Effect of Location of Tetanic Stimuli on Photoplethysmogram Under General Anesthesia

Sponsor

University of California, San Francisco (Other)

Overall Status

Completed

CT.gov ID

NCT05899686

Collaborator

(none)

Enrollment

Location

Arm

3.5

Actual Duration (Months)

3.4

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The effect of the location of tetanic stimulus on photoplethysmography signals will be studied in patients under general anesthesia.

Condition or Disease	Intervention/Treatment	Phase
Stress Reaction	Device: Tetanic Stimulus	N/A

Detailed Description

A 5 second 100 Hz 70 mA tetanic stimulus will be applied to three different locations (Ulnar nerve, Facial nerve, Posterior Tibial nerve) in a random order in patients who are under general anesthesia. Tetanic stimuli are used routinely during general anesthesia to assess effectiveness of neuromuscular blockade. These tetanic stimuli are noxious stimuli that elicit a stress response which can be quantified using photoplethysmography. This study investigates if the magnitude of the tetanus induced stress response is dependent on the location of the tetanic stimulus as measured by photoplethysmography.

Study Design

Study Type:

Interventional

Actual Enrollment :

12 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Diagnostic

Official Title:

Effect of Tetanic Stimuli on Photoplethysmogram During General Anesthesia

Actual Study Start Date :

Jan 27, 2016

Actual Primary Completion Date :

May 12, 2016

Actual Study Completion Date :

May 12, 2016

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Tetanic Stimulus all participants receive the same intervention	Device: Tetanic Stimulus 5 second 100 Hz 70 mA tetanic stimulus will be applied to three different locations in a random order

Arm

Intervention/Treatment

Experimental: Tetanic Stimulus

all participants receive the same intervention

Device: Tetanic Stimulus

5 second 100 Hz 70 mA tetanic stimulus will be applied to three different locations in a random order

Outcome Measures

Primary Outcome Measures

Tetanic stimulus induced change in photoplethysmography light transmission (in analog to digital units as measured using a pulse oximeter) from pre stimulus baseline [Maximum light transmission change from pre tetanic stimulus baseline within 60 seconds after the tetanic stimulus]
Tetanic stimulation will induce peripheral vasoconstriction. This will be measured using photoplethysmography. During peripheral vasoconstriction the light transmission through finger will increase. The primary outcome will be the maximum change in light transmission (as measured by photoplethysmography) within 60 seconds after a tetanic stimulus as compared to pre stimulus baseline values. These maximal light transmission changes will be compared between the three different tetanic stimulus sites

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Surgical patients
Undergoing general anesthesia
Able to consent in english
18 years of age or older

Exclusion Criteria:

Under 18 years of age
unable to consent in english
receiving regional anesthesia

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of California San Francisco	San Francisco	California	United States	94134

Sponsors and Collaborators

University of California, San Francisco

Investigators

Principal Investigator: Pekka Talke, MD, University of California, San Francisco

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

University of California, San Francisco

ClinicalTrials.gov Identifier:

NCT05899686

Other Study ID Numbers:

PT1502

First Posted:

Jun 12, 2023

Last Update Posted:

Jun 12, 2023

Last Verified:

Jun 1, 2023

Individual Participant Data (IPD) Sharing Statement:

Yes

Plan to Share IPD:

Yes

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Yes

Keywords provided by University of California, San Francisco

photoplethysmography

stress response

Additional relevant MeSH terms:

Fractures, Stress

Study Results

No Results Posted as of Jun 12, 2023