RESCUE-STEMI: Thrombolysis in STEMI Patients Compared With pPCI on Recanalization Time in the Context of the COVID-19 Outbreak.
Study Details
Study Description
Brief Summary
During the outbreak of COVID-19, for patients with acute ST-segment elevation myocardial infarction with unclear infection, the time of primary PCI is uncertain, and it is often expected to exceed 90 minutes or even 120 minutes. In indicated patients, intravenous thrombolysis has significantly improved the recanalization time of criminal vessels.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
During the outbreak of COVID-19, for patients with acute ST-segment elevation myocardial infarction with unclear infection, the time of primary PCI is uncertain, and it is often expected to exceed 90 minutes or even 120 minutes. In indicated patients, intravenous thrombolysis has significantly improved the recanalization time of criminal vessels. The purpose of this study was to compare the time from first medical contact to patency and safety (specifically symptom improvement, ECG ST segment) between intravenous thrombolysis and concurrent patients with possible primary PCI in a prospective, multicenter, non-randomized controlled manner. Significant fall, angiographic examination showed criminal blood vessel TIMI blood flow grade 2-3)
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Thrombolysis Group Patients who meet the conditions for intravenous thrombolysis are included in the intravenous thrombolysis group. Regardless of whether the thrombolysis is successful or not, CAG examination is performed afterwards to clarify the vascular condition, and PCI is performed if necessary. |
Drug: Thrombolytic
Standard intravenous thrombolysis.
Other Names:
|
| Other: PCI Group Eligible patients undergoing primary PCI. |
Procedure: percutaneous coronary stenting
Percutaneous coronary stenting
Other Names:
|
Outcome Measures
Primary Outcome Measures
- recanalization [within 24 hours]
Coronary angiography to check for recanalization after thrombolysis（Yes or No）
- recanalization time [within 2 hours]
From first medical contact(FMC) time to recanalization time.
Secondary Outcome Measures
- Major bleeding event [7 day]
Whether there is a major bleeding event with drug thrombolysis（Yes or No）
- Malignant arrhythmia [12 hours]
Malignant arrhythmia incidence
Eligibility Criteria
Criteria
Inclusion Criteria:
- ECG confirms acute ST-segment elevation myocardial infarction；The estimated time from FMC to recanalization is more than 120 minutes；
Exclusion Criteria:
- Intracranial hemorrhage or stroke within the past 6 months; central nervous system injury, tumor or arteriovenous malformation; bleeding disease with known cause; suspected aortic dissection; non-compressible puncture surgery within 24 hours, etc.; 1 week of pregnancy or postpartum; uncontrolled hypertension; advanced liver disease; active peptic ulcer; prolonged or invasive CPR;
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Shanghai Tenth People's Hospital | Shanghai | Shanghai | China | 200072 |
Sponsors and Collaborators
- Ya-Wei Xu
Investigators
- Study Director: Yawei Xu, Doctor, Shanghai 10th People's Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- RESCUE-STEMI