Brain Activity Changes After Structured Cognitive-motor Exercise for People With Stroke
Study Details
Study Description
Brief Summary
To assess the effects of a dual-task exercise program on cognitive-motor interference during dual-task walking and the associated changes in brain activity.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Stroke is one of the leading causes of chronic disability in Hong Kong and other parts of the world. Mobility dysfunctions are among the most common impairments observed after stroke. Restoration of mobility is also a top priority in rehabilitation goal-setting by stroke patients. In daily life, functional ambulation in the community requires the ability to maintain walking balance while simultaneously engaging in other attention-demanding tasks (i.e., dual-tasking), such as walking when holding a conversation, or crossing the street while attending to traffic signals. There is increasing evidence that performing a cognitive task in conjunction with a mobility task would cause more severe degradation of one or both tasks among stroke patients when compared with age-matched able-bodied individuals. This phenomenon, termed "cognitive-motor interference", should warrant detailed study, since it has an important impact on community-living among people with stroke.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Dual-task training Mobility tasks performed in conjunction with cognitive tasks |
Behavioral: Dual-task training
This group will receive 30 min of dual-task exercise training and 30 min of stretching exercises in each session. The dual-task component involves walking activities performed in conjunction with cognitive activities. For the stretching exercise component, no cognitive load will be added.
|
| Active Comparator: Single-task training Separate cognitive and mobility exercises |
Behavioral: Single-task training
This group will undergo 30 min of single-task mobility training and another 30 min of single-task cognitive activities. The cognitive and mobility exercises will be the same as those in the dual-task group, but they will be performed separately. No extra cognitive load will be imposed during the mobility exercises. No additional motor demand will be imposed during the cognitive exercises, as the participants will be sitting.
|
| Active Comparator: Control group Upper limb strengthening and flexibility exercises |
Behavioral: Control group
This group will undergo 30 min of stretching exercises (same as the dual-task group) and another 30 min of upper limb strengthening exercises performed primarily in the sitting or lying position. No cognitive load will be added.
|
Outcome Measures
Primary Outcome Measures
- Dual-task gait speed [Through study completion, an average of 1 year]
Gait speed under dual-task condition will be recorded
- Dual-task cognitive performance [Through study completion, an average of 1 year]
Number of correct responses will be measured during dual-task walking
Secondary Outcome Measures
- Dual-task gait performance 1 [Through study completion, an average of 1 year]
Gait cadence will be measured during dual-task walking
- Dual-task gait performance 2 [Through study completion, an average of 1 year]
Stride length will be measured during dual-task walking
- Dual-task gait performance 3 [Through study completion, an average of 1 year]
Trunk stability will be measured during dual-task walking
- Oxyhemoglobin concentration changes of the brain [Through study completion, an average of 1 year]
Oxyhemoglobin concentration changes will be measured using functional near infra-red spectroscopy during dual-task walking
Other Outcome Measures
- Single-task walking speed [Through study completion, an average of 1 year]
10-meter walking test will be used to assess single-task walking speed in meters per second
- Balance 1 [Through study completion, an average of 1 year]
Mini Balance Evaluation Systems Test will be used to assess postural control, with total points from 0-28. Higher points indicate better performance.
- Balance 2 [Through study completion, an average of 1 year]
Activities-specific Balance Confidence Scale will be used to assess confidence of functional balance performance, with total points from 0-100. Higher points indicate better performance.
- Cognitive performance [Through study completion, an average of 1 year]
Stroop color word test will be used to assess executive function
- Cognitive performance 1 [Through study completion, an average of 1 year]
Digit Span Test will be used to assess working memory
- Cognitive performance 2 [Through study completion, an average of 1 year]
Montreal Cognitive Assessment will be used to assess global cognition, with total points from 0-30. Higher points indicate better performance.
- Fall incidence [Through study completion, an average of 1 year]
Monthly telephone interviews for recording fall incidence
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Diagnosis of stroke confirmed by brain scan reports
-
Community-living
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Stroke onset ≥ 6 months
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Aged 50 years or older
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Modified Rankin scale 1-3
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Capable of following verbal instructions
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Montreal Cognitive Assessment score ≥ 22
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Ability to walk for 1 min independently with or without a walking aid
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Not receiving formal rehabilitation elsewhere
Exclusion Criteria:
-
Other neurological disorders
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Pain or other comorbidities that seriously affect the ability to walk
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Contraindications to exercise (e.g., angina).
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | The Hong Kong Polytechnic University | Hong Kong | Hong Kong | 000000 |
Sponsors and Collaborators
- The Hong Kong Polytechnic University
- Research Grants Council, Hong Kong
Investigators
- Principal Investigator: Marco Yiu Chung PANG, PhD, The Hong Kong Polytechnic University
- Study Director: Xun LI, MSc, The Hong Kong Polytechnic University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- P0037680