Stress Reactivity and Nicotine Addiction Among African American and White Smokers
Study Details
Study Description
Brief Summary
The purpose of this study is to examine racial differences in smoking behaviors and stress responses between African American and white male smokers.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Cigarette smoking is a leading cause of morbidity and mortality from lung cancer among adults in the US. Stress relief and smoking cessation is the best preventive strategy for reducing lung cancer risk and addressing racial disparities in outcomes. Despite this, racial differences are found among those that make quit attempts. Stress has been found to be related to smoking initiation, maintenance, and relapse. Yet, differences in stress responses have not been examined between African American and white smokers. Therefore, this study will examine racial differences in stress responses and smoking behaviors between African American and white male smokers
Study Design
Outcome Measures
Primary Outcome Measures
- Examining racial differences in acute stress responses [Within 1 month following baseline]
Examine racial differences in acute stress responses using a validated psychological stress challenge called the Trier Social Stress Test (TSST)
- Examining changes in daily cortisol patterns according to race [Baseline, 4- and 8 weeks post Trier Social Stress Test laboratory visit]
Examine racial differences in daily diurnal cortisol slopes to evaluate hypothalamic-pituitary-adrenal-axis dysregulation and acute stress
- Examine changes in stress responses and smoking behaviors as it relates to social determinant factors [Baseline, 4- and 8-weeks post Trier Social Stress Test laboratory visit]
Patients will be administered a survey using validated measures to examine socioeconomic, structural, and psychosocial stressors that impact daily stress and smoking behaviors
Eligibility Criteria
Criteria
Inclusion Criteria:
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African American and white males
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Between the ages of 18-75 years old
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Smoke at least 5 to 10 cigarettes per day
Exclusion Criteria:
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Smokers who have a serious cognitive disorder
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Have a personal history of lung cancer
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Personal history of usage of illicit drug and alcohol abuse
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Enrollment in a smoking cessation treatment program during the past 6 months
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Current use of a nicotine replacement therapy
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Have any positive responses on the Mini International Neuropsychiatric Interview (MINI) screener
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Medical University of South Carolina | Charleston | South Carolina | United States | 29425 |
Sponsors and Collaborators
- Medical University of South Carolina
- Virginia Commonwealth University
- City of Hope Medical Center
Investigators
- Principal Investigator: Chanita Hughes-Halbert, PhD, University of Southern California
Study Documents (Full-Text)
More Information
Publications
None provided.- 00116801