Sodium Bicarbonate Supplementation in Athletes

Sponsor

Poznan University of Life Sciences (Other)

Overall Status

Completed

CT.gov ID

NCT03165357

Collaborator

Poznan University of PhysED (Other)

Enrollment

Location

Arms

5.8

Actual Duration (Months)

4.4

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study was to verify the effect of 10-day sodium bicarbonate (NaHCO3) and placebo (PLA) supplementation on body composition, physical capacity, as well as concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.

Condition or Disease	Intervention/Treatment	Phase
Supplementation Sport	Dietary Supplement: Sodium bicarbonate supplementation Dietary Supplement: Placebo treatment	Phase 3

Detailed Description

Sodium bicarbonate (NaHCO3) was proposed as an ergogenic agent, because it improves high-intensity and resistance exercise performance. Until now the major limitation to NaHCO3 supplementation has been the gastrointestinal (GI) side effects. Therefore, this study aims to examine the effect of chronic, progressive- dose NaHCO3 ingestion on physical capacity, body composition and concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.

Study Design

Study Type:

Interventional

Actual Enrollment :

26 participants

Allocation:

Randomized

Intervention Model:

Crossover Assignment

Masking:

Triple (Participant, Investigator, Outcomes Assessor)

Primary Purpose:

Treatment

Official Title:

The Effect of Sodium Bicarbonate Supplementation on Physical Capacity and Body Composition in Trained Athletes

Actual Study Start Date :

Oct 10, 2015

Actual Primary Completion Date :

Mar 10, 2016

Actual Study Completion Date :

Apr 5, 2016

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Sodium bicarbonate Group taking oral NaHCO3 supplementation in a progressive-dose regimen. Interventions: The experimental procedure for each athlete included a 10-day NaHCO3 supplementation in a progressive-dose regimen in order to reduce the likelihood of gastrointestinal side effects (from 37.5 to 150 mg ∙ kg-1). NaHCO3 was administered in the form of unmarked disk-shaped tablets (Alkala T, SANUM, Poland). The tablets were ingested with at least 250 mL of water and could be either swallowed or dissolved in the mouth. On training days the supplements were taken in the morning, in the evening and 1.5 hours before training session. On rest days the supplements were taken in the morning, in the afternoon and in the evening. Between the 10-day NaHCO3 and PLA or a PLA and NaHCO3 treatments, a 14-day washout period was introduced.	Dietary Supplement: Sodium bicarbonate supplementation
Placebo Comparator: Placebo (maltodextrin) Group taking oral supplementation with placebo (maltodextrin). Interventions: The experimental procedure for each athlete included a 10-day placebo administration. Placebo was ingested with at least 250 mL of water. On training days the supplements were taken in the morning, in the evening and 1.5 hours before training session. On rest days the supplements were taken in the morning, in the afternoon and in the evening. Between the 10-day NaHCO3 and PLA or a PLA and NaHCO3 treatments, a 14-day washout period was introduced.	Dietary Supplement: Placebo treatment

Arm

Intervention/Treatment

Experimental: Sodium bicarbonate

Group taking oral NaHCO3 supplementation in a progressive-dose regimen. Interventions: The experimental procedure for each athlete included a 10-day NaHCO3 supplementation in a progressive-dose regimen in order to reduce the likelihood of gastrointestinal side effects (from 37.5 to 150 mg ∙ kg-1). NaHCO3 was administered in the form of unmarked disk-shaped tablets (Alkala T, SANUM, Poland). The tablets were ingested with at least 250 mL of water and could be either swallowed or dissolved in the mouth. On training days the supplements were taken in the morning, in the evening and 1.5 hours before training session. On rest days the supplements were taken in the morning, in the afternoon and in the evening. Between the 10-day NaHCO3 and PLA or a PLA and NaHCO3 treatments, a 14-day washout period was introduced.

Dietary Supplement: Sodium bicarbonate supplementation

Placebo Comparator: Placebo (maltodextrin)

Group taking oral supplementation with placebo (maltodextrin). Interventions: The experimental procedure for each athlete included a 10-day placebo administration. Placebo was ingested with at least 250 mL of water. On training days the supplements were taken in the morning, in the evening and 1.5 hours before training session. On rest days the supplements were taken in the morning, in the afternoon and in the evening. Between the 10-day NaHCO3 and PLA or a PLA and NaHCO3 treatments, a 14-day washout period was introduced.

Dietary Supplement: Placebo treatment

Outcome Measures

Primary Outcome Measures

Changes in aerobic capacity after sodium bicarbonate supplementation [Baseline and after 10 days]
The incremental cycling test (ICT)
Changes in specific performance capacity after sodium bicarbonate supplementation [Baseline and after 10 days]
The CrossFit-specific physical fitness test: Fight Gone Bad (FGB)

Secondary Outcome Measures

Changes in fat mass and fat free mass after sodium bicarbonate supplementation [Baseline and after 10 days]
Fat mass (kg) and fat free mass (kg) analysis
Changes of red and white blood cell concentration in blood after sodium bicarbonate supplementation [Baseline and after 10 days]
Red blood cells (RBC) [mln/mm³] and white blood cells (WBC) [mln/mm³] concentration analysis
Changes in blood glucose and hemoglobin concentration after sodium bicarbonate supplementation [Baseline and after 10 days]
Hemoglobin (Hb) [g/dl] and glucose [g/dl] concentration analysis
Changes in blood hematocrit levels after sodium bicarbonate supplementation [Baseline and after 10 days]
Hematocrit (HCT) [%] level analysis
Changes of lactate and pyruvate concentration in blood after sodium bicarbonate supplementation [Baseline and after 10 days]
Lactate [mmol/L] and pyruvate [mmol/L] concentration analysis
Changes of creatine kinase and lactate dehydrogenase activity in blood after sodium bicarbonate supplementation [Baseline and after 10 days]
Creatine kinase [U/L] and lactate dehydrogenase [U/L] activity analysis

Eligibility Criteria

Criteria

Ages Eligible for Study:

20 Years to 43 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

written consent to participate,
a current medical clearance to practice sports,
training experience: at least 2 years (of CrossFit training),
minimum of 3 workout sessions (CrossFit) a week,
20-43 years.

Exclusion Criteria:

current injury,
any health-related contraindication,
declared general feeling of being unwell,
unwilling to follow the study protocol.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Poznan University of Life Sciences, ul.Wojska Polskiego 31	Poznań	Wielkopolska	Poland	60-624

Sponsors and Collaborators

Poznan University of Life Sciences
Poznan University of PhysED

Investigators

Study Chair: Jan Jeszka, Professor, Department of Hygiene and Human Nutrition, Poznan University of Life Sciences, Poznan, Poland

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Poznan University of Life Sciences

ClinicalTrials.gov Identifier:

NCT03165357

Other Study ID Numbers:

ULS00002

First Posted:

May 24, 2017

Last Update Posted:

May 24, 2017

Last Verified:

May 1, 2017

Individual Participant Data (IPD) Sharing Statement:

Undecided

Plan to Share IPD:

Undecided

Keywords provided by Poznan University of Life Sciences

Crossfit

Sodium bicarbonate

Physical capacity

Study Results

No Results Posted as of May 24, 2017