Effectiveness of Standard Therapy of Acne Vulgaris
Study Details
Study Description
Brief Summary
This study was to evaluate the effectiveness of standard therapy for acne vulgaris (AV) based on the clinical practice guidelines (CPG) in Indonesia. The main questions it aims to answer were:
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How is the clinical characteristics of patients with AV in dr.Cipto Mangunkusumo Hospital?
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How is the effectiveness of standard therapy for AV based on the CPG in Indonesia in reducing the number of non-inflammatory, inflammatory, and total lesions and degree of acne severity?
The clinical pratice guideline (CPG) used for analysis was CPG by dr.Cipto Mangunkusumo Hospital 2017 in line with the date of patient visit. Data of 724 patients with AV in dr.Cipto Mangunkusumo Hospital as recorded in the medical records were assessed for eligibility. Data of 3-month-follow-up data of included subjects were collected and analyzed.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Objective: To evaluate the effectiveness of standard therapy for acne vulgaris (AV) based on the guidelines in Indonesia Design: An analytical retrospective observational study conducted from April 2023 through July 2023 using medical records of new acne patients between 2017 to 2019 from Dr. Cipto Mangunkusumo National Central General Hospital. A total sample of patients with AV who received standard therapy for acne vulgaris based on the guideline by Dr.Cipto Mangunkusumo Hospital in 2017 and not associated with systemic diseases or drugs were included. Patients were classified into mild, moderate, or severe acne using Lehmann grading system. Primary outcomes were changes in the number of non-inflammatory, inflammatory, and total lesions, and the proportion of acne severity after 3 months of therapy.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| General This research is an observational study. There was no control and experimental group. |
Outcome Measures
Primary Outcome Measures
- Change in non-inflammatory acne lesion count [week-12]
Change in the sum of the number of open and closed comedones
- Change in inflammatory acne lesion count [week-12]
Change in the sum of the number of papules, pustules, nodes, and cysts
- Change in total acne lesioncount [week-12]
Change in the sums of the number of non-inflammatory and inflammatory lesions
- Change in acne severity [week-12]
Change in the acne severity based on Lehmann grading system (2002), which classified acne into mild, moderate, and severe
Eligibility Criteria
Criteria
Inclusion Criteria:
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New patients with acne vulgaris in the year 2017 to 2019
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Complete medical record data of 3-month follow-up, including data of: name, medical record number, sex, age, job, level of education, visit date, number of non-inflammatory, inflammatory, and total acne lesions, diagnosis of acne vulgaris based on Lehmann grading system
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Acne treatment based on clinical practice guideline by dr.Cipto Mangunkusumo Hospital 2017
Exclusion Criteria:
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Follow-up data less than 3 times in 3 months
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Incomplete medical record
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AV diagnosis without data on severity
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History of systemic diseases associated with acne such as polycystic ovarian syndrome and Cushing syndrome
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History of allergy with one or more standard acne therapy based on the clinical practice guideline
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Received acne therapy not aligned with clinical practice guideline by dr.Cipto Mangunkusumo Hospital
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | dr.Cipto Mangunkusumo National Central General Hospital | Jakarta Pusat | Jakarta | Indonesia | 10430 |
Sponsors and Collaborators
- Indonesia University
- Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia
- Ministry of Education, Culture, Research, and Technology of the Republic of Indonesia
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Department of Dermatology and Venereology dr. Cipto Mangunkusumo National Central General Hospital. Clinical Practice Guideline for Acne Vulgaris [Panduan Praktik Klinis Akne Vulgaris]. RSCM; 2017.
- Goh C, Cheng C, Agak G, et al. Acne vulgaris. In: Kang S, Amagai M, Bruckner AL, et al., eds. Fitzpatrick's Dermatology. 9th ed. McGraw-Hill; 2019:1391-1418.
- Lehmann HP, Robinson KA, Andrews JS, Holloway V, Goodman SN. Acne therapy: a methodologic review. J Am Acad Dermatol. 2002 Aug;47(2):231-40. doi: 10.1067/mjd.2002.120912.
- Tan AU, Schlosser BJ, Paller AS. A review of diagnosis and treatment of acne in adult female patients. Int J Womens Dermatol. 2017 Dec 23;4(2):56-71. doi: 10.1016/j.ijwd.2017.10.006. eCollection 2018 Jun.
- Wasitaatmadja SM, Arimuko A, Norawati L, Bernadette I, Legiawati L, eds. Acne Management Guideline in Indonesia: Results Summary of Indonesian Acne Expert Meeting 2015 [ Pedoman Tata Laksana Akne Di Indonesia: Resume Hasil Indonesian Acne Expert Meeting 2015]. 2nd ed. Kelompok Studi Dermatologi Kosmetik Indonesia PERDOSKI; 2016.
- Wasitaatmadja SM, ed. Acne [Akne]. Badan Penerbit Fakultas Kedokteran Universitas Indonesia; 2018.
- Widaty S, Soebono H, Nilasari H, et al., eds. Akne. In: Clinical Practice Guidelines for Dermatology and Venereology Specialists in Indonesia [Panduan praktik klinis bagi dokter spesialis kulit dan kelamin di Indonesia]. Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI); 2017:248-254.
- UIDV