SEME: Stress and Emotional Memory

Sponsor

University Hospital, Caen (Other)

Overall Status

Completed

CT.gov ID

NCT02510755

Collaborator

(none)

Enrollment

Location

Arms

Duration (Months)

0.5

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

A broad group of disorders is associated with severe stress existence in children or adolescents. The most characteristic result, and one of the most serious being the state of post-traumatic stress disorder (PTSD), whose main source consists of physical or sexual violence, and to a lesser extent, accidents public road or natural disaster, whose child was the subject or witness. PTSD is associated with a deleterious effect on cognition and including the mnemonic operation. The painful reminder of the traumatic event is one of the most disabling symptoms. However, there are many other memory disorders that experimental studies gradually update. They maintain a close link with emotional regulation that disturbed you know if PTSD. However the majority of studies on emotion and cognition and their relationship with brain activity took adult subject. Work in adolescents are few on the morphological study, on rare neurobehavioral and reduced to two studies of functional neuroimaging. Contrary to what is observed in adults, morphological studies report consistently, no reduction in hippocampal volume. There is no study in the idle state. Two studies in functional MRI, the first highlighted in PTSD patients inhibition of the activity of the anterior cingulate cortex (ACC) to stimuli such as to evoke the trauma, a second reported increased activity in the prefrontal cortex Median (mPFC) in a inhibition. The objective task of our study is to evaluate the impact of psychological trauma on brain structures involved in the emotional component of the memory (amygdala, hippocampus, prefrontal cortex in particular). For this, the investigators will take in 33 adolescents, including patients with posttraumatic symptomatology and matched controls free of trauma age, several neuroimaging exams, anatomical and functional. The functional review will include some rest and another in activation during episodic memory task designed to assess the influence of self-perception on memory impairment observed in patients. The investigators will check, for each group of patients and controls, the involvement of cortical structures in relation to the regulation of emotional memory (CCA, amygdala and hippocampus). The anatomy of the hippocampus benefit specific imaging methods developed in the unit INSERM U923. Endocrine correlates of stress tests will be studied by a fully-traumatic by salivary cortisol sampling.

This research will clarify the mechanisms involved in emotional and memory impairments secondary to psychological trauma, their relationship with self (judgment and self-esteem) and studying their morphological substrates. A longer-term goal is to offer help in the diagnosis and monitoring of young patients with posttraumatic symptomatology.

Condition or Disease	Intervention/Treatment	Phase
Stress Disorders, Post-Traumatic	Other: MRI	N/A

Study Design

Study Type:

Interventional

Actual Enrollment :

19 participants

Allocation:

Non-Randomized

Intervention Model:

Parallel Assignment

Masking:

None (Open Label)

Primary Purpose:

Diagnostic

Official Title:

Stress and Emotional Memory : Functional Neuroanatomy of Post-traumatic Stress Disorder in Adolescents

Study Start Date :

May 1, 2012

Actual Primary Completion Date :

Apr 1, 2015

Actual Study Completion Date :

Apr 1, 2015

Arms and Interventions

Arm	Intervention/Treatment
Other: PTSD group PTSD group	Other: MRI
Other: Healthy Volunteers Healthy Volunteers, age-matched controls.	Other: MRI

Arm

Intervention/Treatment

Other: PTSD group

PTSD group

Other: MRI

Other: Healthy Volunteers

Healthy Volunteers, age-matched controls.

Other: MRI

Outcome Measures

Primary Outcome Measures

Amplitude of the BOLD fMRI signal measured at rest and during cognitive tasks (activation) [baseline]

Eligibility Criteria

Criteria

Ages Eligible for Study:

13 Years to 18 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Subjects aged 13-18 years
Informed consent signed by the legal representative and adolescents (e) itself.
Speaking French as their mother tongue
patients:subjects with a history of psychological trauma (eg, accidents of public roads (without head trauma), physical or sexual violence) recruited in the care services of hospitals, the diagnosis of chronic PTSD is made using a standardized interview (SCID).
Healthy controls : subjects who do not have a history of psychological trauma, nor PTSD

Exclusion Criteria:

ASD, schizophrenia, ADHD
Head injury with loss of consciousness
Regular or recent use of alcohol or drugs
chronic neurological or endocrine disorder
use of medication that could interfere with the mnemonic or metabolic measurements (psychotropic, hypnotics, anxiolytics, neuroleptics, benzodiazepines, drugs, antiepileptics anti-inflammatory, anti-histamines, central analgesics and muscle relaxants)
Contraindications to MRI (claustrophobia, metallic object intracorporal)
Manual Predominance left
Severe mental retardation evaluated using two subtests from the WISC-IV scales and WAIS III
Reading Disorders valued using the read speed test

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Service de Pédopsychiatrie	Caen		France	14000

Sponsors and Collaborators

University Hospital, Caen

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

University Hospital, Caen

ClinicalTrials.gov Identifier:

NCT02510755

Other Study ID Numbers:

10-035

First Posted:

Jul 29, 2015

Last Update Posted:

Jul 29, 2015

Last Verified:

Jul 1, 2015

Additional relevant MeSH terms:

Stress Disorders, Traumatic

Stress Disorders, Post-Traumatic

Study Results

No Results Posted as of Jul 29, 2015