Cogmos: Cognitive-motor Training Post-stroke - a Pilot Randomized Controlled Trial
Study Details
Study Description
Brief Summary
Stroke is a leading and growing cause of long-term adult disability. Up to 80% of stroke patients have impaired manual dexterity reducing their independence, return to work and quality of life. Cognitive impairment is also common after stroke and growing evidence suggests a cognitive-motor interdependence with relevance for motor recovery. Previous studies show increased cognitive-motor interference (measured in dual-task) in stroke patients and that combining motor and cognitive task training (in a dual-task) may improve motor function above that achieved by single-task training. This project addresses post-stroke dexterity impairment and its relation to dual-task interference, i.e., the decrease in motor performance when performing a concurrent cognitive task. The overall goal is to provide a proof-of-concept for a dual-task interference training protocol post-stroke. We aim to establish therapeutic efficacy of dual-task vs single-task dexterity training in chronic stroke patients.Single-task training involves visuomotor finger force tracking and dual-task has an additional cognitive components including visual distraction and working memory. Training will be done 4 days/week over four weeks (total 16 sessions). Each session will include 20 mins of conventional therapy (stretching, functional exercises) followed by 40 mins motor task training (either single or dual task). This pilot randomized clinical trial will include 40 stroke patients (> 6 months after stroke). Repeated clinical and fine-grained motor measurements will be obtained pre and post intervention and at 3 months follow-up.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: Single-task Visuomotor training |
Behavioral: Visuomotor force control training
Single-task training involves visuomotor finger force tracking and dual-task has an additional cognitive components including visual distraction and working memory.
|
| Experimental: Dual-task Visuomotor + cognitive components training |
Behavioral: Visuomotor force control training
Single-task training involves visuomotor finger force tracking and dual-task has an additional cognitive components including visual distraction and working memory.
|
Outcome Measures
Primary Outcome Measures
- Fugl-Meyer Assessment change (FMA change) [At baseline and at 3 to assess change.]
Assesses sensory and movement related functions in the upper extremity (0 points max impairment summed up to 66 points max no detected impairment)
Secondary Outcome Measures
- Box and Block change (BBT change) [At baseline and at 3 to assess change.]
Assesses gross dexterity by timing how many blocks can be grasped and displaced in one minute (measured as blocks/min)
- Logical reasoning change (WAIS IV matrices change) [At baseline and at 3 to assess change.]
Assesses intelligence through four composite socres: verbal comprehension, perceptual reasoning, working memory and processing speed (scored from 45 to 155).
- Attention change (D-KEFS trail making test 1-5) [[At baseline and at 3 to assess change.]
Trail making test assesses attention capacites in five conditions: visual scanning, number sequencing, letter sequencing, number-letter sequencing, and motor speed (the speed of each condition is noted in seconds, max 150seconds).
- Executive function change (D-KEFS FAS, D-KEFS tower) [At baseline and at 3 to assess change.]
Assesses executive function capacities such as spatial planning, rule learning, inhibition of impulsive responding, inhibition of perseverative responding, and establishing and maintaining instructional set. Scoring: raw scores are converted to scaled scores through established age and gender normative data, Mean=10, standard deviation=3).
Eligibility Criteria
Criteria
Inclusion Criteria:
-
adults with clinical diagnosis of stroke and history of upper limb hemiparesis. Arm and hand paresis is defined as weakness according to Manual Muscle Testing (score less than 4/5 in one upper limb muscles)
-
reported difficulty in opening/closing of hand or difficulty in using the hand in daily activities
Exclusion Criteria:
-
inability to grasp and displace an object (minimum score of 1 on Box and Block Test, BBT)
-
impaired cognition (MOCA score <23)
-
cerebellar stroke
-
aphasia disturbing communication and understanding of training task
-
neglect interfering with ability to see task on screen
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Danderyd Hospital, Division of Rehabilitation Medicine, Dept. of Clinical Sciences, Karolinska Institutet | Stockholm | Danderyd | Sweden | S18288 |
| 2 | Department of Rehabilitation Medicine, Danderyd Hospital | Danderyd | Stockholm | Sweden | SE-18288 |
Sponsors and Collaborators
- Danderyd Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- COGMOS-pilotRCT