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Effects of Exercise on Patients With Hemiparetic Stroke

Sponsor
US Department of Veterans Affairs (U.S. Fed)
Overall Status
Completed
CT.gov ID
NCT00018421
Collaborator
(none)
1
Location
47
Duration (Months)

Study Details

Study Description

Brief Summary

This randomized trial investigates the hypothesis that regular aerobic exercise training using a task specific gait training modality will improve cardiovascular fitness, functional mobility, and reduce risk factors for recurrent cardiovascular events in chronic hemiparetic stroke patients, when compared to matched controls performing just stretching.

Condition or Disease Intervention/Treatment Phase
  • Procedure: Treadmill Exercise
 N/A

Detailed Description

The aims are to determine whether 6 months progressive graded treadmill training: 1) improves cardiovascular fitness levels and reduces the excessive energy demands of hemiparetic gait, as defined by oxygen consumption levels based on open circuit spirometry during peak and submaximal exercise ambulation tasks; 2) increases free living physical activity measured by portable kinematic recording devices and quantitative in vivo determination of energy expenditure using stable isotopes; and, 3) improves the cardiovascular-metabolic risk factor profile including measures of key endogenous fibrinolysis regulatory enzymes [plasma tissue plasminogen activator (t-PA) and its main circulating inhibitor (PAI-1)], fasting lipoprotein lipid profiles, blood pressure, and oral glucose tolerance and insulin responses. Measurements of body composition at baseline and after training will further determine the effects of aerobic exercise training on muscle mass and central obesity.

Study Design

Study Type:
Interventional
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Primary Purpose:
Treatment
Official Title:
Effects of Exercise on Patients With Hemiparetic Stroke
Study Start Date :
Jul 1, 1997
Study Completion Date :
Jun 1, 2001

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    40 Years to 80 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No

    Males or Females Ages 40 yrs to 80 yrs who are chronic hemiparetic stroke patients.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 VA Maryland Health Care System Baltimore Maryland United States 21201

    Sponsors and Collaborators

    • US Department of Veterans Affairs

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00018421
    Other Study ID Numbers:
    • CADE-RA
    First Posted:
    Jul 5, 2001
    Last Update Posted:
    Jan 21, 2009
    Last Verified:
    Dec 1, 2004
    Keywords provided by , ,
    Cerebrovascular Disorders
    Exercise
    Rehabilitation
    Additional relevant MeSH terms:
    Stroke
    Hemiplegia
    Cardiovascular Diseases

    Study Results

    No Results Posted as of Jan 21, 2009