Combining MyoCI With Memory Reactivation to Improve Motor Recovery After Stroke
Study Details
Study Description
Brief Summary
This study will examine the combination of myoelectric computer interface (MyoCI) training with targeted memory reactivation (TMR) in chronic stroke survivors. The study aims to determine whether this training-plus-sleep combination will generalize to improve arm motor function over an extended training protocol in stroke survivors.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: All phase TMR TMR during every stage of sleep |
Other: Targeted Memory Reactivation (TMR)
Targeted memory reactivation (TMR) refers to the process of playing audio cues associated with specific learned material quietly during sleep in order to strengthen consolidation of specific memories during sleep.
|
| Experimental: Slow-wave sleep (SWS) only TMR TMR during slow-wave sleep only |
Other: Targeted Memory Reactivation (TMR)
Targeted memory reactivation (TMR) refers to the process of playing audio cues associated with specific learned material quietly during sleep in order to strengthen consolidation of specific memories during sleep.
|
| Experimental: Reduced frequency TMR TMR during only subset of sessions |
Other: Targeted Memory Reactivation (TMR)
Targeted memory reactivation (TMR) refers to the process of playing audio cues associated with specific learned material quietly during sleep in order to strengthen consolidation of specific memories during sleep.
|
| Sham Comparator: Sham TMR Patients receive no TMR |
Other: Targeted Memory Reactivation (TMR)
Targeted memory reactivation (TMR) refers to the process of playing audio cues associated with specific learned material quietly during sleep in order to strengthen consolidation of specific memories during sleep.
|
Outcome Measures
Primary Outcome Measures
- Wolf Motor Function Test (WMFT) [change from baseline at 6 weeks]
The WMFT evaluates upper extremity function on a continuous scale. It measures the time it takes to perform 15 different tasks, with a time limit of 120 s per task.
Secondary Outcome Measures
- Fugl-Meyer Assessment of Upper Extremity (UE) Motor Function [change from baseline at 6 weeks]
The FMA-UE is a measure of impairment. Maximum score is 66 on the motor function portion. Items are scored on a 3-point ordinal scale.
- Fugl-Meyer Assessment of Upper Extremity (UE) Motor Function [change from baseline at 10 weeks]
The FMA-UE is a measure of impairment. Maximum score is 66 on the motor function portion. Items are scored on a 3-point ordinal scale.
- Motor Activity Log (MAL) [change from baseline at 6 weeks]
The MAL is a validated measure of home-based arm function, both quantity and quality of use in 30 different activities of daily living.
- Motor Activity Log (MAL) [change from baseline at 10 weeks]
The MAL is a validated measure of home-based arm function, both quantity and quality of use in 30 different activities of daily living.
- Modified Ashworth Scale [change from baseline at 6 weeks]
The Modified Ashworth Scale is a measure of spasticity, which is graded on a scale of 0-4 per joint tested.
- Modified Ashworth Scale [change from baseline at 10 weeks]
The Modified Ashworth Scale is a measure of spasticity, which is graded on a scale of 0-4 per joint tested.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Age at enrollment is 21 or older
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Hemiparesis from first ever stroke affecting arm movement at least 6 months prior to screening
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Severe to moderate motor impairment (FMA-UE of 7-40)
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At least some voluntary shoulder and elbow muscle activation
Exclusion Criteria:
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Inability to follow instructions of the MyoCI task
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Visual impairment (such as hemianopia) preventing full view of screen
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Anesthesia or neglect in the affected arm, or visual hemineglect (score of 2 on the NIH Stroke Scale Extinction and Inattention subtest)
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Participation in another study on the affected arm within 6 weeks of enrollment or any pharmacological study
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Inability to understand or follow commands in English due to aphasia or other reason
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Diffuse or multifocal infarcts in both hemispheres
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Substantial arm pain preventing participation for 90 minutes a day
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Spasticity treatment (pharmacological or Botox) within last 3 months
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Ferromagnetic implants that are MRI incompatible
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Northwestern University | Chicago | Illinois | United States | 60611 |
Sponsors and Collaborators
- Northwestern University
Investigators
- Principal Investigator: Marc W Slutzky, MD/PhD, Northwestern University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- SP0052149