Stereotactic Radiosurgery Prognosis Assessment for Spinal Tumors Based on Radiomics
Study Details
Study Description
Brief Summary
This study aims to assess multimodal Radiomics-based prediction model for prognostic prediction in spinal tumors.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Sensitivity for prediction recurrence and survival of currently available prognostic scores is limited. This study proposes to establish a multimodal radiomics model for identifying tumor recurrence and prognostic prediction of spinal tumors. The study will investigate the relationship between the radiomics and the tumor microenvironment. The study includes the construction of multimodal radiomics-based prediction model and the validation of the prediction model.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| spinal tumors, CT, MRI, PET-CT stereotactic radiosurgery Patients who had spinal tumors and completed the CT, MRI or PET-CT examination before and after stereotactic radiosurgery. |
Other: No interventions
As this is a prognosis evaluation study, there are no interventions.
|
Outcome Measures
Primary Outcome Measures
- PFS [1 years]
progression-free survival
Secondary Outcome Measures
- Overall survival (OS) [1 years]
defined as the time from the beginning of diagnosis of spinal tumors to the death with any causes
- ORR [3 months]
objective response rate
- DCR [3 months]
disease control rate
- Recurrence free survival (RFS) [1 year]
defined as time between randomization and the time of any recurrence of ipsilateral chest, breast, regional lymph node recurrence, distant metastases, or death occurred
Eligibility Criteria
Criteria
Inclusion Criteria:
A diagnosis of spinal tumors for which SBRT is appropriate Karnofsky Performance Status >60 Life expectancy of at least 3 months No contraindication to undergoing MR imaging Age >18 Complete the CT MRI or PET-CT examination before and after treatment Accept stereotactic radiosurgery
Exclusion Criteria:
Subjects unable to undergo MRI (includes non-MRI compatible material or devices and severe claustrophobia) Subjects with prior procedural intervention to the involved vertebral body that would result in artifact (kyphoplasty, screw and/or rod placement); minimally invasive surgery without instrumentation of the involved vertebral body and instrumentation immediately above or below the index lesion is allowed.
Subjects with spinal cord compression; minimally invasive "separation" surgery to first resect the epidural component is allowed Pregnant or breast-feeding women Allergy to standard IV contrast agents used in MRI
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Department of Radiation Oncology Cancer Center, Peking University Third Hospital 49# North Garden Rd.,Haidian Dist. | Beijing | Beijing | China | 100191 |
Sponsors and Collaborators
- Zhuang Hongqing
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- SBRTradiomics