Ipilimumab With or Without Bevacizumab in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

• Sponsor: National Cancer Institute (NCI) (NIH)
• Overall Status: Active, not recruiting
• CT.gov ID: NCT01950390
• Collaborator: (none)
• Enrollment: 168
• Locations: 489
• Arms: 2
• Anticipated Duration (Months): 107.6
• Patients Per Site: 0.3
• Patients Per Site Per Month: 0

Study Details

Study Description

Brief Summary

This randomized phase II trial studies how well ipilimumab with or without bevacizumab works in treating patients with stage III-IV melanoma that cannot be removed by surgery. Immunotherapy with monoclonal antibodies, such as ipilimumab and bevacizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

Condition or Disease	Intervention/Treatment	Phase
Stage IIIC Cutaneous Melanoma AJCC v7; Stage IV Cutaneous Melanoma AJCC v6 and v7; Unresectable Melanoma	Biological: Bevacizumab; Biological: Ipilimumab	Phase 2

Detailed Description

PRIMARY OBJECTIVES:

1. To compare overall survival for patients receiving ipilimumab plus bevacizumab versus ipilimumab alone.

SECONDARY OBJECTIVES:

1. To evaluate the progression free survival, response rate and safety in patients receiving ipilimumab plus bevacizumab versus ipilimumab alone.

2. To evaluate the utility of immune related response criteria (irRC) in patients receiving ipilimumab plus bevacizumab versus ipilimumab alone.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM A:

INDUCTION THERAPY: Patients receive ipilimumab intravenously (IV) over 90 minutes on day 1. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity.

MAINTENANCE THERAPY: Beginning cycle 8, patients receive ipilimumab IV over 90 minutes on day

1. Cycles repeat every 12 weeks in the absence of disease progression or unacceptable toxicity.

ARM B:

INDUCTION THERAPY: Patients receive ipilimumab IV over 90 minutes and bevacizumab IV over 30-90 minutes on day 1. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity.

MAINTENANCE THERAPY: Patients receive bevacizumab as in Induction Therapy. Beginning cycle 8, patients also receive ipilimumab IV over 90 minutes on day 1. Cycles repeat every 12 weeks in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up for 5 years.

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 168 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: A Randomized Phase II Trial of Ipilimumab With or Without Bevacizumab in Patients With Unresectable Stage III or Stage IV Melanoma
• Actual Study Start Date: Dec 13, 2013
• Anticipated Primary Completion Date: Dec 1, 2022
• Anticipated Study Completion Date: Dec 1, 2022

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: Arm A (ipilimumab) INDUCTION THERAPY: Patients receive ipilimumab IV over 90 minutes on day 1. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. MAINTENANCE THERAPY: Beginning cycle 8, patients receive ipilimumab IV over 90 minutes on day 1. Cycles repeat every 12 weeks in the absence of disease progression or unacceptable toxicity.	Biological: Ipilimumab; Given IV; Other Names: Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody BMS-734016 Ipilimumab Biosimilar CS1002 MDX-010 MDX-CTLA4 Yervoy
Experimental: Arm B (ipilimumab and bevacizumab) INDUCTION THERAPY: Patients receive ipilimumab IV over 90 minutes and bevacizumab IV over 30-90 minutes on day 1. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. MAINTENANCE THERAPY: Patients receive bevacizumab as in Induction Therapy. Beginning cycle 8, patients also receive ipilimumab IV over 90 minutes on day 1. Cycles repeat every 12 weeks in the absence of disease progression or unacceptable toxicity.	Biological: Bevacizumab; Given IV; Other Names: ABP 215 Anti-VEGF Anti-VEGF Humanized Monoclonal Antibody Anti-VEGF Monoclonal Antibody SIBP04 Anti-VEGF rhuMAb Avastin Bevacizumab awwb Bevacizumab Biosimilar ABP 215 Bevacizumab Biosimilar BEVZ92 Bevacizumab Biosimilar BI 695502 Bevacizumab Biosimilar CBT 124 Bevacizumab Biosimilar CT-P16 Bevacizumab Biosimilar FKB238 Bevacizumab Biosimilar GB-222 Bevacizumab Biosimilar HD204 Bevacizumab Biosimilar HLX04 Bevacizumab Biosimilar IBI305 Bevacizumab Biosimilar LY01008 Bevacizumab Biosimilar MIL60 Bevacizumab Biosimilar Mvasi Bevacizumab Biosimilar MYL-1402O Bevacizumab Biosimilar QL 1101 Bevacizumab Biosimilar RPH-001 Bevacizumab Biosimilar SCT501 Bevacizumab Biosimilar Zirabev Bevacizumab-awwb Bevacizumab-bvzr BP102 BP102 Biosimilar HD204 Immunoglobulin G1 (Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF Light Chain, Dimer Mvasi MYL-1402O Recombinant Humanized Anti-VEGF Monoclonal Antibody rhuMab-VEGF SCT501 SIBP 04 SIBP-04 SIBP04 Zirabev ; Biological: Ipilimumab; Given IV; Other Names: Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody BMS-734016 Ipilimumab Biosimilar CS1002 MDX-010 MDX-CTLA4 Yervoy

Outcome Measures

Primary Outcome Measures

1. Overall survival (OS) [Time from randomization to death from any cause, assessed up to 5 years]

   OS distributions will be estimated using the Kaplan-Meier method. The distribution of OS will be compared using the stratified log rank test with one-sided overall type I error rate of 0.100 (adjusting for the one interim analysis) and the hazard ratio of OS will be estimated using the stratified Cox proportional hazard model and one-sided 90% repeated confidence interval will be constructed.

Secondary Outcome Measures

1. Progression-free survival (PFS) [Time from randomization to disease progression or death (whichever occurs first), assessed up to 5 years]

   Evaluated based on international criteria proposed by the Response Evaluation Criteria in Solid Tumors (RECIST) guideline (version 1.1). Will be estimated using the Kaplan-Meier method. PFS distributions will be compared using the log rank test.

2. Response [Up to 5 years]

   Defined by the RECIST guidelines (version 1.1). The Kappa statistics which measures the degree of agreement between the RECIST-based response and of immune related response criteria (irRC) will be estimated. McNemar's test will be used to evaluate the agreement between irRC and RECIST-based clinical response.

3. Incidence of adverse events (AE) [Up to 90 days after completion of study treatment]

   Defined using the Common Terminology Criteria for Adverse Events version 4.0 criteria (version 5.0 effective April 1,2018). Toxicity rate for individual AEs, categorized AEs and worst degree AEs will be compared using the Chi-square of Fisher's exact test. Two-sided p-values will be reported for these comparisons.

4. Immune response [Up to 5 years]

   Assessed using the utility of irRC. McNemar's test will be used to evaluate the agreement between irRC and RECIST-based clinical response. The landmark analysis will be conducted to evaluate the association between PFS/OS and irRC.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Eastern Cooperative Oncology Group (ECOG) performance status: 0 or 1

• Untreated or previously received one treatment regimen for measurable unresectable stage III or stage IV melanoma (American Joint Committee on Cancer [AJCC] 2010) (for BRAF wild-type, and regardless of human leukocyte antigen [HLA] type); untreated or previously received up to two treatment regimens for measurable unresectable stage III or stage IV melanoma (AJCC 2010) (for BRAF mutant, and regardless of HLA type; if 2 prior regimens, one should be a BRAF inhibitor); this does not include any therapies given in the adjuvant setting

• Prior treatment (chemotherapy [chemo], radiation, hormone, and immune therapies) must be completed > 4 weeks prior to randomization (> 6 weeks prior to randomization for nitrosoureas, mitomycin C, and checkpoint inhibitors)

• Patients who received prior therapy with anthracyclines should have a baseline multigated acquisition scan (MUGA) or echocardiogram (echo) with a normal ejection fraction within 28 days prior to randomization

• Patients must have recovered from any acute toxicity associated with prior therapy by the start of study treatment

• Women must not be pregnant or breast-feeding due to the unknown effects on the fetus or infant; all females of childbearing potential must have a blood test or urine study within 2 weeks prior to randomization to rule out pregnancy; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

• All sites of disease must be evaluated within 4 weeks prior to randomization; patients must have measurable disease

• White blood cell (WBC) >= 2000/uL (obtained within 4 weeks prior to randomization)

• Absolute neutrophil count (ANC) >= 1000/uL (obtained within 4 weeks prior to randomization)

• Platelets >= 75 x 10^3/uL (obtained within 4 weeks prior to randomization)

• Hemoglobin >= 9 g/dL (obtained within 4 weeks prior to randomization)

• Creatinine =< 2.0 x upper limit of normal (ULN) (obtained within 4 weeks prior to randomization)

• Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x ULN for patients without liver metastases and =< 5 x ULN for patients with liver metastases (obtained within 4 weeks prior to randomization)

• Serum bilirubin =< 2.0 x ULN (except patients with Gilbert's syndrome, who must have a total bilirubin less than 3.0 mg/dL) (obtained within 4 weeks prior to randomization)

• Patients BRAF mutation status must be known

• No concomitant therapy with any of the following: interleukin (IL) 2, interferon, or other non-study immunotherapy regimens; cytotoxic chemotherapy; immunosuppressive agents; other investigational therapies; or chronic use of systemic corticosteroids; must have been discontinued >= 4 weeks prior to randomization

• No infection with human immunodeficiency virus (HIV); due to the mechanism of action of ipilimumab and bevacizumab, activity and side effects in an immune compromised patient are unknown

• No active infection with hepatitis B

• No active or chronic infection with hepatitis C

• Patients are ineligible if they have any history of central nervous system (CNS) metastases

• Patients are ineligible if they have a history of any other malignancy from which the patient has been disease-free for less than 2 years, with the exception of adequately treated and cured basal or squamous cell skin cancer, superficial bladder cancer or carcinoma in situ of the cervix

• Patients are ineligible if they have a history of autoimmune disease, as follows: patients with a history of inflammatory bowel disease are excluded from this study as are patients with a history of symptomatic disease (e.g., rheumatoid arthritis, systemic progressive sclerosis [scleroderma], systemic lupus erythematosus, autoimmune vasculitis [e.g., Wegener's granulomatosis]); patients with motor neuropathy considered of autoimmune origin (e.g., Guillain-Barre syndrome and myasthenia gravis) are excluded; patients with a history of autoimmune thyroiditis are eligible if their current thyroid disorder is treated and stable with replacement or other medical therapy

• Patients are ineligible if they have an active infection

• Patients are ineligible if they have a history of prior treatment with ipilimumab, bevacizumab, or prior tumor CD137 agonist or CTLA-4 inhibitor or agonist; patients may be treatment naive or have had one prior systemic therapy for metastatic disease as outlined in the eligibility criteria; patients may have received PD-1 or PD-L1 as per current protocol eligibility, although they are not currently commercially approved in the front line setting

• Patients are ineligible if they have a history of any underlying medical or psychiatric conditions or require any medications or treatment that in the opinion of the principal investigator may interfere with compliance, make the administration of study drug hazardous or obscure the interpretation of adverse events, such as a condition associated with frequent diarrhea

• Patients are ineligible if they have any concurrent medical condition requiring the use of systemic steroids; (use of inhaled or topical steroids is acceptable)

• Patients are ineligible if they have inadequately controlled hypertension (defined as systolic blood pressure > 150 and/or diastolic blood pressure > 100 mmHg on antihypertensive medications)

• Patients are excluded if they have any prior history of hypertensive crisis or hypertensive encephalopathy

• Patients are excluded if they have New York Heart Association (NYHA) grade II or greater congestive heart failure

• Patients are excluded if they have a history of myocardial infarction or unstable angina within 6 months prior to randomization

• Patients are excluded if they have a history of stroke or transient ischemic attack within 6 months prior to randomization

• Patients are excluded if they have known significant vascular disease (e.g., aortic aneurysm, aortic dissection)

• Patients are excluded if they have symptomatic peripheral vascular disease

• Patients are excluded if they have evidence of bleeding diathesis or coagulopathy

• Patients are excluded if they have had a surgical procedure or a significant traumatic injury within 28 days prior to randomization

• Patients are excluded if they have had a biopsy or other minor surgical procedure, excluding placement of a vascular access device, within 7 days prior to randomization

• Patients are excluded if they have history of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to randomization

• Patients are excluded if they have a non-healing wound or ulcer

• Patients are excluded if they have proteinuria at screening as demonstrated by either:

• Urine dipstick for proteinuria >= 2+ (patients discovered to have >= 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate =< 1 g of protein in 24 hours to be eligible) OR

• Urine protein: creatinine (UPC) ratio >= 1.0 at screening; for UPC ratio > 1, a 24 hour urine protein should be obtained and the level should be < 1000 mg; NOTE: urine protein should be screened by urine analysis for UPC ratio; a UPC ratio of 1 is roughly equivalent to a 24-hour urine protein of 1 g

• Patients must not have known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies

• Patients are excluded if they have a history of hemoptysis (bright red blood of 1/2 teaspoon or more per episode) within 3 months prior to randomization

• Patients are excluded if they have current, ongoing treatment with full-dose warfarin or its equivalent (i.e., unfractionated and/or low molecular weight heparin); subjects should have not taken full-dose warfarin or equivalent for at least 2 weeks prior to randomization

• Patients are excluded if they have current or recent (within 10 days of enrollment) use of aspirin (> 325 mg/day) or chronic use of other non-steroidal anti-inflammatory drugs (NSAIDs)

• Patients are excluded if they use medications that inhibit platelet function (e.g., dipyridamole, epoprostenol, eptifibatide, clopidogrel, cilostazol, abciximab, ticlopidine, and ibuprofen and related compounds) unless subject has been off treatment for at least 2 weeks prior to randomization

• Patients are excluded if they have known involvement of melanoma within the gastrointestinal tract

• Patients are excluded for any non-oncology vaccine therapy used for prevention of infectious diseases (for up to 1 month before or after any dose of ipilimumab)

• Women of childbearing potential and sexually active males must agree to practice abstinence or use an accepted and effective method of contraception

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	United States	35233
2	University of South Alabama Mitchell Cancer Institute	Mobile	Alabama	United States	36688
3	Kaiser Permanente-Anaheim	Anaheim	California	United States	92806
4	Kaiser Permanente-Baldwin Park	Baldwin Park	California	United States	91706
5	Kaiser Permanente-Bellflower	Bellflower	California	United States	90706
6	Kaiser Permanente-Fontana	Fontana	California	United States	92335
7	Kaiser Permanente - Harbor City	Harbor City	California	United States	90710
8	Kaiser Permanente-Irvine	Irvine	California	United States	92618
9	Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	United States	90027
10	Kaiser Permanente West Los Angeles	Los Angeles	California	United States	90034
11	Kaiser Permanente - Panorama City	Panorama City	California	United States	91402
12	Kaiser Permanente-Riverside	Riverside	California	United States	92505
13	Kaiser Permanente-San Diego Mission	San Diego	California	United States	92108
14	Kaiser Permanente-San Diego Zion	San Diego	California	United States	92120
15	Kaiser Permanente-San Marcos	San Marcos	California	United States	92078
16	Kaiser Permanente-Woodland Hills	Woodland Hills	California	United States	91367
17	Smilow Cancer Hospital Care Center at Saint Francis	Hartford	Connecticut	United States	06105
18	Eastern Connecticut Hematology and Oncology Associates	Norwich	Connecticut	United States	06360
19	Stamford Hospital/Bennett Cancer Center	Stamford	Connecticut	United States	06904
20	Beebe Medical Center	Lewes	Delaware	United States	19958
21	Christiana Gynecologic Oncology LLC	Newark	Delaware	United States	19713
22	Delaware Clinical and Laboratory Physicians PA	Newark	Delaware	United States	19713
23	Helen F Graham Cancer Center	Newark	Delaware	United States	19713
24	Medical Oncology Hematology Consultants PA	Newark	Delaware	United States	19713
25	Christiana Care Health System-Christiana Hospital	Newark	Delaware	United States	19718
26	Beebe Health Campus	Rehoboth Beach	Delaware	United States	19971
27	TidalHealth Nanticoke / Allen Cancer Center	Seaford	Delaware	United States	19973
28	Christiana Care Health System-Wilmington Hospital	Wilmington	Delaware	United States	19801
29	MedStar Georgetown University Hospital	Washington	District of Columbia	United States	20007
30	Lakeland Regional Health Hollis Cancer Center	Lakeland	Florida	United States	33805
31	Mount Sinai Medical Center	Miami Beach	Florida	United States	33140
32	Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	United States	30322
33	Lewis Cancer and Research Pavilion at Saint Joseph's/Candler	Savannah	Georgia	United States	31405
34	Pali Momi Medical Center	'Aiea	Hawaii	United States	96701
35	Queen's Cancer Center - Pearlridge	'Aiea	Hawaii	United States	96701
36	The Cancer Center of Hawaii-Pali Momi	'Aiea	Hawaii	United States	96701
37	Hawaii Cancer Care Inc - Waterfront Plaza	Honolulu	Hawaii	United States	96813
38	Queen's Medical Center	Honolulu	Hawaii	United States	96813
39	Straub Clinic and Hospital	Honolulu	Hawaii	United States	96813
40	University of Hawaii Cancer Center	Honolulu	Hawaii	United States	96813
41	Hawaii Cancer Care Inc-Liliha	Honolulu	Hawaii	United States	96817
42	Kuakini Medical Center	Honolulu	Hawaii	United States	96817
43	Queen's Cancer Center - Kuakini	Honolulu	Hawaii	United States	96817
44	The Cancer Center of Hawaii-Liliha	Honolulu	Hawaii	United States	96817
45	Kapiolani Medical Center for Women and Children	Honolulu	Hawaii	United States	96826
46	Wilcox Memorial Hospital and Kauai Medical Clinic	Lihue	Hawaii	United States	96766
47	Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	United States	83706
48	Saint Alphonsus Cancer Care Center-Caldwell	Caldwell	Idaho	United States	83605
49	Kootenai Health - Coeur d'Alene	Coeur d'Alene	Idaho	United States	83814
50	Walter Knox Memorial Hospital	Emmett	Idaho	United States	83617
51	Idaho Urologic Institute-Meridian	Meridian	Idaho	United States	83642
52	Saint Alphonsus Medical Center-Nampa	Nampa	Idaho	United States	83686
53	Kootenai Clinic Cancer Services - Post Falls	Post Falls	Idaho	United States	83854
54	Kootenai Cancer Clinic	Sandpoint	Idaho	United States	83864
55	Rush - Copley Medical Center	Aurora	Illinois	United States	60504
56	Saint Joseph Medical Center	Bloomington	Illinois	United States	61701
57	Illinois CancerCare-Bloomington	Bloomington	Illinois	United States	61704
58	Illinois CancerCare-Canton	Canton	Illinois	United States	61520
59	Memorial Hospital of Carbondale	Carbondale	Illinois	United States	62902
60	SIH Cancer Institute	Carterville	Illinois	United States	62918
61	Illinois CancerCare-Carthage	Carthage	Illinois	United States	62321
62	Centralia Oncology Clinic	Centralia	Illinois	United States	62801
63	Northwestern University	Chicago	Illinois	United States	60611
64	UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital	Chicago	Illinois	United States	60657
65	Carle on Vermilion	Danville	Illinois	United States	61832
66	Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	United States	62526
67	Decatur Memorial Hospital	Decatur	Illinois	United States	62526
68	Heartland Cancer Research NCORP	Decatur	Illinois	United States	62526
69	Carle Physician Group-Effingham	Effingham	Illinois	United States	62401
70	Crossroads Cancer Center	Effingham	Illinois	United States	62401
71	Illinois CancerCare-Eureka	Eureka	Illinois	United States	61530
72	NorthShore University HealthSystem-Evanston Hospital	Evanston	Illinois	United States	60201
73	Illinois CancerCare-Galesburg	Galesburg	Illinois	United States	61401
74	Western Illinois Cancer Treatment Center	Galesburg	Illinois	United States	61401
75	NorthShore University HealthSystem-Glenbrook Hospital	Glenview	Illinois	United States	60026
76	Hematology Oncology Associates of Illinois-Highland Park	Highland Park	Illinois	United States	60035
77	NorthShore University HealthSystem-Highland Park Hospital	Highland Park	Illinois	United States	60035
78	AMITA Health Cancer Institute and Outpatient Center	Hinsdale	Illinois	United States	60521
79	Hinsdale Hematology Oncology Associates Incorporated	Hinsdale	Illinois	United States	60521
80	Duly Health and Care Joliet	Joliet	Illinois	United States	60435
81	Presence Saint Mary's Hospital	Kankakee	Illinois	United States	60901
82	Illinois CancerCare-Kewanee Clinic	Kewanee	Illinois	United States	61443
83	AMG Libertyville - Oncology	Libertyville	Illinois	United States	60048
84	Illinois CancerCare-Macomb	Macomb	Illinois	United States	61455
85	Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	United States	61938
86	Garneau, Stewart C MD (UIA Investigator)	Moline	Illinois	United States	61265
87	Porubcin, Michael MD (UIA Investigator)	Moline	Illinois	United States	61265
88	Spector, David MD (UIA Investigator)	Moline	Illinois	United States	61265
89	Trinity Medical Center	Moline	Illinois	United States	61265
90	Illinois CancerCare-Monmouth	Monmouth	Illinois	United States	61462
91	Good Samaritan Regional Health Center	Mount Vernon	Illinois	United States	62864
92	Illinois Cancer Specialists-Niles	Niles	Illinois	United States	60714
93	Carle Cancer Institute Normal	Normal	Illinois	United States	61761
94	Cancer Care Center of O'Fallon	O'Fallon	Illinois	United States	62269
95	Illinois CancerCare-Ottawa Clinic	Ottawa	Illinois	United States	61350
96	Ottawa Regional Hospital and Healthcare Center	Ottawa	Illinois	United States	61350
97	Radiation Oncology of Northern Illinois	Ottawa	Illinois	United States	61350
98	Illinois CancerCare-Pekin	Pekin	Illinois	United States	61554
99	OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center	Pekin	Illinois	United States	61554
100	Proctor Hospital	Peoria	Illinois	United States	61614
101	Illinois CancerCare-Peoria	Peoria	Illinois	United States	61615
102	OSF Saint Francis Radiation Oncology at Peoria Cancer Center	Peoria	Illinois	United States	61615
103	Methodist Medical Center of Illinois	Peoria	Illinois	United States	61636
104	OSF Saint Francis Medical Center	Peoria	Illinois	United States	61637
105	Illinois CancerCare-Peru	Peru	Illinois	United States	61354
106	Valley Radiation Oncology	Peru	Illinois	United States	61354
107	Illinois CancerCare-Princeton	Princeton	Illinois	United States	61356
108	SwedishAmerican Regional Cancer Center/ACT	Rockford	Illinois	United States	61114
109	Hematology Oncology Associates of Illinois - Skokie	Skokie	Illinois	United States	60076
110	North Shore Medical Center	Skokie	Illinois	United States	60076
111	Central Illinois Hematology Oncology Center	Springfield	Illinois	United States	62702
112	Southern Illinois University School of Medicine	Springfield	Illinois	United States	62702
113	Springfield Clinic	Springfield	Illinois	United States	62702
114	Memorial Medical Center	Springfield	Illinois	United States	62781
115	Southwest Illinois Health Services LLP	Swansea	Illinois	United States	62226
116	Carle Cancer Center	Urbana	Illinois	United States	61801
117	The Carle Foundation Hospital	Urbana	Illinois	United States	61801
118	Rush-Copley Healthcare Center	Yorkville	Illinois	United States	60560
119	Indiana University/Melvin and Bren Simon Cancer Center	Indianapolis	Indiana	United States	46202
120	Franciscan Saint Anthony Health-Michigan City	Michigan City	Indiana	United States	46360
121	Woodland Cancer Care Center	Michigan City	Indiana	United States	46360
122	Reid Health	Richmond	Indiana	United States	47374
123	Mary Greeley Medical Center	Ames	Iowa	United States	50010
124	McFarland Clinic PC - Ames	Ames	Iowa	United States	50010
125	Constantinou, Costas L MD (UIA Investigator)	Bettendorf	Iowa	United States	52722
126	McFarland Clinic PC-Boone	Boone	Iowa	United States	50036
127	Medical Oncology and Hematology Associates-West Des Moines	Clive	Iowa	United States	50325
128	Iowa Methodist Medical Center	Des Moines	Iowa	United States	50309
129	Medical Oncology and Hematology Associates-Des Moines	Des Moines	Iowa	United States	50309
130	Medical Oncology and Hematology Associates-Laurel	Des Moines	Iowa	United States	50314
131	Iowa Lutheran Hospital	Des Moines	Iowa	United States	50316
132	JCHC McCreery Cancer Center	Fairfield	Iowa	United States	52556
133	McFarland Clinic PC-Trinity Cancer Center	Fort Dodge	Iowa	United States	50501
134	McFarland Clinic PC-Jefferson	Jefferson	Iowa	United States	50129
135	McFarland Clinic PC-Marshalltown	Marshalltown	Iowa	United States	50158
136	Mercy Medical Center - North Iowa	Mason City	Iowa	United States	50401
137	Ottumwa Regional Health Center	Ottumwa	Iowa	United States	52501
138	Siouxland Regional Cancer Center	Sioux City	Iowa	United States	51101
139	Mercy Medical Center-Sioux City	Sioux City	Iowa	United States	51102
140	Saint Luke's Regional Medical Center	Sioux City	Iowa	United States	51104
141	Methodist West Hospital	West Des Moines	Iowa	United States	50266-7700
142	Cancer Center of Kansas - Chanute	Chanute	Kansas	United States	66720
143	Cancer Center of Kansas - Dodge City	Dodge City	Kansas	United States	67801
144	Cancer Center of Kansas - El Dorado	El Dorado	Kansas	United States	67042
145	Cancer Center of Kansas - Fort Scott	Fort Scott	Kansas	United States	66701
146	Cancer Center of Kansas-Independence	Independence	Kansas	United States	67301
147	Cancer Center of Kansas-Kingman	Kingman	Kansas	United States	67068
148	Lawrence Memorial Hospital	Lawrence	Kansas	United States	66044
149	Cancer Center of Kansas-Liberal	Liberal	Kansas	United States	67905
150	Cancer Center of Kansas-Manhattan	Manhattan	Kansas	United States	66502
151	Cancer Center of Kansas - McPherson	McPherson	Kansas	United States	67460
152	Cancer Center of Kansas - Newton	Newton	Kansas	United States	67114
153	Cancer Center of Kansas - Parsons	Parsons	Kansas	United States	67357
154	Cancer Center of Kansas - Pratt	Pratt	Kansas	United States	67124
155	Cancer Center of Kansas - Salina	Salina	Kansas	United States	67401
156	Cancer Center of Kansas - Wellington	Wellington	Kansas	United States	67152
157	Associates In Womens Health	Wichita	Kansas	United States	67208
158	Cancer Center of Kansas-Wichita Medical Arts Tower	Wichita	Kansas	United States	67208
159	Ascension Via Christi Hospitals Wichita	Wichita	Kansas	United States	67214
160	Cancer Center of Kansas - Wichita	Wichita	Kansas	United States	67214
161	Wichita NCI Community Oncology Research Program	Wichita	Kansas	United States	67214
162	Cancer Center of Kansas - Winfield	Winfield	Kansas	United States	67156
163	Oncology Hematology Care Inc-Crestview	Crestview Hills	Kentucky	United States	41017
164	The James Graham Brown Cancer Center at University of Louisville	Louisville	Kentucky	United States	40202
165	LSU Health Baton Rouge-North Clinic	Baton Rouge	Louisiana	United States	70805
166	Louisiana Hematology Oncology Associates LLC	Baton Rouge	Louisiana	United States	70809
167	Mary Bird Perkins Cancer Center	Baton Rouge	Louisiana	United States	70809
168	Our Lady of the Lake Physicians Group - Medical Oncology	Baton Rouge	Louisiana	United States	70809
169	Mary Bird Perkins Cancer Center - Covington	Covington	Louisiana	United States	70433
170	Mary Bird Perkins Cancer Center - Houma	Houma	Louisiana	United States	70360
171	Harold Alfond Center for Cancer Care	Augusta	Maine	United States	04330
172	Eastern Maine Medical Center	Bangor	Maine	United States	04401
173	Lafayette Family Cancer Center-EMMC	Brewer	Maine	United States	04412
174	Penobscot Bay Medical Center	Rockport	Maine	United States	04856
175	MedStar Franklin Square Medical Center/Weinberg Cancer Institute	Baltimore	Maryland	United States	21237
176	Massachusetts General Hospital Cancer Center	Boston	Massachusetts	United States	02114
177	Brigham and Women's Hospital	Boston	Massachusetts	United States	02115
178	Beth Israel Deaconess Medical Center	Boston	Massachusetts	United States	02215
179	Dana-Farber Cancer Institute	Boston	Massachusetts	United States	02215
180	Baystate Medical Center	Springfield	Massachusetts	United States	01199
181	Bixby Medical Center	Adrian	Michigan	United States	49221
182	Hickman Cancer Center	Adrian	Michigan	United States	49221
183	Michigan Cancer Research Consortium NCORP	Ann Arbor	Michigan	United States	48106
184	Saint Joseph Mercy Hospital	Ann Arbor	Michigan	United States	48106
185	University of Michigan Comprehensive Cancer Center	Ann Arbor	Michigan	United States	48109
186	Bronson Battle Creek	Battle Creek	Michigan	United States	49017
187	Saint Joseph Mercy Brighton	Brighton	Michigan	United States	48114
188	Trinity Health IHA Medical Group Hematology Oncology - Brighton	Brighton	Michigan	United States	48114
189	Saint Joseph Mercy Canton	Canton	Michigan	United States	48188
190	Trinity Health IHA Medical Group Hematology Oncology - Canton	Canton	Michigan	United States	48188
191	Caro Cancer Center	Caro	Michigan	United States	48723
192	Saint Joseph Mercy Chelsea	Chelsea	Michigan	United States	48118
193	Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital	Chelsea	Michigan	United States	48118
194	Hematology Oncology Consultants-Clarkston	Clarkston	Michigan	United States	48346
195	Newland Medical Associates-Clarkston	Clarkston	Michigan	United States	48346
196	Beaumont Hospital - Dearborn	Dearborn	Michigan	United States	48124
197	Wayne State University/Karmanos Cancer Institute	Detroit	Michigan	United States	48201
198	Ascension Saint John Hospital	Detroit	Michigan	United States	48236
199	Great Lakes Cancer Management Specialists-Doctors Park	East China Township	Michigan	United States	48054
200	Genesee Cancer and Blood Disease Treatment Center	Flint	Michigan	United States	48503
201	Genesee Hematology Oncology PC	Flint	Michigan	United States	48503
202	Genesys Hurley Cancer Institute	Flint	Michigan	United States	48503
203	Hurley Medical Center	Flint	Michigan	United States	48503
204	Mercy Health Saint Mary's	Grand Rapids	Michigan	United States	49503
205	Spectrum Health at Butterworth Campus	Grand Rapids	Michigan	United States	49503
206	Academic Hematology Oncology Specialists	Grosse Pointe Woods	Michigan	United States	48236
207	Great Lakes Cancer Management Specialists-Van Elslander Cancer Center	Grosse Pointe Woods	Michigan	United States	48236
208	Michigan Breast Specialists-Grosse Pointe Woods	Grosse Pointe Woods	Michigan	United States	48236
209	Allegiance Health	Jackson	Michigan	United States	49201
210	Bronson Methodist Hospital	Kalamazoo	Michigan	United States	49007
211	West Michigan Cancer Center	Kalamazoo	Michigan	United States	49007
212	Borgess Medical Center	Kalamazoo	Michigan	United States	49048
213	Sparrow Hospital	Lansing	Michigan	United States	48912
214	Hope Cancer Clinic	Livonia	Michigan	United States	48154
215	Trinity Health Saint Mary Mercy Livonia Hospital	Livonia	Michigan	United States	48154
216	Great Lakes Cancer Management Specialists-Macomb Medical Campus	Macomb	Michigan	United States	48044
217	Michigan Breast Specialists-Macomb Township	Macomb	Michigan	United States	48044
218	Saint Mary's Oncology/Hematology Associates of Marlette	Marlette	Michigan	United States	48453
219	Mercy Memorial Hospital	Monroe	Michigan	United States	48162
220	Toledo Clinic Cancer Centers-Monroe	Monroe	Michigan	United States	48162
221	Mercy Health Mercy Campus	Muskegon	Michigan	United States	49444
222	Lakeland Hospital Niles	Niles	Michigan	United States	49120
223	21st Century Oncology-Pontiac	Pontiac	Michigan	United States	48341
224	Hope Cancer Center	Pontiac	Michigan	United States	48341
225	Newland Medical Associates-Pontiac	Pontiac	Michigan	United States	48341
226	Saint Joseph Mercy Oakland	Pontiac	Michigan	United States	48341
227	Lake Huron Medical Center	Port Huron	Michigan	United States	48060
228	Spectrum Health Reed City Hospital	Reed City	Michigan	United States	49677
229	Great Lakes Cancer Management Specialists-Rochester Hills	Rochester Hills	Michigan	United States	48309
230	Ascension Saint Mary's Hospital	Saginaw	Michigan	United States	48601
231	Oncology Hematology Associates of Saginaw Valley PC	Saginaw	Michigan	United States	48604
232	Lakeland Medical Center Saint Joseph	Saint Joseph	Michigan	United States	49085
233	Marie Yeager Cancer Center	Saint Joseph	Michigan	United States	49085
234	Bhadresh Nayak MD PC-Sterling Heights	Sterling Heights	Michigan	United States	48312
235	Ascension Saint Joseph Hospital	Tawas City	Michigan	United States	48764
236	Munson Medical Center	Traverse City	Michigan	United States	49684
237	Advanced Breast Care Center PLLC	Warren	Michigan	United States	48088
238	Great Lakes Cancer Management Specialists-Macomb Professional Building	Warren	Michigan	United States	48093
239	Macomb Hematology Oncology PC	Warren	Michigan	United States	48093
240	Michigan Breast Specialists-Warren	Warren	Michigan	United States	48093
241	Saint John Macomb-Oakland Hospital	Warren	Michigan	United States	48093
242	Saint Mary's Oncology/Hematology Associates of West Branch	West Branch	Michigan	United States	48661
243	Metro Health Hospital	Wyoming	Michigan	United States	49519
244	Huron Gastroenterology PC	Ypsilanti	Michigan	United States	48106
245	Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus	Ypsilanti	Michigan	United States	48197
246	Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	United States	56601
247	Coborn Cancer Center at Saint Cloud Hospital	Saint Cloud	Minnesota	United States	56303
248	Saint Cloud Hospital	Saint Cloud	Minnesota	United States	56303
249	Parkland Health Center-Bonne Terre	Bonne Terre	Missouri	United States	63628
250	Cox Cancer Center Branson	Branson	Missouri	United States	65616
251	Saint Francis Medical Center	Cape Girardeau	Missouri	United States	63703
252	Southeast Cancer Center	Cape Girardeau	Missouri	United States	63703
253	Capital Region Southwest Campus	Jefferson City	Missouri	United States	65109
254	Freeman Health System	Joplin	Missouri	United States	64804
255	Mercy Hospital Joplin	Joplin	Missouri	United States	64804
256	Delbert Day Cancer Institute at PCRMC	Rolla	Missouri	United States	65401
257	Mercy Clinic-Rolla-Cancer and Hematology	Rolla	Missouri	United States	65401
258	Saint Louis Cancer and Breast Institute-South City	Saint Louis	Missouri	United States	63109
259	Missouri Baptist Medical Center	Saint Louis	Missouri	United States	63131
260	Mercy Hospital Saint Louis	Saint Louis	Missouri	United States	63141
261	Sainte Genevieve County Memorial Hospital	Sainte Genevieve	Missouri	United States	63670
262	Mercy Hospital Springfield	Springfield	Missouri	United States	65804
263	CoxHealth South Hospital	Springfield	Missouri	United States	65807
264	Missouri Baptist Sullivan Hospital	Sullivan	Missouri	United States	63080
265	Missouri Baptist Outpatient Center-Sunset Hills	Sunset Hills	Missouri	United States	63127
266	Community Hospital of Anaconda	Anaconda	Montana	United States	59711
267	Billings Clinic Cancer Center	Billings	Montana	United States	59101
268	Saint Vincent Healthcare	Billings	Montana	United States	59101
269	Montana Cancer Consortium NCORP	Billings	Montana	United States	59102
270	Bozeman Deaconess Hospital	Bozeman	Montana	United States	59715
271	Saint James Community Hospital and Cancer Treatment Center	Butte	Montana	United States	59701
272	Benefis Healthcare- Sletten Cancer Institute	Great Falls	Montana	United States	59405
273	Great Falls Clinic	Great Falls	Montana	United States	59405
274	Saint Peter's Community Hospital	Helena	Montana	United States	59601
275	Kalispell Regional Medical Center	Kalispell	Montana	United States	59901
276	Saint Patrick Hospital - Community Hospital	Missoula	Montana	United States	59802
277	Community Medical Hospital	Missoula	Montana	United States	59804
278	Nebraska Hematology and Oncology	Lincoln	Nebraska	United States	68506
279	Nebraska Cancer Research Center	Lincoln	Nebraska	United States	68510
280	Southeast Nebraska Cancer Center - 68th Street Place	Lincoln	Nebraska	United States	68516
281	Faith Regional Health Services Carson Cancer Center	Norfolk	Nebraska	United States	68701
282	Great Plains Health Callahan Cancer Center	North Platte	Nebraska	United States	69101
283	Missouri Valley Cancer Consortium	Omaha	Nebraska	United States	68106
284	Alegent Health Immanuel Medical Center	Omaha	Nebraska	United States	68122
285	Alegent Health Bergan Mercy Medical Center	Omaha	Nebraska	United States	68124
286	Nebraska Cancer Specialists - Omaha	Omaha	Nebraska	United States	68124
287	Alegent Health Lakeside Hospital	Omaha	Nebraska	United States	68130
288	Oncology Hematology West PC	Omaha	Nebraska	United States	68130
289	Urology Cancer Center PC	Omaha	Nebraska	United States	68130
290	Creighton University Medical Center	Omaha	Nebraska	United States	68131
291	Regional West Medical Center Cancer Center	Scottsbluff	Nebraska	United States	69361
292	Cancer and Blood Specialists-Henderson	Henderson	Nevada	United States	89052
293	Comprehensive Cancer Centers of Nevada - Henderson	Henderson	Nevada	United States	89052
294	Las Vegas Cancer Center-Henderson	Henderson	Nevada	United States	89052
295	Comprehensive Cancer Centers of Nevada-Southeast Henderson	Henderson	Nevada	United States	89074
296	GenesisCare USA - Henderson	Henderson	Nevada	United States	89074
297	University Medical Center of Southern Nevada	Las Vegas	Nevada	United States	89102
298	Cancer and Blood Specialists-Shadow	Las Vegas	Nevada	United States	89106
299	Radiation Oncology Centers of Nevada Central	Las Vegas	Nevada	United States	89106
300	GenesisCare USA - Las Vegas	Las Vegas	Nevada	United States	89109
301	HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway	Las Vegas	Nevada	United States	89109
302	HealthCare Partners Medical Group Oncology/Hematology-San Martin	Las Vegas	Nevada	United States	89113
303	Radiation Oncology Centers of Nevada Southeast	Las Vegas	Nevada	United States	89119
304	Cancer Therapy and Integrative Medicine	Las Vegas	Nevada	United States	89121
305	Cancer and Blood Specialists-Tenaya	Las Vegas	Nevada	United States	89128
306	Comprehensive Cancer Centers of Nevada - Northwest	Las Vegas	Nevada	United States	89128
307	GenesisCare USA - Vegas Tenaya	Las Vegas	Nevada	United States	89128
308	HealthCare Partners Medical Group Oncology/Hematology-Tenaya	Las Vegas	Nevada	United States	89128
309	Comprehensive Cancer Centers of Nevada-Summerlin	Las Vegas	Nevada	United States	89144
310	Las Vegas Cancer Center-Medical Center	Las Vegas	Nevada	United States	89148-2405
311	Comprehensive Cancer Centers of Nevada	Las Vegas	Nevada	United States	89148
312	GenesisCare USA - Fort Apache	Las Vegas	Nevada	United States	89148
313	OptumCare Cancer Care at Fort Apache	Las Vegas	Nevada	United States	89148
314	HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills	Las Vegas	Nevada	United States	89149
315	Comprehensive Cancer Centers of Nevada - Central Valley	Las Vegas	Nevada	United States	89169
316	Nevada Cancer Research Foundation NCORP	Las Vegas	Nevada	United States	89169
317	Dartmouth Hitchcock Medical Center	Lebanon	New Hampshire	United States	03756
318	Norris Cotton Cancer Center-Manchester	Manchester	New Hampshire	United States	03102
319	Norris Cotton Cancer Center-Nashua	Nashua	New Hampshire	United States	03063
320	Hackensack University Medical Center	Hackensack	New Jersey	United States	07601
321	Inspira Medical Center Mullica Hill	Mullica Hill	New Jersey	United States	08062
322	Inspira Medical Center Vineland	Vineland	New Jersey	United States	08360
323	Hematology Oncology Associates of Central New York-Auburn	Auburn	New York	United States	13021
324	Montefiore Medical Center-Einstein Campus	Bronx	New York	United States	10461
325	Montefiore Medical Center-Weiler Hospital	Bronx	New York	United States	10461
326	Montefiore Medical Center - Moses Campus	Bronx	New York	United States	10467
327	Mary Imogene Bassett Hospital	Cooperstown	New York	United States	13326
328	Hematology Oncology Associates of Central New York-East Syracuse	East Syracuse	New York	United States	13057
329	Hematology Oncology Associates of Central New York-Onondaga Hill	Syracuse	New York	United States	13215
330	Dickstein Cancer Treatment Center	White Plains	New York	United States	10601
331	Southeastern Medical Oncology Center-Clinton	Clinton	North Carolina	United States	28328
332	Southeastern Medical Oncology Center-Goldsboro	Goldsboro	North Carolina	United States	27534
333	Wayne Memorial Hospital	Goldsboro	North Carolina	United States	27534
334	Hendersonville Hematology and Oncology at Pardee	Hendersonville	North Carolina	United States	28791
335	Margaret R Pardee Memorial Hospital	Hendersonville	North Carolina	United States	28791
336	Southeastern Medical Oncology Center-Jacksonville	Jacksonville	North Carolina	United States	28546
337	Vidant Oncology-Kinston	Kinston	North Carolina	United States	28501
338	Iredell Memorial Hospital	Statesville	North Carolina	United States	28677
339	Sanford Bismarck Medical Center	Bismarck	North Dakota	United States	58501
340	Sanford Broadway Medical Center	Fargo	North Dakota	United States	58122
341	Sanford Clinic North-Fargo	Fargo	North Dakota	United States	58122
342	Sanford Roger Maris Cancer Center	Fargo	North Dakota	United States	58122
343	Altru Cancer Center	Grand Forks	North Dakota	United States	58201
344	Summa Health System - Akron Campus	Akron	Ohio	United States	44304
345	Strecker Cancer Center-Belpre	Belpre	Ohio	United States	45714
346	Toledo Clinic Cancer Centers-Bowling Green	Bowling Green	Ohio	United States	43402
347	Aultman Health Foundation	Canton	Ohio	United States	44710
348	Dayton Physicians LLC-Miami Valley South	Centerville	Ohio	United States	45459
349	Miami Valley Hospital South	Centerville	Ohio	United States	45459
350	Adena Regional Medical Center	Chillicothe	Ohio	United States	45601
351	Oncology Hematology Care Inc-Eden Park	Cincinnati	Ohio	United States	45202
352	Oncology Hematology Care Inc-Mercy West	Cincinnati	Ohio	United States	45211
353	The Christ Hospital	Cincinnati	Ohio	United States	45219
354	Oncology Hematology Care Inc-Anderson	Cincinnati	Ohio	United States	45230
355	Oncology Hematology Care Inc-Kenwood	Cincinnati	Ohio	United States	45236
356	Oncology Hematology Care Inc-Blue Ash	Cincinnati	Ohio	United States	45242
357	Case Western Reserve University	Cleveland	Ohio	United States	44106
358	Mount Carmel East Hospital	Columbus	Ohio	United States	43213
359	Columbus Oncology and Hematology Associates Inc	Columbus	Ohio	United States	43214
360	Riverside Methodist Hospital	Columbus	Ohio	United States	43214
361	Columbus NCI Community Oncology Research Program	Columbus	Ohio	United States	43215
362	Grant Medical Center	Columbus	Ohio	United States	43215
363	The Mark H Zangmeister Center	Columbus	Ohio	United States	43219
364	Mount Carmel Health Center West	Columbus	Ohio	United States	43222
365	Doctors Hospital	Columbus	Ohio	United States	43228
366	Good Samaritan Hospital - Dayton	Dayton	Ohio	United States	45406
367	Miami Valley Hospital	Dayton	Ohio	United States	45409
368	Dayton Physician LLC-Miami Valley Hospital North	Dayton	Ohio	United States	45415
369	Miami Valley Hospital North	Dayton	Ohio	United States	45415
370	Delaware Health Center-Grady Cancer Center	Delaware	Ohio	United States	43015
371	Delaware Radiation Oncology	Delaware	Ohio	United States	43015
372	Grady Memorial Hospital	Delaware	Ohio	United States	43015
373	Oncology Hematology Care Inc-Healthplex	Fairfield	Ohio	United States	45014
374	Armes Family Cancer Center	Findlay	Ohio	United States	45840
375	Blanchard Valley Hospital	Findlay	Ohio	United States	45840
376	Orion Cancer Care	Findlay	Ohio	United States	45840
377	Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	United States	45005-1066
378	Dayton Physicians LLC-Atrium	Franklin	Ohio	United States	45005
379	Dayton Physicians LLC-Wayne	Greenville	Ohio	United States	45331
380	Wayne Hospital	Greenville	Ohio	United States	45331
381	Greater Dayton Cancer Center	Kettering	Ohio	United States	45409
382	Kettering Medical Center	Kettering	Ohio	United States	45429
383	Fairfield Medical Center	Lancaster	Ohio	United States	43130
384	Lancaster Radiation Oncology	Lancaster	Ohio	United States	43130
385	Lima Memorial Hospital	Lima	Ohio	United States	45804
386	Marietta Memorial Hospital	Marietta	Ohio	United States	45750
387	OhioHealth Marion General Hospital	Marion	Ohio	United States	43302
388	Toledo Clinic Cancer Centers-Maumee	Maumee	Ohio	United States	43537
389	Toledo Radiation Oncology at Northwest Ohio Onocolgy Center	Maumee	Ohio	United States	43537
390	Dayton Physicians LLC-Signal Point	Middletown	Ohio	United States	45042
391	Knox Community Hospital	Mount Vernon	Ohio	United States	43050
392	Licking Memorial Hospital	Newark	Ohio	United States	43055
393	Newark Radiation Oncology	Newark	Ohio	United States	43055
394	Saint Charles Hospital	Oregon	Ohio	United States	43616
395	Toledo Clinic Cancer Centers-Oregon	Oregon	Ohio	United States	43616
396	Southern Ohio Medical Center	Portsmouth	Ohio	United States	45662
397	Dayton Physicians LLC-Wilson	Sidney	Ohio	United States	45365
398	Springfield Regional Cancer Center	Springfield	Ohio	United States	45504
399	Springfield Regional Medical Center	Springfield	Ohio	United States	45505
400	ProMedica Flower Hospital	Sylvania	Ohio	United States	43560
401	Mercy Hospital of Tiffin	Tiffin	Ohio	United States	44883
402	ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital	Toledo	Ohio	United States	43606
403	Saint Vincent Mercy Medical Center	Toledo	Ohio	United States	43608
404	University of Toledo	Toledo	Ohio	United States	43614
405	Toledo Community Hospital Oncology Program CCOP	Toledo	Ohio	United States	43617
406	Mercy Health - Saint Anne Hospital	Toledo	Ohio	United States	43623
407	Toledo Clinic Cancer Centers-Toledo	Toledo	Ohio	United States	43623
408	Dayton Physicians LLC-Upper Valley	Troy	Ohio	United States	45373
409	Upper Valley Medical Center	Troy	Ohio	United States	45373
410	Fulton County Health Center	Wauseon	Ohio	United States	43567
411	Saint Ann's Hospital	Westerville	Ohio	United States	43081
412	Genesis Healthcare System Cancer Care Center	Zanesville	Ohio	United States	43701
413	University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	United States	73104
414	Mercy Hospital Oklahoma City	Oklahoma City	Oklahoma	United States	73120
415	Oklahoma Cancer Specialists and Research Institute-Tulsa	Tulsa	Oklahoma	United States	74146
416	Saint Alphonsus Medical Center-Baker City	Baker City	Oregon	United States	97814
417	Saint Alphonsus Medical Center-Ontario	Ontario	Oregon	United States	97914
418	Salem Hospital	Salem	Oregon	United States	97301
419	Jefferson Abington Hospital	Abington	Pennsylvania	United States	19001
420	Lehigh Valley Hospital-Cedar Crest	Allentown	Pennsylvania	United States	18103
421	Lehigh Valley Hospital - Muhlenberg	Bethlehem	Pennsylvania	United States	18017
422	Bryn Mawr Hospital	Bryn Mawr	Pennsylvania	United States	19010
423	Geisinger Medical Center	Danville	Pennsylvania	United States	17822
424	Doylestown Hospital	Doylestown	Pennsylvania	United States	18901
425	Geisinger Medical Center-Cancer Center Hazleton	Hazleton	Pennsylvania	United States	18201
426	Penn State Milton S Hershey Medical Center	Hershey	Pennsylvania	United States	17033-0850
427	Lancaster General Hospital	Lancaster	Pennsylvania	United States	17602
428	Geisinger Medical Oncology-Lewisburg	Lewisburg	Pennsylvania	United States	17837
429	Lewistown Hospital	Lewistown	Pennsylvania	United States	17044
430	Riddle Memorial Hospital	Media	Pennsylvania	United States	19063
431	Paoli Memorial Hospital	Paoli	Pennsylvania	United States	19301
432	Fox Chase Cancer Center	Philadelphia	Pennsylvania	United States	19111
433	University of Pittsburgh Cancer Institute (UPCI)	Pittsburgh	Pennsylvania	United States	15232
434	Geisinger Cancer Services-Pottsville	Pottsville	Pennsylvania	United States	17901
435	Community Medical Center	Scranton	Pennsylvania	United States	18510
436	Scranton Hematology Oncology	Scranton	Pennsylvania	United States	18510
437	Geisinger Medical Oncology-Selinsgrove	Selinsgrove	Pennsylvania	United States	17870
438	Geisinger Medical Group	State College	Pennsylvania	United States	16801
439	Mount Nittany Medical Center	State College	Pennsylvania	United States	16803
440	Chester County Hospital	West Chester	Pennsylvania	United States	19380
441	Reading Hospital	West Reading	Pennsylvania	United States	19611
442	Geisinger Wyoming Valley/Henry Cancer Center	Wilkes-Barre	Pennsylvania	United States	18711
443	Lankenau Medical Center	Wynnewood	Pennsylvania	United States	19096
444	AnMed Health Cancer Center	Anderson	South Carolina	United States	29621
445	Prisma Health Cancer Institute - Spartanburg	Boiling Springs	South Carolina	United States	29316
446	Prisma Health Cancer Institute - Easley	Easley	South Carolina	United States	29640
447	Greenville Health System Cancer Institute-Andrews	Greenville	South Carolina	United States	29601
448	Prisma Health Cancer Institute - Butternut	Greenville	South Carolina	United States	29605
449	Prisma Health Cancer Institute - Faris	Greenville	South Carolina	United States	29605
450	Prisma Health Greenville Memorial Hospital	Greenville	South Carolina	United States	29605
451	Prisma Health Cancer Institute - Eastside	Greenville	South Carolina	United States	29615
452	Prisma Health Cancer Institute - Greer	Greer	South Carolina	United States	29650
453	Prisma Health Cancer Institute - Seneca	Seneca	South Carolina	United States	29672
454	Rapid City Regional Hospital	Rapid City	South Dakota	United States	57701
455	Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	United States	57104
456	Avera Cancer Institute	Sioux Falls	South Dakota	United States	57105
457	Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	United States	57117-5134
458	Fredericksburg Oncology Inc	Fredericksburg	Virginia	United States	22401
459	West Virginia University Healthcare	Morgantown	West Virginia	United States	26506
460	Langlade Hospital and Cancer Center	Antigo	Wisconsin	United States	54409
461	HSHS Sacred Heart Hospital	Eau Claire	Wisconsin	United States	54701
462	Marshfield Clinic Cancer Center at Sacred Heart	Eau Claire	Wisconsin	United States	54701
463	Bellin Memorial Hospital	Green Bay	Wisconsin	United States	54301
464	UW Cancer Center Johnson Creek	Johnson Creek	Wisconsin	United States	53038
465	Gundersen Lutheran Medical Center	La Crosse	Wisconsin	United States	54601
466	University of Wisconsin Carbone Cancer Center	Madison	Wisconsin	United States	53792
467	Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	United States	54449
468	Marshfield Medical Center	Marshfield	Wisconsin	United States	54449
469	Medical College of Wisconsin	Milwaukee	Wisconsin	United States	53226
470	Marshfield Clinic-Minocqua Center	Minocqua	Wisconsin	United States	54548
471	ProHealth D N Greenwald Center	Mukwonago	Wisconsin	United States	53149
472	ProHealth Oconomowoc Memorial Hospital	Oconomowoc	Wisconsin	United States	53066
473	Ascension Saint Mary's Hospital	Rhinelander	Wisconsin	United States	54501
474	Saint Mary's Hospital	Rhinelander	Wisconsin	United States	54501
475	Lakeview Medical Center-Marshfield Clinic	Rice Lake	Wisconsin	United States	54868
476	Marshfield Medical Center-Rice Lake	Rice Lake	Wisconsin	United States	54868
477	Ascension Saint Michael's Hospital	Stevens Point	Wisconsin	United States	54481
478	ProHealth Waukesha Memorial Hospital	Waukesha	Wisconsin	United States	53188
479	UW Cancer Center at ProHealth Care	Waukesha	Wisconsin	United States	53188
480	Aspirus Regional Cancer Center	Wausau	Wisconsin	United States	54401
481	Marshfield Clinic-Wausau Center	Wausau	Wisconsin	United States	54401
482	Ascension Saint Clare's Hospital	Weston	Wisconsin	United States	54476
483	Diagnostic and Treatment Center	Weston	Wisconsin	United States	54476
484	Marshfield Medical Center - Weston	Weston	Wisconsin	United States	54476
485	Aspirus Cancer Care - Wisconsin Rapids	Wisconsin Rapids	Wisconsin	United States	54494
486	Marshfield Clinic - Wisconsin Rapids Center	Wisconsin Rapids	Wisconsin	United States	54494
487	Big Horn Basin Cancer Center	Cody	Wyoming	United States	82414
488	Billings Clinic-Cody	Cody	Wyoming	United States	82414
489	Welch Cancer Center	Sheridan	Wyoming	United States	82801

Sponsors and Collaborators

• National Cancer Institute (NCI)

Investigators

• Principal Investigator: Frank S Hodi, ECOG-ACRIN Cancer Research Group

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: National Cancer Institute (NCI)
• ClinicalTrials.gov Identifier: NCT01950390
• Other Study ID Numbers: NCI-2013-01732; NCI-2013-01732; E3612; ECOG-E3612; E3612; E3612; U10CA180820; U10CA021115; U24CA196172
• First Posted: Sep 25, 2013
• Last Update Posted: Jul 28, 2022
• Last Verified: Jun 1, 2022

• Additional relevant MeSH terms: Melanoma; Skin Neoplasms; Bevacizumab; Antineoplastic Agents, Immunological; Ipilimumab; Endothelial Growth Factors; Antibodies; Immunoglobulins; Antibodies, Monoclonal; Immunoglobulin G

Study Results

No Results Posted as of Jul 28, 2022