A Study on Brain Activity During Transcranial Direct Current Stimulation in Stroke Patients

Sponsor
Samsung Medical Center (Other)
Overall Status
Completed
CT.gov ID
NCT04549753
Collaborator
(none)
30
1
1
2.8
10.6

Study Details

Study Description

Brief Summary

The purpose of this study is to identify the characteristics of neural plasticity seen in stroke patients by measuring the changes in brain activity during stimulation using functional near-infrared spectroscopy (fNIRS) when applying transcranial direct current stimulation (tDCS) for the purpose of enhancing finger function.

Condition or Disease Intervention/Treatment Phase
  • Device: Transcranial direct current simulation
N/A

Study Design

Study Type:
Interventional
Actual Enrollment :
30 participants
Allocation:
N/A
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
A Study on Brain Activity During Transcranial Direct Current Stimulation for Improving Finger-Hand Function in Stroke Patients
Actual Study Start Date :
Sep 15, 2020
Actual Primary Completion Date :
Dec 10, 2020
Actual Study Completion Date :
Dec 10, 2020

Arms and Interventions

Arm Intervention/Treatment
Experimental: tDCS stimulation group

Patients receive four sessions of tDCS stimulation over C3 (patient with left-sided lesion) or C4 (patient with right-sided lesion) based on 10-20 system.

Device: Transcranial direct current simulation
Four sessions of stimulation over C3 (patient with left-sided lesion) or C4 (patient with right-sided lesion) based on 10-20 system

Outcome Measures

Primary Outcome Measures

  1. Changes in cortical activity using fNIRS signals during brain stimulation [Baseline and about 10 days (immediately after brain stimulation sessions)]

    Cortical activities before and after brain stimulation sessions are compared.

Secondary Outcome Measures

  1. Changes in motor evoked potential [Baseline and about 10 days (immediately after brain stimulation sessions)]

    Resting motor threshold (rMT) and amplitude of motor evoked potential in first dorsal interosseous muscle are measured. These outcomes are measured by transcranial magnetic stimulation over the motor hotspot. The rMT is defined as the minimum stimulus intensity that produced a minimal motor evoked response at rest. The amplitude means peak to peak of the muscle response.

  2. 9-hole pegboard test [Baseline and about 10 days (immediately after brain stimulation sessions)]

    The test is a standardized, quantitative assessment used to measure finger dexterity of a patient.

  3. Grip & Tip pinch strength test [Baseline and about 10 days (immediately after brain stimulation sessions)]

    The test is to measure the maximum isometric strength of hand, forearm, and finger muscles.

  4. Box & Block test [Baseline and about 10 days (immediately after brain stimulation sessions)]

    The test is used to measure the gross manual dexterity of a patient, or of a person using an upper limb prosthetic device.

  5. Fugl-Meyer Assessment [Baseline and about 10 days (immediately after brain stimulation sessions)]

    The score is a stroke-specific, performance-based impairment index. The degree of impairment of upper and lower limbs is measured.

  6. Finger tapping test [Baseline and about 10 days (immediately after brain stimulation sessions)]

    Response time is measured during finger tapping task.

Eligibility Criteria

Criteria

Ages Eligible for Study:
19 Years to 80 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  • Unilateral stroke patients

  • Chronic patients over 6 months after onset

  • Subcortical stroke

  • Patients with the movement of fingers

Exclusion Criteria:
  • History of psychiatric disease

  • Significant other neurological diseases except for stroke

  • Difficult to perform this experiment

  • Patients with metal implants

  • History of epilepsy

  • Pregnancy

  • Skin defect at the site of electrode attachment

Contacts and Locations

Locations

Site City State Country Postal Code
1 Samsung Medical Center Seoul Korea, Republic of 06351

Sponsors and Collaborators

  • Samsung Medical Center

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Samsung Medical Center
ClinicalTrials.gov Identifier:
NCT04549753
Other Study ID Numbers:
  • 2020-04-183
First Posted:
Sep 16, 2020
Last Update Posted:
Mar 10, 2021
Last Verified:
Sep 1, 2020
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of Mar 10, 2021