The Suitability of Sniff Dog as a Tool in Screening Tumors
Study Details
Study Description
Brief Summary
Previous studies have demonstrated that sniff dogs can identify cancer patients from healthy subjects through sniffing exhaled breath air or blood or serum or urine or feces. It is hypothesized that sniff dogs may be used as a tool in screening cancer patients in health examination. Trained dogs will sniff serum from participants who are attending the annual health examination to identify potential or high risk subjects, and the results will be compared with the outcome of the traditional health examination, and the high risk subjects will be followed periodically for at least five years.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| faculty staff and their adult family members faculties and their adult family members of the Third Xiang-Ya Hospital |
Outcome Measures
Primary Outcome Measures
- Sensitivity and specificity in screening cancer patients [up to 5 years]
The results that obtained from the dogs will be compared with these of the pathological examinations. Sensitivity = the No. of patients identified by the dogs as cancers / the No. of patients suffering from cancer confirmed by pathological examination. Specificity = No. of subjects signaled by the dog as non-cancers / No. of subjects confirmed by pathological examination or the currently used methods as non-cancer subjects or at the end of the study, 5 years later still without cancer.
Secondary Outcome Measures
- Behavior patterns of sniff dogs to different diseases [up to 5 years]
The behavior (lying before the tank for positive, neglecting the tanks) of the dog will be recorded and compared with the results of the pathological examination.
Other Outcome Measures
- The substances used by the sniff dogs to identifying tumors [up to 5 years]
GCMS etc will be used to compare the volatile compounds between the sera from cancers patients and the from normal subjects, the suspected VOCs will be tested by the dog for conformation.
Eligibility Criteria
Criteria
Inclusion Criteria:
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old than 20 years
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currently without cancer diagnosed with pathological examination
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allow the study team to examine his/her case history and incoming record
Exclusion Criteria:
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cancer patients with pathological diagnosis
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who does not allow the study team to examine his/her case history and incoming record
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | The Third Xiang-Ya Hospital | Changsha | Hunan | China | 410013 |
Sponsors and Collaborators
- Chang-Qing Gao
Investigators
- Principal Investigator: Chang-Qing Gao, MD PhD, Central South University
Study Documents (Full-Text)
None provided.More Information
Publications
- Church J, Williams H. Another sniffer dog for the clinic? Lancet. 2001 Sep 15;358(9285):930.
- Ehmann R, Boedeker E, Friedrich U, Sagert J, Dippon J, Friedel G, Walles T. Canine scent detection in the diagnosis of lung cancer: revisiting a puzzling phenomenon. Eur Respir J. 2012 Mar;39(3):669-76. doi: 10.1183/09031936.00051711. Epub 2011 Aug 18.
- Horvath G, Järverud GA, Järverud S, Horváth I. Human ovarian carcinomas detected by specific odor. Integr Cancer Ther. 2008 Jun;7(2):76-80. doi: 10.1177/1534735408319058. Epub 2008 May 27.
- McCulloch M, Jezierski T, Broffman M, Hubbard A, Turner K, Janecki T. Diagnostic accuracy of canine scent detection in early- and late-stage lung and breast cancers. Integr Cancer Ther. 2006 Mar;5(1):30-9.
- Willis CM, Church SM, Guest CM, Cook WA, McCarthy N, Bransbury AJ, Church MR, Church JC. Olfactory detection of human bladder cancer by dogs: proof of principle study. BMJ. 2004 Sep 25;329(7468):712.
- Xiang-Ya 0001