CON-INSULA: Structural Cartography of the Insula in Temporal Epilepsy Patients
Study Details
Study Description
Brief Summary
The purpose of this study is to investigate insula structural connectivity in temporal epilepsy patients. Insula being at the interface of frontal, parietal, occipital and temporal lobes, its structural organization reflects the brain function. We hypothetize that insular structural organization will be different according to the different subtypes of temporal epilepsy.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
The purpose of this study is to investigate insula structural connectivity in temporal epilepsy patients. Insula being at the interface of frontal, parietal, occipital and temporal lobes, its structural organization reflects the brain function. We hypothetize that insular structural organization will be different according to the different subtypes of temporal epilepsy.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| mesio-temporal epilepsy patients suffering from mesiotemporal epilepsy type |
Other: MRI
structural imaging
|
| basal temporal epilepsy patients suffering from basal temporal epilepsy type |
Other: MRI
structural imaging
|
| temporal lateral epilepsy patients suffering from temporal lateral epilepsy type |
Other: MRI
structural imaging
|
| operculo insular epilepsy patients suffering from operculo insular epilepsy type |
Other: MRI
structural imaging
|
| temporo-insular epilepsy patients suffering from temporo- insular epilepsy type |
Other: MRI
structural imaging
|
| healthy subjects non epileptic patients |
Other: MRI
structural imaging
|
Outcome Measures
Primary Outcome Measures
- cartography of insula in temporal epilepsy patients [1 year after the last inclusion]
Compared with healthy group, definition of different patterns of insular structural connectivity in epileptic patients
Secondary Outcome Measures
- Correlation structural cartography and electroclinical data [1 year after the last inclusion]
correlation between patterns of insular structural connectivity and subtypes of epilepsy defined by electroclinical data
Eligibility Criteria
Criteria
Inclusion Criteria:
-
epileptic patients: temporal epilepsy or temporal plus epilepsy (temporomesial epilepsy, basal temporal epilepsy, mesio lateral or lateral epilepsy, temporo insular epilepsy, operculo insular epilepsy)
-
patients who underwent video EEG monitoring with recorded seizures (at least one)
-
patients who underwent a brain MRI with DTI sequence before epilepsy surgery
-
patients who did not refuse the use of their clinical and MRI data for this study
Exclusion Criteria:
-
patients younger than 15 years old
-
patients with previous brain surgery (before MRI)
-
uncompleted MRI sequences (DTI, T1 anatomical)
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Central Hospital nancy | Nancy | France | 54000 |
Sponsors and Collaborators
- Central Hospital, Nancy, France
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal
- University Hospital, Lille
- Hospices Civils de Lyon
Investigators
- Principal Investigator: Louise Tyvaert, MD PHD, CHRU Nancy, CRAN UMR 7039 Université de Lorraine
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2020PI218