Stereotactic Margins in Localized Bronchial Cancer (T1/T2a, N0)

Sponsor

University Hospital, Strasbourg, France (Other)

Overall Status

Recruiting

CT.gov ID

NCT05605236

Collaborator

(none)

300

Enrollment

Location

34.5

Anticipated Duration (Months)

8.7

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Bronchopulmonary cancer is the first cause of mortality in the world. We want to update the margins used in stereotactic radiotherapy, in the context of localized lung cancer, of non-surgical management.

The investigators wish to redefine the stereotactic radiotherapy margins according to the histological type in localized non-small cell lung cancer.

Indeed, these criteria were previously defined on a smaller cohort, in the context of 3D radiotherapy (mainly T3, T4 tumors). In addition, the incidence of radiation pneumonitis is highly dependent on the irradiated lung volume, which in turn depends on the CTV margins used.

Condition or Disease	Intervention/Treatment	Phase
Bronchial Cancer

Study Design

Study Type:

Observational

Anticipated Enrollment :

300 participants

Observational Model:

Case-Only

Time Perspective:

Retrospective

Official Title:

Stereotactic Margins in Localized Bronchial Cancer (T1/T2a, N0)

Actual Study Start Date :

Feb 16, 2020

Anticipated Primary Completion Date :

Dec 1, 2022

Anticipated Study Completion Date :

Dec 31, 2022

Outcome Measures

Primary Outcome Measures

Retrospective histological study of tumor cell dissemination around the tumor [Files analysed retrospectively from January 01, 2009 to December 31, 2019 will be examined]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Inclusion criteria:

Major subject (≥18 years old)
Subject operated on at HUS for T1/T2a N0 stage lung adenocarcinoma or squamous cell carcinoma before 30/09/2019
CT scan available on the HUS imaging server or on CD
Subject who has not expressed opposition to the use of his or her data for research purposes

Exclusion Criteria:

Subject who has expressed opposition to participating in the study
Impossibility to give the subject informed information (difficulties in understanding the subject, ...)
Subject under legal protection
Subject under guardianship or curatorship