medical Center	Omaha	Nebraska	United States	68198
670	University Medical Center of Southern Nevada	Las Vegas	Nevada	United States	89102
671	Nevada Cancer Institute-Summerlin Campus	Las Vegas	Nevada	United States	89135
672	Nevada Cancer Research Foundation NCORP	Las Vegas	Nevada	United States	89169
673	Renown Regional Medical Center	Reno	Nevada	United States	89502
674	New Hampshire Oncology Hematology PA-Concord	Concord	New Hampshire	United States	03301
675	Wentworth-Douglass Hospital	Dover	New Hampshire	United States	03820
676	Exeter Hospital	Exeter	New Hampshire	United States	03833
677	Cheshire Medical Center-Dartmouth-Hitchcock Keene	Keene	New Hampshire	United States	03431
678	LRGHealthcare-Lakes Region General Hospital	Laconia	New Hampshire	United States	03246
679	Solinsky Center for Cancer Care	Manchester	New Hampshire	United States	03103
680	Foundation Medical Partners	Nashua	New Hampshire	United States	03060
681	Saint Joseph Hospital	Nashua	New Hampshire	United States	03060
682	Portsmouth Regional Hospital	Portsmouth	New Hampshire	United States	03802
683	Ocean Medical Center	Brick	New Jersey	United States	08724
684	Cooper Hospital University Medical Center	Camden	New Jersey	United States	08103
685	Veterans Adminstration New Jersey Health Care System	East Orange	New Jersey	United States	07018-1095
686	Englewood Hospital and Medical Center	Englewood	New Jersey	United States	07631
687	Hunterdon Medical Center	Flemington	New Jersey	United States	08822
688	CentraState Medical Center	Freehold	New Jersey	United States	07728
689	The Cancer Institute of New Jersey Hamilton	Hamilton	New Jersey	United States	08690
690	Morristown Medical Center	Morristown	New Jersey	United States	07960
691	Virtua Memorial	Mount Holly	New Jersey	United States	08060
692	Jersey Shore Medical Center	Neptune	New Jersey	United States	07753
693	Saint Peter's University Hospital	New Brunswick	New Jersey	United States	08901
694	Rutgers Cancer Institute of New Jersey	New Brunswick	New Jersey	United States	08903
695	Newark Beth Israel Medical Center	Newark	New Jersey	United States	07112
696	Capital Health Medical Center-Hopewell	Pennington	New Jersey	United States	08534
697	Saint Luke's Hospital-Warren Campus	Phillipsburg	New Jersey	United States	08865
698	Penn Medicine Princeton Health	Plainsboro	New Jersey	United States	08536
699	AtlantiCare Regional Medical Center -Main Campus	Pomona	New Jersey	United States	08240
700	Riverview Medical Center/Booker Cancer Center	Red Bank	New Jersey	United States	07701
701	Valley Hospital	Ridgewood	New Jersey	United States	07450
702	Robert Wood Johnson University Hospital Somerset	Somerville	New Jersey	United States	08876
703	Sparta Cancer Treatment Center	Sparta	New Jersey	United States	07871
704	Overlook Hospital	Summit	New Jersey	United States	07902
705	Saint Francis Medical Center	Trenton	New Jersey	United States	08629
706	Inspira Medical Center Vineland	Vineland	New Jersey	United States	08360
707	Virtua Voorhees	Voorhees	New Jersey	United States	08043
708	Lovelace Medical Center-Saint Joseph Square	Albuquerque	New Mexico	United States	87102
709	University of New Mexico Cancer Center	Albuquerque	New Mexico	United States	87102
710	Hematology Oncology Associates	Albuquerque	New Mexico	United States	87106
711	Presbyterian Kaseman Hospital	Albuquerque	New Mexico	United States	87110
712	Memorial Medical Center - Las Cruces	Las Cruces	New Mexico	United States	88011
713	Memorial Medical Center-Main Campus	Las Cruces	New Mexico	United States	88011
714	Christus Saint Vincent Regional Cancer Center	Santa Fe	New Mexico	United States	87505
715	New York Oncology Hematology PC - Albany	Albany	New York	United States	12206
716	New York Oncology Hematology PC - Albany Medical Center	Albany	New York	United States	12208
717	Montefiore Medical Center-Weiler Hospital	Bronx	New York	United States	10461
718	Montefiore Medical Center - Moses Campus	Bronx	New York	United States	10467
719	Kings County Hospital	Brooklyn	New York	United States	11203
720	State University of New York Downstate Medical Center	Brooklyn	New York	United States	11203
721	Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus	Brooklyn	New York	United States	11209
722	Maimonides Medical Center	Brooklyn	New York	United States	11219
723	Coney Island Hospital	Brooklyn	New York	United States	11235
724	Veterans Affairs Western New York Health Care System-Buffalo	Buffalo	New York	United States	14215
725	New York Oncology Hematology PC - Clifton Park	Clifton Park	New York	United States	12065
726	Finger Lakes Hematology and Oncology	Clifton Springs	New York	United States	14432
727	Mary Imogene Bassett Hospital	Cooperstown	New York	United States	13326
728	Hematology Oncology Associates of Central New York-East Syracuse	East Syracuse	New York	United States	13057
729	Arnot Ogden Medical Center/Falck Cancer Center	Elmira	New York	United States	14905
730	Adirondack Cancer Center	Glens Falls	New York	United States	12801
731	Glens Falls Hospital	Glens Falls	New York	United States	12801
732	New York Oncology Hematology PC-Hudson	Hudson	New York	United States	12534
733	Northwell Health NCORP	Lake Success	New York	United States	11042
734	Northwell Health/Center for Advanced Medicine	Lake Success	New York	United States	11042
735	North Shore University Hospital	Manhasset	New York	United States	11030
736	Garnet Health Medical Center	Middletown	New York	United States	10940
737	NYU Winthrop Hospital	Mineola	New York	United States	11501
738	Mount Kisco Medical Group	Mount Kisco	New York	United States	10549
739	Northern Westchester Hospital	Mount Kisco	New York	United States	10549
740	Long Island Jewish Medical Center	New Hyde Park	New York	United States	11040
741	Mount Sinai Union Square	New York	New York	United States	10003
742	Laura and Isaac Perlmutter Cancer Center at NYU Langone	New York	New York	United States	10016
743	Mount Sinai West	New York	New York	United States	10019
744	NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center	New York	New York	United States	10032
745	NYP/Weill Cornell Medical Center	New York	New York	United States	10065
746	Nyack Hospital	Nyack	New York	United States	10960
747	Hudson Valley Hematology Oncology Associates	Poughkeepsie	New York	United States	12601
748	MidHudson Regional Hospital of Westchester Medical Center	Poughkeepsie	New York	United States	12601
749	The Dyson Center for Cancer Care	Poughkeepsie	New York	United States	12601
750	Vassar Brothers Medical Center	Poughkeepsie	New York	United States	12601
751	Highland Hospital	Rochester	New York	United States	14620
752	Interlakes Foundation Inc-Rochester	Rochester	New York	United States	14623
753	University of Rochester	Rochester	New York	United States	14642
754	Staten Island University Hospital	Staten Island	New York	United States	10305
755	Stony Brook University Medical Center	Stony Brook	New York	United States	11794
756	State University of New York Upstate Medical University	Syracuse	New York	United States	13210
757	Syracuse Veterans Administration Medical Center	Syracuse	New York	United States	13210
758	New York Oncology Hematology PC - Troy	Troy	New York	United States	12180
759	Faxton-Saint Luke's Healthcare	Utica	New York	United States	13502
760	Dickstein Cancer Treatment Center	White Plains	New York	United States	10601
761	Randolph Hospital	Asheboro	North Carolina	United States	27203
762	Mission Hospital	Asheville	North Carolina	United States	28801
763	Cone Health Cancer Center at Alamance Regional	Burlington	North Carolina	United States	27215
764	Waverly Hematology Oncology	Cary	North Carolina	United States	27518
765	UNC Lineberger Comprehensive Cancer Center	Chapel Hill	North Carolina	United States	27599
766	Carolinas Medical Center/Levine Cancer Institute	Charlotte	North Carolina	United States	28203
767	Novant Health Presbyterian Medical Center	Charlotte	North Carolina	United States	28204
768	Atrium Health Cabarrus/LCI-Concord	Concord	North Carolina	United States	28025
769	Durham VA Medical Center	Durham	North Carolina	United States	27705
770	Southeastern Medical Oncology Center-Goldsboro	Goldsboro	North Carolina	United States	27534
771	Wayne Memorial Hospital	Goldsboro	North Carolina	United States	27534
772	Cone Health Cancer Center	Greensboro	North Carolina	United States	27403
773	Margaret R Pardee Memorial Hospital	Hendersonville	North Carolina	United States	28791
774	AdventHealth Hendersonville	Hendersonville	North Carolina	United States	28792
775	Vidant Oncology-Kinston	Kinston	North Carolina	United States	28501
776	Atrium Health Union/LCI-Union	Monroe	North Carolina	United States	28112
777	FirstHealth of the Carolinas-Moore Regional Hospital	Pinehurst	North Carolina	United States	28374
778	UNC Rex Cancer Center	Raleigh	North Carolina	United States	27607
779	Annie Penn Memorial Hospital	Reidsville	North Carolina	United States	27320
780	Rutherford Hospital	Rutherfordton	North Carolina	United States	28139
781	Atrium Health Cleveland/LCI-Cleveland	Shelby	North Carolina	United States	28150
782	Iredell Memorial Hospital	Statesville	North Carolina	United States	28677
783	Marion L Shepard Cancer Center at Vidant Beaufort Hospital	Washington	North Carolina	United States	27889
784	Novant Health Forsyth Medical Center	Winston-Salem	North Carolina	United States	27103
785	Southeast Clinical Oncology Research Consortium NCORP	Winston-Salem	North Carolina	United States	27104
786	Mid Dakota Clinic	Bismarck	North Dakota	United States	58501
787	Saint Alexius Medical Center	Bismarck	North Dakota	United States	58501
788	Sanford Bismarck Medical Center	Bismarck	North Dakota	United States	58501
789	Veterans Administration Medical Center	Fargo	North Dakota	United States	58102
790	Sanford Broadway Medical Center	Fargo	North Dakota	United States	58122
791	Sanford Clinic North-Fargo	Fargo	North Dakota	United States	58122
792	Sanford Roger Maris Cancer Center	Fargo	North Dakota	United States	58122
793	Altru Cancer Center	Grand Forks	North Dakota	United States	58201
794	Summa Health System - Akron Campus	Akron	Ohio	United States	44304
795	Cleveland Clinic Akron General	Akron	Ohio	United States	44307
796	Summa Health System - Barberton Campus	Barberton	Ohio	United States	44203
797	Cleveland Clinic Cancer Center Beachwood	Beachwood	Ohio	United States	44122
798	UHHS-Chagrin Highlands Medical Center	Beachwood	Ohio	United States	44122
799	Mary Rutan Hospital	Bellefontaine	Ohio	United States	43311
800	Toledo Clinic Cancer Centers-Bowling Green	Bowling Green	Ohio	United States	43402
801	Cleveland Clinic Mercy Hospital	Canton	Ohio	United States	44708
802	Aultman Health Foundation	Canton	Ohio	United States	44710
803	Geauga Hospital	Chardon	Ohio	United States	44024
804	Adena Regional Medical Center	Chillicothe	Ohio	United States	45601
805	The Christ Hospital	Cincinnati	Ohio	United States	45219
806	University of Cincinnati Cancer Center-UC Medical Center	Cincinnati	Ohio	United States	45219
807	Case Western Reserve University	Cleveland	Ohio	United States	44106
808	MetroHealth Medical Center	Cleveland	Ohio	United States	44109
809	Cleveland Clinic Cancer Center/Fairview Hospital	Cleveland	Ohio	United States	44111
810	Cleveland Clinic Foundation	Cleveland	Ohio	United States	44195
811	North Coast Cancer Care-Clyde	Clyde	Ohio	United States	43410
812	Ohio State University Comprehensive Cancer Center	Columbus	Ohio	United States	43210
813	Mount Carmel East Hospital	Columbus	Ohio	United States	43213
814	Riverside Methodist Hospital	Columbus	Ohio	United States	43214
815	Columbus NCI Community Oncology Research Program	Columbus	Ohio	United States	43215
816	Grant Medical Center	Columbus	Ohio	United States	43215
817	The Mark H Zangmeister Center	Columbus	Ohio	United States	43219
818	Mount Carmel Health Center West	Columbus	Ohio	United States	43222
819	Doctors Hospital	Columbus	Ohio	United States	43228
820	Grandview Hospital	Dayton	Ohio	United States	45405
821	Good Samaritan Hospital - Dayton	Dayton	Ohio	United States	45406
822	Miami Valley Hospital	Dayton	Ohio	United States	45409
823	Miami Valley Hospital North	Dayton	Ohio	United States	45415
824	Dayton Veterans Affairs Medical Center	Dayton	Ohio	United States	45428
825	Dayton NCI Community Oncology Research Program	Dayton	Ohio	United States	45459
826	Grady Memorial Hospital	Delaware	Ohio	United States	43015
827	Hematology Oncology Center Incorporated	Elyria	Ohio	United States	44035
828	Mercy Cancer Center-Elyria	Elyria	Ohio	United States	44035
829	Blanchard Valley Hospital	Findlay	Ohio	United States	45840
830	Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	United States	45005-1066
831	Fremont Memorial Hospital	Fremont	Ohio	United States	43420
832	Wayne Hospital	Greenville	Ohio	United States	45331
833	Cleveland Clinic Cancer Center Independence	Independence	Ohio	United States	44131
834	Kettering Medical Center	Kettering	Ohio	United States	45429
835	Fairfield Medical Center	Lancaster	Ohio	United States	43130
836	Saint Rita's Medical Center	Lima	Ohio	United States	45801
837	Lima Memorial Hospital	Lima	Ohio	United States	45804
838	OhioHealth Mansfield Hospital	Mansfield	Ohio	United States	44903
839	Marietta Memorial Hospital	Marietta	Ohio	United States	45750
840	Saint Luke's Hospital	Maumee	Ohio	United States	43537
841	Toledo Clinic Cancer Centers-Maumee	Maumee	Ohio	United States	43537
842	Toledo Radiation Oncology at Northwest Ohio Onocolgy Center	Maumee	Ohio	United States	43537
843	Hillcrest Hospital Cancer Center	Mayfield Heights	Ohio	United States	44124
844	UH Seidman Cancer Center at Lake Health Mentor Campus	Mentor	Ohio	United States	44060
845	UH Seidman Cancer Center at Southwest General Hospital	Middleburg Heights	Ohio	United States	44130
846	Knox Community Hospital	Mount Vernon	Ohio	United States	43050
847	Licking Memorial Hospital	Newark	Ohio	United States	43055
848	Fisher-Titus Medical Center	Norwalk	Ohio	United States	44857
849	Saint Charles Hospital	Oregon	Ohio	United States	43616
850	Toledo Clinic Cancer Centers-Oregon	Oregon	Ohio	United States	43616
851	University Hospitals Parma Medical Center	Parma	Ohio	United States	44129
852	Southern Ohio Medical Center	Portsmouth	Ohio	United States	45662
853	Firelands Regional Medical Center	Sandusky	Ohio	United States	44870
854	North Coast Cancer Care	Sandusky	Ohio	United States	44870
855	UH Seidman Cancer Center at Firelands Regional Medical Center	Sandusky	Ohio	United States	44870
856	Springfield Regional Medical Center	Springfield	Ohio	United States	45505
857	Trinity's Tony Teramana Cancer Center	Steubenville	Ohio	United States	43952
858	Cleveland Clinic Cancer Center Strongsville	Strongsville	Ohio	United States	44136
859	ProMedica Flower Hospital	Sylvania	Ohio	United States	43560
860	Mercy Hospital of Tiffin	Tiffin	Ohio	United States	44883
861	ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital	Toledo	Ohio	United States	43606
862	Saint Vincent Mercy Medical Center	Toledo	Ohio	United States	43608
863	University of Toledo	Toledo	Ohio	United States	43614
864	Toledo Community Hospital Oncology Program CCOP	Toledo	Ohio	United States	43617
865	Mercy Health - Saint Anne Hospital	Toledo	Ohio	United States	43623
866	Toledo Clinic Cancer Centers-Toledo	Toledo	Ohio	United States	43623
867	Upper Valley Medical Center	Troy	Ohio	United States	45373
868	Fulton County Health Center	Wauseon	Ohio	United States	43567
869	Saint Ann's Hospital	Westerville	Ohio	United States	43081
870	UHHS-Westlake Medical Center	Westlake	Ohio	United States	44145
871	Clinton Memorial Hospital	Wilmington	Ohio	United States	45177
872	Cleveland Clinic Wooster Family Health and Surgery Center	Wooster	Ohio	United States	44691
873	Wright-Patterson Medical Center	Wright-Patterson Air Force Base	Ohio	United States	45433
874	Greene Memorial Hospital	Xenia	Ohio	United States	45385
875	Forum Health Cancer Care Center	Youngstown	Ohio	United States	44501
876	Genesis Healthcare System Cancer Care Center	Zanesville	Ohio	United States	43701
877	Cancer Centers of Southwest Oklahoma Research	Lawton	Oklahoma	United States	73505
878	Cancer Care Associates-Norman	Norman	Oklahoma	United States	73071
879	University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	United States	73104
880	Cancer Care Associates	Oklahoma City	Oklahoma	United States	73120
881	Mercy Hospital Oklahoma City	Oklahoma City	Oklahoma	United States	73120
882	Mercy Physicians of Oklahoma-Lakeside	Oklahoma City	Oklahoma	United States	73120
883	Natalie Warren Bryant Cancer Center at Saint Francis	Tulsa	Oklahoma	United States	74136
884	Saint Charles Health System	Bend	Oregon	United States	97701
885	Clackamas Radiation Oncology Center	Clackamas	Oregon	United States	97015
886	Bay Area Hospital	Coos Bay	Oregon	United States	97420
887	Three Rivers Community Hospital	Grants Pass	Oregon	United States	97527
888	Legacy Mount Hood Medical Center	Gresham	Oregon	United States	97030
889	Sky Lakes Medical Center - Cancer Treatment Center	Klamath Falls	Oregon	United States	97601
890	Asante Health System	Medford	Oregon	United States	97504
891	Providence Medford Medical Center	Medford	Oregon	United States	97504
892	Rogue Valley Medical Center	Medford	Oregon	United States	97504
893	Providence Milwaukie Hospital	Milwaukie	Oregon	United States	97222
894	Providence Newberg Medical Center	Newberg	Oregon	United States	97132
895	Providence Willamette Falls Medical Center	Oregon City	Oregon	United States	97045
896	Legacy Good Samaritan Hospital and Medical Center	Portland	Oregon	United States	97210
897	Providence Portland Medical Center	Portland	Oregon	United States	97213
898	Adventist Medical Center	Portland	Oregon	United States	97216
899	Providence Saint Vincent Medical Center	Portland	Oregon	United States	97225
900	Compass Oncology Rose Quarter	Portland	Oregon	United States	97227
901	Kaiser Permanente Northwest	Portland	Oregon	United States	97227
902	Legacy Emanuel Hospital and Health Center	Portland	Oregon	United States	97227
903	Oregon Health and Science University	Portland	Oregon	United States	97239
904	Salem Hospital	Salem	Oregon	United States	97301
905	Mid-Columbia Medical Center/Celilo Cancer Center	The Dalles	Oregon	United States	97058
906	Legacy Meridian Park Hospital	Tualatin	Oregon	United States	97062
907	Jefferson Abington Hospital	Abington	Pennsylvania	United States	19001
908	Lehigh Valley Hospital-Cedar Crest	Allentown	Pennsylvania	United States	18103
909	Saint Luke's University Hospital-Bethlehem Campus	Bethlehem	Pennsylvania	United States	18015
910	Lehigh Valley Hospital - Muhlenberg	Bethlehem	Pennsylvania	United States	18017
911	Bryn Mawr Hospital	Bryn Mawr	Pennsylvania	United States	19010
912	Butler Memorial Hospital	Butler	Pennsylvania	United States	16001
913	Geisinger Medical Center	Danville	Pennsylvania	United States	17822
914	Mercy Fitzgerald Hospital	Darby	Pennsylvania	United States	19023-1291
915	Doylestown Hospital	Doylestown	Pennsylvania	United States	18901
916	Delaware County Memorial Hospital	Drexel Hill	Pennsylvania	United States	19026
917	Oncology Hematology Associates of Northern Pennsylvania	DuBois	Pennsylvania	United States	15801
918	Pocono Medical Center	East Stroudsburg	Pennsylvania	United States	18301
919	Easton Hospital	Easton	Pennsylvania	United States	18042
920	Ephrata Cancer Center	Ephrata	Pennsylvania	United States	17522
921	UPMC Hillman Cancer Center Erie	Erie	Pennsylvania	United States	16505
922	UPMC Hamot	Erie	Pennsylvania	United States	16550
923	Adams Cancer Center	Gettysburg	Pennsylvania	United States	17325
924	Cherry Tree Cancer Center	Hanover	Pennsylvania	United States	17331
925	UPMC Pinnacle Cancer Center/Community Osteopathic Campus	Harrisburg	Pennsylvania	United States	17109
926	Geisinger Medical Center-Cancer Center Hazleton	Hazleton	Pennsylvania	United States	18201
927	Penn State Milton S Hershey Medical Center	Hershey	Pennsylvania	United States	17033-0850
928	Lancaster General Hospital	Lancaster	Pennsylvania	United States	17602
929	Saint Mary Medical and Regional Cancer Center	Langhorne	Pennsylvania	United States	19047
930	Central PA Hematology-Medical Oncology Associates PC	Lemoyne	Pennsylvania	United States	17043
931	Lewistown Hospital	Lewistown	Pennsylvania	United States	17044
932	Holy Redeemer Hospital and Medical Center	Meadowbrook	Pennsylvania	United States	19046
933	Riddle Memorial Hospital	Media	Pennsylvania	United States	19063
934	Forbes Hospital	Monroeville	Pennsylvania	United States	15146
935	Allegheny Valley Hospital	Natrona Heights	Pennsylvania	United States	15065
936	Paoli Memorial Hospital	Paoli	Pennsylvania	United States	19301
937	University of Pennsylvania/Abramson Cancer Center	Philadelphia	Pennsylvania	United States	19104
938	Pennsylvania Hospital	Philadelphia	Pennsylvania	United States	19107
939	Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	United States	19107
940	Fox Chase Cancer Center	Philadelphia	Pennsylvania	United States	19111
941	Jefferson Torresdale Hospital	Philadelphia	Pennsylvania	United States	19114
942	Chestnut Hill Health System	Philadelphia	Pennsylvania	United States	19118
943	Einstein Medical Center Philadelphia	Philadelphia	Pennsylvania	United States	19141
944	Mercy Hospital of Philadelphia	Philadelphia	Pennsylvania	United States	19143
945	Allegheny General Hospital	Pittsburgh	Pennsylvania	United States	15212
946	University of Pittsburgh Cancer Institute (UPCI)	Pittsburgh	Pennsylvania	United States	15232
947	VA Pittsburgh Healthcare System	Pittsburgh	Pennsylvania	United States	15240
948	Pottstown Hospital	Pottstown	Pennsylvania	United States	19464
949	Penn State Health Saint Joseph Medical Center	Reading	Pennsylvania	United States	19605
950	Guthrie Medical Group PC-Robert Packer Hospital	Sayre	Pennsylvania	United States	18840
951	Mercy Hospital	Scranton	Pennsylvania	United States	18501
952	Hematology and Oncology Associates of North East Pennsylvania	Scranton	Pennsylvania	United States	18508
953	Scranton Hematology Oncology	Scranton	Pennsylvania	United States	18510
954	Grand View Hospital	Sellersville	Pennsylvania	United States	18960
955	Geisinger Medical Group	State College	Pennsylvania	United States	16801
956	Mount Nittany Medical Center	State College	Pennsylvania	United States	16803
957	Associates In Hematology Oncology PC-Upland	Upland	Pennsylvania	United States	19013
958	Reading Hospital	West Reading	Pennsylvania	United States	19611
959	Geisinger Wyoming Valley/Henry Cancer Center	Wilkes-Barre	Pennsylvania	United States	18711
960	Geisinger South Wilkes-Barre	Wilkes-Barre	Pennsylvania	United States	18765
961	UPMC Susquehanna	Williamsport	Pennsylvania	United States	17701
962	Lankenau Medical Center	Wynnewood	Pennsylvania	United States	19096
963	Main Line Health NCORP	Wynnewood	Pennsylvania	United States	19096
964	WellSpan Health-York Hospital	York	Pennsylvania	United States	17403
965	Hematology and Oncology Associates of Rhode Island Inc	Cranston	Rhode Island	United States	02920
966	Memorial Hospital of Rhode Island	Pawtucket	Rhode Island	United States	02860
967	Rhode Island Hospital	Providence	Rhode Island	United States	02903
968	Miriam Hospital	Providence	Rhode Island	United States	02906
969	Kent Hospital	Warwick	Rhode Island	United States	02886
970	AnMed Health Cancer Center	Anderson	South Carolina	United States	29621
971	AnMed Health Hospital	Anderson	South Carolina	United States	29621
972	Prisma Health Cancer Institute - Spartanburg	Boiling Springs	South Carolina	United States	29316
973	Roper Hospital	Charleston	South Carolina	United States	29401
974	Medical University of South Carolina	Charleston	South Carolina	United States	29425
975	Prisma Health Cancer Institute - Easley	Easley	South Carolina	United States	29640
976	McLeod Regional Medical Center	Florence	South Carolina	United States	29506
977	Greenville Health System Cancer Institute-Andrews	Greenville	South Carolina	United States	29601
978	Saint Francis Hospital	Greenville	South Carolina	United States	29601
979	Prisma Health Cancer Institute - Butternut	Greenville	South Carolina	United States	29605
980	Prisma Health Cancer Institute - Faris	Greenville	South Carolina	United States	29605
981	Prisma Health Greenville Memorial Hospital	Greenville	South Carolina	United States	29605
982	Prisma Health Cancer Institute - Eastside	Greenville	South Carolina	United States	29615
983	Self Regional Healthcare	Greenwood	South Carolina	United States	29646
984	Prisma Health Cancer Institute - Greer	Greer	South Carolina	United States	29650
985	Levine Cancer Institute-Rock Hill	Rock Hill	South Carolina	United States	29732
986	Prisma Health Cancer Institute - Seneca	Seneca	South Carolina	United States	29672
987	Spartanburg Medical Center	Spartanburg	South Carolina	United States	29303
988	Avera Cancer Institute-Aberdeen	Aberdeen	South Dakota	United States	57401
989	Rapid City Regional Hospital	Rapid City	South Dakota	United States	57701
990	Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	United States	57104
991	Avera Cancer Institute	Sioux Falls	South Dakota	United States	57105
992	Medical X-Ray Center	Sioux Falls	South Dakota	United States	57105
993	Avera McKennan Hospital and University Health Center	Sioux Falls	South Dakota	United States	57117-5045
994	Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	United States	57117-5134
995	Wellmont Medical Associates Oncology and Hematology-Bristol	Bristol	Tennessee	United States	37620
996	Erlanger Medical Center	Chattanooga	Tennessee	United States	37403
997	Vanderbilt-Ingram Cancer Center Cool Springs	Franklin	Tennessee	United States	37067
998	Jones Clinic	Germantown	Tennessee	United States	38138
999	Jackson-Madison County General Hospital	Jackson	Tennessee	United States	38301
1000	Wellmont Holston Valley Hospital and Medical Center	Kingsport	Tennessee	United States	37660
1001	Thompson Cancer Survival Center	Knoxville	Tennessee	United States	37916
1002	University of Tennessee - Knoxville	Knoxville	Tennessee	United States	37920
1003	University of Tennessee Health Science Center	Memphis	Tennessee	United States	38163
1004	Nashville Oncology Associates PC	Nashville	Tennessee	United States	37203
1005	Meharry Medical College	Nashville	Tennessee	United States	37208
1006	Vanderbilt University/Ingram Cancer Center	Nashville	Tennessee	United States	37232
1007	The Don and Sybil Harrington Cancer Center	Amarillo	Texas	United States	79106
1008	Dallas VA Medical Center	Dallas	Texas	United States	75216
1009	Medical City Dallas Hospital	Dallas	Texas	United States	75230
1010	Texas Health Presbyterian Hospital Dallas	Dallas	Texas	United States	75231
1011	Parkland Memorial Hospital	Dallas	Texas	United States	75235
1012	Baylor University Medical Center	Dallas	Texas	United States	75246
1013	Clements University Hospital	Dallas	Texas	United States	75390
1014	UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	United States	75390
1015	Brooke Army Medical Center	Fort Sam Houston	Texas	United States	78234
1016	Wilford Hall Medical Center	Lackland Air Force Base	Texas	United States	78236
1017	Texas Tech University Health Sciences Center-Lubbock	Lubbock	Texas	United States	79430
1018	Audie L Murphy VA Hospital	San Antonio	Texas	United States	78229
1019	Cancer Therapy and Research Center at The UT Health Science Center at San Antonio	San Antonio	Texas	United States	78229
1020	University Hospital	San Antonio	Texas	United States	78229
1021	University of Texas Health Science Center at San Antonio	San Antonio	Texas	United States	78229
1022	Scott and White Memorial Hospital	Temple	Texas	United States	76508
1023	Huntsman Cancer Institute/University of Utah	Salt Lake City	Utah	United States	84112
1024	Southwestern Vermont Medical Center	Bennington	Vermont	United States	05201
1025	Central Vermont Medical Center/National Life Cancer Treatment	Berlin	Vermont	United States	05602
1026	University of Vermont and State Agricultural College	Burlington	Vermont	United States	05405
1027	Sentara Martha Jefferson Hospital	Charlottesville	Virginia	United States	22901
1028	University of Virginia Cancer Center	Charlottesville	Virginia	United States	22908
1029	Danville Regional Medical Center	Danville	Virginia	United States	24541
1030	Fredericksburg Oncology Inc	Fredericksburg	Virginia	United States	22401
1031	Hematology Oncology Associates of Fredericksburg Inc	Fredericksburg	Virginia	United States	22408
1032	Virginia Oncology Associates-Hampton	Hampton	Virginia	United States	23666
1033	Centra Lynchburg Hematology-Oncology Clinic Inc	Lynchburg	Virginia	United States	24501
1034	Sovah Health Martinsville	Martinsville	Virginia	United States	24115
1035	Southwest VA Regional Cancer Center	Norton	Virginia	United States	24273
1036	Hunter Holmes McGuire Veterans Administration Medical Center	Richmond	Virginia	United States	23249
1037	Virginia Commonwealth University/Massey Cancer Center	Richmond	Virginia	United States	23298
1038	Cancer Care Center at Island Hospital	Anacortes	Washington	United States	98221
1039	MultiCare Auburn Medical Center	Auburn	Washington	United States	98001
1040	Overlake Medical Center	Bellevue	Washington	United States	98004
1041	PeaceHealth Saint Joseph Medical Center	Bellingham	Washington	United States	98225
1042	Harrison HealthPartners Hematology and Oncology-Bremerton	Bremerton	Washington	United States	98310
1043	Highline Medical Center-Main Campus	Burien	Washington	United States	98166
1044	Providence Regional Cancer System-Centralia	Centralia	Washington	United States	98531
1045	Swedish Cancer Institute-Edmonds	Edmonds	Washington	United States	98026
1046	Providence Regional Cancer Partnership	Everett	Washington	United States	98201
1047	Saint Francis Hospital	Federal Way	Washington	United States	98003
1048	Swedish Cancer Institute-Issaquah	Issaquah	Washington	United States	98029
1049	Kadlec Clinic Hematology and Oncology	Kennewick	Washington	United States	99336
1050	EvergreenHealth Medical Center	Kirkland	Washington	United States	98033
1051	Seattle Cancer Care Alliance at EvergreenHealth	Kirkland	Washington	United States	98034
1052	Providence Regional Cancer System-Lacey	Lacey	Washington	United States	98503
1053	Saint Clare Hospital	Lakewood	Washington	United States	98499
1054	Skagit Valley Hospital	Mount Vernon	Washington	United States	98274
1055	Providence - Saint Peter Hospital	Olympia	Washington	United States	98506-5166
1056	Olympic Medical Center	Port Angeles	Washington	United States	98362
1057	Harrison HealthPartners Hematology and Oncology-Poulsbo	Poulsbo	Washington	United States	98370
1058	MultiCare Good Samaritan Hospital	Puyallup	Washington	United States	98372
1059	Valley Medical Center	Renton	Washington	United States	98055
1060	Virginia Mason Medical Center	Seattle	Washington	United States	98101
1061	Harborview Medical Center	Seattle	Washington	United States	98104
1062	Minor and James Medical PLLC	Seattle	Washington	United States	98104
1063	Pacific Medical Center-First Hill	Seattle	Washington	United States	98104
1064	Fred Hutchinson Cancer Research Center	Seattle	Washington	United States	98109
1065	Kaiser Permanente Washington	Seattle	Washington	United States	98112
1066	Swedish Medical Center-First Hill	Seattle	Washington	United States	98122-4307
1067	Pacific Cancer Research Consortium NCORP	Seattle	Washington	United States	98122
1068	University of Washington Medical Center - Montlake	Seattle	Washington	United States	98195
1069	PeaceHealth United General Medical Center	Sedro-Woolley	Washington	United States	98284
1070	Cancer Care Northwest - Spokane South	Spokane	Washington	United States	99202
1071	Evergreen Hematology and Oncology PS	Spokane	Washington	United States	99218
1072	Rockwood Clinic	Spokane	Washington	United States	99220
1073	MultiCare Allenmore Hospital	Tacoma	Washington	United States	98405
1074	MultiCare Tacoma General Hospital	Tacoma	Washington	United States	98405
1075	Northwest NCI Community Oncology Research Program	Tacoma	Washington	United States	98405
1076	Saint Joseph Medical Center	Tacoma	Washington	United States	98405
1077	Madigan Army Medical Center	Tacoma	Washington	United States	98431
1078	PeaceHealth Southwest Medical Center	Vancouver	Washington	United States	98664
1079	Compass Oncology Vancouver	Vancouver	Washington	United States	98684
1080	Legacy Salmon Creek Hospital	Vancouver	Washington	United States	98686
1081	Wenatchee Valley Hospital and Clinics	Wenatchee	Washington	United States	98801
1082	West Virginia University Charleston Division	Charleston	West Virginia	United States	25304
1083	Edwards Comprehensive Cancer Center	Huntington	West Virginia	United States	25701
1084	Saint Mary's Medical Center	Huntington	West Virginia	United States	25702
1085	West Virginia University Healthcare	Morgantown	West Virginia	United States	26506
1086	Wheeling Hospital/Schiffler Cancer Center	Wheeling	West Virginia	United States	26003
1087	ThedaCare Regional Cancer Center	Appleton	Wisconsin	United States	54911
1088	Aurora Cancer Care-Southern Lakes VLCC	Burlington	Wisconsin	United States	53105
1089	Marshfield Clinic-Chippewa Center	Chippewa Falls	Wisconsin	United States	54729
1090	HSHS Sacred Heart Hospital	Eau Claire	Wisconsin	United States	54701
1091	Marshfield Clinic Cancer Center at Sacred Heart	Eau Claire	Wisconsin	United States	54701
1092	Mayo Clinic Health System-Eau Claire Clinic	Eau Claire	Wisconsin	United States	54701
1093	Mayo Clinic Health System Eau Claire Hospital-Luther Campus	Eau Claire	Wisconsin	United States	54703
1094	Saint Agnes Hospital/Agnesian Cancer Center	Fond Du Lac	Wisconsin	United States	54935
1095	Aurora Cancer Care-Franklin	Franklin	Wisconsin	United States	53132
1096	Aurora Health Care Germantown Health Center	Germantown	Wisconsin	United States	53022
1097	Aurora Cancer Care-Glendale	Glendale	Wisconsin	United States	53212
1098	Green Bay Oncology at Saint Vincent Hospital	Green Bay	Wisconsin	United States	54301-3526
1099	Bellin Memorial Hospital	Green Bay	Wisconsin	United States	54301
1100	Saint Vincent Hospital Cancer Center Green Bay	Green Bay	Wisconsin	United States	54301
1101	Green Bay Oncology Limited at Saint Mary's Hospital	Green Bay	Wisconsin	United States	54303
1102	Saint Vincent Hospital Cancer Center at Saint Mary's	Green Bay	Wisconsin	United States	54303
1103	Aurora BayCare Medical Center	Green Bay	Wisconsin	United States	54311
1104	Mercyhealth Hospital and Cancer Center - Janesville	Janesville	Wisconsin	United States	53548
1105	UW Cancer Center Johnson Creek	Johnson Creek	Wisconsin	United States	53038
1106	Aurora Cancer Care-Kenosha South	Kenosha	Wisconsin	United States	53142
1107	Gundersen Lutheran Medical Center	La Crosse	Wisconsin	United States	54601
1108	Mayo Clinic Health System-Franciscan Healthcare	La Crosse	Wisconsin	United States	54601
1109	Dean Hematology and Oncology Clinic	Madison	Wisconsin	United States	53717
1110	University of Wisconsin Carbone Cancer Center	Madison	Wisconsin	United States	53792
1111	Holy Family Memorial Hospital	Manitowoc	Wisconsin	United States	54221
1112	Aurora Bay Area Medical Group-Marinette	Marinette	Wisconsin	United States	54143
1113	Bay Area Medical Center	Marinette	Wisconsin	United States	54143
1114	Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	United States	54449
1115	Marshfield Medical Center	Marshfield	Wisconsin	United States	54449
1116	Ascension Columbia Saint Mary's Hospital Ozaukee	Mequon	Wisconsin	United States	53097
1117	Ascension Southeast Wisconsin Hospital - Saint Joseph Campus	Milwaukee	Wisconsin	United States	53210
1118	Ascension Columbia Saint Mary's Hospital - Milwaukee	Milwaukee	Wisconsin	United States	53211
1119	Aurora Saint Luke's Medical Center	Milwaukee	Wisconsin	United States	53215
1120	Medical College of Wisconsin	Milwaukee	Wisconsin	United States	53226
1121	Aurora Sinai Medical Center	Milwaukee	Wisconsin	United States	53233
1122	Marshfield Clinic-Minocqua Center	Minocqua	Wisconsin	United States	54548
1123	Cancer Center of Western Wisconsin	New Richmond	Wisconsin	United States	54017
1124	Saint Vincent Hospital Cancer Center at Oconto Falls	Oconto Falls	Wisconsin	United States	54154
1125	Vince Lombardi Cancer Clinic - Oshkosh	Oshkosh	Wisconsin	United States	54904
1126	Ascension All Saints Hospital	Racine	Wisconsin	United States	53405
1127	Aurora Cancer Care-Racine	Racine	Wisconsin	United States	53406
1128	Ascension Saint Mary's Hospital	Rhinelander	Wisconsin	United States	54501
1129	Marshfield Medical Center-Rice Lake	Rice Lake	Wisconsin	United States	54868
1130	HSHS Saint Nicholas Hospital	Sheboygan	Wisconsin	United States	53081
1131	Vince Lombardi Cancer Clinic-Sheboygan	Sheboygan	Wisconsin	United States	53081
1132	Ascension Saint Michael's Hospital	Stevens Point	Wisconsin	United States	54481
1133	Green Bay Oncology - Sturgeon Bay	Sturgeon Bay	Wisconsin	United States	54235
1134	Aurora Medical Center in Summit	Summit	Wisconsin	United States	53066
1135	Vince Lombardi Cancer Clinic-Two Rivers	Two Rivers	Wisconsin	United States	54241
1136	Aurora Cancer Care-Waukesha	Waukesha	Wisconsin	United States	53188
1137	Aspirus Regional Cancer Center	Wausau	Wisconsin	United States	54401
1138	Marshfield Clinic-Wausau Center	Wausau	Wisconsin	United States	54401
1139	Aurora Cancer Care-Milwaukee West	Wauwatosa	Wisconsin	United States	53226
1140	Diagnostic and Treatment Center	Weston	Wisconsin	United States	54476
1141	Marshfield Medical Center - Weston	Weston	Wisconsin	United States	54476
1142	Aspirus Cancer Care - Wisconsin Rapids	Wisconsin Rapids	Wisconsin	United States	54494
1143	Marshfield Clinic - Wisconsin Rapids Center	Wisconsin Rapids	Wisconsin	United States	54494
1144	Rocky Mountain Oncology	Casper	Wyoming	United States	82609
1145	Welch Cancer Center	Sheridan	Wyoming	United States	82801
1146	Cross Cancer Institute	Edmonton	Alberta	Canada	T6G 1Z2
1147	BCCA-Vancouver Cancer Centre	Vancouver	British Columbia	Canada	V5Z 4E6
1148	CancerCare Manitoba	Winnipeg	Manitoba	Canada	R3E 0V9
1149	The Moncton Hospital	Moncton	New Brunswick	Canada	E1C 6Z8
1150	QEII Health Sciences Centre/Nova Scotia Health Authority	Halifax	Nova Scotia	Canada	B3H 2Y9
1151	Royal Victoria Regional Health Centre	Barrie	Ontario	Canada	L4M 6M2
1152	London Regional Cancer Program	London	Ontario	Canada	N6A 4L6
1153	Trillium Health Partners - Mississauga Hospital	Mississauga	Ontario	Canada	L5B 1B8
1154	Ottawa Hospital and Cancer Center-General Campus	Ottawa	Ontario	Canada	K1H 8L6
1155	Algoma District Cancer Program Sault Area Hospital	Sault Ste Marie	Ontario	Canada	P6B 0A8
1156	Health Sciences North	Sudbury	Ontario	Canada	P3E 5J1
1157	Thunder Bay Regional Health Science Centre	Thunder Bay	Ontario	Canada	P7B 6V4
1158	University Health Network-Princess Margaret Hospital	Toronto	Ontario	Canada	M5G 2M9
1159	Trillium Health Partners - Queensway Health Centre	Toronto	Ontario	Canada	M9C 1A5
1160	CSSS Champlain-Charles Le Moyne	Greenfield Park	Quebec	Canada	J4V 2H1
1161	McGill University Department of Oncology	Montreal	Quebec	Canada	H2W 1S6
1162	Allan Blair Cancer Centre	Regina	Saskatchewan	Canada	S4T 7T1
1163	Saskatoon Cancer Centre	Saskatoon	Saskatchewan	Canada	S7N 4H4
1164	Tallaght University Hospital	Dublin	Co Dublin	Ireland	24
1165	Saint Vincent's University Hospital	Dublin	Co Dublin	Ireland	4
1166	Mater Misericordiae University Hospital	Dublin	Co Dublin	Ireland	7
1167	Mater Private Hospital	Dublin	Co Dublin	Ireland	7
1168	Beaumont Hospital	Dublin	Co Dublin	Ireland	9
1169	University College Hospital Galway	Galway	Co Galway	Ireland
1170	Mid-Western Regional Hospital	Limerick	Co Limerick	Ireland	9
1171	University Hospital Waterford	Waterford	Co Waterford	Ireland	9
1172	Cork University Hospital	Cork		Ireland
1173	Saint James Hospital	Dublin		Ireland	8
1174	Instituto Nacional de Enfermedades Neoplasicas	Lima		Peru	Lima 34
1175	University Of Pretoria	Pretoria		South Africa	0002

Sponsors and Collaborators

• National Cancer Institute (NCI)
• Cancer and Leukemia Group B
• NCIC Clinical Trials Group
• North Central Cancer Treatment Group
• Southwest Oncology Group

Investigators

• Principal Investigator: Heather A Wakelee, ECOG-ACRIN Cancer Research Group

Study Documents (Full-Text)

None provided.

More Information

Additional Information:

• Data Available: Select individual patient-level data from this trial can be requested from the NCTN/NCORP Data Archive.

Publications

None provided.

• Responsible Party: National Cancer Institute (NCI)
• ClinicalTrials.gov Identifier: NCT00324805
• Other Study ID Numbers: NCI-2009-00509; NCI-2009-00509; 09-0404; E1505; CDR0000475774; ECOG-E1505; E1505; E1505; U10CA180820; U10CA021115
• First Posted: May 11, 2006
• Last Update Posted: Aug 8, 2022
• Last Verified: Mar 1, 2022

• Additional relevant MeSH terms: Carcinoma; Carcinoma, Non-Small-Cell Lung; Gemcitabine; Bevacizumab; Antineoplastic Agents, Immunological; Cisplatin; Docetaxel; Pemetrexed; Vinorelbine; Endothelial Growth Factors; Antibodies; Immunoglobulins; Antibodies, Monoclonal; Immunoglobulin G

Study Results

Participant Flow

Recruitment Details	Patients were recruited between June 1, 2007 and September 20, 2013 from ECOG-ACRIN, SWOG, RTOG, CALGB, NCCTG, NCIC-CTG, NSABP, ACOSOG, and CTSU sites.

Arm/Group Title	Arm I (Chemotherapy)	Arm II (Chemotherapy, Bevacizumab)
Arm/Group Description	Patients receive one of the following. For all, treatment repeats every 21 days for up to 4 courses in the absence of disease progression or unacceptable toxicity. REGIMEN 1: Vinorelbine ditartrate 30 mg/m2 intravenously (IV) on days 1 and 8, cisplatin 75 mg/m2 IV over 60 minutes on day 1 REGIMEN 2: Docetaxel 75 mg/m2 IV and cisplastin 75 mg/m2 IV on day 1 REGIMEN 3: Gemcitabine hydrochloride 1200 mg/m2 IV on days 1 and 8, cisplatin 75 mg/m2 IV on day 1 REGIMEN 4 (non-squamous histology only): Pemetrexed disodium 500mg/m2 IV and cisplatin 75 mg/m2 IV on day 1 Cisplatin: Given IV Docetaxel: Given IV Gemcitabine Hydrochloride: Given IV Pemetrexed Disodium: Given IV Vinorelbine: Given IV	Patients receive chemotherapy as in Arm I. Patients also receive bevacizumab IV over 30-90 minutes on day 1. Treatment with bevacizumab repeats every 21 days for up to 1 year. Bevacizumab: Given IV Cisplatin: Given IV Docetaxel: Given IV Gemcitabine Hydrochloride: Given IV Pemetrexed Disodium: Given IV Vinorelbine: Given IV
Period Title: Overall Study
STARTED	749	752
Started Assigned Therapy	737	735
COMPLETED	599	269
NOT COMPLETED	150	483

Baseline Characteristics

Arm/Group Title	Arm I (Chemotherapy)	Arm II (Chemotherapy, Bevacizumab)	Total
Arm/Group Description	Patients receive one of the following. For all, treatment repeats every 21 days for up to 4 courses in the absence of disease progression or unacceptable toxicity. REGIMEN 1: Vinorelbine ditartrate 30 mg/m2 IV on days 1 and 8, cisplatin 75 mg/m2 IV over 60 minutes on day 1 REGIMEN 2: Docetaxel 75 mg/m2 IV and cisplastin 75 mg/m2 IV on day 1 REGIMEN 3: Gemcitabine hydrochloride 1200 mg/m2 IV on days 1 and 8, cisplatin 75 mg/m2 IV on day 1 REGIMEN 4 (non-squamous histology only): Pemetrexed disodium 500mg/m2 IV and cisplatin 75 mg/m2 IV on day 1 Cisplatin: Given IV Docetaxel: Given IV Gemcitabine Hydrochloride: Given IV Pemetrexed Disodium: Given IV Vinorelbine: Given IV	Patients receive chemotherapy as in Arm I. Patients also receive bevacizumab IV over 30-90 minutes on day 1. Treatment with bevacizumab repeats every 21 days for up to 1 year. Bevacizumab: Given IV Cisplatin: Given IV Docetaxel: Given IV Gemcitabine Hydrochloride: Given IV Pemetrexed Disodium: Given IV Vinorelbine: Given IV	Total of all reporting groups
Overall Participants	749	752	1501
Age (years) [Mean (Standard Deviation) ]
Mean (Standard Deviation) [years]	60.7 (9.0)	60.8 (8.7)	60.8 (8.8)
Sex: Female, Male (Count of Participants)
Female	374 49.9%	381 50.7%	755 50.3%
Male	375 50.1%	371 49.3%	746 49.7%
Ethnicity (NIH/OMB) (Count of Participants)
Hispanic or Latino	19 2.5%	29 3.9%	48 3.2%
Not Hispanic or Latino	680 90.8%	688 91.5%	1368 91.1%
Unknown or Not Reported	50 6.7%	35 4.7%	85 5.7%
Race (NIH/OMB) (Count of Participants)
American Indian or Alaska Native	1 0.1%	5 0.7%	6 0.4%
Asian	22 2.9%	16 2.1%	38 2.5%
Native Hawaiian or Other Pacific Islander	3 0.4%	2 0.3%	5 0.3%
Black or African American	74 9.9%	57 7.6%	131 8.7%
White	642 85.7%	660 87.8%	1302 86.7%
More than one race	0 0%	0 0%	0 0%
Unknown or Not Reported	7 0.9%	12 1.6%	19 1.3%
Chemotherapy (Count of Participants)
Cisplatin/Vinorelbine	187 25%	190 25.3%	377 25.1%
Cisplatin/Docetaxel	172 23%	171 22.7%	343 22.9%
Cisplatin/Gemcitabine	142 19%	141 18.8%	283 18.9%
Cisplatin/Pemetrexed	248 33.1%	249 33.1%	497 33.1%
Unknown/Missing	0 0%	1 0.1%	1 0.1%
Histology (Count of Participants)
Squamous	216 28.8%	206 27.4%	422 28.1%
Adenocarcinoma	424 56.6%	450 59.8%	874 58.2%
Large cell	22 2.9%	16 2.1%	38 2.5%
Bronchioloalveolar carcinoma (BAC)	8 1.1%	5 0.7%	13 0.9%
Not otherwise specified (NOS)	24 3.2%	16 2.1%	40 2.7%
Combined/mixed	45 6%	48 6.4%	93 6.2%
Other	10 1.3%	10 1.3%	20 1.3%
Unknown/missing	0 0%	1 0.1%	1 0.1%
Performance Status (Count of Participants)
Fully active	439 58.6%	440 58.5%	879 58.6%
Ambulatory	310 41.4%	310 41.2%	620 41.3%
Unknown/missing	0 0%	2 0.3%	2 0.1%
Urine protein:creatinine (UPC) ratio (ratio) [Mean (Standard Deviation) ]
Mean (Standard Deviation) [ratio]	0.31 (3.10)	0.18 (0.92)	0.25 (2.28)
Urine protein (mg/dL) [Mean (Standard Deviation) ]
Mean (Standard Deviation) [mg/dL]	95.26 (32.28)	100.25 (32.28)	97.79 (41.86)

Outcome Measures

1. Primary Outcome

Title	Overall Survival
Description	Overall survival (OS) was defined as the time from randomization to death from any cause, and patients who were thought to be alive at the time of final analysis were censored at the last date of contact. The study failed to meet its primary endpoint.
Time Frame	From registration to death, up to 10 years

Outcome Measure Data

Analysis Population Description

All enrolled patients

Arm/Group Title	Arm I (Chemotherapy)	Arm II (Chemotherapy, Bevacizumab)
Arm/Group Description	Patients receive one of the following. For all, treatment repeats every 21 days for up to 4 courses in the absence of disease progression or unacceptable toxicity. REGIMEN 1: Vinorelbine ditartrate 30 mg/m2 IV on days 1 and 8, cisplatin 75 mg/m2 IV over 60 minutes on day 1 REGIMEN 2: Docetaxel 75 mg/m2 IV and cisplastin 75 mg/m2 IV on day 1 REGIMEN 3: Gemcitabine hydrochloride 1200 mg/m2 IV on days 1 and 8, cisplatin 75 mg/m2 IV on day 1 REGIMEN 4 (non-squamous histology only): Pemetrexed disodium 500mg/m2 IV and cisplatin 75 mg/m2 IV on day 1 Cisplatin: Given IV Docetaxel: Given IV Gemcitabine Hydrochloride: Given IV Pemetrexed Disodium: Given IV Vinorelbine: Given IV	Patients receive chemotherapy as in Arm I. Patients also receive bevacizumab IV over 30-90 minutes on day 1. Treatment with bevacizumab repeats every 21 days for up to 1 year. Bevacizumab: Given IV Cisplatin: Given IV Docetaxel: Given IV Gemcitabine Hydrochloride: Given IV Pemetrexed Disodium: Given IV Vinorelbine: Given IV
Measure Participants	749	752
Median (95% Confidence Interval) [months]	NA	85.8

Statistical Analysis 1

Statistical Analysis Overview	Comparison Group Selection	Arm I (Chemotherapy), Arm II (Chemotherapy, Bevacizumab)
	Comments
	Type of Statistical Test	Superiority
	Comments
Statistical Test of Hypothesis	p-Value	0.90
	Comments
	Method	Regression, Cox
	Comments
Method of Estimation	Estimation Parameter	Hazard Ratio (HR)
	Estimated Value	0.99
	Confidence Interval	(2-Sided) 95%; 0.82 to 1.19
	Parameter Dispersion	Type: Value:
	Estimation Comments	Arm II versus Arm I

2. Secondary Outcome

Title	Disease-free Survival
Description	Disease-free survival (DFS) was defined as the time from randomization to an event. Events include disease recurrence, new primary of lung cancer, second primaries or death, whichever occurred first; however, it should be noted that patients with new primaries at other non-lung sites should have continued followup for recurrence of the original cancer. Patients that have not had an event reported at analysis were censored at their last date of disease assessment.
Time Frame	From registration to death, up to 10 years

Outcome Measure Data

Analysis Population Description

All enrolled patients

Arm/Group Title	Arm I (Chemotherapy)	Arm II (Chemotherapy, Bevacizumab)
Arm/Group Description	Patients receive one of the following. For all, treatment repeats every 21 days for up to 4 courses in the absence of disease progression or unacceptable toxicity. REGIMEN 1: Vinorelbine ditartrate 30 mg/m2 IV on days 1 and 8, cisplatin 75 mg/m2 IV over 60 minutes on day 1 REGIMEN 2: Docetaxel 75 mg/m2 IV and cisplastin 75 mg/m2 IV on day 1 REGIMEN 3: Gemcitabine hydrochloride 1200 mg/m2 IV on days 1 and 8, cisplatin 75 mg/m2 IV on day 1 REGIMEN 4 (non-squamous histology only): Pemetrexed disodium 500mg/m2 IV and cisplatin 75 mg/m2 IV on day 1 Cisplatin: Given IV Docetaxel: Given IV Gemcitabine Hydrochloride: Given IV Pemetrexed Disodium: Given IV Vinorelbine: Given IV	Patients receive chemotherapy as in Arm I. Patients also receive bevacizumab IV over 30-90 minutes on day 1. Treatment with bevacizumab repeats every 21 days for up to 1 year. Bevacizumab: Given IV Cisplatin: Given IV Docetaxel: Given IV Gemcitabine Hydrochloride: Given IV Pemetrexed Disodium: Given IV Vinorelbine: Given IV
Measure Participants	749	752
Median (95% Confidence Interval) [months]	42.9	40.6

Statistical Analysis 1

Statistical Analysis Overview	Comparison Group Selection	Arm I (Chemotherapy), Arm II (Chemotherapy, Bevacizumab)
	Comments
	Type of Statistical Test	Superiority
	Comments
Statistical Test of Hypothesis	p-Value	0.95
	Comments
	Method	Regression, Cox
	Comments
Method of Estimation	Estimation Parameter	Hazard Ratio (HR)
	Estimated Value	0.99
	Confidence Interval	(2-Sided) 95%; 0.86 to 1.15
	Parameter Dispersion	Type: Value:
	Estimation Comments	Arm II vs. Arm I

3. Other Pre-specified Outcome

Title	Toxicity Rates as Assessed by the National Cancer Institute Common Terminology Criteria for Adverse Events Version 4.0
Description	If the difference in the rate of a particular category of toxicities between the 2 arms (N=750 per arm) is at least 5% (4% vs. 9%), 96% power can be attained assuming a significance level of 5% (two-sided Chi Square test) and that the lower toxicity rate for one arm is 4%. A difference in the rates of grade 3-5 arterial thromboembolic events and bleeding events will be monitored and assessed between the treatment arms.
Time Frame	Up to 1 year post-treatment

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title

Arm/Group Description

4. Other Pre-specified Outcome

Title	Perform Analyses of Tissue and Blood to Establish Factors That Predict for Clinical Outcome in Patients Receiving Chemotherapy, With or Without Bevacizumab, for Resected Early Stage NSCLC.
Time Frame	From registration to death, up to 10 years

Outcome Measure Data

Analysis Population Description

Data for these studies were not collected

Arm/Group Title	Arm I (Chemotherapy)	Arm II (Chemotherapy, Bevacizumab)
Arm/Group Description	Patients receive one of the following. For all, treatment repeats every 21 days for up to 4 courses in the absence of disease progression or unacceptable toxicity. REGIMEN 1: Vinorelbine ditartrate 30 mg/m2 IV on days 1 and 8, cisplatin 75 mg/m2 IV over 60 minutes on day 1 REGIMEN 2: Docetaxel 75 mg/m2 IV and cisplastin 75 mg/m2 IV on day 1 REGIMEN 3: Gemcitabine hydrochloride 1200 mg/m2 IV on days 1 and 8, cisplatin 75 mg/m2 IV on day 1 REGIMEN 4 (non-squamous histology only): Pemetrexed disodium 500mg/m2 IV and cisplatin 75 mg/m2 IV on day 1 Cisplatin: Given IV Docetaxel: Given IV Gemcitabine Hydrochloride: Given IV Pemetrexed Disodium: Given IV Vinorelbine: Given IV	Patients receive chemotherapy as in Arm I. Patients also receive bevacizumab IV over 30-90 minutes on day 1. Treatment with bevacizumab repeats every 21 days for up to 1 year. Bevacizumab: Given IV Cisplatin: Given IV Docetaxel: Given IV Gemcitabine Hydrochloride: Given IV Pemetrexed Disodium: Given IV Vinorelbine: Given IV
Measure Participants	0	0

5. Other Pre-specified Outcome

Title	To Determine Whether Smoking Status is Linked to Outcome for Patients With Resected Stage IB - IIIA NSCLC Treated With Chemotherapy With or Without Bevacizumab in the Adjuvant Setting.
Time Frame	From registration to death, up to 10 years

Outcome Measure Data

Analysis Population Description

Data were not collected

Arm/Group Title	Arm I (Chemotherapy)	Arm II (Chemotherapy, Bevacizumab)
Arm/Group Description	Patients receive one of the following. For all, treatment repeats every 21 days for up to 4 courses in the absence of disease progression or unacceptable toxicity. REGIMEN 1: Vinorelbine ditartrate 30 mg/m2 IV on days 1 and 8, cisplatin 75 mg/m2 IV over 60 minutes on day 1 REGIMEN 2: Docetaxel 75 mg/m2 IV and cisplastin 75 mg/m2 IV on day 1 REGIMEN 3: Gemcitabine hydrochloride 1200 mg/m2 IV on days 1 and 8, cisplatin 75 mg/m2 IV on day 1 REGIMEN 4 (non-squamous histology only): Pemetrexed disodium 500mg/m2 IV and cisplatin 75 mg/m2 IV on day 1 Cisplatin: Given IV Docetaxel: Given IV Gemcitabine Hydrochloride: Given IV Pemetrexed Disodium: Given IV Vinorelbine: Given IV	Patients receive chemotherapy as in Arm I. Patients also receive bevacizumab IV over 30-90 minutes on day 1. Treatment with bevacizumab repeats every 21 days for up to 1 year. Bevacizumab: Given IV Cisplatin: Given IV Docetaxel: Given IV Gemcitabine Hydrochloride: Given IV Pemetrexed Disodium: Given IV Vinorelbine: Given IV
Measure Participants	0	0

Adverse Events

Time Frame	Assessed every 3 weeks while on treatment and for 30 days after the end of treatment
Adverse Event Reporting Description	One patient who did not start treatment submitted an adverse event report
Arm/Group Title	Arm I (Chemotherapy)		Arm II (Chemotherapy, Bevacizumab)
Arm/Group Description	Patients receive one of the following. For all, treatment repeats every 21 days for up to 4 courses in the absence of disease progression or unacceptable toxicity. REGIMEN 1: Vinorelbine ditartrate 30 mg/m2 IV on days 1 and 8, cisplatin 75 mg/m2 IV over 60 minutes on day 1 REGIMEN 2: Docetaxel 75 mg/m2 IV and cisplastin 75 mg/m2 IV on day 1 REGIMEN 3: Gemcitabine hydrochloride 1200 mg/m2 IV on days 1 and 8, cisplatin 75 mg/m2 IV on day 1 REGIMEN 4 (non-squamous histology only): Pemetrexed disodium 500mg/m2 IV and cisplatin 75 mg/m2 IV on day 1 Cisplatin: Given IV Docetaxel: Given IV Gemcitabine Hydrochloride: Given IV Pemetrexed Disodium: Given IV Vinorelbine: Given IV		Patients receive chemotherapy as in Arm I. Patients also receive bevacizumab IV over 30-90 minutes on day 1. Treatment with bevacizumab repeats every 21 days for up to 1 year. Bevacizumab: Given IV Cisplatin: Given IV Docetaxel: Given IV Gemcitabine Hydrochloride: Given IV Pemetrexed Disodium: Given IV Vinorelbine: Given IV
All Cause Mortality
	Arm I (Chemotherapy)		Arm II (Chemotherapy, Bevacizumab)
	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events
Total	/ (NaN)		/ (NaN)
Serious Adverse Events
	Arm I (Chemotherapy)		Arm II (Chemotherapy, Bevacizumab)
	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events
Total	424/738 (57.5%)		563/735 (76.6%)
Blood and lymphatic system disorders
Anemia	52/738 (7%)		40/735 (5.4%)
Febrile neutropenia	31/738 (4.2%)		43/735 (5.9%)
Cardiac disorders
Acute coronary syndrome	0/738 (0%)		1/735 (0.1%)
Atrial fibrillation	2/738 (0.3%)		2/735 (0.3%)
Atrial flutter	0/738 (0%)		1/735 (0.1%)
Cardiac arrest	0/738 (0%)		1/735 (0.1%)
Chest pain - cardiac	0/738 (0%)		1/735 (0.1%)
Heart failure	0/738 (0%)		3/735 (0.4%)
Left ventricular systolic dysfunction	1/738 (0.1%)		1/735 (0.1%)
Myocardial infarction	1/738 (0.1%)		7/735 (1%)
Sinus tachycardia	0/738 (0%)		2/735 (0.3%)
Cardiac disorders - Other, specify	1/738 (0.1%)		0/735 (0%)
Ear and labyrinth disorders
Hearing impaired	6/738 (0.8%)		2/735 (0.3%)
Tinnitus	4/738 (0.5%)		4/735 (0.5%)
Eye disorders
Blurred vision	1/738 (0.1%)		1/735 (0.1%)
Photophobia	0/738 (0%)		1/735 (0.1%)
Retinal detachment	0/738 (0%)		1/735 (0.1%)
Gastrointestinal disorders
Abdominal distension	0/738 (0%)		2/735 (0.3%)
Abdominal pain	5/738 (0.7%)		22/735 (3%)
Cheilitis	1/738 (0.1%)		0/735 (0%)
Colitis	5/738 (0.7%)		2/735 (0.3%)
Colonic hemorrhage	0/738 (0%)		2/735 (0.3%)
Colonic obstruction	0/738 (0%)		1/735 (0.1%)
Colonic perforation	1/738 (0.1%)		1/735 (0.1%)
Constipation	8/738 (1.1%)		5/735 (0.7%)
Diarrhea	15/738 (2%)		31/735 (4.2%)
Duodenal perforation	0/738 (0%)		1/735 (0.1%)
Dyspepsia	1/738 (0.1%)		1/735 (0.1%)
Dysphagia	1/738 (0.1%)		2/735 (0.3%)
Enterocolitis	1/738 (0.1%)		1/735 (0.1%)
Esophageal pain	1/738 (0.1%)		0/735 (0%)
Gastric hemorrhage	0/738 (0%)		1/735 (0.1%)
Gastritis	1/738 (0.1%)		2/735 (0.3%)
Gastroesophageal reflux disease	1/738 (0.1%)		0/735 (0%)
Gastrointestinal pain	1/738 (0.1%)		0/735 (0%)
Ileus	3/738 (0.4%)		3/735 (0.4%)
Mucositis oral	4/738 (0.5%)		12/735 (1.6%)
Nausea	63/738 (8.5%)		74/735 (10.1%)
Pancreatitis	1/738 (0.1%)		0/735 (0%)
Rectal hemorrhage	0/738 (0%)		2/735 (0.3%)
Small intestinal obstruction	1/738 (0.1%)		1/735 (0.1%)
Stomach pain	1/738 (0.1%)		1/735 (0.1%)
Toothache	0/738 (0%)		1/735 (0.1%)
Vomiting	38/738 (5.1%)		47/735 (6.4%)
Gastrointestinal disorders - Other	1/738 (0.1%)		2/735 (0.3%)
General disorders
Fatigue	66/738 (8.9%)		92/735 (12.5%)
Fever	0/738 (0%)		2/735 (0.3%)
Infusion site extravasation	0/738 (0%)		1/735 (0.1%)
Multi-organ failure	0/738 (0%)		1/735 (0.1%)
Non-cardiac chest pain	3/738 (0.4%)		6/735 (0.8%)
Pain	2/738 (0.3%)		1/735 (0.1%)
Sudden death NOS	0/738 (0%)		1/735 (0.1%)
Hepatobiliary disorders
Cholecystitis	0/738 (0%)		1/735 (0.1%)
Immune system disorders
Allergic reaction	0/738 (0%)		1/735 (0.1%)
Anaphylaxis	7/738 (0.9%)		6/735 (0.8%)
Autoimmune disorder	1/738 (0.1%)		0/735 (0%)
Cytokine release syndrome	0/738 (0%)		1/735 (0.1%)
Serum sickness	0/738 (0%)		1/735 (0.1%)
Infections and infestations
Anorectal infection	1/738 (0.1%)		0/735 (0%)
Bladder infection	0/738 (0%)		1/735 (0.1%)
Bronchial infection	3/738 (0.4%)		1/735 (0.1%)
Catheter related infection	0/738 (0%)		3/735 (0.4%)
Device related infection	1/738 (0.1%)		0/735 (0%)
Enterocolitis infectious	2/738 (0.3%)		2/735 (0.3%)
Esophageal infection	0/738 (0%)		1/735 (0.1%)
Gum infection	2/738 (0.3%)		0/735 (0%)
Lung infection	8/738 (1.1%)		11/735 (1.5%)
Pleural infection	0/738 (0%)		2/735 (0.3%)
Sepsis	4/738 (0.5%)		5/735 (0.7%)
Skin infection	2/738 (0.3%)		1/735 (0.1%)
Tooth infection	0/738 (0%)		1/735 (0.1%)
Upper respiratory infection	1/738 (0.1%)		4/735 (0.5%)
Urinary tract infection	4/738 (0.5%)		5/735 (0.7%)
Infections and infestations - Other	10/738 (1.4%)		18/735 (2.4%)
Injury, poisoning and procedural complications
Vascular access complication	2/738 (0.3%)		3/735 (0.4%)
Wound dehiscence	0/738 (0%)		4/735 (0.5%)
Investigations
Alanine aminotransferase increased	2/738 (0.3%)		0/735 (0%)
Alkaline phosphatase increased	1/738 (0.1%)		0/735 (0%)
Aspartate aminotransferase increased	2/738 (0.3%)		0/735 (0%)
Cardiac troponin I increased	1/738 (0.1%)		0/735 (0%)
Creatinine increased	6/738 (0.8%)		9/735 (1.2%)
INR increased	0/738 (0%)		1/735 (0.1%)
Lipase increased	1/738 (0.1%)		1/735 (0.1%)
Lymphocyte count decreased	7/738 (0.9%)		11/735 (1.5%)
Neutrophil count decreased	237/738 (32.1%)		273/735 (37.1%)
Platelet count decreased	30/738 (4.1%)		44/735 (6%)
Weight loss	1/738 (0.1%)		1/735 (0.1%)
White blood cell decreased	41/738 (5.6%)		42/735 (5.7%)
Investigations - Other, specify	1/738 (0.1%)		1/735 (0.1%)
Metabolism and nutrition disorders
Acidosis	0/738 (0%)		2/735 (0.3%)
Anorexia	9/738 (1.2%)		19/735 (2.6%)
Dehydration	40/738 (5.4%)		45/735 (6.1%)
Hypercalcemia	1/738 (0.1%)		0/735 (0%)
Hyperglycemia	11/738 (1.5%)		9/735 (1.2%)
Hyperkalemia	4/738 (0.5%)		1/735 (0.1%)
Hypoalbuminemia	1/738 (0.1%)		3/735 (0.4%)
Hypocalcemia	3/738 (0.4%)		6/735 (0.8%)
Hypoglycemia	0/738 (0%)		1/735 (0.1%)
Hypokalemia	20/738 (2.7%)		13/735 (1.8%)
Hypomagnesemia	5/738 (0.7%)		4/735 (0.5%)
Hyponatremia	44/738 (6%)		66/735 (9%)
Hypophosphatemia	0/738 (0%)		4/735 (0.5%)
Musculoskeletal and connective tissue disorders
Arthralgia	3/738 (0.4%)		5/735 (0.7%)
Back pain	0/738 (0%)		1/735 (0.1%)
Bone pain	0/738 (0%)		1/735 (0.1%)
Chest wall pain	0/738 (0%)		1/735 (0.1%)
Generalized muscle weakness	6/738 (0.8%)		7/735 (1%)
Muscle weakness lower limb	0/738 (0%)		1/735 (0.1%)
Myalgia	4/738 (0.5%)		2/735 (0.3%)
Neck pain	0/738 (0%)		1/735 (0.1%)
Pain in extremity	1/738 (0.1%)		1/735 (0.1%)
Nervous system disorders
Ataxia	1/738 (0.1%)		3/735 (0.4%)
Cognitive disturbance	1/738 (0.1%)		1/735 (0.1%)
Dizziness	4/738 (0.5%)		12/735 (1.6%)
Dysphasia	1/738 (0.1%)		1/735 (0.1%)
Headache	5/738 (0.7%)		18/735 (2.4%)
Intracranial hemorrhage	1/738 (0.1%)		1/735 (0.1%)
Ischemia cerebrovascular	0/738 (0%)		1/735 (0.1%)
Memory impairment	0/738 (0%)		1/735 (0.1%)
Neuralgia	0/738 (0%)		1/735 (0.1%)
Peripheral motor neuropathy	2/738 (0.3%)		1/735 (0.1%)
Peripheral sensory neuropathy	5/738 (0.7%)		5/735 (0.7%)
Reversible posterior leukoencephalopathy	0/738 (0%)		3/735 (0.4%)
Seizure	1/738 (0.1%)		3/735 (0.4%)
Stroke	1/738 (0.1%)		0/735 (0%)
Syncope	8/738 (1.1%)		10/735 (1.4%)
Nervous system disorders - Other	0/738 (0%)		5/735 (0.7%)
Psychiatric disorders
Anxiety	1/738 (0.1%)		0/735 (0%)
Confusion	1/738 (0.1%)		4/735 (0.5%)
Depression	3/738 (0.4%)		0/735 (0%)
Insomnia	0/738 (0%)		2/735 (0.3%)
Renal and urinary disorders
Acute kidney injury	6/738 (0.8%)		6/735 (0.8%)
Chronic kidney disease	1/738 (0.1%)		3/735 (0.4%)
Hematuria	0/738 (0%)		1/735 (0.1%)
Proteinuria	2/738 (0.3%)		17/735 (2.3%)
Urinary retention	1/738 (0.1%)		0/735 (0%)
Reproductive system and breast disorders
Testicular pain	1/738 (0.1%)		0/735 (0%)
Respiratory, thoracic and mediastinal disorders
Aspiration	2/738 (0.3%)		1/735 (0.1%)
Bronchopleural fistula	0/738 (0%)		2/735 (0.3%)
Bronchopulmonary hemorrhage	0/738 (0%)		3/735 (0.4%)
Cough	2/738 (0.3%)		6/735 (0.8%)
Dyspnea	8/738 (1.1%)		17/735 (2.3%)
Epistaxis	2/738 (0.3%)		4/735 (0.5%)
Hoarseness	0/738 (0%)		1/735 (0.1%)
Hypoxia	0/738 (0%)		5/735 (0.7%)
Laryngeal edema	0/738 (0%)		1/735 (0.1%)
Pleural effusion	1/738 (0.1%)		2/735 (0.3%)
Pneumonitis	3/738 (0.4%)		1/735 (0.1%)
Pulmonary hypertension	1/738 (0.1%)		1/735 (0.1%)
Respiratory failure	0/738 (0%)		1/735 (0.1%)
Respiratory thoracic mediastinal - Other	1/738 (0.1%)		1/735 (0.1%)
Skin and subcutaneous tissue disorders
Rash maculo-papular	1/738 (0.1%)		3/735 (0.4%)
Stevens-Johnson syndrome	0/738 (0%)		1/735 (0.1%)
Vascular disorders
Hematoma	0/738 (0%)		1/735 (0.1%)
Hypertension	19/738 (2.6%)		200/735 (27.2%)
Hypotension	7/738 (0.9%)		11/735 (1.5%)
Peripheral ischemia	0/738 (0%)		1/735 (0.1%)
Thromboembolic event	12/738 (1.6%)		33/735 (4.5%)
Other (Not Including Serious) Adverse Events
	Arm I (Chemotherapy)		Arm II (Chemotherapy, Bevacizumab)
	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events
Total	474/738 (64.2%)		509/735 (69.3%)
Blood and lymphatic system disorders
Anemia	256/738 (34.7%)		183/735 (24.9%)
General disorders
Fatigue	62/738 (8.4%)		68/735 (9.3%)
Investigations
Creatinine increased	169/738 (22.9%)		247/735 (33.6%)
Neutrophil count decreased	220/738 (29.8%)		236/735 (32.1%)
Platelet count decreased	48/738 (6.5%)		49/735 (6.7%)
Nervous system disorders
Peripheral sensory neuropathy	53/738 (7.2%)		58/735 (7.9%)
Renal and urinary disorders
Proteinuria	3/738 (0.4%)		48/735 (6.5%)
Vascular disorders
Hypertension	2/738 (0.3%)		50/735 (6.8%)

Limitations/Caveats

[Not Specified]

More Information

Certain Agreements

Principal Investigators are NOT employed by the organization sponsoring the study.

The only disclosure restriction on the PI is that the sponsor can review results communications prior to public release and can embargo communications regarding trial results for a period that is less than or equal to 60 days. The sponsor cannot require changes to the communication and cannot extend the embargo.