Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAF Mutant Melanoma That Cannot Be Removed by Surgery
Sponsor
National Cancer Institute (NCI) (NIH)
Overall Status
Active, not recruiting
CT.gov ID
NCT02196181
Collaborator
(none)
280
760
2
101.3
0.4
0
Study Details
Study Description
Brief Summary
This phase II trial studies how well dabrafenib and trametinib work in treating patients with stage III-IV melanoma that cannot be removed by surgery and contains a B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutation. Dabrafenib and trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 2 |
Detailed Description
PRIMARY OBJECTIVE:
- To compare progression-free survival with intermittent dosing and continuous dosing of dabrafenib and trametinib among patients with metastatic BRAF V600E/K mutant melanoma.
SECONDARY OBJECTIVES:
-
To estimate the frequency and severity of toxicities of the two dosing schedules.
-
To compare the frequency and severity of fever >= grade 1 per Common Terminology Criteria for Adverse Events (CTCAE) 4.0 of the two dosing schedules.
-
To compare the response rate (complete and partial response, confirmed and unconfirmed), overall survival, and survival after progression between the two dosing schedules on step 2.
TRANSLATIONAL MEDICINE OBJECTIVES:
-
To evaluate whether acquired molecular events leading to reactivation of the MAPK pathway are more common among patients on the continuous dosing arm than on the intermittent dosing arm using circulating tumor deoxyribonucleic acid (DNA) (ctDNA).
-
To assess the prognostic association between baseline biomarkers and early molecular events with progression free survival (PFS).
-
To explore the potential interaction between treatment arm and baseline biomarkers/early molecular events with PFS.
-
To bank tissue and whole blood in anticipation of future studies to evaluate molecular events associated with clinical benefit and disease progression in patients treated with continuous versus intermittent dabrafenib and trametinib.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM I (CONTINUOUS DOSING): Patients receive dabrafenib orally (PO) twice daily (BID) and trametinib PO once daily (QD) on days 1-56 of each cycle. Cycles repeat every 56 days in the absence of disease progression or unacceptable toxicity. Patients also undergo PET/CT or CT scans in week 1 of cycle 2 and at off treatment follow up prior to progression.
ARM II (INTERMITTENT DOSING): Patients receive dabrafenib PO BID and trametinib PO QD on days 1-7 and 29-56 of each cycle. Cycles repeat every 56 days in the absence of disease progression or unacceptable toxicity. Patients also undergo PET/CT or CT scans in week 1 of cycle 2 and at off treatment follow up prior to progression.
After completion of study treatment, patients are followed up every 6 months for 3 years and then yearly for 2 years.
Study Design
Study Type:
Interventional
Anticipated Enrollment
:
280 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
A Randomized Phase II Trial of Intermittent Versus Continuous Dosing of Dabrafenib (NSC-763760) and Trametinib (NSC-763093) in BRAF V600E/K Mutant Melanoma
Actual Study Start Date
:
Jul 22, 2014
Anticipated Primary Completion Date
:
Dec 31, 2022
Anticipated Study Completion Date
:
Dec 31, 2022
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Arm I (continuous dosing) Patients receive dabrafenib PO BID and trametinib PO QD on days 1-56 of each cycle. Cycles repeat every 56 days in the absence of disease progression or unacceptable toxicity. Patients also undergo PET/CT or CT scans in week 1 of cycle 2 and at off treatment follow up prior to progression. |
Procedure: Computed Tomography
Undergo CT or PET/CT
Other Names:
Drug: Dabrafenib Mesylate
Given PO
Other Names:
Procedure: Positron Emission Tomography
Undergo PET/CT
Other Names:
Drug: Trametinib Dimethyl Sulfoxide
Given PO
Other Names:
|
| Experimental: Arm II (intermittent dosing) Patients receive dabrafenib PO BID and trametinib PO QD on days 1-7 and 29-56 of each cycle. Cycles repeat every 56 days in the absence of disease progression or unacceptable toxicity. Patients also undergo PET/CT or CT scans in week 1 of cycle 2 and at off treatment follow up prior to progression. |
Procedure: Computed Tomography
Undergo CT or PET/CT
Other Names:
Drug: Dabrafenib Mesylate
Given PO
Other Names:
Procedure: Positron Emission Tomography
Undergo PET/CT
Other Names:
Drug: Trametinib Dimethyl Sulfoxide
Given PO
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Progression-free survival (PFS) [Measured from date of randomization, assessed up to 5 years]
Testing of the superiority of intermittent dosing of dabrafenib and trametinib compared to continuous dosing with these two same agents will be based on progression-free survival. Stratified Cox regression models stratified by stratification factors will be used for all analyses.
Secondary Outcome Measures
- Overall survival [Up to 5 years]
Overall survival between patients on each arm and survival after progression will be compared using Cox regression models.
- Response rates [Up to 5 years]
Response rates between arms will be compared using Fisher's exact test.
- Rates of fever [Up to 5 years]
Defined as >= grade 3 per Common Terminology Criteria for Adverse Events (CTCAE) version (v)4.0 with attribution possibly, probably, or definitely related to treatment; or any >= grade 1 per CTCAE v4.0 with attribution possibly, probably, or definitely related to treatment with chills, dehydration, hypotension, dizziness, or muscle weakness per CTCAE v4.0 with attribution possibly, probably, or definitely related to treatment reported during the same course. Rates of fever between arms will also be compared using Fisher's exact test.
Other Outcome Measures
- Molecular events leading to reactivation of the MAPK pathway [Up to 5 years]
Compared between patients of the two treatment groups.
- Change in biomarkers associated with PFS of archived tissue [Baseline up to 5 years]
Cox regression analyses will be used to evaluate biomarkers' associations with PFS.
- Interaction between baseline biomarkers and treatment arm [Baseline up to 5 years]
Cox regression analyses will be used to evaluate biomarkers' associations with PFS.
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
STEP 1: REGISTRATION
-
Patients must have histologically or cytologically confirmed stage IV or unresectable stage III BRAF V600E or BRAF V600K mutant melanoma
-
Patients must have BRAF V600E or BRAF V600K mutation identified by a Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory; acceptable analytic techniques include but are not restricted to DNA sequencing, pyrosequencing, polymerase chain reaction (PCR), melting point assays, and immunohistochemistry
-
Contrast-enhanced computed tomography (CT) scans of the neck, chest, abdomen and pelvis are required; a whole body positron emission tomography (PET)/CT scan with diagnostic quality images and intravenous iodinated contrast may be used in lieu of a contrast enhanced CT of the neck, chest, abdomen and pelvis; contrast may be omitted if the treating investigator believes that exposure to contrast poses an excessive risk to the patient; patients must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1; all measurable lesions must be assessed within 28 days prior to registration; tests to assess non-measurable disease must be performed within 42 days prior to registration; all disease must be assessed and documented on the Baseline Tumor Assessment Form (RECIST 1.1)
-
Patients with a history of brain metastases are eligible if the patient is asymptomatic with no residual neurological dysfunction and has not received enzyme-reducing anti-epileptic drugs or corticosteroids for at least 7 days prior to registration
-
Patients must be age >= 18 years of age
-
Absolute neutrophil count (ANC) >= 1,200/ul (obtained within 28 days prior to registration)
-
Platelets >= 100,000/ul (obtained within 28 days prior to registration)
-
Hemoglobin >= 9 g/dL (obtained within 28 days prior to registration)
-
Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) (or =< 2.5 x upper limit of normal [ULN] with Gilbert's syndrome) (obtained within 28 days prior to registration)
-
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (or < 5 x IULN for patients with known liver metastases) (obtained within 28 days prior to registration)
-
Serum albumin >= 2.5 g/dL (obtained within 28 days prior to registration)
-
Serum creatinine =< 1.5 mg/dL OR measured or calculated creatinine clearance >= 50 mL/min; creatinine measurements must be obtained within 28 days prior to registration
-
Patients must have lactate dehydrogenase (LDH) obtained within 28 days prior to registration in order to obtain baseline stratification information
-
Patients must have a left ventricular ejection fraction (LVEF) >= institutional lower limit of normal (ILLN) by echocardiogram (ECHO) or multi gated acquisition scan (MUGA) within 28 days prior to registration
-
Patients must have corrected QT (QTc) =< 480 msec by electrocardiogram (ECG) (corrected using the Bazett's formula) within 28 days prior to registration
-
Patients must be able to take oral medications; patients must not have any impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of protocol treatment (e.g. ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome or small bowel resection)
-
Patients receiving anticoagulation treatment are allowed to participate with international normalized ratio (INR) established within the therapeutic range
-
Patients with known human immunodeficiency virus (HIV) may be eligible providing they meet the following additional criteria:
-
Cluster of differentiation (CD)4 cells >= 500/uL
-
Serum HIV viral load of < 25,000 IU/ml
-
No current antiretroviral therapy
-
Tests must be obtained within 28 days prior to registration; patients who are HIV positive (+) and do not meet all of these criteria are not eligible for this study (HIV/hepatitis testing are not required for patients without known infection)
-
Pre-study history and physical must be obtained with 28 days prior to registration
-
Patients must have dermatology exam obtained within 28 days prior to registration to obtain baseline measurement; exam to be performed by treating physician or designated dermatologist
-
Patients must have Zubrod performance status of 0, 1 or 2
-
No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for three years; exception: patients with known history of colon cancer, cancer of the pancreas, or any cancer known to harbor an activating RAS mutation are ineligible regardless of stage or time since diagnosis
-
Patients must be offered the opportunity to participate in specimen banking
-
Patients with cutaneous or superficial lesions that do not require imaging guidance for biopsy must be willing to undergo biopsies for tissue submission and blood draws for translational medicine
-
Patients or their legally authorized representative must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
-
As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
-
STEP 2: RANDOMIZATION
-
After completing one cycle of therapy, patients will be registered for randomization between intermittent and continuous dosing, provided that they were eligible for the initial step 1 registration and satisfy the following criteria
-
Patients must be registered to step 2: randomization within +/- 5 days of starting cycle 2; patients MUST NOT be registered prior to the day 56 disease assessment
Exclusion Criteria:
-
Patients must not have received a prior BRAF or mitogen-activated protein kinase kinase (MEK) inhibitor
-
Patients must not have received any anti-cancer drug within 28 days prior to registration, and must not have received any nitrosoureas or mitomycin C within 42 days prior to registration
-
Patients must not have received any major surgery or immunotherapy within 28 days prior to registration
-
Patients must not have any unresolved toxicity greater than National Cancer Institute (NCI)-CTCAE version (v) 4.0 grade 1 from previous anti-cancer therapy except alopecia within 7 days prior to registration
-
Patients with known history or current evidence of retinal vein occlusion (RVO) or central serous retinopathy (CSR) are not eligible:
-
History of RVO or CSR, or predisposing factors to RVO or CSR (e.g. uncontrolled glaucoma or ocular hypertension, uncontrolled systemic disease such as hypertension, diabetes mellitus, or history of hyperviscosity or hypercoagulability syndromes)
-
Visible retinal pathology as assessed by ophthalmic exam that is considered a risk factor for RVO or CSR such as:
-
Evidence of new optic disc cupping
-
Evidence of new visual field defects
-
Intraocular pressure > 21 mmHg
-
NOTE: ophthalmic exam is required for all patients; exam must be obtained within 28 days prior to registration
-
Patients must not have a history of pneumonitis or interstitial lung disease
-
Patients must not have any grade II/III/IV cardiac disease as defined by the New York Heart Association criteria (i.e., patients with cardiac disease resulting in marked limitation of physical activity or resulting in inability to carry on any physical activity without discomfort), unstable angina pectoris, myocardial infarction within 6 months, or serious uncontrolled cardiac arrhythmia; abnormal cardiac valve morphology (>= grade 2) documented by echocardiogram (subjects with grade 1 abnormalities [i.e., mild regurgitation/stenosis]) can be entered on study; patients with a history of atrial fibrillation must have atrial fibrillation controlled for at least 30 days prior to registration
-
Patients with known hepatitis B or hepatitis C are not eligible, regardless of concomitant antiretroviral therapy or current viral load
-
Patients must not be pregnant or nursing because of the risk of fetal harm; women/men of reproductive potential must have agreed to use an effective contraceptive method; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures; hormonal contraception is not allowed due to drug interactions which can render hormonal contraceptives ineffective
-
Patients must not have unequivocal disease progression (by RECIST v1.1) during the first cycle; patients must have disease assessed using the same method as baseline within +/- 5 days of the day 56 scheduled assessment (between days 51-55 of cycle 1, or days 1-5 of cycle 2); all disease must be assessed and documented on the follow-up tumor assessment form (RECIST 1.1)
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | United States | 35233 |
| 2 | Anchorage Associates in Radiation Medicine | Anchorage | Alaska | United States | 98508 |
| 3 | Anchorage Radiation Therapy Center | Anchorage | Alaska | United States | 99504 |
| 4 | Alaska Breast Care and Surgery LLC | Anchorage | Alaska | United States | 99508 |
| 5 | Alaska Oncology and Hematology LLC | Anchorage | Alaska | United States | 99508 |
| 6 | Alaska Regional Hospital | Anchorage | Alaska | United States | 99508 |
| 7 | Alaska Women's Cancer Care | Anchorage | Alaska | United States | 99508 |
| 8 | Anchorage Oncology Centre | Anchorage | Alaska | United States | 99508 |
| 9 | Katmai Oncology Group | Anchorage | Alaska | United States | 99508 |
| 10 | Providence Alaska Medical Center | Anchorage | Alaska | United States | 99508 |
| 11 | Fairbanks Memorial Hospital | Fairbanks | Alaska | United States | 99701 |
| 12 | Banner University Medical Center - Tucson | Tucson | Arizona | United States | 85719 |
| 13 | University of Arizona Cancer Center-North Campus | Tucson | Arizona | United States | 85719 |
| 14 | Yuma Regional Medical Center | Yuma | Arizona | United States | 85364 |
| 15 | Mercy Hospital Fort Smith | Fort Smith | Arkansas | United States | 72903 |
| 16 | CHI Saint Vincent Cancer Center Hot Springs | Hot Springs | Arkansas | United States | 71913 |
| 17 | NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro | Arkansas | United States | 72401 |
| 18 | John L McClellan Memorial Veterans Hospital | Little Rock | Arkansas | United States | 72205 |
| 19 | University of Arkansas for Medical Sciences | Little Rock | Arkansas | United States | 72205 |
| 20 | Highlands Oncology Group - Rogers | Rogers | Arkansas | United States | 72758 |
| 21 | Kaiser Permanente-Anaheim | Anaheim | California | United States | 92806 |
| 22 | Kaiser Permanente-Deer Valley Medical Center | Antioch | California | United States | 94531 |
| 23 | PCR Oncology | Arroyo Grande | California | United States | 93420 |
| 24 | Kaiser Permanente-Baldwin Park | Baldwin Park | California | United States | 91706 |
| 25 | Kaiser Permanente-Bellflower | Bellflower | California | United States | 90706 |
| 26 | Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California | United States | 91505 |
| 27 | Epic Care-Dublin | Dublin | California | United States | 94568 |
| 28 | Bay Area Breast Surgeons Inc | Emeryville | California | United States | 94608 |
| 29 | Epic Care Partners in Cancer Care | Emeryville | California | United States | 94608 |
| 30 | Kaiser Permanente-Fontana | Fontana | California | United States | 92335 |
| 31 | Kaiser Permanente-Fremont | Fremont | California | United States | 94538 |
| 32 | Kaiser Permanente-Fresno | Fresno | California | United States | 93720 |
| 33 | Kaiser Permanente - Harbor City | Harbor City | California | United States | 90710 |
| 34 | Kaiser Permanente-Irvine | Irvine | California | United States | 92618 |
| 35 | Loma Linda University Medical Center | Loma Linda | California | United States | 92354 |
| 36 | Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | United States | 90027 |
| 37 | Kaiser Permanente West Los Angeles | Los Angeles | California | United States | 90034 |
| 38 | UCLA / Jonsson Comprehensive Cancer Center | Los Angeles | California | United States | 90095 |
| 39 | Contra Costa Regional Medical Center | Martinez | California | United States | 94553-3156 |
| 40 | Kaiser Permanente-Modesto | Modesto | California | United States | 95356 |
| 41 | Alta Bates Summit Medical Center - Summit Campus | Oakland | California | United States | 94609 |
| 42 | Bay Area Tumor Institute | Oakland | California | United States | 94609 |
| 43 | Hematology and Oncology Associates-Oakland | Oakland | California | United States | 94609 |
| 44 | Kaiser Permanente Oakland-Broadway | Oakland | California | United States | 94611 |
| 45 | Kaiser Permanente-Oakland | Oakland | California | United States | 94611 |
| 46 | Kaiser Permanente - Panorama City | Panorama City | California | United States | 91402 |
| 47 | Kaiser Permanente-Rancho Cordova Cancer Center | Rancho Cordova | California | United States | 95670 |
| 48 | Eisenhower Medical Center | Rancho Mirage | California | United States | 92270 |
| 49 | Kaiser Permanente-Redwood City | Redwood City | California | United States | 94063 |
| 50 | Kaiser Permanente-Richmond | Richmond | California | United States | 94801 |
| 51 | Kaiser Permanente-Riverside | Riverside | California | United States | 92505 |
| 52 | Rohnert Park Cancer Center | Rohnert Park | California | United States | 94928 |
| 53 | Kaiser Permanente-Roseville | Roseville | California | United States | 95661 |
| 54 | The Permanente Medical Group-Roseville Radiation Oncology | Roseville | California | United States | 95678 |
| 55 | Kaiser Permanente Downtown Commons | Sacramento | California | United States | 95814 |
| 56 | Kaiser Permanente-South Sacramento | Sacramento | California | United States | 95823 |
| 57 | South Sacramento Cancer Center | Sacramento | California | United States | 95823 |
| 58 | Kaiser Permanente - Sacramento | Sacramento | California | United States | 95825 |
| 59 | Kaiser Permanente-San Diego Mission | San Diego | California | United States | 92108 |
| 60 | Kaiser Permanente-San Diego Zion | San Diego | California | United States | 92120 |
| 61 | Kaiser Permanente-San Francisco | San Francisco | California | United States | 94115 |
| 62 | UCSF Medical Center-Mount Zion | San Francisco | California | United States | 94115 |
| 63 | Kaiser Permanente-Santa Teresa-San Jose | San Jose | California | United States | 95119 |
| 64 | Kaiser Permanente San Leandro | San Leandro | California | United States | 94577 |
| 65 | Kaiser Permanente-San Marcos | San Marcos | California | United States | 92078 |
| 66 | Kaiser Permanente-San Rafael | San Rafael | California | United States | 94903 |
| 67 | Kaiser San Rafael-Gallinas | San Rafael | California | United States | 94903 |
| 68 | Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | United States | 95051 |
| 69 | Kaiser Permanente-Santa Rosa | Santa Rosa | California | United States | 95403 |
| 70 | Kaiser Permanente Cancer Treatment Center | South San Francisco | California | United States | 94080 |
| 71 | Kaiser Permanente-South San Francisco | South San Francisco | California | United States | 94080 |
| 72 | Kaiser Permanente-Stockton | Stockton | California | United States | 95210 |
| 73 | Kaiser Permanente Medical Center-Vacaville | Vacaville | California | United States | 95688 |
| 74 | Kaiser Permanente-Vallejo | Vallejo | California | United States | 94589 |
| 75 | Kaiser Permanente-Walnut Creek | Walnut Creek | California | United States | 94596 |
| 76 | Epic Care Cyberknife Center | Walnut Creek | California | United States | 94597 |
| 77 | Kaiser Permanente-Woodland Hills | Woodland Hills | California | United States | 91367 |
| 78 | Rocky Mountain Cancer Centers-Aurora | Aurora | Colorado | United States | 80012 |
| 79 | The Medical Center of Aurora | Aurora | Colorado | United States | 80012 |
| 80 | University of Colorado Hospital | Aurora | Colorado | United States | 80045 |
| 81 | Boulder Community Hospital | Boulder | Colorado | United States | 80301 |
| 82 | Rocky Mountain Cancer Centers-Boulder | Boulder | Colorado | United States | 80304 |
| 83 | Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | United States | 80907 |
| 84 | Rocky Mountain Cancer Centers-Penrose | Colorado Springs | Colorado | United States | 80907 |
| 85 | Denver Health Medical Center | Denver | Colorado | United States | 80204 |
| 86 | Kaiser Permanente-Franklin | Denver | Colorado | United States | 80205 |
| 87 | The Women's Imaging Center | Denver | Colorado | United States | 80209 |
| 88 | Porter Adventist Hospital | Denver | Colorado | United States | 80210 |
| 89 | Colorado Blood Cancer Institute | Denver | Colorado | United States | 80218 |
| 90 | Presbyterian - Saint Lukes Medical Center - Health One | Denver | Colorado | United States | 80218 |
| 91 | Rocky Mountain Cancer Centers-Midtown | Denver | Colorado | United States | 80218 |
| 92 | SCL Health Saint Joseph Hospital | Denver | Colorado | United States | 80218 |
| 93 | Rocky Mountain Cancer Centers-Rose | Denver | Colorado | United States | 80220 |
| 94 | Rose Medical Center | Denver | Colorado | United States | 80220 |
| 95 | Mercy Medical Center | Durango | Colorado | United States | 81301 |
| 96 | Southwest Oncology PC | Durango | Colorado | United States | 81301 |
| 97 | Mountain Blue Cancer Care Center - Swedish | Englewood | Colorado | United States | 80113 |
| 98 | Swedish Medical Center | Englewood | Colorado | United States | 80113 |
| 99 | Poudre Valley Hospital | Fort Collins | Colorado | United States | 80524 |
| 100 | Mountain Blue Cancer Care Center | Golden | Colorado | United States | 80401 |
| 101 | National Jewish Health-Western Hematology Oncology | Golden | Colorado | United States | 80401 |
| 102 | Saint Mary's Hospital and Regional Medical Center | Grand Junction | Colorado | United States | 81501 |
| 103 | Grand Valley Oncology | Grand Junction | Colorado | United States | 81505 |
| 104 | North Colorado Medical Center | Greeley | Colorado | United States | 80631 |
| 105 | Rocky Mountain Cancer Centers-Greenwood Village | Greenwood Village | Colorado | United States | 80111 |
| 106 | Good Samaritan Medical Center | Lafayette | Colorado | United States | 80026 |
| 107 | Kaiser Permanente-Rock Creek | Lafayette | Colorado | United States | 80026 |
| 108 | Rocky Mountain Cancer Centers-Lakewood | Lakewood | Colorado | United States | 80228 |
| 109 | Saint Anthony Hospital | Lakewood | Colorado | United States | 80228 |
| 110 | Rocky Mountain Cancer Centers-Littleton | Littleton | Colorado | United States | 80120 |
| 111 | Littleton Adventist Hospital | Littleton | Colorado | United States | 80122 |
| 112 | Kaiser Permanente-Lone Tree | Lone Tree | Colorado | United States | 80124 |
| 113 | Rocky Mountain Cancer Centers-Sky Ridge | Lone Tree | Colorado | United States | 80124 |
| 114 | Sky Ridge Medical Center | Lone Tree | Colorado | United States | 80124 |
| 115 | Longmont United Hospital | Longmont | Colorado | United States | 80501 |
| 116 | Rocky Mountain Cancer Centers-Longmont | Longmont | Colorado | United States | 80501 |
| 117 | McKee Medical Center | Loveland | Colorado | United States | 80539 |
| 118 | Parker Adventist Hospital | Parker | Colorado | United States | 80138 |
| 119 | Rocky Mountain Cancer Centers-Parker | Parker | Colorado | United States | 80138 |
| 120 | Saint Mary Corwin Medical Center | Pueblo | Colorado | United States | 81004 |
| 121 | Rocky Mountain Cancer Centers - Pueblo | Pueblo | Colorado | United States | 81008 |
| 122 | National Jewish Health-Northern Hematology Oncology | Thornton | Colorado | United States | 80260 |
| 123 | Rocky Mountain Cancer Centers-Thornton | Thornton | Colorado | United States | 80260 |
| 124 | SCL Health Lutheran Medical Center | Wheat Ridge | Colorado | United States | 80033 |
| 125 | Beebe Medical Center | Lewes | Delaware | United States | 19958 |
| 126 | Christiana Gynecologic Oncology LLC | Newark | Delaware | United States | 19713 |
| 127 | Delaware Clinical and Laboratory Physicians PA | Newark | Delaware | United States | 19713 |
| 128 | Helen F Graham Cancer Center | Newark | Delaware | United States | 19713 |
| 129 | Medical Oncology Hematology Consultants PA | Newark | Delaware | United States | 19713 |
| 130 | Christiana Care Health System-Christiana Hospital | Newark | Delaware | United States | 19718 |
| 131 | Beebe Health Campus | Rehoboth Beach | Delaware | United States | 19971 |
| 132 | TidalHealth Nanticoke / Allen Cancer Center | Seaford | Delaware | United States | 19973 |
| 133 | Christiana Care Health System-Wilmington Hospital | Wilmington | Delaware | United States | 19801 |
| 134 | AdventHealth Altamonte | Altamonte Springs | Florida | United States | 32701 |
| 135 | Mount Sinai Comprehensive Cancer Center at Aventura | Aventura | Florida | United States | 33180 |
| 136 | Holy Cross Hospital | Fort Lauderdale | Florida | United States | 33308 |
| 137 | University of Florida Health Science Center - Gainesville | Gainesville | Florida | United States | 32610 |
| 138 | AdventHealth Kissimmee | Kissimmee | Florida | United States | 34744 |
| 139 | Mount Sinai Medical Center | Miami Beach | Florida | United States | 33140 |
| 140 | AdventHealth Medical Group Urology at Orlando | Orlando | Florida | United States | 32803 |
| 141 | AdventHealth Orlando | Orlando | Florida | United States | 32803 |
| 142 | Orlando Health Cancer Institute | Orlando | Florida | United States | 32806 |
| 143 | AdventHealth East Orlando | Orlando | Florida | United States | 32822 |
| 144 | AdventHealth Winter Park | Winter Park | Florida | United States | 32792 |
| 145 | Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | United States | 30322 |
| 146 | Low Country Cancer Care | Savannah | Georgia | United States | 31404 |
| 147 | Memorial Health University Medical Center | Savannah | Georgia | United States | 31404 |
| 148 | Summit Cancer Care-Memorial | Savannah | Georgia | United States | 31404 |
| 149 | Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia | United States | 31405 |
| 150 | Summit Cancer Care-Candler | Savannah | Georgia | United States | 31405 |
| 151 | Hawaii Cancer Care - Savio | 'Aiea | Hawaii | United States | 96701 |
| 152 | Pali Momi Medical Center | 'Aiea | Hawaii | United States | 96701 |
| 153 | Queen's Cancer Center - Pearlridge | 'Aiea | Hawaii | United States | 96701 |
| 154 | The Cancer Center of Hawaii-Pali Momi | 'Aiea | Hawaii | United States | 96701 |
| 155 | Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Hawaii | United States | 96813 |
| 156 | Island Urology | Honolulu | Hawaii | United States | 96813 |
| 157 | Queen's Cancer Cenrer - POB I | Honolulu | Hawaii | United States | 96813 |
| 158 | Queen's Medical Center | Honolulu | Hawaii | United States | 96813 |
| 159 | Straub Clinic and Hospital | Honolulu | Hawaii | United States | 96813 |
| 160 | University of Hawaii Cancer Center | Honolulu | Hawaii | United States | 96813 |
| 161 | Hawaii Cancer Care Inc-Liliha | Honolulu | Hawaii | United States | 96817 |
| 162 | Kuakini Medical Center | Honolulu | Hawaii | United States | 96817 |
| 163 | Queen's Cancer Center - Kuakini | Honolulu | Hawaii | United States | 96817 |
| 164 | The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii | United States | 96817 |
| 165 | Kaiser Permanente Moanalua Medical Center | Honolulu | Hawaii | United States | 96819 |
| 166 | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | United States | 96826 |
| 167 | Tripler Army Medical Center | Honolulu | Hawaii | United States | 96859 |
| 168 | Wilcox Memorial Hospital and Kauai Medical Clinic | Lihue | Hawaii | United States | 96766 |
| 169 | Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | United States | 83706 |
| 170 | Saint Luke's Cancer Institute - Boise | Boise | Idaho | United States | 83712 |
| 171 | Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | United States | 83605 |
| 172 | Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | United States | 83814 |
| 173 | Walter Knox Memorial Hospital | Emmett | Idaho | United States | 83617 |
| 174 | Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | United States | 83619 |
| 175 | Idaho Urologic Institute-Meridian | Meridian | Idaho | United States | 83642 |
| 176 | Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | United States | 83642 |
| 177 | Saint Alphonsus Medical Center-Nampa | Nampa | Idaho | United States | 83686 |
| 178 | Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | United States | 83686 |
| 179 | Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | United States | 83854 |
| 180 | Kootenai Cancer Clinic | Sandpoint | Idaho | United States | 83864 |
| 181 | Saint Luke's Cancer Institute - Twin Falls | Twin Falls | Idaho | United States | 83301 |
| 182 | Rush - Copley Medical Center | Aurora | Illinois | United States | 60504 |
| 183 | Saint Joseph Medical Center | Bloomington | Illinois | United States | 61701 |
| 184 | Illinois CancerCare-Bloomington | Bloomington | Illinois | United States | 61704 |
| 185 | Illinois CancerCare-Canton | Canton | Illinois | United States | 61520 |
| 186 | Memorial Hospital of Carbondale | Carbondale | Illinois | United States | 62902 |
| 187 | SIH Cancer Institute | Carterville | Illinois | United States | 62918 |
| 188 | Illinois CancerCare-Carthage | Carthage | Illinois | United States | 62321 |
| 189 | Centralia Oncology Clinic | Centralia | Illinois | United States | 62801 |
| 190 | Carle on Vermilion | Danville | Illinois | United States | 61832 |
| 191 | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | United States | 62526 |
| 192 | Decatur Memorial Hospital | Decatur | Illinois | United States | 62526 |
| 193 | Carle Physician Group-Effingham | Effingham | Illinois | United States | 62401 |
| 194 | Crossroads Cancer Center | Effingham | Illinois | United States | 62401 |
| 195 | Illinois CancerCare-Eureka | Eureka | Illinois | United States | 61530 |
| 196 | NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | United States | 60201 |
| 197 | Illinois CancerCare-Galesburg | Galesburg | Illinois | United States | 61401 |
| 198 | Western Illinois Cancer Treatment Center | Galesburg | Illinois | United States | 61401 |
| 199 | Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | United States | 60134 |
| 200 | NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois | United States | 60026 |
| 201 | NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois | United States | 60035 |
| 202 | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | United States | 61443 |
| 203 | Illinois CancerCare-Macomb | Macomb | Illinois | United States | 61455 |
| 204 | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | United States | 61938 |
| 205 | Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
| 206 | Good Samaritan Regional Health Center | Mount Vernon | Illinois | United States | 62864 |
| 207 | Cancer Care Center of O'Fallon | O'Fallon | Illinois | United States | 62269 |
| 208 | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | United States | 61350 |
| 209 | Radiation Oncology of Northern Illinois | Ottawa | Illinois | United States | 61350 |
| 210 | Illinois CancerCare-Pekin | Pekin | Illinois | United States | 61554 |
| 211 | OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center | Pekin | Illinois | United States | 61554 |
| 212 | Illinois CancerCare-Peoria | Peoria | Illinois | United States | 61615 |
| 213 | OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria | Illinois | United States | 61615 |
| 214 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
| 215 | OSF Saint Francis Medical Center | Peoria | Illinois | United States | 61637 |
| 216 | Illinois CancerCare-Peru | Peru | Illinois | United States | 61354 |
| 217 | Valley Radiation Oncology | Peru | Illinois | United States | 61354 |
| 218 | Illinois CancerCare-Princeton | Princeton | Illinois | United States | 61356 |
| 219 | SwedishAmerican Regional Cancer Center/ACT | Rockford | Illinois | United States | 61114 |
| 220 | Genesis Cancer Center - Silvis | Silvis | Illinois | United States | 61282 |
| 221 | North Shore Medical Center | Skokie | Illinois | United States | 60076 |
| 222 | Central Illinois Hematology Oncology Center | Springfield | Illinois | United States | 62702 |
| 223 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62702 |
| 224 | Springfield Clinic | Springfield | Illinois | United States | 62702 |
| 225 | Memorial Medical Center | Springfield | Illinois | United States | 62781 |
| 226 | Southwest Illinois Health Services LLP | Swansea | Illinois | United States | 62226 |
| 227 | Carle Cancer Center | Urbana | Illinois | United States | 61801 |
| 228 | The Carle Foundation Hospital | Urbana | Illinois | United States | 61801 |
| 229 | Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | United States | 60555 |
| 230 | Rush-Copley Healthcare Center | Yorkville | Illinois | United States | 60560 |
| 231 | Deaconess Clinic Downtown | Evansville | Indiana | United States | 47713 |
| 232 | Franciscan Saint Anthony Health-Michigan City | Michigan City | Indiana | United States | 46360 |
| 233 | Woodland Cancer Care Center | Michigan City | Indiana | United States | 46360 |
| 234 | Memorial Regional Cancer Center Day Road | Mishawaka | Indiana | United States | 46545 |
| 235 | Chancellor Center for Oncology | Newburgh | Indiana | United States | 47630 |
| 236 | Reid Health | Richmond | Indiana | United States | 47374 |
| 237 | Memorial Hospital of South Bend | South Bend | Indiana | United States | 46601 |
| 238 | Mary Greeley Medical Center | Ames | Iowa | United States | 50010 |
| 239 | McFarland Clinic PC - Ames | Ames | Iowa | United States | 50010 |
| 240 | University of Iowa Healthcare Cancer Services Quad Cities | Bettendorf | Iowa | United States | 52722 |
| 241 | McFarland Clinic PC-Boone | Boone | Iowa | United States | 50036 |
| 242 | Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa | United States | 50325 |
| 243 | Mercy Cancer Center-West Lakes | Clive | Iowa | United States | 50325 |
| 244 | Alegent Health Mercy Hospital | Council Bluffs | Iowa | United States | 51503 |
| 245 | Greater Regional Medical Center | Creston | Iowa | United States | 50801 |
| 246 | Genesis Medical Center - East Campus | Davenport | Iowa | United States | 52803 |
| 247 | Genesis Cancer Care Institute | Davenport | Iowa | United States | 52804 |
| 248 | Iowa Cancer Specialists | Davenport | Iowa | United States | 52807 |
| 249 | Iowa Methodist Medical Center | Des Moines | Iowa | United States | 50309 |
| 250 | Medical Oncology and Hematology Associates-Des Moines | Des Moines | Iowa | United States | 50309 |
| 251 | Broadlawns Medical Center | Des Moines | Iowa | United States | 50314 |
| 252 | Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa | United States | 50314 |
| 253 | Mercy Medical Center - Des Moines | Des Moines | Iowa | United States | 50314 |
| 254 | Iowa Lutheran Hospital | Des Moines | Iowa | United States | 50316 |
| 255 | McFarland Clinic PC-Trinity Cancer Center | Fort Dodge | Iowa | United States | 50501 |
| 256 | Trinity Regional Medical Center | Fort Dodge | Iowa | United States | 50501 |
| 257 | McFarland Clinic PC-Jefferson | Jefferson | Iowa | United States | 50129 |
| 258 | McFarland Clinic PC-Marshalltown | Marshalltown | Iowa | United States | 50158 |
| 259 | Siouxland Regional Cancer Center | Sioux City | Iowa | United States | 51101 |
| 260 | Methodist West Hospital | West Des Moines | Iowa | United States | 50266-7700 |
| 261 | Mercy Medical Center-West Lakes | West Des Moines | Iowa | United States | 50266 |
| 262 | Cancer Center of Kansas - Chanute | Chanute | Kansas | United States | 66720 |
| 263 | Coffeyville Regional Medical Center | Coffeyville | Kansas | United States | 67337 |
| 264 | Cancer Center of Kansas - Dodge City | Dodge City | Kansas | United States | 67801 |
| 265 | Cancer Center of Kansas - El Dorado | El Dorado | Kansas | United States | 67042 |
| 266 | Newman Regional Health | Emporia | Kansas | United States | 66801 |
| 267 | Cancer Center of Kansas - Fort Scott | Fort Scott | Kansas | United States | 66701 |
| 268 | Central Care Cancer Center - Garden City | Garden City | Kansas | United States | 67846 |
| 269 | Saint Catherine Hospital | Garden City | Kansas | United States | 67846 |
| 270 | Central Care Cancer Center - Great Bend | Great Bend | Kansas | United States | 67530 |
| 271 | Saint Rose Ambulatory and Surgery Center | Great Bend | Kansas | United States | 67530 |
| 272 | HaysMed University of Kansas Health System | Hays | Kansas | United States | 67601 |
| 273 | Cancer Center of Kansas-Independence | Independence | Kansas | United States | 67301 |
| 274 | University of Kansas Cancer Center-West | Kansas City | Kansas | United States | 66112 |
| 275 | University of Kansas Cancer Center | Kansas City | Kansas | United States | 66160 |
| 276 | Cancer Center of Kansas-Kingman | Kingman | Kansas | United States | 67068 |
| 277 | Lawrence Memorial Hospital | Lawrence | Kansas | United States | 66044 |
| 278 | Kansas Institute of Medicine Cancer and Blood Center | Lenexa | Kansas | United States | 66219 |
| 279 | Minimally Invasive Surgery Hospital | Lenexa | Kansas | United States | 66219 |
| 280 | Cancer Center of Kansas-Liberal | Liberal | Kansas | United States | 67905 |
| 281 | Cancer Center of Kansas-Manhattan | Manhattan | Kansas | United States | 66502 |
| 282 | Cancer Center of Kansas - McPherson | McPherson | Kansas | United States | 67460 |
| 283 | Cancer Center of Kansas - Newton | Newton | Kansas | United States | 67114 |
| 284 | Olathe Health Cancer Center | Olathe | Kansas | United States | 66061 |
| 285 | Menorah Medical Center | Overland Park | Kansas | United States | 66209 |
| 286 | University of Kansas Cancer Center-Overland Park | Overland Park | Kansas | United States | 66210 |
| 287 | Saint Luke's South Hospital | Overland Park | Kansas | United States | 66213 |
| 288 | Cancer Center of Kansas - Parsons | Parsons | Kansas | United States | 67357 |
| 289 | Ascension Via Christi - Pittsburg | Pittsburg | Kansas | United States | 66762 |
| 290 | Cancer Center of Kansas - Pratt | Pratt | Kansas | United States | 67124 |
| 291 | Cancer Center of Kansas - Salina | Salina | Kansas | United States | 67401 |
| 292 | Salina Regional Health Center | Salina | Kansas | United States | 67401 |
| 293 | University of Kansas Health System Saint Francis Campus | Topeka | Kansas | United States | 66606 |
| 294 | Cancer Center of Kansas - Wellington | Wellington | Kansas | United States | 67152 |
| 295 | University of Kansas Hospital-Westwood Cancer Center | Westwood | Kansas | United States | 66205 |
| 296 | Associates In Womens Health | Wichita | Kansas | United States | 67208 |
| 297 | Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas | United States | 67208 |
| 298 | Ascension Via Christi Hospitals Wichita | Wichita | Kansas | United States | 67214 |
| 299 | Cancer Center of Kansas - Wichita | Wichita | Kansas | United States | 67214 |
| 300 | Cancer Center of Kansas - Winfield | Winfield | Kansas | United States | 67156 |
| 301 | Flaget Memorial Hospital | Bardstown | Kentucky | United States | 40004 |
| 302 | Baptist Health Corbin | Corbin | Kentucky | United States | 40701 |
| 303 | Commonwealth Cancer Center-Corbin | Corbin | Kentucky | United States | 40701 |
| 304 | Oncology Hematology Care Inc-Crestview | Crestview Hills | Kentucky | United States | 41017 |
| 305 | Baptist Health Hardin | Elizabethtown | Kentucky | United States | 42701 |
| 306 | Baptist Health Lexington | Lexington | Kentucky | United States | 40503 |
| 307 | Saint Joseph Radiation Oncology Resource Center | Lexington | Kentucky | United States | 40504 |
| 308 | Saint Joseph Hospital East | Lexington | Kentucky | United States | 40509 |
| 309 | Saint Joseph London | London | Kentucky | United States | 40741 |
| 310 | Jewish Hospital | Louisville | Kentucky | United States | 40202 |
| 311 | The James Graham Brown Cancer Center at University of Louisville | Louisville | Kentucky | United States | 40202 |
| 312 | Baptist Health Louisville | Louisville | Kentucky | United States | 40207 |
| 313 | Saints Mary and Elizabeth Hospital | Louisville | Kentucky | United States | 40215 |
| 314 | UofL Health Medical Center Northeast | Louisville | Kentucky | United States | 40245 |
| 315 | Baptist Health Madisonville/Merle Mahr Cancer Center | Madisonville | Kentucky | United States | 42431 |
| 316 | Baptist Health Paducah | Paducah | Kentucky | United States | 42003 |
| 317 | Jewish Hospital Medical Center South | Shepherdsville | Kentucky | United States | 40165 |
| 318 | Harold Alfond Center for Cancer Care | Augusta | Maine | United States | 04330 |
| 319 | Eastern Maine Medical Center | Bangor | Maine | United States | 04401 |
| 320 | Waldo County General Hospital | Belfast | Maine | United States | 04915 |
| 321 | MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford | Biddeford | Maine | United States | 04005 |
| 322 | Lafayette Family Cancer Center-EMMC | Brewer | Maine | United States | 04412 |
| 323 | Stephens Memorial Hospital | Norway | Maine | United States | 04268 |
| 324 | Penobscot Bay Medical Center | Rockport | Maine | United States | 04856 |
| 325 | MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford | Sanford | Maine | United States | 04073 |
| 326 | Maine Medical Partners - South Portland | South Portland | Maine | United States | 04106 |
| 327 | Greater Baltimore Medical Center | Baltimore | Maryland | United States | 21204 |
| 328 | Walter Reed National Military Medical Center | Bethesda | Maryland | United States | 20889-5600 |
| 329 | Boston Medical Center | Boston | Massachusetts | United States | 02118 |
| 330 | Lahey Hospital and Medical Center | Burlington | Massachusetts | United States | 01805 |
| 331 | Winchester Hospital | Winchester | Massachusetts | United States | 01890 |
| 332 | Hickman Cancer Center | Adrian | Michigan | United States | 49221 |
| 333 | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | United States | 48109 |
| 334 | Bronson Battle Creek | Battle Creek | Michigan | United States | 49017 |
| 335 | Beaumont Hospital - Dearborn | Dearborn | Michigan | United States | 48124 |
| 336 | Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | United States | 48201 |
| 337 | Weisberg Cancer Treatment Center | Farmington Hills | Michigan | United States | 48334 |
| 338 | Beaumont Hospital - Farmington Hills | Farmington Hills | Michigan | United States | 48336 |
| 339 | Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids | Michigan | United States | 49503 |
| 340 | Mercy Health Saint Mary's | Grand Rapids | Michigan | United States | 49503 |
| 341 | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | United States | 49503 |
| 342 | William Beaumont Hospital-Grosse Pointe | Grosse Pointe | Michigan | United States | 48230 |
| 343 | Bronson Methodist Hospital | Kalamazoo | Michigan | United States | 49007 |
| 344 | West Michigan Cancer Center | Kalamazoo | Michigan | United States | 49007 |
| 345 | Borgess Medical Center | Kalamazoo | Michigan | United States | 49048 |
| 346 | Toledo Clinic Cancer Centers-Monroe | Monroe | Michigan | United States | 48162 |
| 347 | Mercy Health Mercy Campus | Muskegon | Michigan | United States | 49444 |
| 348 | Lakeland Hospital Niles | Niles | Michigan | United States | 49120 |
| 349 | Huron Medical Center PC | Port Huron | Michigan | United States | 48060 |
| 350 | Lake Huron Medical Center | Port Huron | Michigan | United States | 48060 |
| 351 | Spectrum Health Reed City Hospital | Reed City | Michigan | United States | 49677 |
| 352 | Michigan Cancer Specialists | Roseville | Michigan | United States | 48066 |
| 353 | Oakland Colon Rectal Associates | Royal Oak | Michigan | United States | 48067 |
| 354 | Comprehensive Medical Center PLLC | Royal Oak | Michigan | United States | 48073 |
| 355 | Hematology Oncology Consultants PC | Royal Oak | Michigan | United States | 48073 |
| 356 | Oakland Medical Group | Royal Oak | Michigan | United States | 48073 |
| 357 | William Beaumont Hospital-Royal Oak | Royal Oak | Michigan | United States | 48073 |
| 358 | Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan | United States | 49085 |
| 359 | Marie Yeager Cancer Center | Saint Joseph | Michigan | United States | 49085 |
| 360 | Premier Hematology Oncology Care | Sterling Heights | Michigan | United States | 48312 |
| 361 | Mitchell Folbe MD PC | Sterling Heights | Michigan | United States | 48314 |
| 362 | Munson Medical Center | Traverse City | Michigan | United States | 49684 |
| 363 | Michigan Institute of Urology-Town Center | Troy | Michigan | United States | 48084 |
| 364 | Claudia BR Herke MD PC | Troy | Michigan | United States | 48085 |
| 365 | William Beaumont Hospital - Troy | Troy | Michigan | United States | 48085 |
| 366 | Hematology Oncology Consultants PC-Troy | Troy | Michigan | United States | 48098 |
| 367 | Metro Health Hospital | Wyoming | Michigan | United States | 49519 |
| 368 | Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota | United States | 56401 |
| 369 | Fairview Ridges Hospital | Burnsville | Minnesota | United States | 55337 |
| 370 | Mercy Hospital | Coon Rapids | Minnesota | United States | 55433 |
| 371 | Essentia Health Cancer Center | Duluth | Minnesota | United States | 55805 |
| 372 | Essentia Health Saint Mary's Medical Center | Duluth | Minnesota | United States | 55805 |
| 373 | Miller-Dwan Hospital | Duluth | Minnesota | United States | 55805 |
| 374 | Fairview Southdale Hospital | Edina | Minnesota | United States | 55435 |
| 375 | Lake Region Healthcare Corporation-Cancer Care | Fergus Falls | Minnesota | United States | 56537 |
| 376 | Unity Hospital | Fridley | Minnesota | United States | 55432 |
| 377 | Hutchinson Area Health Care | Hutchinson | Minnesota | United States | 55350 |
| 378 | Fairview Clinics and Surgery Center Maple Grove | Maple Grove | Minnesota | United States | 55369 |
| 379 | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | United States | 55109 |
| 380 | Saint John's Hospital - Healtheast | Maplewood | Minnesota | United States | 55109 |
| 381 | Abbott-Northwestern Hospital | Minneapolis | Minnesota | United States | 55407 |
| 382 | Hennepin County Medical Center | Minneapolis | Minnesota | United States | 55415 |
| 383 | Health Partners Inc | Minneapolis | Minnesota | United States | 55454 |
| 384 | Monticello Cancer Center | Monticello | Minnesota | United States | 55362 |
| 385 | New Ulm Medical Center | New Ulm | Minnesota | United States | 56073 |
| 386 | North Memorial Medical Health Center | Robbinsdale | Minnesota | United States | 55422 |
| 387 | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | United States | 55416 |
| 388 | Regions Hospital | Saint Paul | Minnesota | United States | 55101 |
| 389 | United Hospital | Saint Paul | Minnesota | United States | 55102 |
| 390 | Saint Francis Regional Medical Center | Shakopee | Minnesota | United States | 55379 |
| 391 | Lakeview Hospital | Stillwater | Minnesota | United States | 55082 |
| 392 | Ridgeview Medical Center | Waconia | Minnesota | United States | 55387 |
| 393 | Rice Memorial Hospital | Willmar | Minnesota | United States | 56201 |
| 394 | Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | United States | 55125 |
| 395 | Fairview Lakes Medical Center | Wyoming | Minnesota | United States | 55092 |
| 396 | University of Mississippi Medical Center | Jackson | Mississippi | United States | 39216 |
| 397 | Singing River Hospital | Pascagoula | Mississippi | United States | 39581 |
| 398 | Central Care Cancer Center - Bolivar | Bolivar | Missouri | United States | 65613 |
| 399 | Parkland Health Center-Bonne Terre | Bonne Terre | Missouri | United States | 63628 |
| 400 | Cox Cancer Center Branson | Branson | Missouri | United States | 65616 |
| 401 | Saint Francis Medical Center | Cape Girardeau | Missouri | United States | 63703 |
| 402 | Southeast Cancer Center | Cape Girardeau | Missouri | United States | 63703 |
| 403 | University of Missouri - Ellis Fischel | Columbia | Missouri | United States | 65212 |
| 404 | Centerpoint Medical Center LLC | Independence | Missouri | United States | 64057 |
| 405 | Capital Region Southwest Campus | Jefferson City | Missouri | United States | 65109 |
| 406 | Freeman Health System | Joplin | Missouri | United States | 64804 |
| 407 | Mercy Hospital Joplin | Joplin | Missouri | United States | 64804 |
| 408 | Truman Medical Centers | Kansas City | Missouri | United States | 64108 |
| 409 | Saint Luke's Hospital of Kansas City | Kansas City | Missouri | United States | 64111 |
| 410 | Heartland Hematology and Oncology Associates Incorporated | Kansas City | Missouri | United States | 64118 |
| 411 | The University of Kansas Cancer Center-South | Kansas City | Missouri | United States | 64131 |
| 412 | Research Medical Center | Kansas City | Missouri | United States | 64132 |
| 413 | University of Kansas Cancer Center - North | Kansas City | Missouri | United States | 64154 |
| 414 | University of Kansas Cancer Center - Lee's Summit | Lee's Summit | Missouri | United States | 64064 |
| 415 | Saint Luke's East - Lee's Summit | Lee's Summit | Missouri | United States | 64086 |
| 416 | Liberty Radiation Oncology Center | Liberty | Missouri | United States | 64068 |
| 417 | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | United States | 65401 |
| 418 | Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | United States | 65401 |
| 419 | Heartland Regional Medical Center | Saint Joseph | Missouri | United States | 64506 |
| 420 | Saint Louis Cancer and Breast Institute-South City | Saint Louis | Missouri | United States | 63109 |
| 421 | Mercy Hospital South | Saint Louis | Missouri | United States | 63128 |
| 422 | Missouri Baptist Medical Center | Saint Louis | Missouri | United States | 63131 |
| 423 | Mercy Hospital Saint Louis | Saint Louis | Missouri | United States | 63141 |
| 424 | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | United States | 63670 |
| 425 | Mercy Hospital Springfield | Springfield | Missouri | United States | 65804 |
| 426 | CoxHealth South Hospital | Springfield | Missouri | United States | 65807 |
| 427 | Missouri Baptist Sullivan Hospital | Sullivan | Missouri | United States | 63080 |
| 428 | Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri | United States | 63127 |
| 429 | Community Hospital of Anaconda | Anaconda | Montana | United States | 59711 |
| 430 | Billings Clinic Cancer Center | Billings | Montana | United States | 59101 |
| 431 | Saint Vincent Healthcare | Billings | Montana | United States | 59101 |
| 432 | Saint Vincent Frontier Cancer Center | Billings | Montana | United States | 59102 |
| 433 | Bozeman Deaconess Hospital | Bozeman | Montana | United States | 59715 |
| 434 | Saint James Community Hospital and Cancer Treatment Center | Butte | Montana | United States | 59701 |
| 435 | Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | United States | 59405 |
| 436 | Great Falls Clinic | Great Falls | Montana | United States | 59405 |
| 437 | Saint Peter's Community Hospital | Helena | Montana | United States | 59601 |
| 438 | Kalispell Regional Medical Center | Kalispell | Montana | United States | 59901 |
| 439 | Saint Patrick Hospital - Community Hospital | Missoula | Montana | United States | 59802 |
| 440 | Community Medical Hospital | Missoula | Montana | United States | 59804 |
| 441 | CHI Health Saint Francis | Grand Island | Nebraska | United States | 68803 |
| 442 | Heartland Hematology and Oncology | Kearney | Nebraska | United States | 68845 |
| 443 | CHI Health Good Samaritan | Kearney | Nebraska | United States | 68847 |
| 444 | Saint Elizabeth Regional Medical Center | Lincoln | Nebraska | United States | 68510 |
| 445 | Alegent Health Immanuel Medical Center | Omaha | Nebraska | United States | 68122 |
| 446 | Hematology and Oncology Consultants PC | Omaha | Nebraska | United States | 68122 |
| 447 | Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska | United States | 68124 |
| 448 | Alegent Health Lakeside Hospital | Omaha | Nebraska | United States | 68130 |
| 449 | Creighton University Medical Center | Omaha | Nebraska | United States | 68131 |
| 450 | University of Nebraska Medical Center | Omaha | Nebraska | United States | 68198 |
| 451 | Midlands Community Hospital | Papillion | Nebraska | United States | 68046 |
| 452 | Carson Tahoe Regional Medical Center | Carson City | Nevada | United States | 89703 |
| 453 | Cancer and Blood Specialists-Henderson | Henderson | Nevada | United States | 89052 |
| 454 | Comprehensive Cancer Centers of Nevada - Henderson | Henderson | Nevada | United States | 89052 |
| 455 | Comprehensive Cancer Centers of Nevada-Horizon Ridge | Henderson | Nevada | United States | 89052 |
| 456 | Las Vegas Cancer Center-Henderson | Henderson | Nevada | United States | 89052 |
| 457 | OptumCare Cancer Care at Seven Hills | Henderson | Nevada | United States | 89052 |
| 458 | Comprehensive Cancer Centers of Nevada-Southeast Henderson | Henderson | Nevada | United States | 89074 |
| 459 | GenesisCare USA - Henderson | Henderson | Nevada | United States | 89074 |
| 460 | Desert West Surgery | Las Vegas | Nevada | United States | 89102 |
| 461 | OptumCare Cancer Care at Charleston | Las Vegas | Nevada | United States | 89102 |
| 462 | University Medical Center of Southern Nevada | Las Vegas | Nevada | United States | 89102 |
| 463 | Hope Cancer Care of Nevada | Las Vegas | Nevada | United States | 89103 |
| 464 | Cancer and Blood Specialists-Shadow | Las Vegas | Nevada | United States | 89106 |
| 465 | Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada | United States | 89106 |
| 466 | GenesisCare USA - Las Vegas | Las Vegas | Nevada | United States | 89109 |
| 467 | HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway | Las Vegas | Nevada | United States | 89109 |
| 468 | Sunrise Hospital and Medical Center | Las Vegas | Nevada | United States | 89109 |
| 469 | HealthCare Partners Medical Group Oncology/Hematology-San Martin | Las Vegas | Nevada | United States | 89113 |
| 470 | Radiation Oncology Centers of Nevada Southeast | Las Vegas | Nevada | United States | 89119 |
| 471 | Cancer Therapy and Integrative Medicine | Las Vegas | Nevada | United States | 89121 |
| 472 | Ann M Wierman MD LTD | Las Vegas | Nevada | United States | 89128 |
| 473 | Cancer and Blood Specialists-Tenaya | Las Vegas | Nevada | United States | 89128 |
| 474 | Comprehensive Cancer Centers of Nevada - Northwest | Las Vegas | Nevada | United States | 89128 |
| 475 | GenesisCare USA - Vegas Tenaya | Las Vegas | Nevada | United States | 89128 |
| 476 | HealthCare Partners Medical Group Oncology/Hematology-Tenaya | Las Vegas | Nevada | United States | 89128 |
| 477 | OptumCare Cancer Care at MountainView | Las Vegas | Nevada | United States | 89128 |
| 478 | Comprehensive Cancer Centers of Nevada - Town Center | Las Vegas | Nevada | United States | 89144 |
| 479 | Comprehensive Cancer Centers of Nevada-Summerlin | Las Vegas | Nevada | United States | 89144 |
| 480 | Summerlin Hospital Medical Center | Las Vegas | Nevada | United States | 89144 |
| 481 | Las Vegas Cancer Center-Medical Center | Las Vegas | Nevada | United States | 89148-2405 |
| 482 | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | United States | 89148 |
| 483 | GenesisCare USA - Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 484 | OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 485 | HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills | Las Vegas | Nevada | United States | 89149 |
| 486 | Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada | United States | 89169 |
| 487 | University Cancer Center | Las Vegas | Nevada | United States | 89169 |
| 488 | Hope Cancer Care of Nevada-Pahrump | Pahrump | Nevada | United States | 89048 |
| 489 | Renown Regional Medical Center | Reno | Nevada | United States | 89502 |
| 490 | Saint Mary's Regional Medical Center | Reno | Nevada | United States | 89503 |
| 491 | Radiation Oncology Associates | Reno | Nevada | United States | 89509 |
| 492 | Ocean Medical Center | Brick | New Jersey | United States | 08724 |
| 493 | Hackensack University Medical Center | Hackensack | New Jersey | United States | 07601 |
| 494 | Bayshore Community Hospital | Holmdel | New Jersey | United States | 07733 |
| 495 | Southern Ocean County Medical Center | Manahawkin | New Jersey | United States | 08050 |
| 496 | Morristown Medical Center | Morristown | New Jersey | United States | 07960 |
| 497 | Jersey Shore Medical Center | Neptune | New Jersey | United States | 07753 |
| 498 | Riverview Medical Center/Booker Cancer Center | Red Bank | New Jersey | United States | 07701 |
| 499 | Overlook Hospital | Summit | New Jersey | United States | 07902 |
| 500 | Northwell Health/Center for Advanced Medicine | Lake Success | New York | United States | 11042 |
| 501 | Garnet Health Medical Center | Middletown | New York | United States | 10940 |
| 502 | NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York | United States | 10032 |
| 503 | University of Rochester | Rochester | New York | United States | 14642 |
| 504 | Mission Hospital | Asheville | North Carolina | United States | 28801 |
| 505 | AdventHealth Infusion Center Asheville | Asheville | North Carolina | United States | 28803 |
| 506 | Messino Cancer Centers | Asheville | North Carolina | United States | 28806 |
| 507 | Novant Health Presbyterian Medical Center | Charlotte | North Carolina | United States | 28204 |
| 508 | Novant Health Carolina Surgical - Randolph | Charlotte | North Carolina | United States | 28207 |
| 509 | Oncology Specialists of Charlotte | Charlotte | North Carolina | United States | 28207 |
| 510 | Southern Oncology Specialists-Charlotte | Charlotte | North Carolina | United States | 28262 |
| 511 | Sampson Radiation Oncology | Clinton | North Carolina | United States | 28328 |
| 512 | Southeastern Medical Oncology Center-Clinton | Clinton | North Carolina | United States | 28328 |
| 513 | AdventHealth Infusion Center Haywood | Clyde | North Carolina | United States | 28721 |
| 514 | Southeastern Medical Oncology Center-Goldsboro | Goldsboro | North Carolina | United States | 27534 |
| 515 | Wayne Memorial Hospital | Goldsboro | North Carolina | United States | 27534 |
| 516 | Wayne Radiation Oncology | Goldsboro | North Carolina | United States | 27534 |
| 517 | Hendersonville Hematology and Oncology at Pardee | Hendersonville | North Carolina | United States | 28791 |
| 518 | Margaret R Pardee Memorial Hospital | Hendersonville | North Carolina | United States | 28791 |
| 519 | AdventHealth Hendersonville | Hendersonville | North Carolina | United States | 28792 |
| 520 | Novant Health Cancer Institute - Huntersville | Huntersville | North Carolina | United States | 28078 |
| 521 | Southern Oncology Specialists-Huntersville | Huntersville | North Carolina | United States | 28078 |
| 522 | Onslow Memorial Hospital | Jacksonville | North Carolina | United States | 28546 |
| 523 | Southeastern Medical Oncology Center-Jacksonville | Jacksonville | North Carolina | United States | 28546 |
| 524 | Vidant Oncology-Kenansville | Kenansville | North Carolina | United States | 28349 |
| 525 | Vidant Oncology-Kinston | Kinston | North Carolina | United States | 28501 |
| 526 | Matthews Radiation Oncology Center | Matthews | North Carolina | United States | 28105 |
| 527 | Novant Health Cancer Institute - Matthews | Matthews | North Carolina | United States | 28105 |
| 528 | Novant Health Cancer Institute - Mooresville | Mooresville | North Carolina | United States | 28117 |
| 529 | Vidant Oncology-Richlands | Richlands | North Carolina | United States | 28574 |
| 530 | Essentia Health Cancer Center-South University Clinic | Fargo | North Dakota | United States | 58103 |
| 531 | Indu and Raj Soin Medical Center | Beavercreek | Ohio | United States | 45431 |
| 532 | Strecker Cancer Center-Belpre | Belpre | Ohio | United States | 45714 |
| 533 | Saint Elizabeth Boardman Hospital | Boardman | Ohio | United States | 44512 |
| 534 | Dayton Physicians LLC-Miami Valley South | Centerville | Ohio | United States | 45459 |
| 535 | Miami Valley Hospital South | Centerville | Ohio | United States | 45459 |
| 536 | Adena Regional Medical Center | Chillicothe | Ohio | United States | 45601 |
| 537 | Oncology Hematology Care Inc-Eden Park | Cincinnati | Ohio | United States | 45202 |
| 538 | Oncology Hematology Care Inc-Mercy West | Cincinnati | Ohio | United States | 45211 |
| 539 | University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | United States | 45219 |
| 540 | Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio | United States | 45220 |
| 541 | Oncology Hematology Care Inc-Anderson | Cincinnati | Ohio | United States | 45230 |
| 542 | Oncology Hematology Care Inc-Kenwood | Cincinnati | Ohio | United States | 45236 |
| 543 | Bethesda North Hospital | Cincinnati | Ohio | United States | 45242 |
| 544 | Oncology Hematology Care Inc-Blue Ash | Cincinnati | Ohio | United States | 45242 |
| 545 | TriHealth Cancer Institute-Westside | Cincinnati | Ohio | United States | 45247 |
| 546 | TriHealth Cancer Institute-Anderson | Cincinnati | Ohio | United States | 45255 |
| 547 | Ohio State University Comprehensive Cancer Center | Columbus | Ohio | United States | 43210 |
| 548 | Columbus Oncology and Hematology Associates Inc | Columbus | Ohio | United States | 43214 |
| 549 | Riverside Methodist Hospital | Columbus | Ohio | United States | 43214 |
| 550 | Grant Medical Center | Columbus | Ohio | United States | 43215 |
| 551 | The Mark H Zangmeister Center | Columbus | Ohio | United States | 43219 |
| 552 | Mount Carmel Health Center West | Columbus | Ohio | United States | 43222 |
| 553 | Doctors Hospital | Columbus | Ohio | United States | 43228 |
| 554 | Good Samaritan Hospital - Dayton | Dayton | Ohio | United States | 45406 |
| 555 | Miami Valley Hospital | Dayton | Ohio | United States | 45409 |
| 556 | Dayton Physician LLC-Miami Valley Hospital North | Dayton | Ohio | United States | 45415 |
| 557 | Miami Valley Hospital North | Dayton | Ohio | United States | 45415 |
| 558 | Delaware Health Center-Grady Cancer Center | Delaware | Ohio | United States | 43015 |
| 559 | Delaware Radiation Oncology | Delaware | Ohio | United States | 43015 |
| 560 | Grady Memorial Hospital | Delaware | Ohio | United States | 43015 |
| 561 | Oncology Hematology Care Inc-Healthplex | Fairfield | Ohio | United States | 45014 |
| 562 | Armes Family Cancer Center | Findlay | Ohio | United States | 45840 |
| 563 | Blanchard Valley Hospital | Findlay | Ohio | United States | 45840 |
| 564 | Orion Cancer Care | Findlay | Ohio | United States | 45840 |
| 565 | Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | United States | 45005-1066 |
| 566 | Dayton Physicians LLC-Atrium | Franklin | Ohio | United States | 45005 |
| 567 | Dayton Physicians LLC-Wayne | Greenville | Ohio | United States | 45331 |
| 568 | Wayne Hospital | Greenville | Ohio | United States | 45331 |
| 569 | Greater Dayton Cancer Center | Kettering | Ohio | United States | 45409 |
| 570 | First Dayton Cancer Care | Kettering | Ohio | United States | 45420 |
| 571 | Kettering Medical Center | Kettering | Ohio | United States | 45429 |
| 572 | Fairfield Medical Center | Lancaster | Ohio | United States | 43130 |
| 573 | Marietta Memorial Hospital | Marietta | Ohio | United States | 45750 |
| 574 | Toledo Clinic Cancer Centers-Maumee | Maumee | Ohio | United States | 43537 |
| 575 | Toledo Radiation Oncology at Northwest Ohio Onocolgy Center | Maumee | Ohio | United States | 43537 |
| 576 | Knox Community Hospital | Mount Vernon | Ohio | United States | 43050 |
| 577 | Licking Memorial Hospital | Newark | Ohio | United States | 43055 |
| 578 | Newark Radiation Oncology | Newark | Ohio | United States | 43055 |
| 579 | Saint Charles Hospital | Oregon | Ohio | United States | 43616 |
| 580 | Mercy Health Perrysburg Cancer Center | Perrysburg | Ohio | United States | 43551 |
| 581 | Southern Ohio Medical Center | Portsmouth | Ohio | United States | 45662 |
| 582 | Dayton Physicians LLC-Wilson | Sidney | Ohio | United States | 45365 |
| 583 | Springfield Regional Cancer Center | Springfield | Ohio | United States | 45504 |
| 584 | Springfield Regional Medical Center | Springfield | Ohio | United States | 45505 |
| 585 | Mercy Health - Saint Anne Hospital | Toledo | Ohio | United States | 43623 |
| 586 | Toledo Clinic Cancer Centers-Toledo | Toledo | Ohio | United States | 43623 |
| 587 | Dayton Physicians LLC-Upper Valley | Troy | Ohio | United States | 45373 |
| 588 | Upper Valley Medical Center | Troy | Ohio | United States | 45373 |
| 589 | Saint Joseph Warren Hospital | Warren | Ohio | United States | 44484 |
| 590 | University of Cincinnati Cancer Center-West Chester | West Chester | Ohio | United States | 45069 |
| 591 | Saint Ann's Hospital | Westerville | Ohio | United States | 43081 |
| 592 | Wright-Patterson Medical Center | Wright-Patterson Air Force Base | Ohio | United States | 45433 |
| 593 | Saint Elizabeth Youngstown Hospital | Youngstown | Ohio | United States | 44501 |
| 594 | Genesis Healthcare System Cancer Care Center | Zanesville | Ohio | United States | 43701 |
| 595 | Cancer Centers of Southwest Oklahoma Research | Lawton | Oklahoma | United States | 73505 |
| 596 | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 597 | Integris Southwest Medical Center | Oklahoma City | Oklahoma | United States | 73109 |
| 598 | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | United States | 73120 |
| 599 | Integris Cancer Institute of Oklahoma | Oklahoma City | Oklahoma | United States | 73142 |
| 600 | Oklahoma Cancer Specialists and Research Institute-Tulsa | Tulsa | Oklahoma | United States | 74146 |
| 601 | Saint Alphonsus Medical Center-Baker City | Baker City | Oregon | United States | 97814 |
| 602 | Saint Charles Health System | Bend | Oregon | United States | 97701 |
| 603 | Clackamas Radiation Oncology Center | Clackamas | Oregon | United States | 97015 |
| 604 | Providence Cancer Institute Clackamas Clinic | Clackamas | Oregon | United States | 97015 |
| 605 | Bay Area Hospital | Coos Bay | Oregon | United States | 97420 |
| 606 | Providence Newberg Medical Center | Newberg | Oregon | United States | 97132 |
| 607 | Saint Alphonsus Medical Center-Ontario | Ontario | Oregon | United States | 97914 |
| 608 | Providence Willamette Falls Medical Center | Oregon City | Oregon | United States | 97045 |
| 609 | Providence Portland Medical Center | Portland | Oregon | United States | 97213 |
| 610 | Providence Saint Vincent Medical Center | Portland | Oregon | United States | 97225 |
| 611 | Kaiser Permanente Northwest | Portland | Oregon | United States | 97227 |
| 612 | Saint Charles Health System-Redmond | Redmond | Oregon | United States | 97756 |
| 613 | Jefferson Abington Hospital | Abington | Pennsylvania | United States | 19001 |
| 614 | UPMC-Heritage Valley Health System Beaver | Beaver | Pennsylvania | United States | 15009 |
| 615 | Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania | United States | 19317 |
| 616 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822 |
| 617 | UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania | United States | 15601 |
| 618 | Geisinger Medical Center-Cancer Center Hazleton | Hazleton | Pennsylvania | United States | 18201 |
| 619 | UPMC-Johnstown/John P. Murtha Regional Cancer Center | Johnstown | Pennsylvania | United States | 15901 |
| 620 | Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania | United States | 17837 |
| 621 | Lewistown Hospital | Lewistown | Pennsylvania | United States | 17044 |
| 622 | UPMC Cancer Center at UPMC McKeesport | McKeesport | Pennsylvania | United States | 15132 |
| 623 | UPMC-Coraopolis/Heritage Valley Radiation Oncology | Moon | Pennsylvania | United States | 15108 |
| 624 | UPMC-Magee Womens Hospital | Pittsburgh | Pennsylvania | United States | 15213 |
| 625 | UPMC-Presbyterian Hospital | Pittsburgh | Pennsylvania | United States | 15213 |
| 626 | UPMC-Saint Margaret | Pittsburgh | Pennsylvania | United States | 15215 |
| 627 | University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | United States | 15232 |
| 628 | UPMC-Shadyside Hospital | Pittsburgh | Pennsylvania | United States | 15232 |
| 629 | UPMC-Passavant Hospital | Pittsburgh | Pennsylvania | United States | 15237 |
| 630 | UPMC-Saint Clair Hospital Cancer Center | Pittsburgh | Pennsylvania | United States | 15243 |
| 631 | Geisinger Cancer Services-Pottsville | Pottsville | Pennsylvania | United States | 17901 |
| 632 | Community Medical Center | Scranton | Pennsylvania | United States | 18510 |
| 633 | Geisinger Medical Oncology-Selinsgrove | Selinsgrove | Pennsylvania | United States | 17870 |
| 634 | UPMC Cancer Center at UPMC Northwest | Seneca | Pennsylvania | United States | 16346 |
| 635 | Geisinger Medical Group | State College | Pennsylvania | United States | 16801 |
| 636 | UPMC Uniontown Hospital Radiation Oncology | Uniontown | Pennsylvania | United States | 15401 |
| 637 | UPMC Washington Hospital Radiation Oncology | Washington | Pennsylvania | United States | 15301 |
| 638 | Reading Hospital | West Reading | Pennsylvania | United States | 19611 |
| 639 | Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | United States | 18711 |
| 640 | UPMC Susquehanna | Williamsport | Pennsylvania | United States | 17701 |
| 641 | AnMed Health Cancer Center | Anderson | South Carolina | United States | 29621 |
| 642 | Roper Hospital | Charleston | South Carolina | United States | 29401 |
| 643 | Charleston Oncology - Roper | Charleston | South Carolina | United States | 29403 |
| 644 | Lowcountry Hematology Oncology PA-North Charleston | Charleston | South Carolina | United States | 29406 |
| 645 | Bon Secours Saint Francis Hospital | Charleston | South Carolina | United States | 29414 |
| 646 | Charleston Oncology - Saint Francis | Charleston | South Carolina | United States | 29414 |
| 647 | Lowcountry Hematology Oncology PA-West Ashley | Charleston | South Carolina | United States | 29414 |
| 648 | Gibbs Cancer Center-Gaffney | Gaffney | South Carolina | United States | 29341 |
| 649 | Saint Francis Hospital | Greenville | South Carolina | United States | 29601 |
| 650 | Saint Francis Cancer Center | Greenville | South Carolina | United States | 29607 |
| 651 | Gibbs Cancer Center-Pelham | Greer | South Carolina | United States | 29651 |
| 652 | Lowcountry Hematology Oncology PA-Mount Pleasant | Mount Pleasant | South Carolina | United States | 29464 |
| 653 | Spartanburg Medical Center | Spartanburg | South Carolina | United States | 29303 |
| 654 | MGC Hematology Oncology-Union | Union | South Carolina | United States | 29379 |
| 655 | Rapid City Regional Hospital | Rapid City | South Dakota | United States | 57701 |
| 656 | Bristol Regional Medical Center | Bristol | Tennessee | United States | 37620 |
| 657 | Wellmont Medical Associates Oncology and Hematology-Bristol | Bristol | Tennessee | United States | 37620 |
| 658 | Memorial Hospital | Chattanooga | Tennessee | United States | 37404 |
| 659 | Pulmonary Medicine Center of Chattanooga-Hixson | Hixson | Tennessee | United States | 37343 |
| 660 | Wellmont Medical Associates Oncology and Hematology-Johnson City | Johnson City | Tennessee | United States | 37604 |
| 661 | Ballad Health Cancer Care - Kingsport | Kingsport | Tennessee | United States | 37660 |
| 662 | Wellmont Holston Valley Hospital and Medical Center | Kingsport | Tennessee | United States | 37660 |
| 663 | Memorial GYN Plus | Ooltewah | Tennessee | United States | 37363 |
| 664 | Saint Joseph Regional Cancer Center | Bryan | Texas | United States | 77802 |
| 665 | American Fork Hospital / Huntsman Intermountain Cancer Center | American Fork | Utah | United States | 84003 |
| 666 | Sandra L Maxwell Cancer Center | Cedar City | Utah | United States | 84720 |
| 667 | Farmington Health Center | Farmington | Utah | United States | 84025 |
| 668 | Logan Regional Hospital | Logan | Utah | United States | 84321 |
| 669 | Intermountain Medical Center | Murray | Utah | United States | 84107 |
| 670 | McKay-Dee Hospital Center | Ogden | Utah | United States | 84403 |
| 671 | Utah Valley Regional Medical Center | Provo | Utah | United States | 84604 |
| 672 | Riverton Hospital | Riverton | Utah | United States | 84065 |
| 673 | Saint George Regional Medical Center | Saint George | Utah | United States | 84770 |
| 674 | Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah | United States | 84106 |
| 675 | Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | United States | 84112 |
| 676 | LDS Hospital | Salt Lake City | Utah | United States | 84143 |
| 677 | South Jordan Health Center | South Jordan | Utah | United States | 84009 |
| 678 | Wellmont Medical Associates-Bristol | Bristol | Virginia | United States | 24201 |
| 679 | Southwest VA Regional Cancer Center | Norton | Virginia | United States | 24273 |
| 680 | Providence Regional Cancer System-Aberdeen | Aberdeen | Washington | United States | 98520 |
| 681 | Cancer Care Center at Island Hospital | Anacortes | Washington | United States | 98221 |
| 682 | MultiCare Auburn Medical Center | Auburn | Washington | United States | 98001 |
| 683 | Virginia Mason Bainbridge Island Medical Center | Bainbridge Island | Washington | United States | 98110 |
| 684 | Overlake Medical Center | Bellevue | Washington | United States | 98004 |
| 685 | Swedish Cancer Institute-Eastside Oncology Hematology | Bellevue | Washington | United States | 98005 |
| 686 | PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | United States | 98225 |
| 687 | Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington | United States | 98310 |
| 688 | Harrison Medical Center | Bremerton | Washington | United States | 98310 |
| 689 | Highline Medical Center-Main Campus | Burien | Washington | United States | 98166 |
| 690 | Providence Regional Cancer System-Centralia | Centralia | Washington | United States | 98531 |
| 691 | Swedish Cancer Institute-Edmonds | Edmonds | Washington | United States | 98026 |
| 692 | Saint Elizabeth Hospital | Enumclaw | Washington | United States | 98022 |
| 693 | Providence Regional Cancer Partnership | Everett | Washington | United States | 98201 |
| 694 | Virginia Mason Federal Way Medical Center | Federal Way | Washington | United States | 98002 |
| 695 | Saint Francis Hospital | Federal Way | Washington | United States | 98003 |
| 696 | Tacoma/Valley Radiation Oncology Centers-Gig Harbor | Gig Harbor | Washington | United States | 98332 |
| 697 | MultiCare Gig Harbor Medical Park | Gig Harbor | Washington | United States | 98335 |
| 698 | Swedish Cancer Institute-Issaquah | Issaquah | Washington | United States | 98029 |
| 699 | Northwest Cancer Clinic | Kennewick | Washington | United States | 99336 |
| 700 | Providence Regional Cancer System-Lacey | Lacey | Washington | United States | 98503 |
| 701 | Saint Clare Hospital | Lakewood | Washington | United States | 98499 |
| 702 | PeaceHealth Saint John Medical Center | Longview | Washington | United States | 98632 |
| 703 | Virginia Mason Lynnwood Medical Center | Lynnwood | Washington | United States | 98036 |
| 704 | Jefferson Healthcare | Port Townsend | Washington | United States | 98368 |
| 705 | Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo | Washington | United States | 98370 |
| 706 | Peninsula Cancer Center | Poulsbo | Washington | United States | 98370 |
| 707 | MultiCare Good Samaritan Hospital | Puyallup | Washington | United States | 98372 |
| 708 | Tacoma/Valley Radiation Oncology Centers-Puyallup | Puyallup | Washington | United States | 98372 |
| 709 | Valley Medical Center | Renton | Washington | United States | 98055 |
| 710 | Virginia Mason Medical Center | Seattle | Washington | United States | 98101 |
| 711 | Minor and James Medical PLLC | Seattle | Washington | United States | 98104 |
| 712 | Pacific Gynecology Specialists | Seattle | Washington | United States | 98104 |
| 713 | Swedish Medical Center-Ballard Campus | Seattle | Washington | United States | 98107 |
| 714 | Kaiser Permanente Washington | Seattle | Washington | United States | 98112 |
| 715 | Swedish Medical Center-First Hill | Seattle | Washington | United States | 98122-4307 |
| 716 | PeaceHealth United General Medical Center | Sedro-Woolley | Washington | United States | 98284 |
| 717 | Providence Regional Cancer System-Shelton | Shelton | Washington | United States | 98584 |
| 718 | MultiCare Deaconess Cancer and Blood Specialty Center - Valley | Spokane Valley | Washington | United States | 99216 |
| 719 | MultiCare Deaconess Cancer and Blood Specialty Center - Downtown | Spokane | Washington | United States | 99204 |
| 720 | MultiCare Deaconess Cancer and Blood Specialty Center - North | Spokane | Washington | United States | 99218 |
| 721 | Tacoma/Valley Radiation Oncology Centers-Jackson Hall | Tacoma | Washington | United States | 97405 |
| 722 | Franciscan Research Center-Northwest Medical Plaza | Tacoma | Washington | United States | 98405 |
| 723 | MultiCare Tacoma General Hospital | Tacoma | Washington | United States | 98405 |
| 724 | Northwest Medical Specialties PLLC | Tacoma | Washington | United States | 98405 |
| 725 | Tacoma/Valley Radiation Oncology Centers-Saint Joe's | Tacoma | Washington | United States | 98405 |
| 726 | PeaceHealth Southwest Medical Center | Vancouver | Washington | United States | 98664 |
| 727 | Providence Saint Mary Regional Cancer Center | Walla Walla | Washington | United States | 99362 |
| 728 | North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima | Washington | United States | 98902 |
| 729 | Providence Regional Cancer System-Yelm | Yelm | Washington | United States | 98597 |
| 730 | Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin | United States | 53105 |
| 731 | Aurora Health Center-Fond du Lac | Fond Du Lac | Wisconsin | United States | 54937 |
| 732 | Aurora Health Care Germantown Health Center | Germantown | Wisconsin | United States | 53022 |
| 733 | Aurora Cancer Care-Grafton | Grafton | Wisconsin | United States | 53024 |
| 734 | Aurora BayCare Medical Center | Green Bay | Wisconsin | United States | 54311 |
| 735 | UW Cancer Center Johnson Creek | Johnson Creek | Wisconsin | United States | 53038 |
| 736 | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | United States | 53142 |
| 737 | Gundersen Lutheran Medical Center | La Crosse | Wisconsin | United States | 54601 |
| 738 | University of Wisconsin Carbone Cancer Center | Madison | Wisconsin | United States | 53792 |
| 739 | Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin | United States | 54143 |
| 740 | Bay Area Medical Center | Marinette | Wisconsin | United States | 54143 |
| 741 | Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin | United States | 53209 |
| 742 | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | United States | 53215 |
| 743 | Medical College of Wisconsin | Milwaukee | Wisconsin | United States | 53226 |
| 744 | Aurora Sinai Medical Center | Milwaukee | Wisconsin | United States | 53233 |
| 745 | ProHealth D N Greenwald Center | Mukwonago | Wisconsin | United States | 53149 |
| 746 | Cancer Center of Western Wisconsin | New Richmond | Wisconsin | United States | 54017 |
| 747 | ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | United States | 53066 |
| 748 | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | United States | 54904 |
| 749 | Aurora Cancer Care-Racine | Racine | Wisconsin | United States | 53406 |
| 750 | Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin | United States | 53081 |
| 751 | Aurora Medical Center in Summit | Summit | Wisconsin | United States | 53066 |
| 752 | Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin | United States | 54241 |
| 753 | ProHealth Waukesha Memorial Hospital | Waukesha | Wisconsin | United States | 53188 |
| 754 | UW Cancer Center at ProHealth Care | Waukesha | Wisconsin | United States | 53188 |
| 755 | Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin | United States | 53226 |
| 756 | Aurora West Allis Medical Center | West Allis | Wisconsin | United States | 53227 |
| 757 | Cheyenne Regional Medical Center-West | Cheyenne | Wyoming | United States | 82001 |
| 758 | Big Horn Basin Cancer Center | Cody | Wyoming | United States | 82414 |
| 759 | Billings Clinic-Cody | Cody | Wyoming | United States | 82414 |
| 760 | Welch Cancer Center | Sheridan | Wyoming | United States | 82801 |
Sponsors and Collaborators
- National Cancer Institute (NCI)
Investigators
- Principal Investigator: Alain P Algazi, Southwest Oncology Group
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT02196181
Other Study ID Numbers:
- NCI-2014-01470
- NCI-2014-01470
- S1221
- S1320
- S1320
- S1320
- U10CA180888
- U10CA032102
- NCT02199730
First Posted:
Jul 21, 2014
Last Update Posted:
Aug 19, 2022
Last Verified:
Jul 1, 2022