LAACS-2: Left Atrium Appendage Closure by Surgery-2

Sponsor

Helena DOMINGUEZ (Other)

Overall Status

Recruiting

CT.gov ID

NCT03724318

Collaborator

Rigshospitalet, Denmark (Other), Aarhus University Hospital Skejby (Other), Vall d'Hebron Barcelona Hospital Campus (Other), Sahlgrenska University Hospital, Sweden (Other)

1,500

Enrollment

Locations

Arms

91.5

Anticipated Duration (Months)

375

Patients Per Site

4.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Atrial fibrillation is a heart rhythm disorder that often occurs after heart surgery. During atrial fibrillation blood cloths may form, predominantly in the left atrial appendage, a small sac in the wall of the left side of the heart. Some heart surgeons close this appendage to protect against stroke, particularly in patients with a history of atrial fibrillation, yet there is little evidence to support the efficacy and safety of this practice.

We therefore conducted the Left Atrial Appendage Closure by Surgery (LAACS) study (2010-2016) were patients in whom the appendage was closed (by chance) suffered fewer brain damages that patients where it remained open. Although encouraging, these results were not only based on strokes, but also on scars without symptoms found in brain scans. The following LAACS-2 study will include a sufficient number of patients to determine whether future guidelines should advise to close systematically the left atrium appendage during a heart operation.

Condition or Disease	Intervention/Treatment	Phase
Stroke, Ischemic Atrial Fibrillation	Procedure: closure of the left atrium appendage	N/A

Detailed Description

Aim:

The overall aim of the project is to provide lifelong protection against brain damage related to atrial fibrillation, to patients who undergo open heart surgery.

Background:

Formation of thrombi in the left atrium appendage (LAA) during atrial Fibrillation (AF) can provoke strokes, 1-3 that can be efficiently prevented with anti-coagulant medicines. 4. Nevertheless AF that occurs after heart surgery is considered a phenomenon rather than a definite diagnosis, and systematic use of anti-coagulation is not recommended. 5,6 Nevertheless, such post-operative AF carries a substantial detrimental prognosis. 7-12 This is important since post-operative AF occurs in about 35% of patients after coronary by-pass (CABG) and up to 50% after mitral valve surgery. 11,13,14 The investigators hypothesis is that systematic closure of the LAA, in addition to planned open-heart surgery, can reduce cerebral embolisms derived from thrombus formation in the left atrium. The investigators performed the LAACS study (clinicaltrial.gov NCT02378116) to test this hypothesis, which is the first randomized study that shows a protective effect of closure of the LAA during surgery, against ischemic damage of the brain, a question that has eagerly been sought in the scientific community. 1-3 The results of the LAACS trial demonstrate a benefit including clinical significant stroke and silent infarctions, 15 with 5 (5%) primary events in the LAACS-group and 14 (16%) in the control group (Hazard ratio 0.3; 95% CI: 0.1-0.8, p=0.02). Nevertheless, a limited number of patients were randomized in LAACS (N 187) of whom 141 followed the procedure. Expectedly, differences on stroke were not significant. Hence, although encouraging, results should be proven in a larger trial, before a systematic closure of the LAA can be recommended as a routine procedure during open-heart surgery. The main purpose of LAACS2 is to provide evidence to support or not such procedure.

Methods:

The target population is that of patients older than 18 years, that await their first-time open-heart surgery. The investigators design the project as an open, parallel study where patients will be randomized to closure of the LAA, in addition to planned open heart surgery. The LAA will remain open in the control group.

Inclusion and randomization:

Patients are identified among referrals for thoracic surgery in the respective departments and will receive written information and contacted by telephone prior to their admission. Both, patients with and without previous diagnosis of AF will be invited to participate. For inclusion and exclusion criteria (see 'eligibility').

Since use of anti-coagulants provides protection against thrombus formation, the patients will be stratified by ongoing use of anti-coagulant medications, which includes patients with planned mechanic valve replacement, in blocks of 16 patients randomized 1:1 in each strata.

Beyond closure of the LAA or control, patients will be managed according to general practice, without restrictions on the preferred use of medications for rhythm control, or conversion procedures.

Method of LAA closure:

The LAACS procedure is routinely conducted on patients undergoing per-operative ablation for AF during CABG and valve operations. Nevertheless, insufficient closure of the LAA is of major concern, as an incomplete closure may even be harming3. Accordingly, experimental 16,17 and clinical studies 18,19 support the efficacy of closure of the LAA with a clip device rather than a single suture 2,19,20. Pre-clinic studies using the AtriClip device have complete occlusion, at least, for the first 90 days following the procedure 18,21. Therefore, the standard procedure for LAA closure in the LAACS 2 trial is using AtriClip devices (AtriCure Inc., West Chester, Ohio, USA).

Tissue, blood and urine samples:

During operation, a biopsy from the right atrial appendage (approximately 3 g) is taken from all patients, and from the LAA (approximately 1 g) if patients are ungoing LAACS. Furthermore, approximately 15 mL of venous blood and 30 mL of urine is drawn during surgery.

All samples are immediately frozen in liquid nitrogen and transported on dry ice to a -80 °C freezer. Samples will be analyzed when the last sample has been drawn.

Follow-up:

The participants will be followed for at least two years, until the end of the study. Follow-up is based on yearly contact with the patients' hospital records and telephone contact, if medical records are not available.

The first 10 participants in each site will be invited to participate in an imaging study, one year after the operation, to assess the quality of the closure. Imaging will be esophagus echocardiography or a computed tomography scan, according to the imaging facilities available in the site.

All patients with AF onset after the operation, before discharge, were there has not been recorded recurrence of AF by the end of the first year of follow-up will be invited to participate in long-term continuous ambulatory heart-rhythm monitoring (Holter for at least seven days).

Patients may decline to participate in the additional imaging and Holter monitoring and remain in the study for follow-up.

The first 10 patients in each site will be invited to participate in an imaging study, one year after the operation, to assess the quality of the closure. Imaging will be esophagus echocardiography or a computed tomography scan, according to the imaging facilities available in the site.

Patients may decline to participate in the additional imaging and Holter monitoring and remain in the study for follow-up.

Definition of AF and recurrence of AF:

AF onset in the days following the operation, until discharge, detected in clinical settings are considered as "per-operative AF". Recurrence of AF detected during the first three months following the operation are considered "early recurrence" and recurrence beyond three months after the operation detected in clinical settings are considered "late recurrence". In patients undergoing Holter monitoring in the study, occurrence of AF for 30 seconds or longer will be considered diagnostic for AF recurrence.

Power calculation for primary endpoint stroke and minor stroke (transitory cerebral ischemia):

Stroke has an incidence of 1-5% in the years following heart surgery 7,22-24. Chang et al. pooled data from studies comparing outcomes after PCI and CABG (from the SYNTAX, BEST and PRECOMBAT trials), which provides an estimate of 3,7% incidence of stroke in the first three years following coronary by-pass operations25. In the LAACS study, after a mean follow-up of 3,6 years after first-time heart surgery, the investigators found an incidence of 3.2% of stroke (3 of n 64) in patients who underwent surgical closure of the LAA, while in control patients in whom LAA remained open, there was 11.3% (8 in n 77) incidence of stroke, which is a 75% reduction. To achieve a corresponding reduction in the LAACS trial, with a significance level of 0.05 and 90% power, over three years, it would be necessary to include 600 patients in each group. If the occurrence of stroke is equivalent to the poled data on CABG, that is 3,7%, and based on the effect of surgical closure of the LAA in LAACS, one can expect a benefit of a 4,2% absolute reduction of stroke after 3 years follow-up. With a significance level of 0.05 and a 90% power, it is necessary to include 1200-1400 patients (calculated manually and using web calculators www.biomath.info/power/chsq.htm , www.dssresearch.com and www.optimizely.com ) Finally, to counter potential cross-over cases, the investigators plan to include 2000 patients.

Power calculation for secondary combined endpoint of stroke, minor stroke or findings of silent brain infarctions (SBI):

According to data from the Framingham offspring study, AF increases odds for SBI by OR 2.16, 26 and the prevalence of SBI among cardiac patients without previously recognized stroke has been found between 89% and 92% (for paroxysmal and persistent AF, respectively), compared to 46% in patients without AF. 27,which predicts future strokes.28,29.

Furthermore, AF is strongly associated to findings of SBI on patients with mechanic valve thrombosis (OR 5,6, 95% CI 1,32-23,87). 30 Short after surgery, SBI are present in magnetic resonance imaging (MRI) scans on 20-30% of patients one month after CABG,31,32 while it increases to 50-70 % four months after a mitral valve operation.33 Nevertheless, while there are many possible causes for SBI immediately after the operation, AF will be more likely to be the primary cause in the subsequent years. 26 Accordingly, among patients with type 2 diabetes (which is known to have an equivalent for cardiovascular events as those with diagnosed cardiovascular disease, 34 MRI revealed SBI in 61% with AF, compared with 29% without AF.29 Based on these data, the investigators assume that AF will be responsible for a combination SBI and stroke SBI in the LAACS2 control population, and that it will be possible to demonstrate a 12% reduction among those undergoing the LAACS procedure, including 35 patients in each group, with a 90% power and a 0.05 significance level.

Power calculation for harm of the LAACS procedure:

Incomplete LAA closure may render a more thrombogenic surface than the innate LAA surface.2,19,20 The relative risk for stroke related to incomplete LAA closure has been estimated between 10 to 25% compared to those with complete LAA closure.13,35 Accordingly, the investigators can evaluate whether an equivalent problem occurs in the LAACS2, including between 359 to 1455 patients in the LAACS2 study, with a 90% power and a 0.05 significance level. Hence, the 2000 patients the investigators plan to include, as calculated for the primary endpoint should suffice to evaluate a possible harm of the procedure.

Study Design

Study Type:

Interventional

Anticipated Enrollment :

1500 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Intervention Model Description:

Open-label, parallel, randomized, control trialOpen-label, parallel, randomized, control trial

Masking:

None (Open Label)

Primary Purpose:

Prevention

Official Title:

Left Atrium Appendage Closure by Surgery-2

Actual Study Start Date :

Mar 17, 2019

Anticipated Primary Completion Date :

Oct 31, 2025

Anticipated Study Completion Date :

Oct 31, 2026

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: Closure Patients randomized to the active Group will undergo closure of the left atrium appendage during Heart surgery by means of commercial clips	Procedure: closure of the left atrium appendage closure of the left atrium appendage in addition to the planned Heart operation
No Intervention: Control The left atrium appendage will remain open in patients randomized to the control group

Arm

Intervention/Treatment

Active Comparator: Closure

Patients randomized to the active Group will undergo closure of the left atrium appendage during Heart surgery by means of commercial clips

Procedure: closure of the left atrium appendage

closure of the left atrium appendage in addition to the planned Heart operation

No Intervention: Control

The left atrium appendage will remain open in patients randomized to the control group

Outcome Measures

Primary Outcome Measures

Number of participants with Stroke occurrence including Transitory cerebral ischemia (TCI) [at least two years, until end of follow-up]
Stroke is an acute episode of focal dysfunction of the brain, retina, or spinal cord lasting longer than 24 h, or of any duration if imaging (CT or MRI) or autopsy show focal infarction relevant to the symptoms. Transitory cerebral ischemia is defined as above, but with symptoms lasting less than 24 h. Endpoints will be assigned by two independent neurologists, who are blinded to what procedure the patient undergo. In case of discrepancy, the events will be assigned by consensus.

Secondary Outcome Measures

Combined end-point of Stroke, TCI or Silent brain infarction [at least two years, until end of follow-up]
Stroke and TCI as above. Silent Brain infarctions described by radiologists as fresh infarctions found in clinical settings with CT-scans or brain-MRI scans
Number of participants who die [at least two years, until end of follow-up]
Death of any cause

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Patients referred for planned first-time heart surgery:
Coronary artery by-pass surgery (CABG)
Valve surgery
Combined CABG and valve surgery

Exclusion Criteria:

Endocarditis
No possible follow-up
Planned closure of the left atrium appendage as part of surgery

Contacts and Locations

Locations

	Site	City	Country
1	Aarhus University Hospital Skejby	Aarhus	Denmark
2	Rigshospitalet	Copenhagen	Denmark
3	Hospital Universitario Vall d'Hebron	Barcelona	Spain
4	Sahlgrenska University Hospital	Göteborg	Sweden