ABSAI: Association Between Stroke and Adrenal Incidentalomas
Study Details
Study Description
Brief Summary
Adrenal incidentalomas (AIs) are commonly encountered in transsection imaging which purpose not for suspected adrenal disease. However, part of AIs in patients is associated with Stroke. Stroke is a diseases which could cause of disability and death worldwide. In clinical practice, detailed information about the association between stroke and AIs is not available. In this study, the investigators aimed to investigate the risk for disability and death in the large group of stroke patients with AIs.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Background:
Adrenal incidentalomas (AIs) are commonly encountered in transsection imaging which purpose not for suspected adrenal disease. However, part of AIs in patients is associated with Stroke . The investigators aimed to investigate the risk for disability and death in the large group of stroke patients with AIs.
Objective:
To measure the association between stroke and levels of autonomous cortisol secretion in patients with AIs.
Design:
Part 1, Retrospective cohort study.
From April 1, 2021, to September 30, 2021, cohort patients with stroke were recruited in this study. The investigators assess the standardised incidence rate of AIs in all patients. Meanwhile, detail information about stroke disease、patient and AIs characteristics were record.
Part 2, Prospective cohort study.
From Mar 1, 2022, to Feb 29, 2024, cohort patients with stroke plane to recruit in this study. All patient receive the plasma cortisol level after a 1-mg dexamethasone suppression test. The investigators assess the standardised incidence rate of AIs in all patients. Meanwhile, detail information about stroke disease、patient and AIs characteristics would be record.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Cerebral infarction Group Patients with cerebral infarction, and enrolled in our emergency or clinical department. |
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| Intracerebral hemorrhage Group Patients with intracerebral hemorrhage, and enrolled in our emergency or clinical department. |
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| Subarachnoid hemorrhage Group Patients with subarachnoid hemorrhage, and enrolled in our emergency or clinical department. |
Outcome Measures
Primary Outcome Measures
- Incidence rate of Adrenal incidentalomas [5 years]
Assess the standardised incidence rate of AIs in all patients with stroke
- Plasma cortisol level [5 years]
Plasma cortisol level after a 1-mg dexamethasone suppression test
Secondary Outcome Measures
- Diameter of Adrenal incidentalomas [5 years]
Maximal axial diameter of adrenal incidentalomas by computed tomography scan; Millimetre as a metric unit of length in this study
Eligibility Criteria
Criteria
Inclusion Criteria:
- stroke disease , such as Cerebral infarction、Intracerebral hemorrhage and Subarachnoid hemorrhage.
Exclusion Criteria:
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presence of metastatic cancer;
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AIs smaller than 1 cm;
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nonadenoma lesions, such as myelolipomas,hemorrhages, and cysts;
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oral glucocorticoid treatment with more than single doses in the past 3 months;
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use of inhaled steroids or medication affecting dexamethasone metabolism;
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systemic estrogen treatment.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Hao Yan | Beijing | China | 100053 |
Sponsors and Collaborators
- Xuanwu Hospital, Beijing
Investigators
- Study Director: Tong W Ou, Dr., Department of Urology, Xuanwu Hospital, Capital Medical University
Study Documents (Full-Text)
None provided.More Information
Publications
- Ebbehoj A, Li D, Kaur RJ, Zhang C, Singh S, Li T, Atkinson E, Achenbach S, Khosla S, Arlt W, Young WF, Rocca WA, Bancos I. Epidemiology of adrenal tumours in Olmsted County, Minnesota, USA: a population-based cohort study. Lancet Diabetes Endocrinol. 2020 Nov;8(11):894-902. doi: 10.1016/S2213-8587(20)30314-4.
- Fassnacht M, Arlt W, Bancos I, Dralle H, Newell-Price J, Sahdev A, Tabarin A, Terzolo M, Tsagarakis S, Dekkers OM. Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors. Eur J Endocrinol. 2016 Aug;175(2):G1-G34. doi: 10.1530/EJE-16-0467.
- Kjellbom A, Lindgren O, Puvaneswaralingam S, Löndahl M, Olsen H. Association Between Mortality and Levels of Autonomous Cortisol Secretion by Adrenal Incidentalomas : A Cohort Study. Ann Intern Med. 2021 Aug;174(8):1041-1049. doi: 10.7326/M20-7946. Epub 2021 May 25.
- yanh-stroke&adrenal