Racial Discrimination and Stress Response

Sponsor
Western Kentucky University (Other)
Overall Status
Not yet recruiting
CT.gov ID
NCT05820659
Collaborator
(none)
160
1
1
22.5
7.1

Study Details

Study Description

Brief Summary

The goal of this study is to learn about whether ethnic minority adolescents' racial discrimination experience is related to dysregulated biological responses to subtle racism, and how the relationship may be attenuated or exacerbated by a set of social and cognitive factors. The main questions it aims to answer are:

  • to reveal the relationship between racial discrimination experiences and ethnic minority adolescents' stress response to subtle racism

  • to test parental ethnic-racial socialization, children's attribution to subtle racism and their racial identity as potential risk and protective factors.

Condition or Disease Intervention/Treatment Phase
  • Behavioral: peer rejection task
N/A

Detailed Description

Racial discrimination experiences constitute significant risks for ethnic minority youth's physical and mental health problems. One explanation poses that chronic stress can lead to altered, dysregulated stress responses, which can make individuals susceptible to health problems. Currently, there is no experimental study that comprehensively measure ethnic minority youth's stress response to subtle racism, or investigate the contributing roles of racial discrimination experience and possible risk and protective factors.

A community sample of 11-14-year-old ethnic minority adolescents (40 Latino American, 40 Black/African American) and their parents will be recruited. The study employs an adapted peer rejection task which has been widely used with youth, and carefully designed to elicit the experience of subtle racial discrimination from White peers. Adolescents' cardiovascular activity and saliva samples will be taken at multiple time points before, during, and after the peer rejection task, tapping on response involving hypothalamic-pituitary-adrenal (HPA) axis, autonomic nervous system (ANS), and inflammatory mediator (IM). Adolescents will report their racial discrimination experience, make attribution about the peer rejection experience, and rate their racial identity. Parents will complete a questionnaire to report their ethnic-racial socialization practices.

The goals of this proposal are: 1) Reveal the relationship between racial discrimination experiences and ethnic minority adolescents' stress response to subtle racism; and 2) Test parental ethnic-racial socialization, children's attribution to subtle racism and their racial identity as potential risk and protective factors.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
160 participants
Allocation:
N/A
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)
Primary Purpose:
Basic Science
Official Title:
Racial Discrimination and Dysregulated Stress Response: Risk/Protective Factors
Anticipated Study Start Date :
Jun 15, 2023
Anticipated Primary Completion Date :
Apr 30, 2025
Anticipated Study Completion Date :
Apr 30, 2025

Arms and Interventions

Arm Intervention/Treatment
Experimental: stress inducing task

Adolescents will complete an adapted peer rejection task on the computer to elicit the experience of subtle racial discrimination from White peers.

Behavioral: peer rejection task
Adolescents will be informed that two peers will take turns to choose who they will chat with for different topics. Participants will not be chosen by virtual White peers 75% of the time. In reality, White peers are computerized avatars and whether or not adolescents are chosen by those peers is programmed with E-prime software.

Outcome Measures

Primary Outcome Measures

  1. change in cardiovascular activity [participants' blood pressure will be continuously monitored 10 minute before, during, and 45 minutes after the peer rejection task.]

    participants' diastolic and systolic blood pressure will be continuously monitored.

  2. change in stress hormones [participants' salivary samples will be collected at five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)]

    participants' salivary samples will be collected, frozen, and assayed for cortisol.

  3. change in inflammatory biomarker of Interleukin 6 [participants' salivary samples will be collected at five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)]

    participants' salivary samples will be collected, frozen, and assayed for inflammatory biomarker of Interleukin-6

  4. change in inflammatory biomarker of C-reactive protein [participants' salivary samples will be collected at five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)]

    participants' salivary samples will be collected, frozen, and assayed for inflammatory biomarker of C-reactive protein

  5. attribution about the peer rejection [right after the peer rejection task]

    participants will complete the questionnaire, Attribution About The Peer Rejection (AATPR) to rate the likelihood of various reasons for the experience of peer rejection using a 5-point scale. The higher total score for the 4 racial reasons (possible range: 4-20) indicates the higher tendency of making racial attribution about the peer rejection.

Eligibility Criteria

Criteria

Ages Eligible for Study:
11 Years to 69 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • 6th-8th graders

  • identified as Latino American or Black/African American

  • Living in Warren county of Kentucky

  • Parents of eligible adolescents

Exclusion Criteria:
Adolescents will not participate in the peer rejection task when they report to have:
  • frequent experiences of peer victimization

  • frequent experiences of racial discrimination

  • severe depression

  • severe social anxiety disorder

  • severe generalized anxiety disorder

Contacts and Locations

Locations

Site City State Country Postal Code
1 Western Kentucky University Bowling Green Kentucky United States 42101

Sponsors and Collaborators

  • Western Kentucky University

Investigators

  • Principal Investigator: Qingfang Song, Ph.D, Western Kentucky University

Study Documents (Full-Text)

None provided.

More Information

Publications

Responsible Party:
Western Kentucky University
ClinicalTrials.gov Identifier:
NCT05820659
Other Study ID Numbers:
  • U5GMACGETKJ1
First Posted:
Apr 20, 2023
Last Update Posted:
Apr 20, 2023
Last Verified:
Apr 1, 2023
Individual Participant Data (IPD) Sharing Statement:
Yes
Plan to Share IPD:
Yes
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Western Kentucky University
Additional relevant MeSH terms:

Study Results

No Results Posted as of Apr 20, 2023