Thyroxin in Subclinical Hypothyroidism
Subclinical hypothyroidism(SCH) is the elevated thyroid stimulating hormone (TSH) with normal free Thyroxine levels and it is a mild or compensated form of primary hypothyroidism. It has been suggested that SCH is more prevalent in infertile women (especially in women with ovulatory disorders.Various rates of SCH was reported in infertile women in different populations
|Condition or Disease||Intervention/Treatment||Phase|
Despite well-established recommendations on screening and treatment of overt hypothyroid in infertile women, there is a controversy regard the treatment of SCH in infertile women .
There are few published data on the prevalence of SCH and the outcome of treatment of SCH in infertile women, many were conducted during IVF cycles . Moreover there are inconsistent results in these studies being authors advised to treat SCH before IVF and some other articles find out no any benefit regarding treatment with Thyroxine in SCH
Arms and Interventions
|Experimental: Sub clinical hypothyroid women
Levothyroxine sodium(Euthyrox 50µg and 25 µg MerckSerono) treatment was initiated and the women were followed in a combined clinic of endocrinologist and Gynecologist. 2.5 µg of Thyroxine daily was prescribed to women with TSH more than 2.5 mIU/L. Women with TSH more than 4mIU/L were given 50 µg daily . When pregnancy was confirmed Thyroxine was continued till 13 weeks gestation .
Thyroxine was prescribed with the diagnosis of SCH and continued when pregnancy was confirmed
Primary Outcome Measures
- Pregnancy [2 years]
Pregnancy was confirmed using human chorionic gonadotropin hormone (hCG) estimation from blood
Secondary Outcome Measures
- Miscarriage rate [13 weeks]
viability and growth of embryos were confirmed by ultrasound
TSH more than 2.5 and normal T3,T4 levels
Negative for Anti-thyroid antibodies
current history of overt hypo or hyperthyroidism
recurrent pregnancy loss
women having franked causes for infertility like tubal blockage, pelvic inflammatory disease, endometriosis , ,uterine factor
Ovarian dysfunction or decreased ovarian reserve
abnormal seminal fluid analysis or male factor
Contacts and Locations
LocationsNo locations specified.
Sponsors and Collaborators
- Hawler Medical University
- Principal Investigator: Ariana Kh. Jawad, CABOG, Hawler Medical University
Study Documents (Full-Text)None provided.