Laryngeal Adaptation for Speech and Swallowing
Study Details
Study Description
Brief Summary
This study will test laryngeal adaptation in speech and swallowing function in healthy adults, in patients with cerebral stroke, and in patients with spinocerebellar ataxia type 6. The findings from this proposal will be the first step toward implementing rehabilitation techniques that help patients to prevent speech and swallowing errors before they occur.
Condition or Disease | Intervention/Treatment | Phase |
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|
N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: Stroke without Dysarthria Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm. |
Device: Intermittent Perturbation to Continuous Perturbation
Manipulate the Movement Planning Period (MPP), by interrupting sensory predictions by removing e-stim during the inter-trial interval (Intermittent Perturbation), followed by a washout/de-adaptation period.
Other Names:
Device: Continuous Perturbation to Intermittent Perturbation
Manipulate the Movement Planning Period (MPP), by keep sensory input about the perturbation constant by maintaining e-stim during the inter-trial interval.
Other Names:
|
Experimental: Stroke with Dysarthria Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm. |
Device: Intermittent Perturbation to Continuous Perturbation
Manipulate the Movement Planning Period (MPP), by interrupting sensory predictions by removing e-stim during the inter-trial interval (Intermittent Perturbation), followed by a washout/de-adaptation period.
Other Names:
Device: Continuous Perturbation to Intermittent Perturbation
Manipulate the Movement Planning Period (MPP), by keep sensory input about the perturbation constant by maintaining e-stim during the inter-trial interval.
Other Names:
|
Experimental: SCA6 without Dysarthria Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm. |
Device: Intermittent Perturbation to Continuous Perturbation
Manipulate the Movement Planning Period (MPP), by interrupting sensory predictions by removing e-stim during the inter-trial interval (Intermittent Perturbation), followed by a washout/de-adaptation period.
Other Names:
Device: Continuous Perturbation to Intermittent Perturbation
Manipulate the Movement Planning Period (MPP), by keep sensory input about the perturbation constant by maintaining e-stim during the inter-trial interval.
Other Names:
|
Experimental: SCA6 with Dysarthria Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm. |
Device: Intermittent Perturbation to Continuous Perturbation
Manipulate the Movement Planning Period (MPP), by interrupting sensory predictions by removing e-stim during the inter-trial interval (Intermittent Perturbation), followed by a washout/de-adaptation period.
Other Names:
Device: Continuous Perturbation to Intermittent Perturbation
Manipulate the Movement Planning Period (MPP), by keep sensory input about the perturbation constant by maintaining e-stim during the inter-trial interval.
Other Names:
|
Active Comparator: Age-Matched Controls Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm. |
Device: Intermittent Perturbation to Continuous Perturbation
Manipulate the Movement Planning Period (MPP), by interrupting sensory predictions by removing e-stim during the inter-trial interval (Intermittent Perturbation), followed by a washout/de-adaptation period.
Other Names:
Device: Continuous Perturbation to Intermittent Perturbation
Manipulate the Movement Planning Period (MPP), by keep sensory input about the perturbation constant by maintaining e-stim during the inter-trial interval.
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Laryngeal Adaptation in Speech [Day 1]
To differentiate laryngeal adaptation during speech among cerebral stroke, SCA6, and healthy controls when vocal loudness is perturbed with expiratory loading.
- Laryngeal Adaptation in Swallowing [Day 1]
To differentiate laryngeal adaptation among cerebral stroke, SCA6, and healthy controls when swallowing is perturbed with neck surface electrical stimulation to restrict laryngeal elevation.
Eligibility Criteria
Criteria
Patient Inclusion Criteria:
All stroke and ataxia
Ataxia
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DNA diagnosis of SCA6 and phenotype consistent with the DNA diagnosis
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No recessive, X-linked or mitochondrial
Stroke
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Bilateral or unilateral middle cerebral artery (MCA) stroke
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No structural abnormalities (i.e. nodules)
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Dysphagia involving laryngeal dysfunction
Stroke and ataxia with speech and swallowing disorders
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no structural abnormalities
-
dysphagia involving laryngeal dysfunction
Patient Exclusion Criteria:
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Montreal Cognitive Assess. <24
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Moderate to severe hearing loss
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Barium allergy
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Other confounding speech disorder (i.e. stuttering)
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Chemo-radiation, surgical head and neck treatment
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Smoking Hx in the past 5 yrs or >5 years at any one time
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Twenty one years of age or older
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Breathing disorders or diseases
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- University of Florida
- National Institute on Deafness and Other Communication Disorders (NIDCD)
- National Institutes of Health (NIH)
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- IRB201702917 -A
- R01DC016275-01A1
- OCR19032
- 5R01DC016275-02