Strain for Risk Assessment and Therapeutic Strategies in Patients With Acute Heart Failure (STRATS-AHF) Registry
Sponsor
Seoul National University Hospital (Other)
Overall Status
Active, not recruiting
CT.gov ID
NCT03513653
Collaborator
Seoul National University Bundang Hospital (Other), Chungnam National University Hospital (Other)
4,312
3
168
1437.3
8.6
Study Details
Study Description
Brief Summary
STRATS-AHF (STrain for Risk Assessment and Therapeutic Strategies in patients with Acute Heart Failure) registry enrolled 4,312 patients hospitalized for acute HF from 3 tertiary university hospitals (Seoul National University Bundang Hospital, Seoul National University Hospital, and Chungnam National University Hospital) from January 2009 through December 2016.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Patients with signs or symptoms of heart failure and either lung congestion, or objective findings of left ventricular (LV) systolic dysfunction or structural heart disease, were eligible for the study. Echocardiography was performed and both LV ejection fraction (LVEF) and LV global longitudinal strain (LV-GLS), right ventricular GLS (RV-GLS) were measured.
Study Design
Study Type:
Observational
Actual Enrollment
:
4312 participants
Observational Model:
Cohort
Time Perspective:
Retrospective
Official Title:
Strain for Risk Assessment and Therapeutic Strategies in Patients With Acute Heart Failure (STRATS-AHF) Registry
Actual Study Start Date
:
Jan 1, 2009
Actual Primary Completion Date
:
Sep 5, 2017
Anticipated Study Completion Date
:
Dec 31, 2022
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Acute heart failure Patients hospitalized for acute heart failure and underwent echocardiography with speckle-tracking imaging |
Diagnostic Test: Echocardiography with speckle-tracking imaging
Measurement of left ventricular ejection fraction and global longitudinal strain
Measurement of left atrial reservoir strain (peak atrial longitudinal strain)
Measurement of right ventricular global longitudinal strain
|
Outcome Measures
Primary Outcome Measures
- All-cause mortality [up to 5 years]
Death from any cause
Secondary Outcome Measures
- Hospitalization for heart failure [up to 5 years]
Any hospitalization for acute heart failure after the index hospitalization
- Composite of all-cause mortality and hospitalization for heart failure [up to 5 years]
Death from any cause or any hospitalization for acute heart failure after the index hospitalization
- Ischemic stroke [up to 5 years]
Ischemic stroke (an episode of neurological dysfunction caused by embolism) after the index hospitalization
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
- Patients with signs or symptoms of HF and either lung congestion, or objective findings of LV systolic dysfunction or structural heart disease
Exclusion Criteria:
- Patients who presented with acute coronary syndrome
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do | Korea, Republic of | 13620 |
| 2 | Chungnam National University Hospital | Daejeon | Korea, Republic of | 35015 | |
| 3 | Seoul National University Hospital | Seoul | Korea, Republic of | 03080 |
Sponsors and Collaborators
- Seoul National University Hospital
- Seoul National University Bundang Hospital
- Chungnam National University Hospital
Investigators
- Principal Investigator: Goo-Yeong Cho, MD, PhD, Seoul National University Bundang Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
- Hwang IC, Cho GY, Choi HM, Yoon YE, Park JJ, Park JB, Park JH, Lee SP, Kim HK, Kim YJ, Sohn DW. Derivation and validation of a mortality risk prediction model using global longitudinal strain in patients with acute heart failure. Eur Heart J Cardiovasc Imaging. 2020 Dec 1;21(12):1412-1420. doi: 10.1093/ehjci/jez300.
- Park CS, Park JB, Park JJ, Park JH, Cho GY. Impact of sex and myocardial function on association of obesity with mortality in Asian patients with acute heart failure: a retrospective analysis from the STRATS-AHF registry. BMJ Open. 2020 Feb 10;10(2):e031608. doi: 10.1136/bmjopen-2019-031608.
- Park JH, Hwang IC, Park JJ, Park JB, Cho GY. Prognostic power of left atrial strain in patients with acute heart failure. Eur Heart J Cardiovasc Imaging. 2021 Jan 22;22(2):210-219. doi: 10.1093/ehjci/jeaa013.
- Park JH, Park JJ, Park JB, Cho GY. Prognostic Value of Biventricular Strain in Risk Stratifying in Patients With Acute Heart Failure. J Am Heart Assoc. 2018 Oct 2;7(19):e009331. doi: 10.1161/JAHA.118.009331.
- Park JJ, Choi HM, Hwang IC, Park JB, Park JH, Cho GY. Myocardial Strain for Identification of β-Blocker Responders in Heart Failure with Preserved Ejection Fraction. J Am Soc Echocardiogr. 2019 Nov;32(11):1462-1469.e8. doi: 10.1016/j.echo.2019.06.017. Epub 2019 Sep 17.
- Park JJ, Mebazaa A, Hwang IC, Park JB, Park JH, Cho GY. Phenotyping Heart Failure According to the Longitudinal Ejection Fraction Change: Myocardial Strain, Predictors, and Outcomes. J Am Heart Assoc. 2020 Jun 16;9(12):e015009. doi: 10.1161/JAHA.119.015009. Epub 2020 Jun 10.
- Park JJ, Park JB, Park JH, Cho GY. Global Longitudinal Strain to Predict Mortality in Patients With Acute Heart Failure. J Am Coll Cardiol. 2018 May 8;71(18):1947-1957. doi: 10.1016/j.jacc.2018.02.064.
- Park JJ, Park JH, Hwang IC, Park JB, Cho GY, Marwick TH. Left Atrial Strain as a Predictor of New-Onset Atrial Fibrillation in Patients With Heart Failure. JACC Cardiovasc Imaging. 2020 Oct;13(10):2071-2081. doi: 10.1016/j.jcmg.2020.04.031. Epub 2020 Jul 15.
Responsible Party:
Goo-Yeong Cho,
Professor,
Seoul National University Bundang Hospital
ClinicalTrials.gov Identifier:
NCT03513653
Other Study ID Numbers:
- B-1702/384-111
First Posted:
May 1, 2018
Last Update Posted:
Oct 22, 2020
Last Verified:
Oct 1, 2020
Individual Participant Data (IPD) Sharing Statement:
Undecided
Plan to Share IPD:
Undecided
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Goo-Yeong Cho,
Professor,
Seoul National University Bundang Hospital
Additional relevant MeSH terms: