Study of the Aorta Adaptations to Exercise in Triathletes During Sports Season (CoATri)

Sponsor

Central Hospital, Nancy, France (Other)

Overall Status

Completed

CT.gov ID

NCT03356301

Collaborator

(none)

Enrollment

Location

Arms

15.2

Actual Duration (Months)

4.2

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Regular sustained physical activity creates a cardiac remodelling : it is athlete's heart. In our preliminary work published in 2016, the investigators demonstrated in a small population of triathletes that there is also a vascular remodelling named athlete's artery. Moreover, the investigators know that left ventricle and aorta behave together like a couple. So they want to study by Cardiovascular Magnetic Resonance Imaging the impact of triathlon on the cardiac AND aortic remodelling.

Condition or Disease	Intervention/Treatment	Phase
Stiffness, Aortic Cardiac Remodeling, Ventricular Vascular Remodeling Magnetic Resonance Imaging, Functional Athletes	Device: Cardiac MRI Device: Applanation tonometry	N/A

Study Design

Study Type:

Interventional

Actual Enrollment :

63 participants

Allocation:

Non-Randomized

Intervention Model:

Parallel Assignment

Masking:

None (Open Label)

Primary Purpose:

Basic Science

Official Title:

Study of the Remodeling of the Ascending Aorta During the Sports Season in Long Distance Triathletes Versus Controls

Actual Study Start Date :

Dec 1, 2017

Actual Primary Completion Date :

Mar 8, 2019

Actual Study Completion Date :

Mar 8, 2019

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Triathletes Every triathlete will realize three cardiac MRI exams.The second of those will be done at the fitness peak, 2-3 weeks before the main objective of the sports season. Training will be increased between the study beginning and the first MRI, and the second exam. After each cardiac MRI, an applanation tonometry examination will aslo be performed.	Device: Cardiac MRI Non injected cardiac MRI exam Device: Applanation tonometry Applanation tonometry and ECG
Experimental: Controls Every control subject will also realize three cardiac MRI exams if possible at the same time as the triathletes.They must be not engaged in physical activity more than 150 minutes a week on average. After each cardiac MRI, an applanation tonometry examination will aslo be performed.	Device: Cardiac MRI Non injected cardiac MRI exam Device: Applanation tonometry Applanation tonometry and ECG

Arm

Intervention/Treatment

Experimental: Triathletes

Every triathlete will realize three cardiac MRI exams.The second of those will be done at the fitness peak, 2-3 weeks before the main objective of the sports season. Training will be increased between the study beginning and the first MRI, and the second exam. After each cardiac MRI, an applanation tonometry examination will aslo be performed.

Device: Cardiac MRI

Non injected cardiac MRI exam

Device: Applanation tonometry

Applanation tonometry and ECG

Experimental: Controls

Every control subject will also realize three cardiac MRI exams if possible at the same time as the triathletes.They must be not engaged in physical activity more than 150 minutes a week on average. After each cardiac MRI, an applanation tonometry examination will aslo be performed.

Device: Cardiac MRI

Non injected cardiac MRI exam

Device: Applanation tonometry

Applanation tonometry and ECG

Outcome Measures

Primary Outcome Measures

Aortic compliance in triathletes in mm2/mmHG [at baseline, at the fitness peak (6 to 10 months later) and at recovery (3 to 6 months after the fitness peak)]
aortic compliance = pulsed pressure-to-absolute variation of aortic surface ratio

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 39 Years

Sexes Eligible for Study:

Male

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

to be enrolled in a social security plan.
to have a BMI between 18,5 and 25 kg/m²
to have received full information on the organization of the research and having signed its informed consent
to have carried out a clinical screening adapted to the research

*** Triathlete group:

to have a minimum performance level: between 2h and 2h45 on an M triathlon during the past year (provide proof),
to participate in 2018 in a long distance triathlon, i. e. at least distance L
to have a defined training volume: less than 8 hours per week during the winter months and between 10 and 15 hours per week in preparation of the objective

***Control group:

to have no more than 150 minutes of moderate physical activity per week (footing, brisk walking, cycling, etc.).

Exclusion Criteria:

Persons referred to in Articles L. 1121-5 to L. 1121-8 and L1122-2 of the Public Health Code
Cardiovascular history including Ii.e. known heart rhythm disorders
Chronic disease: diabetes, high blood pressure...
Long-term drug therapies that may modify cardiovascular remodeling such as Conversion Enzyme Inhibitor, Angiotensin II Receptor Antagonist,
Active smoking, even if occasional
Contraindication to MRI